Artelastin is a cytotoxic prenylated flavone that disturbs microtubules and interferes with DNA replication in MCF-7 human breast cancer cells

Life Sciences

Volumn 77, Issue 3, 2005, Pages 293-311

  Pedro, Madalena ^a   Ferreira, Maria Manuel ^b   Cidade, Honorina ^a   Kijjoa, Anake ^a   Bronze Da Rocha, Elsa ^a,b   Nascimento, Maria São José ^a  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Antitumor effect; Artelastin; DNA replication; MCF 7; Microtubules; Prenylated flavone

Indexed keywords

ARTELASTIN; BROXURIDINE; CYTOSTATIC AGENT; CYTOTOXIC AGENT; FLAVONE DERIVATIVE; NSC 710340; UNCLASSIFIED DRUG;

ARTICLE; ARTOCARPUS ELASTICUS; BARK; BREADFRUIT; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL ACTIVITY; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL METABOLISM; CELL NUCLEUS; CELL STIMULATION; CELL STRAIN MCF 7; CELL STRUCTURE; CELL SYNCHRONIZATION; CELL VACUOLE; CELL VIABILITY; CENTROMERE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; DOSE RESPONSE; DRUG ACCUMULATION; DRUG DETERMINATION; DRUG EFFECT; DRUG ISOLATION; DRUG SCREENING; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MEDICINAL PLANT; MICROTUBULE; NICK END LABELING; OBSERVATION; PHASE TRANSITION; PRENYLATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; FLAVONOIDS; HUMANS; MICROTUBULES; MOLECULAR STRUCTURE; PLANT EXTRACTS;

ARTOCARPUS ELASTICUS; MINK CELL FOCUS-FORMING VIRUS;

EID: 18844428633     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.09.049     Document Type: Article

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