Using physiologically-based pharmacokinetic modeling to address nonlinear kinetics and changes in rodent physiology and metabolism due to aging and adaptation in deriving reference values for propylene glycol methyl ether and propylene glycol methyl ether acetate

Risk Analysis

Volumn 25, Issue 2, 2005, Pages 271-284

  Kirman, C R ^a   Sweeney, L M ^b   Corley, R ^c   Gargas, M L ^b  

^a Sapphire Group Inc   (United States)

^b Sapphire Group   (United States)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

PBPK modeling; Propylene glycol methyl ether; Reference concentration; Reference dose; Saturable kinetics

Indexed keywords

DATA ACQUISITION; ENZYME KINETICS; ETHERS; EXTRAPOLATION; LIVING SYSTEMS STUDIES; MATHEMATICAL MODELS; METABOLISM; PHYSIOLOGY; PROPYLENE; SATURATION (MATERIALS COMPOSITION); TISSUE;

PHARMACOKINETIC MODELING; PROPYLENE GLYCOL METHYL ETHER (PGME); REFERENCE CONCENTRATION (RFC); REFERENCE DOSE (RFD);

PHARMACOKINETICS;

PROPANEDIOL DERIVATIVE; PROPYLENE GLYCOL METHYL ETHER; PROPYLENE GLYCOL METHYL ETHER ACETATE; UNCLASSIFIED DRUG;

MODELING; PHYSIOLOGY;

ADAPTATION; AGING; ARTICLE; BRAIN TISSUE; HUMAN; INHALATION; MOUSE; NONHUMAN; NONLINEAR SYSTEM; RAT; REFERENCE VALUE; RISK ASSESSMENT; SEDATION;

RODENTIA;

EID: 18644372500     PISSN: 02724332     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1539-6924.2005.00588.x     Document Type: Article

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