Nodal antaginists in the anterior visceral endoderm prevent the formation of multiple primitive streaks

Developmental Cell

Volumn 3, Issue 5, 2002, Pages 745-756

  Perea Gomez, Aitana ^a   Vella, Francis D J ^a   Shawlot, William ^b   Oulad Abdelghani, Mustapha ^a   Chazaud, Claire ^a   Meno, Chikara ^c   Pfister, Veronique ^a   Chen, Lan ^a   Robertson, Elizabeth ^d   Hamada, Hiroshi ^c   Behringer, Richard R ^b   Ang, Siew Lan ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c OSAKA UNIVERSITY   (Japan)

^d HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTERIOR POSTERIOR AXIS; ARTICLE; CHIMERA; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO PATTERN FORMATION; EMBRYO POLARITY; ENDODERM; GASTRULATION; GENETIC MODEL; MOUSE; MOUSE MUTANT; NONHUMAN; PHENOTYPE; PRIMITIVE STREAK; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; GASTRULA; GENETICS; METABOLISM; MORPHOGENESIS; MUTAGENESIS; PHYSIOLOGY; PRENATAL DEVELOPMENT;

CERBERUS; MAMMALIA;

CER1 PROTEIN, MOUSE; LEFT RIGHT DETERMINATION FACTOR PROTEINS; LEFT-RIGHT DETERMINATION FACTOR PROTEINS; PROTEIN; PROTEIN NODAL; TRANSFORMING GROWTH FACTOR BETA;

ANIMALS; BODY PATTERNING; EMBRYONIC AND FETAL DEVELOPMENT; ENDODERM; GASTRULA; MICE; MUTAGENESIS; PHENOTYPE; PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 18744404768     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(02)00321-0     Document Type: Article

References (58)

1. Agius, E., Oelgeschlager, M., Wessely, O., Kemp, C., and De Robertis, E.M. (2000). Endodermal Nodal-related signals and mesoderm induction in Xenopus. Development 127, 1173-1183.
2. Ang, S.L., Wierda, A., Wong, D., Stevens, K.A., Cascio, S., Rossant, J., and Zaret, K.S. (1993). The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development 119, 1301-1315.
3. Bachiller, D., Klingensmith, J., Kemp, C., Belo, J.A., Anderson, R.M., May, S.R., McMahon, J.A., McMahon, A.P., Harland, R.M., Rossant, J., and De Robertis, E.M. (2000). The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature 403, 658-661.
4. Becksel, A., and Serrano, L. (2000). Engineering stability in gene networks by autoregulation. Nature 405, 590-593.
5. Beddington, R.S., and Robertson, E.J. (1989). An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. Development 105, 733-737.
6. Beddington, R.S., and Robertson, E.J. (1999). Axis development and early asymmetry in mammals. Cell 96, 195-209.
7. Belo, J.A., Bouwmeester, T., Leyns, L., Kertesz, N., Gallo, M., Follettie, M., and De Robertis, E.M. (1997). Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech. Dev. 68, 45-57.
8. Belo, J.A., Bachiller, D., Agius, E., Kemp, C., Borges, A.C., Marques, S., Piccolo, S., and De Robertis, E.M. (2000). Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development. Genesis 26, 265-270.
9. Bertocchini, F., and Stern, C.D. (2002). The hypoblast of the chick embryo positions the primitive streak by antagonizing Nodal signaling. Dev. Cell 3, this issue, 735-744.
10. Brennan, J., Lu, C.C., Norris, D.P., Rodriguez, T.A., Beddington, R.S., and Robertson, E.J. (2001). Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411, 965-969.
11. Candia, A.F., Hu, J., Crosby, J., Lalley, P.A., Noden, D., Nadeau, J.H., and Wright, C.V. (1992). Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development 116, 1123-1136.
12. Chapman, D.L., Agulnik, I., Hancock, S., Silver, L.M., and Papaioannou, V.E. (1996). Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation. Dev. Biol. 180, 534-542.
13. Chen, Y., and Schier, A.F. (2001). The zebrafish Nodal signal Squint functions as a morphogen. Nature 411, 607-610.
14. Collignon, J., Varlet, I., and Robertson, E.J. (1996). Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 381, 155-158.
15. Conlon, F.L., Lyons, K.M., Takaesu, N., Barth, K.S., Kispert, A., Herrmann, B., and Robertson, E.J. (1994). A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120, 1919-1928.
16. Conlon, R.A., and Herrmann, B.G. (1993). Detection of messenger RNA by in situ hybridization to postimplantation embryo whole mounts. Methods Enzymol. 225, 373-383.
17. Dush, M.K., and Martin, G.R. (1992). Analysis of mouse Evx genes: Evx-1 displays graded expression in the primitive streak. Dev. Biol. 151, 273-287.
18. Downs, K.M., and Davies, T. (1993). Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Development 118, 1255-1266.
19. Episkopou, V., Arkell, R., Timmons, P.M., Walsh, J.J., Andrew, R.L., and Swan, D. (2001). Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature 410, 825-830.
20. Filosa, S., Rivera-Perez, J.A., Gomez, A.P., Gansmuller, A., Sasaki, H., Behringer, R.R., and Ang, S.L. (1997). Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development 124, 2843-2854.
21. Gritsman, K., Talbot, W.S., and Schier, A.F. (2000). Nodal signalling patterns the organizer. Development 127, 921-932.
22. Hogan, B., Beddington, R., Constantini, F., and Lacy, E. (1994). Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press).
23. Hoodless, P.A., Pye, M., Chazaud, C., Labbe, E., Attisano, L., Rossant, J., and Wrana, J.L. (2001). FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse. Genes Dev. 15, 1257-1271.
24. Jones, C.M., Kuehn, M.R., Hogan, B.L., Smith, J.C., and Wright, C.V. (1995). Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development 121, 3651-3662.
25. Kimura, C., Yoshinaga, K., Tian, E., Suzuki, M., Aizawa, S., and Matsuo, I. (2000). Visceral endoderm mediates forebrain development by suppressing posteriorizing signals. Dev. Biol. 225, 304-321.
26. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R., and Berns, A. (1991). Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293.
27. Lawson, K.A., and Pedersen, R.A. (1987). Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse. Development 101, 627-652.
28. Lin, T.P., Labosky, P.A., Grabel, L.B., Kozak, C.A., Pitman, J.L., Kleeman, J., and MacLeod, C.L. (1994). The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development. Dev. Biol. 166, 170-179.
29. Liu, P., Wakamiya, M., Shea, M.J., Albrecht, U., Behringer, R.R., and Bradley, A. (1999). Requirement for Wnt3 in vertebrate axis formation. Nat. Genet. 22, 361-365.
30. Lowe, L.A., Yamada, S., and Kuehn, M.R. (2001). Genetic dissection of nodal function in patterning the mouse embryo. Development 128, 1831-1843.
31. Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H., and Hamada, H. (1998). lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 94, 287-297.
32. Meno, C., Gritsman, K., Ohishi, S., Ohfuji, Y., Heckscher, E., Mochida, K., Shimono, A., Kondoh, H., Talbot, W.S., Robertson, E.J., et al. (1999). Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signalling during vertebrate gastrulation. Mol. Cell 4, 287-298.
33. Oulad-Abdelghani, M., Chazaud, C., Bouillet, P., Mattei, M.G., Dolle, P., and Chambon, P. (1998). Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily. Int. J. Dev. Biol. 42, 23-32.
34. Pearce, J.J., and Evans, M.J. (1999). Mml, a mouse Mix-like gene expressed in the primitive streak. Mech. Dev. 87, 189-192.
35. Perea-Gomez, A., Shawlot, W., Sasaki, H., Behringer, R.R., and Ang, S. (1999). HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development 126, 4499-4511.
36. Perea-Gomez, A., Lawson, K.A., Rhinn, M., Zakin, L., Brulet, P., Mazan, S., and Ang, S.L. (2001a). Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo. Development 128, 753-765.
37. Perea-Gomez, A., Rhinn, M., and Ang, S.L. (2001b). Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo. Int. J. Dev. Biol. 45, 311-320.
38. Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T., and De Robertis, E.M. (1999). The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397, 707-710.
39. Popperl, H., Schmidt, C., Wilson, V., Hume, C.R., Dodd, J., Krumlauf, R., and Beddington, R.S. (1997). Misexpression of Cwnt8C in the mouse induces an ectopic embryonic axis and causes a truncation of the anterior neuroectoderm. Development 124, 2997-3005.
40. Rhinn, M., Dierich, A., Shawlot, W., Behringer, R.R., Le Meur, M., and Ang, S.L. (1998). Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development 125, 845-856.
41. Sakuma, R., Ohnishi, Y.Y., Meno, C., Fujii, H., Juan, H., Takeuchi, J., Ogura, T., Li, E., Miyazono, K., and Hamada, H. (2002). Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion. Genes Cells 7, 401-412.
42. Schier, A.F., and Shen, M.M. (2000). Nodal signalling in vertebrate development. Nature 403, 385-389.
43. Shawlot, W., Min Deng, J., Wakamiya, M., and Behringer, R.R. (2000). The cerberus-related gene, Cerr1, is not essential for mouse head formation. Genesis 26, 253-258.
44. Shimono, A., and Behringer, R.R. (1999). Isolation of novel cDNAs by subtractions between the anterior mesendoderm of single mouse gastrula stage embryos. Dev. Biol. 209, 369-380.
45. Simpson, E.H., Johnson, D.K., Hunsicker, P., Suffolk, R., Jordan, S.A., and Jackson, I.J. (1999). The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation. Dev. Biol. 213, 202-206.
46. Skromne, I., and Stern, C.D. (2001). Interactions between Wnt and Vg1 signalling pathways initiate primitive streak formation in the chick embryo. Development 128, 2915-2927.
47. Stanley, E.G., Biben, C., Allison, J., Hartley, L., Wicks, I.P., Campbell, I.K., McKinley, M., Barnett, L., Koentgen, F., Robb, L., and Harvey, R.P. (2000). Targeted insertion of a LacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis. Genesis 26, 259-264.
48. Tam, P.P., and Behringer, R.R. (1997). Mouse gastrulation: the formation of a mammalian body plan. Mech. Dev. 68, 3-25.
49. Thomas, P., and Beddington, R. (1996). Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo. Curr. Biol. 6, 1487-1496.
50. Thomas, P.Q., Brown, A., and Beddington, R.S. (1998). Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development 125, 85-94.
51. Toyama, R., O'Connell, M.L., Wright, C.V., Kuehn, M.R., and Dawid, I.B. (1995). Nodal induces ectopic goosecoid and Lhx1 expression and axis duplication in zebrafish. Development 121, 383-391.
52. Whitman, M. (2001). Nodal signaling in early vertebrate embryos: themes and variations. Dev. Cell 1, 605-617.
53. Wilkinson, D.G., Bhatt, S., and Herrmann, B.G. (1990). Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343, 657-659.
54. Wilkinson, D.G., Bhatt, S., and McMahon, A.P. (1989). Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development. Development 105, 131-136.
55. Winnier, G., Blessing, M., Labosky, P.A., and Hogan, B.L. (1995). Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9, 2105-2116.
56. Yamamoto, M., Meno, C., Sakai, Y., Shiratori, H., Mochida, K., Ikawa, Y., Saijoh, Y., and Hamada, H. (2001). The transcription factor FoxH1 (FAST) mediates Nodal signalling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15, 1242-1256.
57. Zhou, X., Sasaki, H., Lowe, L., Hogan, B.L., and Kuehn, M.R. (1993). Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. Nature 361, 543-547.
58. Zorn, A.M., Butler, K., and Gurdon, J.B. (1999). Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways. Dev. Biol. 209, 282-297.