Stabilization of integrin-linked kinase by binding to Hsp90

Biochemical and Biophysical Research Communications

Volumn 331, Issue 4, 2005, Pages 1061-1068

  Aoyagi, Yumiko ^a   Fujita, Naoya ^a   Tsuruo, Takashi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

17 AAG; Cancer; Geldanamycin; Hsp90; ILK

Indexed keywords

17 ALLYLAMINO 17 DEMETHOXYGELDANAMYCIN; AMINO ACID; BETA INTEGRIN; CELL CYCLE PROTEIN 37; GELDANAMYCIN; GROWTH FACTOR RECEPTOR; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; INTEGRIN LINKED KINASE; KF 58333; PROTEASOME; PROTEIN INHIBITOR; PROTEIN SERINE THREONINE KINASE; RADICICOL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DELETION MUTANT; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

ANIMALS; BINDING SITES; COS CELLS; DOWN-REGULATION; HSP90 HEAT-SHOCK PROTEINS; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES;

EID: 18844377152     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.03.225     Document Type: Article

References (34)

1. K.A. Borkovich, F.W. Farrelly, D.B. Finkelstein, J. Taulien, and S. Lindquist hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures Mol. Cell. Biol. 9 1989 3919 3930
2. S. Sato, N. Fujita, and T. Tsuruo Modulation of Akt kinase activity by binding to Hsp90 Proc. Natl. Acad. Sci. USA 97 2000 10832 10837
3. N. Fujita, S. Sato, and T. Tsuruo Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1 J. Biol. Chem. 277 2002 10346 10353
4. T.W. Schulte, M.V. Blagosklonny, C. Ingui, and L. Neckers Disruption of the Raf-1-Hsp90 molecular complex results in destabilization of Raf-1 and loss of Raf-1-Ras association J. Biol. Chem. 270 1995 24585 24588
5. A. Kamal, L. Thao, J. Sensintaffar, L. Zhang, M.F. Boehm, L.C. Fritz, and F.J. Burrows A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors Nature 425 2003 407 410
6. L. Neckers Hsp90 inhibitors as novel cancer chemotherapeutic agents Trends Mol. Med. 8 2002 S55 S61
7. T. Tsuruo, M. Naito, A. Tomida, N. Fujita, T. Mashima, H. Sakamoto, and N. Haga Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal Cancer Sci. 94 2003 15 21
8. L. Neckers, E. Mimnaugh, and T. Schulte Hsp90 as an anti-cancer target Drug Resist. Updates 2 1999 165 172
9. C. Schneider, L. Sepp-Lorenzino, E. Nimmesgern, O. Ouerfelli, S. Danishefsky, N. Rosen, and F.U. Hartl Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90 Proc. Natl. Acad. Sci. USA 93 1996 14536 14541
10. A. Kamal, M.F. Boehm, and F.J. Burrows Therapeutic and diagnostic implications of Hsp90 activation Trends Mol. Med. 10 2004 283 290
11. 1-integrin-linked protein kinase Nature 379 1996 91 96
12. C. Wu The PINCH-ILK-parvin complexes: assembly, functions and regulation Biochim. Biophys. Acta 1692 2004 55 62
13. C. Brakebusch, and R. Fässler The integrin-actin connection, an eternal love affair EMBO J. 22 2003 2324 2333
14. S. Yamaji, A. Suzuki, Y. Sugiyama, Y. Koide, M. Yoshida, H. Kanamori, H. Mohri, S. Ohno, and Y. Ishigatsubo A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction J. Cell Biol. 153 2001 1251 1264
15. Y. Tu, Y. Huang, Y. Zhang, Y. Hua, and C. Wu A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading J. Cell Biol. 153 2001 585 598
16. M. Delcommenne, C. Tan, V. Gray, L. Rue, J. Woodgett, and S. Dedhar Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase Proc. Natl. Acad. Sci. USA 95 1998 11211 11216
17. G. Radeva, T. Petrocelli, E. Behrend, C.L. Hagesteijn, J. Filmus, J. Slingerland, and S. Dedhar Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression J. Biol. Chem. 272 1997 13937 13944
18. C. Tan, S. Cruet-Hennequart, A. Troussard, L. Fazil, P. Costello, K. Sutton, J. Wheeler, M. Gleave, J. Sanghera, and S. Dedhar Regulation of tumor angiogenesis by integrin-linked kinase (ILK) Cancer Cell 5 2004 79 90
19. A.A. Troussard, P. Costello, T.N. Yoganathan, S. Kumagai, C.D. Roskelley, and S. Dedhar The integrin linked kinase (ILK) induces an invasive phenotype via AP-1 transcription factor-dependent upregulation of matrix metalloproteinase 9 (MMP-9) Oncogene 19 2000 5444 5452
20. G. Hannigan, A.A. Troussard, and S. Dedhar Integrine-linked kinase: a cancer therapeutic target unique among its ILK Nat. Rev. Cancer 5 2005 51 63
21. C. Tan, P. Costello, J. Sanghera, D. Dominguez, J. Baulida, A.G. de Herreros, and S. Dedhar Inhibition of integrin linked kinase (ILK) suppresses β-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC-/- human colon carcinoma cells Oncogene 20 2001 133 140
22. Mammalian gene collection (MGC) program team, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences, Proc. Natl. Acad. Sci. USA 99 (2002) 16899-16903
23. P. Aza-Blanc, C.L. Cooper, K. Wagner, S. Batalov, Q.L. Deveraux, and M.P. Cooke Identification of modulators of TRAIL-induced apoptosis via RNAi-based phenotypic screening Mol. Cell 12 2003 623 627
24. 1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex Blood 96 2000 2284 2291
25. T. Schulte, and L. Neckers The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin Cancer Chemother. Pharmacol. 42 1998 273 279
26. H.-J. Ochel, T. Schulte, P. Nguyen, J. Trepel, and L. Neckers The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase Mol. Genet. Metab. 66 1999 24 30
27. S.D. Blystone Integrating an integrin: a direct route to actin Biochim. Biophys. Acta 1692 2004 47 54
28. S.J. Ullrich, E.A. Robinson, L.W. Law, M. Willingham, and E. Appella A mouse tumor-specific transplantation antigen is a heat shock-related protein Proc. Natl. Acad. Sci. USA 83 1986 3121 3125
29. Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4 Genes Dev. 10 1996 1491 1502
30. A.D. Basso, D.B. Solit, G. Chiosis, B. Giri, P. Tsichlis, and N. Rosen Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function J. Biol. Chem. 277 2002 39858 39866
31. G. Chen, P. Cao, and D.V. Goeddel TNF-induced recruitment and activation of IKK complex require Cdc37 and Hsp90 Mol. Cell. 9 2002 401 410
32. v-src activity in yeast Mol. Biol. Cell 7 1996 1405 1417
33. S.N. Nikolopoulos, and C.E. Turner Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions J. Biol. Chem. 276 2001 23499 23505
34. Y. Miyata, Y. Ikawa, M. Shibuya, and E. Nishida Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily J. Biol. Chem. 276 2001 21841 21848