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Volumn 156, Issue 1 SPEC. ISS., 2005, Pages 193-213

Development of a physiologically based pharmacokinetic model for propylene glycol monomethyl ether and its acetate in rats and humans

Author keywords

PBPK modeling; Propylene glycol monomethyl ether; Propylene glycol monomethyl ether acetate

Indexed keywords

ACETIC ACID; ESTERASE; ETHER DERIVATIVE; GLUCURONIDE; PROPYLENE GLYCOL MONOETHYL ETHER; SULFATE; UNCLASSIFIED DRUG;

EID: 13544269466     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2003.12.078     Document Type: Conference Paper
Times cited : (16)

References (58)
  • 2
    • 0033795067 scopus 로고    scopus 로고
    • Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: An example with acrylic acid
    • M.E. Andersen, P.R. Sarangapani, R. Gentry, H.J. Clewell III, T.R. Covingtin, and C.B. Frederick Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: an example with acrylic acid Toxicol. Sci. 57 2000 312 325
    • (2000) Toxicol. Sci. , vol.57 , pp. 312-325
    • Andersen, M.E.1    Sarangapani, P.R.2    Gentry, R.3    Clewell III, H.J.4    Covingtin, T.R.5    Frederick, C.B.6
  • 3
    • 0000944724 scopus 로고    scopus 로고
    • Ethers of ethylene glycol and derivatives
    • E. Bingham B. Cohrssen C.H. Powell Wiley-Interscience New York
    • R.J. Boatman, and J.B. Knaak Ethers of ethylene glycol and derivatives E. Bingham B. Cohrssen C.H. Powell Patty's Toxicology, 5th ed. vol. 7 2001 Wiley-Interscience New York 73 270 Part D, Chapter 86
    • (2001) Patty's Toxicology, 5th Ed. , vol.7 , pp. 73-270
    • Boatman, R.J.1    Knaak, J.B.2
  • 4
    • 0036204590 scopus 로고    scopus 로고
    • Vinyl acetate-induced intracellular acidification: Implications for risk assessment
    • M.S. Bogdanffy Vinyl acetate-induced intracellular acidification: implications for risk assessment Toxicol. Sci. 66 2002 320 326
    • (2002) Toxicol. Sci. , vol.66 , pp. 320-326
    • Bogdanffy, M.S.1
  • 5
    • 0032822298 scopus 로고    scopus 로고
    • A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity
    • M.S. Bogdanffy, R. Sarangapani, D.R. Plowchalk, A. Jarabek, and M.E. Andersen A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity Toxicol. Sci. 51 1999 19 35
    • (1999) Toxicol. Sci. , vol.51 , pp. 19-35
    • Bogdanffy, M.S.1    Sarangapani, R.2    Plowchalk, D.R.3    Jarabek, A.4    Andersen, M.E.5
  • 8
    • 0032838920 scopus 로고    scopus 로고
    • Assessment of adult and neonatal reproductive parameters in Sprague-Dawley rats exposed to propylene glycol monomethyl ether vapors for two generations
    • E.W. Carney, J.W. Crissman, A.B. Liberacki, C.M. Clements, and W.J. Breslin Assessment of adult and neonatal reproductive parameters in Sprague-Dawley rats exposed to propylene glycol monomethyl ether vapors for two generations Toxicol. Sci. 50 1999 249 258
    • (1999) Toxicol. Sci. , vol.50 , pp. 249-258
    • Carney, E.W.1    Crissman, J.W.2    Liberacki, A.B.3    Clements, C.M.4    Breslin, W.J.5
  • 9
    • 0032838920 scopus 로고    scopus 로고
    • Assessment of adult and neonatal reproductive parameters in Sprague-Dawley rats exposed to propylene glycol monomethyl ether vapors for two generations
    • E.W. Carney, J.W. Crissman, A.B. Liberacki, C.M. Clements, and W.J. Breslin Assessment of adult and neonatal reproductive parameters in Sprague-Dawley rats exposed to propylene glycol monomethyl ether vapors for two generations Toxicol. Sci. 50 1999 249 258
    • (1999) Toxicol. Sci. , vol.50 , pp. 249-258
    • Carney, E.W.1    Crissman, J.W.2    Liberacki, A.B.3    Clements, C.M.4    Breslin, W.J.5
  • 10
    • 12244261617 scopus 로고    scopus 로고
    • Significance of 2-methoxypropionic acid formed from beta-propylene glycol monomethyl ether: Integration of pharmacokinetic and developmental toxicity assessments in rabbits
    • E.W. Carney, L.H. Pottenger, K.A. Johnson, A.B. Liberacki, B. Tornesi, M.D. Dryzga, S.C. Hansen, and W.J. Breslin Significance of 2-methoxypropionic acid formed from beta-propylene glycol monomethyl ether: integration of pharmacokinetic and developmental toxicity assessments in rabbits Toxicol. Sci. 71 2003 217 228
    • (2003) Toxicol. Sci. , vol.71 , pp. 217-228
    • Carney, E.W.1    Pottenger, L.H.2    Johnson, K.A.3    Liberacki, A.B.4    Tornesi, B.5    Dryzga, M.D.6    Hansen, S.C.7    Breslin, W.J.8
  • 13
    • 0028131796 scopus 로고
    • Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans
    • R.A. Corley, G.A. Bormett, and B.I. Ghanayem Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans Toxicol. Appl. Pharmacol. 129 1994 61 79
    • (1994) Toxicol. Appl. Pharmacol. , vol.129 , pp. 61-79
    • Corley, R.A.1    Bormett, G.A.2    Ghanayem, B.I.3
  • 14
    • 0344152375 scopus 로고    scopus 로고
    • Adaptive metabolic and pathologic changes following chronic inhalation of propylene glycol monomethyl ether in rats and mice
    • R.A. Corley, J.W. Crissman, J.M. Redmond, R.J. McGuirk, F.S. Cieszlak, and W.T. Stott Adaptive metabolic and pathologic changes following chronic inhalation of propylene glycol monomethyl ether in rats and mice Occup. Hyg. 2 1996 319 328
    • (1996) Occup. Hyg. , vol.2 , pp. 319-328
    • Corley, R.A.1    Crissman, J.W.2    Redmond, J.M.3    McGuirk, R.J.4    Cieszlak, F.S.5    Stott, W.T.6
  • 15
    • 0030671357 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetics and the dermal absorption of 2-butoxyethanol vapor by humans
    • R.A. Corley, D.A. Markham, C. Banks, P. Delorme, A. Masterman, and J.M. Houle Physiologically based pharmacokinetics and the dermal absorption of 2-butoxyethanol vapor by humans Fund. Appl. Toxicol. 39 1997 120 130
    • (1997) Fund. Appl. Toxicol. , vol.39 , pp. 120-130
    • Corley, R.A.1    Markham, D.A.2    Banks, C.3    Delorme, P.4    Masterman, A.5    Houle, J.M.6
  • 16
    • 0041711967 scopus 로고    scopus 로고
    • Glycol ethers: Ethers of propylene, butylene glycols, and other glycol derivatives
    • E. Bingham B. Cohrssen C.H. Powell Wiley-Interscience New York
    • S.T. Cragg, and R.J. Boatman Glycol ethers: ethers of propylene, butylene glycols, and other glycol derivatives E. Bingham B. Cohrssen C.H. Powell Patty's Toxicology, 5th ed. vol. 7 2001 Wiley-Interscience New York 271 395 Part D, Chapter 87
    • (2001) Patty's Toxicology, 5th Ed. , vol.7 , pp. 271-395
    • Cragg, S.T.1    Boatman, R.J.2
  • 17
    • 0033916089 scopus 로고    scopus 로고
    • Propylene glycol monomethyl ether (PGME) occupational exposure. 1. Biomonitoring by analysis of PGME in urine
    • A. Devanthery, A. Dentan, M. Berode, and P.O. Droz Propylene glycol monomethyl ether (PGME) occupational exposure. 1. Biomonitoring by analysis of PGME in urine Int. Arch. Occup. Hlth. 73 2000 311 315
    • (2000) Int. Arch. Occup. Hlth. , vol.73 , pp. 311-315
    • Devanthery, A.1    Dentan, A.2    Berode, M.3    Droz, P.O.4
  • 18
    • 0036556260 scopus 로고    scopus 로고
    • Propylene glycol monomethyl ether (PGME) occupational exposure. 2. Exposure of human volunteers
    • A. Devanthery, M. Berode, and P.O. Droz Propylene glycol monomethyl ether (PGME) occupational exposure. 2. Exposure of human volunteers Int. Arch. Occup. Hlth. 75 2002 203 208
    • (2002) Int. Arch. Occup. Hlth. , vol.75 , pp. 203-208
    • Devanthery, A.1    Berode, M.2    Droz, P.O.3
  • 19
    • 0020595022 scopus 로고
    • Comparative aspects of the reproductive toxicology by inhalation in rats of ethylene glycol monomethyl ether and propylene glycol monomethyl ether
    • J.E. Doe, D.M. Samuels, D.J. Tinston, and G.A. De Silva Wickramaratne Comparative aspects of the reproductive toxicology by inhalation in rats of ethylene glycol monomethyl ether and propylene glycol monomethyl ether Toxicol. Appl. Pharmacol. 69 1983 43 47
    • (1983) Toxicol. Appl. Pharmacol. , vol.69 , pp. 43-47
    • Doe, J.E.1    Samuels, D.M.2    Tinston, D.J.3    De Silva Wickramaratne, G.A.4
  • 23
    • 0028046575 scopus 로고
    • Determination of 1-methoxy-2-propanol and its metabolite. 1,2-Propanediol in rat and mouse plasma by gas chromatography
    • N.F. Ferrala, B.I. Ghanayem, and A.A. Nomeir Determination of 1-methoxy-2-propanol and its metabolite. 1,2-Propanediol in rat and mouse plasma by gas chromatography J. Chromatogr. B 660 1994 291 296
    • (1994) J. Chromatogr. B , vol.660 , pp. 291-296
    • Ferrala, N.F.1    Ghanayem, B.I.2    Nomeir, A.A.3
  • 25
    • 0000825389 scopus 로고
    • Comparison of four biologically based dosimetry models for the deposition of rapidly metabolized vapors in the rodent nasal cavity
    • C.B. Frederick, J.B. Morris, J.S. Kimbell, K.T. Morgan, and P.W. Scherer Comparison of four biologically based dosimetry models for the deposition of rapidly metabolized vapors in the rodent nasal cavity Inhal. Toxicol. 6 Suppl. 1994 135 157
    • (1994) Inhal. Toxicol. , vol.6 , Issue.SUPPL. , pp. 135-157
    • Frederick, C.B.1    Morris, J.B.2    Kimbell, J.S.3    Morgan, K.T.4    Scherer, P.W.5
  • 27
    • 0034658004 scopus 로고    scopus 로고
    • A toxicokinetic study of inhaled ethylene glycol ethyl ether acetate (EGEEA) and validation of a physiologically based pharmacokinetic model for rats and humans
    • M.L. Gargas, T.R. Tyler, L.M. Sweeney, R.A. Corley, K.K. Weitz, T.J. Mast, D.J. Paustenbach, and S.M. Hays A toxicokinetic study of inhaled ethylene glycol ethyl ether acetate (EGEEA) and validation of a physiologically based pharmacokinetic model for rats and humans Toxicol. Appl. Pharmacol. 165 1 2000 63 73
    • (2000) Toxicol. Appl. Pharmacol. , vol.165 , Issue.1 , pp. 63-73
    • Gargas, M.L.1    Tyler, T.R.2    Sweeney, L.M.3    Corley, R.A.4    Weitz, K.K.5    Mast, T.J.6    Paustenbach, D.J.7    Hays, S.M.8
  • 28
    • 0034658447 scopus 로고    scopus 로고
    • A toxicokinetic study of inhaled ethylene glycol monomethyl ether (2-ME) and validation of a physiologically based pharmacokinetic model for the pregnant rat and human
    • M.L. Gargas, T.R. Tyler, L.M. Sweeney, R.A. Corley, K.K. Weitz, T.J. Mast, D.J. Paustenbach, and S.M. Hays A toxicokinetic study of inhaled ethylene glycol monomethyl ether (2-ME) and validation of a physiologically based pharmacokinetic model for the pregnant rat and human Toxicol. Appl. Pharmacol. 165 1 2000 53 62
    • (2000) Toxicol. Appl. Pharmacol. , vol.165 , Issue.1 , pp. 53-62
    • Gargas, M.L.1    Tyler, T.R.2    Sweeney, L.M.3    Corley, R.A.4    Weitz, K.K.5    Mast, T.J.6    Paustenbach, D.J.7    Hays, S.M.8
  • 29
    • 0000785482 scopus 로고
    • Effect of repeated inhalation of vapors of industrial solvents on animal behavior
    • M.E. Goldberg, H.E. Johnson, U.C. Pozzani, and H.F. Smyth Jr. Effect of repeated inhalation of vapors of industrial solvents on animal behavior Ind. Hyg. J. 25 1964 369 375
    • (1964) Ind. Hyg. J. , vol.25 , pp. 369-375
    • Goldberg, M.E.1    Johnson, H.E.2    Pozzani, U.C.3    Smyth Jr., H.F.4
  • 30
    • 77957179288 scopus 로고
    • Teratologic evaluation of inhaled propylene glycol monomethyl ether in rats and rabbits
    • T.R. Hanley Jr., L.L. Calhoun, B.L. Yano, and K.S. Rao Teratologic evaluation of inhaled propylene glycol monomethyl ether in rats and rabbits Fund. Appl. Toxicol. 4 1984 784 794
    • (1984) Fund. Appl. Toxicol. , vol.4 , pp. 784-794
    • Hanley Jr., T.R.1    Calhoun, L.L.2    Yano, B.L.3    Rao, K.S.4
  • 31
    • 0021645883 scopus 로고
    • Ethylene glycol monomethyl ether (EGME) and propylene glycol monomethyl ether (PGME): Inhalation fertility and teratogenicity studies in rats, mice and rabbits
    • T.R. Hanley Jr., J.T. Young, J.A. John, and K.S. Rao Ethylene glycol monomethyl ether (EGME) and propylene glycol monomethyl ether (PGME): inhalation fertility and teratogenicity studies in rats, mice and rabbits Environ. Hlth. Persp. 57 1984 7 12
    • (1984) Environ. Hlth. Persp. , vol.57 , pp. 7-12
    • Hanley Jr., T.R.1    Young, J.T.2    John, J.A.3    Rao, K.S.4
  • 32
    • 0034652250 scopus 로고    scopus 로고
    • Development of a physiologically based pharmacokinetic model of 2-methoxyethanol and 2-methoxyacetic acid disposition in pregnant rats
    • S.M. Hayes, B.A. Elswick, G.M. Blumenthal, F. Welsch, R.B. Connolly, and M.L. Gargas Development of a physiologically based pharmacokinetic model of 2-methoxyethanol and 2-methoxyacetic acid disposition in pregnant rats Toxicol. Appl. Pharmacol. 163 2000 67 74
    • (2000) Toxicol. Appl. Pharmacol. , vol.163 , pp. 67-74
    • Hayes, S.M.1    Elswick, B.A.2    Blumenthal, G.M.3    Welsch, F.4    Connolly, R.B.5    Gargas, M.L.6
  • 33
    • 77957176511 scopus 로고
    • Prenatal toxicity of inhalation exposure to 2-methoxypropanol-1 in rabbits
    • J. Hellwig, H.-J. Klimisch, and R. Jackh Prenatal toxicity of inhalation exposure to 2-methoxypropanol-1 in rabbits Fund. Appl. Toxicol. 23 1994 608 613
    • (1994) Fund. Appl. Toxicol. , vol.23 , pp. 608-613
    • Hellwig, J.1    Klimisch, H.-J.2    Jackh, R.3
  • 34
    • 85030822979 scopus 로고
    • Snyder, W.S., Cook, M.J., Nasset, E.S., Karhausen, L.R., Howells, G.P., Tipton, I.H. (Eds.), ICRP Publication 23. Pergamon Press, New York, NY, 1975
    • International Commission on Radiation Protection (ICRP), 1975. In: Snyder, W.S., Cook, M.J., Nasset, E.S., Karhausen, L.R., Howells, G.P., Tipton, I.H. (Eds.), Report of the Task Group on Reference Man. ICRP Publication 23. Pergamon Press, New York, NY, 1975, pp. 15-17.
    • (1975) Report of the Task Group on Reference Man , pp. 15-17
  • 36
    • 0038332027 scopus 로고    scopus 로고
    • Factors affecting the extent of dermal absorption of solvent vapours: A human volunteer study
    • K. Jones, J. Cocker, L.J. Dodd, and I. Fraser Factors affecting the extent of dermal absorption of solvent vapours: a human volunteer study Ann. Occup. Hyg. 47 2003 145 150
    • (2003) Ann. Occup. Hyg. , vol.47 , pp. 145-150
    • Jones, K.1    Cocker, J.2    Dodd, L.J.3    Fraser, I.4
  • 37
    • 0030988563 scopus 로고    scopus 로고
    • A biological monitoring study of 1-methoxy-2-propanol: Analytical method development and a human volunteer study
    • K. Jones, D. Dyne, J. Cocker, and H.K. Wilson A biological monitoring study of 1-methoxy-2-propanol: analytical method development and a human volunteer study Sci. Total Environ. 199 1997 23 30
    • (1997) Sci. Total Environ. , vol.199 , pp. 23-30
    • Jones, K.1    Dyne, D.2    Cocker, J.3    Wilson, H.K.4
  • 38
    • 0028256204 scopus 로고
    • Partition coefficients of some acetate esters and alcohols in water, blood, olive oil and rat tissues
    • T. Kaneko, P.Y. Wang, and A. Sato Partition coefficients of some acetate esters and alcohols in water, blood, olive oil and rat tissues Occup. Environ. Med. 51 1994 68 72
    • (1994) Occup. Environ. Med. , vol.51 , pp. 68-72
    • Kaneko, T.1    Wang, P.Y.2    Sato, A.3
  • 39
    • 0021070106 scopus 로고
    • Propylene glycol monomethyl ether: A 13-week inhalation toxicity study in rats and rabbits
    • T.D. Landry, T.S. Gushow, and B.L. Yano Propylene glycol monomethyl ether: a 13-week inhalation toxicity study in rats and rabbits Fund. Appl. Toxicol. 3 1983 627 630
    • (1983) Fund. Appl. Toxicol. , vol.3 , pp. 627-630
    • Landry, T.D.1    Gushow, T.S.2    Yano, B.L.3
  • 40
    • 0021064684 scopus 로고
    • Pulmonary physiology and inhalation dosimetry in rats: Development of a method and two examples
    • T.D. Landry, J.C. Ramsey, and M.J. McKenna Pulmonary physiology and inhalation dosimetry in rats: development of a method and two examples Toxicol. Appl. Pharmacol. 71 1983 72 83
    • (1983) Toxicol. Appl. Pharmacol. , vol.71 , pp. 72-83
    • Landry, T.D.1    Ramsey, J.C.2    McKenna, M.J.3
  • 41
    • 0028326521 scopus 로고
    • Determination of skin:air partition coefficients for volatile chemicals: Experimental method and applications
    • D.R. Mattie, G.D. Bates, G.W. Jepson, J.W. Fisher, and J.N. McDougal Determination of skin:air partition coefficients for volatile chemicals: experimental method and applications Fund. Appl. Toxicol. 22 1994 51 57
    • (1994) Fund. Appl. Toxicol. , vol.22 , pp. 51-57
    • Mattie, D.R.1    Bates, G.D.2    Jepson, G.W.3    Fisher, J.W.4    McDougal, J.N.5
  • 43
    • 77957174897 scopus 로고
    • Prenatal toxicity of 2-methoxypropylacetate-1 in rats and rabbits
    • J. Merkle, H.J. Klimisch, and R. Jackh Prenatal toxicity of 2-methoxypropylacetate-1 in rats and rabbits Fund. Appl. Toxicol. 8 1987 71 79
    • (1987) Fund. Appl. Toxicol. , vol.8 , pp. 71-79
    • Merkle, J.1    Klimisch, H.J.2    Jackh, R.3
  • 44
    • 0019784995 scopus 로고
    • Comparative short-term inhalation toxicity of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in rats and mice
    • R.R. Miller Comparative short-term inhalation toxicity of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in rats and mice Toxicol. Appl. Pharmacol. 61 1981 368 377
    • (1981) Toxicol. Appl. Pharmacol. , vol.61 , pp. 368-377
    • Miller, R.R.1
  • 45
    • 0023232680 scopus 로고
    • Metabolism and disposition of glycol ethers
    • R.R. Miller Metabolism and disposition of glycol ethers Drug Metab. Rev. 18 1987 1 22
    • (1987) Drug Metab. Rev. , vol.18 , pp. 1-22
    • Miller, R.R.1
  • 46
    • 0020679814 scopus 로고
    • Comparative metabolism and disposition of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in male rats
    • R.R. Miller, E.A. Hermann, P.W. Langvardt, M.J. McKenna, and B.A. Schwetz Comparative metabolism and disposition of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in male rats Toxicol. Appl. Pharmacol. 67 1983 229 237
    • (1983) Toxicol. Appl. Pharmacol. , vol.67 , pp. 229-237
    • Miller, R.R.1    Hermann, E.A.2    Langvardt, P.W.3    McKenna, M.J.4    Schwetz, B.A.5
  • 47
    • 0021176250 scopus 로고
    • Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition, and short-term vapor inhalation toxicity studies
    • R.R. Miller, E.A. Hermann, J.T. Young, L.L. Calhoun, and P.E. Kastl Propylene glycol monomethyl ether acetate (PGMEA) metabolism, disposition, and short-term vapor inhalation toxicity studies Toxicol. Appl. Pharmacol. 75 1984 521 530
    • (1984) Toxicol. Appl. Pharmacol. , vol.75 , pp. 521-530
    • Miller, R.R.1    Hermann, E.A.2    Young, J.T.3    Calhoun, L.L.4    Kastl, P.E.5
  • 48
    • 0021285112 scopus 로고
    • Ethylene glycol monomethyl ether and propylene glycol monomethyl ether: Metabolism, disposition, and subchronic inhalation toxicity studies
    • R.R. Miller, E.A. Hermann, J.T. Young, T.D. Landry, and L.L. Calhoun Ethylene glycol monomethyl ether and propylene glycol monomethyl ether: metabolism, disposition, and subchronic inhalation toxicity studies Environ. Hlth. Persp. 57 1984 233 239
    • (1984) Environ. Hlth. Persp. , vol.57 , pp. 233-239
    • Miller, R.R.1    Hermann, E.A.2    Young, J.T.3    Landry, T.D.4    Calhoun, L.L.5
  • 49
    • 0023263384 scopus 로고
    • Nonlinear kinetics of inhaled propylene glycol monomethyl ether in Fischer 344 rats following single and repeated exposures
    • D.A. Morgott, and R.J. Nolan Nonlinear kinetics of inhaled propylene glycol monomethyl ether in Fischer 344 rats following single and repeated exposures Toxicol. Appl. Pharmacol. 89 1987 19 28
    • (1987) Toxicol. Appl. Pharmacol. , vol.89 , pp. 19-28
    • Morgott, D.A.1    Nolan, R.J.2
  • 50
    • 0031062288 scopus 로고    scopus 로고
    • Physiologically based modeling of vinyl acetate uptake, metabolism, and intracellular pH changes in rat nasal cavity
    • D.R. Plowchalk, M.E. Andersen, and M.S. Bogdanffy Physiologically based modeling of vinyl acetate uptake, metabolism, and intracellular pH changes in rat nasal cavity Toxicol. Appl. Pharmacol. 142 1997 386 400
    • (1997) Toxicol. Appl. Pharmacol. , vol.142 , pp. 386-400
    • Plowchalk, D.R.1    Andersen, M.E.2    Bogdanffy, M.S.3
  • 52
    • 13544257168 scopus 로고
    • The pharmacology of the mono methyl ethers of mono-, di-, and tripropylene glycol in the dog with observations on the auricular fibrillation produced by these compounds
    • F.E. Shideman, and L. Procita The pharmacology of the mono methyl ethers of mono-, di-, and tripropylene glycol in the dog with observations on the auricular fibrillation produced by these compounds J. Pharmacol. Exp. Ther. 102 1951 79 87
    • (1951) J. Pharmacol. Exp. Ther. , vol.102 , pp. 79-87
    • Shideman, F.E.1    Procita, L.2
  • 55
    • 77957184091 scopus 로고
    • Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro
    • W.T. Stott, and M.J. McKenna Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro Fund. Appl. Toxicol. 5 1985 399 404
    • (1985) Fund. Appl. Toxicol. , vol.5 , pp. 399-404
    • Stott, W.T.1    McKenna, M.J.2
  • 56
    • 0021231136 scopus 로고
    • The comparative absorption and excretion of chemical vapors by the upper, lower, and intact respiratory tract of rats
    • W.T. Stott, and M.J. McKenna The comparative absorption and excretion of chemical vapors by the upper, lower, and intact respiratory tract of rats Fund. Appl. Toxicol. 4 1984 594 602
    • (1984) Fund. Appl. Toxicol. , vol.4 , pp. 594-602
    • Stott, W.T.1    McKenna, M.J.2


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