Loss of interferon regulatory factor 3 in cells infected with classical swine fever virus involves the N-terminal protease, Npro

Journal of Virology

Volumn 79, Issue 11, 2005, Pages 7239-7247

  La Rocca, S Anna ^a   Herbert, Rebecca J ^a   Crooke, Helen ^b   Drew, Trevor W ^b   Wileman, Thomas E ^a   Powell, Penny P ^a  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^b VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED RNA; INTERFERON REGULATORY FACTOR 3; LEPTOMYCIN B; N TERMINAL PROTEINASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANIMAL CELL; ARTICLE; CELL FRACTIONATION; CONTROLLED STUDY; ENZYME ACTIVITY; INTERFERON PRODUCTION; NONHUMAN; PESTIVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SINDBIS VIRUS; TRANSCRIPTION REGULATION; VIRUS CELL INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATTLE; CELL LINE; CLASSICAL SWINE FEVER VIRUS; DNA, VIRAL; DNA-BINDING PROTEINS; IMMUNITY, NATURAL; INTERFERON REGULATORY FACTOR-3; INTERFERONS; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; RNA, VIRAL; SINDBIS VIRUS; SUPERINFECTION; SWINE; SWINE, MINIATURE; TRANSCRIPTION FACTORS;

ALPHAVIRUS; CLASSICAL SWINE FEVER VIRUS; PESTIVIRUS; SINDBIS VIRUS; SUS SCROFA;

EID: 18744410652     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.11.7239-7247.2005     Document Type: Article

References (44)

1. Baigent, S. J., G. Zhang, M. D. Fray, H. Flick-Smith, S. Goodbourn, and J. W. McCauley. 2002. Inhibition of beta interferon transcription by noncytopathogenic bovine viral diarrhea virus is through an interferon regulatory factor 3-dependent mechanism. J. Virol. 76:8979-8988.
2. Baigent, S. J., S. Goodbourn, and J. W. McCauley. 2004. Differential activation of interferon regulatory factors-3 and -7 by non-cytopathogenic and cytopathogenic bovine viral diarrhoea virus. Vet. Immunol. Immunopathol. 100:135-144.
3. Basler, C. F., and A. Garcia-Sastre. 2002. Viruses and the type I interferon antiviral system: induction and evasion. Int. Rev. Immunol. 21:305-337.
4. Basler, C. F., A. Mikulasova, L. Martinez-Sobrido, J. Paragas, E. Muhlberger, M. Bray, H.-D. Klenk, P. Palsae, and A. Garcia-Sastre. 2003. The Ebola virus vp35 protein inhibits activation of interferon regulatory factor 3. J. Virol. 77:7945-7956.
5. Bensaude, E., J. L. Turner, P. R. Wakeley, D. A. Sweetman, C. Pardieu, T. W. Drew, T. Wileman, and P. P. Powell. 2004. Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cells. J. Gen. Virol. 85:1029-1037.
6. Billecocq, A., M. Spiegel, P. Vialat, A. Kohl, F. Weber, M. Bouloy, and O. Haller. 2004. NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription. J. Virol. 78:9798-9806.
7. Bossert, B., S. Marozin, and K.-K. Conzelmann. 2003. Nonstructural protein NS1 and NS2 of bovine respiratory syncytial virus blocks activation of interferon regulatory factor 3. J. Virol. 77:8661-8668.
8. Charleston, B., M. D. Fray, S. Baigent, B. V. Carr, and W. I. Morrison. 2001. Establishment of persistent infection with non-cytopathic bovine viral diarrhoea virus in cattle is associated with a failure to induce type I interferon. J. Gen. Virol. 82:1893-1897.
9. Edwards, S., J. J. Sands, and J. W. Harkness. 1988. The application of monoclonal antibody panels to characterize pestivirus isolates from ruminants in Great Britain. Arch. Virol. 102:197-206.
10. Fitzgerald, K. A., S. M. McWhirter, K. L. Faia, D. C. Rowe, E. Latz, D. T. Golenbock, A. J. Coyle, S.-M. Liao, and T. Maniatis. 2003. IKKε and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4:491-496.
11. Foy, E., K. Li, C. Wang, R. Sumpter, Jr., M. Ikeda, S. M. Lemon, and M. Gale, Jr. 2003. Regulation of interferon regulatory factor 3 by the hepatitis C virus serine protease. Science 300:1145-1148.
12. Fray, M. D., G. E. Mann, and B. Charleston. 2001. Validation of an Mx/CAT reporter gene assay for the quantification of bovine type-I interferon. J. Immunol. Methods 249:235-244.
13. Goodbourn, S., L. Didcock, and R. E. Randall. 2000. Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. J. Gen. Virol. 81:2341-2364.
14. Grandvaux, N., B. R. ten Oever, M. J. Servant, and J. Hiscott. 2002. The interferon antiviral response: from viral invasion to evasion. Curr. Opin. Infect. Dis. 15:259-267.
15. Heylbroeck, C., S. Balachandran, M. J. Servant, C. DeLuca, G. N. Barber, R. Lin, and J. Hiscott. 2000. The IRF-3 transcription factor mediates Sendai Virus-induced apoptosis. J. Virol. 74:3781-3792.
16. Karpova, A. Y., M. Trost, J. M. Murray, L. C. Cantley, and P. M. Howley. 2002. Interferon regulatory factor-3 is an in vivo target of DNA-PK. Proc. Natl. Acad. Sci. USA 99:2818-2823.
17. Kohl, A., R. F. Clayton, F. Weber, A. Bridgen, R. Randall, and R. Elliott. 2003. Bunymwera virus nonstructural protein NSs counteracts interferon regulatory factor 3-mediated induction of early cell death. J. Virol. 77:7999-8008.
18. Kumar, K. P., K. M. McBride, B. K. Weaver, C. Dingwall, and N. C. Reich. 2000. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol. Cell. Biol. 20:4159-4168.
19. Le May, N., S. Dubaele, L. Proietti De Santis, A. Billecocq, M. Bouloy, and J.-M Egly. 2004. TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus. Cell 116:541-550.
20. Lin, R., C. Heylbroeck, P. Pitha, and J. Hiscott. 1998. Virus-dependent phosphorylation of the IRF3 transcription factor regulated nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol. Cell. Biol. 18:2986-2996.
21. Lowther, W. J., P. A. Moore, K. C. Carter, and P. M. Pitha. 1999. Cloning and functional analysis of the human IRF-3 promoter. DNA Cell Biol. 18:685-692.
22. Macdonald, A., and M. Harris. 2004. Hepatitis C virus NS5A: tales of a promiscuous protein. J. Gen. Virol. 85:2485-2502.
23. pro gene. Vaccine 22:317-328.
24. Munoz-Jordan, J. L., G. G. Sanchez-Burgos, M. Laurent-Rolle, and A. Garcia-Sastre. 2003. Inhibition of interferon signalling by Dengue virus. Proc. Natl. Acad. Sci. USA 100:14333-14338.
25. Paton, D. J., and I. Greiser-Wilke. 2003. Classical swine fever-an update. Res. Vet. Sci. 75:169-178.
26. Paton, D. J., J. J. Sands, J. P. Lowings, J. E. Smith, G. Ibata, and S. Edwards. 1995. A proposed division of the pestivirus genus using monoclonal antibodies, supported by cross-neutralisation assays and genetic sequencing. Vet. Res. 26:92-109.
27. pro. J. Virol. 77:7645-7654.
28. Rumenapf, T., R. Stark, M. Heiman, and H.-J. Theil. 1998. N-terminal protease of pestiviruses: identification of putative catalytic residues by site-directed mutagenesis. J. Virol. 72:2544-2547.
29. Schweizer, M., and E. Peterhans. 2001. Noncytopathic bovine viral diarrhea virus inhibits double-stranded RNA-induced apoptosis and interferon synthesis. J. Virol. 75:4692-4698.
30. Servant, M. J., B. ten Oever, C. LePage, L. Conti, S. Gessani, I. Julunen, R. Lin, and J. Hiscott. 2001. Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3. J. Biol. Chem. 276:355-363.
31. Servant, M. J., N. Grandvaux, and J. Hiscott. 2002. Multiple signaling pathways leading to the activation of interferon regulatory factor 3. Biochem. Pharmacol. 64:985-992.
32. Servant, M. J., N. Grandvaux, B. R. ten Oever, D. Duguay, R. Lin, and J. Hiscott. 2003. Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J. Biol. Chem. 278:9441-9447.
33. Sharma, S., B. R. ten Over, N. Grandvaux, G.-P. Zhou, R. Lin, and J. Hiscott. 2003. Triggering the interferon antiviral response through an IKK-related pathway. Science 300:1148-1151.
34. Smith, E. J., I. Marie, A. Prakash, A. Garcia-Sastre, and D. E. Levy. 2001. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J. Biol. Chem. 276:8951-8957.
35. Summerfield, A., S. M. Knoetig, and K. C. McCullough. 1998. Lymphocyte apoptosis during classical swine fever: implication of activation-induced cell death. J. Virol. 72:1853-1861.
36. Summerfield, A., S. M. Knoetig, R. Tschudin, and K. C. McCullough. 2000. Pathogenesis of granulocytopenia and bone marrow atrophy during classical swine fever involves apoptosis and necrosis of uninfected cells. Virology 272:50-56.
37. Talon, J., C. M. Horvath, R. Polley, C. F. Basler, T. Muster, P. Palese, and A. Garcia-Sastre. 2000. Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J. Virol. 74:7989-7996.
38. Thiel, H. J., P. G. W. Plagemann, and V. Moennig. 1996. Pestiviruses, p. 1059-1073. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology, 3rd ed. Lippincott-Raven, Philadelphia, Pa.
39. Van Gennip, H. G., A. C. Vlot, M. M. Hulst, A. J. De Smit, and R. J. Moormann. 2004. Determinants of virulence of classical swine fever virus strain Brescia. J. Virol. 78:8812-8823.
40. Van Oirschot, J. T. 1988. Description of the virus infection, p. 1-25. In B. Liess (ed.), Classical swine fever and related viral infections. Martinus Nijhoff, Boston, Mass.
41. Wathelet, M. G., C. H. Lin, L. Parekh, L. V. Ronco, P. M. Howley, and T. Maniatis. 1998. Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol. Cell 1:507-518.
42. Weidman, M. K., R. Sharma, S. Raychaudhuri, P. Kunda, W. Tsai, and A. Dasgupta. 2003. The interaction of cytoplasmic viruses with the nucleus. Virus Res. 95:75-85.
43. Wensvoort, G., C. Terpstra, E. P. de Kluijver, C. Kragten, and J. C. Warnaar. 1989. Antigenic differentiation of pestivirus strains with monoclonal antibodies against hog cholera virus. Vet. Microbiol. 21:9-20.
44. Yoneyama, M., W. Suhara, Y. Fukuhara, M. Fukada, K. Nishida, and T. Fujita. 1998. Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF3 and CBP/p300. EMBO J. 17:1087-1095.