Structure-activity requirements for flavone cytotoxicity and binding to tubulin

Journal of Medicinal Chemistry

Volumn 41, Issue 13, 1998, Pages 2333-2338

  Beutler, John A ^a   Hamel, Ernest ^a   Vlietinck, Arnold J ^a,b   Haemers, Achiel ^a,b   Rajan, Padinchare ^a,b   Roitman, James N ^a,c   Cardellina II, John H ^a   Boyd, Michael R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c WESTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CENTAUREIDIN; CENTAUREIDIN DERIVATIVE; CHALCONE DERIVATIVE; COLCHICINE; DOLASTATIN; EUPATORETIN; FLAVONE DERIVATIVE; GALACTOSULFONE SODIUM; NSC 642321; PACLITAXEL; PODOPHYLLOTOXIN; STILBENE DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOPOLYMERS; CELL SURVIVAL; COLCHICINE; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONOIDS; HUMANS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0032543726     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970842h     Document Type: Article

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