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Volumn 174, Issue 10, 2005, Pages 6308-6313

The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD19 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 2 RECEPTOR ALPHA; MACROPHAGE ACTIVATING FACTOR; MACROPHAGE ACTIVATING LIPOPEPTIDE 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 18644372395     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.10.6308     Document Type: Article
Times cited : (63)

References (60)
  • 1
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger, P. 2002. The danger model: a renewed sense of self. Science 296: 301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 2
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12: 991-1045.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 3
    • 0035139983 scopus 로고    scopus 로고
    • Danger signals: SOS to the immune system
    • Gallucci, S., and P. Matzinger. 2001. Danger signals: SOS to the immune system. Curr. Opin. Immunol. 13: 114-119.
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 114-119
    • Gallucci, S.1    Matzinger, P.2
  • 4
    • 0027486404 scopus 로고
    • Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems
    • Holmgren, J., N. Lycke, and C. Czerkinsky. 1993. Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen vector systems. Vaccine 11: 1179-1184.
    • (1993) Vaccine , vol.11 , pp. 1179-1184
    • Holmgren, J.1    Lycke, N.2    Czerkinsky, C.3
  • 6
    • 0029008132 scopus 로고
    • A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity. PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins
    • Roberts, M., A. Bacon, R. Rappuoli, M. Pizza, I. Cropley, G. Douce, G. Dougan, M. Marinaro, J. McGhee, and S, Chatfield. 1995. A mutant pertussis toxin molecule that lacks ADP-ribosyltransferase activity. PT-9K/129G, is an effective mucosal adjuvant for intranasally delivered proteins. Infect. Immun. 63: 2100-2108.
    • (1995) Infect. Immun. , vol.63 , pp. 2100-2108
    • Roberts, M.1    Bacon, A.2    Rappuoli, R.3    Pizza, M.4    Cropley, I.5    Douce, G.6    Dougan, G.7    Marinaro, M.8    McGhee, J.9    Chatfield, S.10
  • 9
    • 0034650420 scopus 로고    scopus 로고
    • Cutting edge: Preferentially the R-stereoisomer of the mycoptasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway
    • Takeuchi, O., A. Kaufmann, K. Grote, T. Kawai, K. Hoshino, M. Morr, P. F. Mühlradt, and S. Akira. 2000. Cutting edge: preferentially the R-stereoisomer of the mycoptasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway. J. Immunol. 164: 554-557.
    • (2000) J. Immunol. , vol.164 , pp. 554-557
    • Takeuchi, O.1    Kaufmann, A.2    Grote, K.3    Kawai, T.4    Hoshino, K.5    Morr, M.6    Mühlradt, P.F.7    Akira, S.8
  • 12
    • 1642272442 scopus 로고    scopus 로고
    • The Toll-like receptor ligand MALP-2 stimulates dendritic cell maturation and modulates proteasome composition and activity
    • Link, C., R. Gavioli, T. Ebensen, A. Canella, E. Reinhard, and C. A. Guzman. 2004. The Toll-like receptor ligand MALP-2 stimulates dendritic cell maturation and modulates proteasome composition and activity. Eur. J. Immunol. 34: 899-907.
    • (2004) Eur. J. Immunol. , vol.34 , pp. 899-907
    • Link, C.1    Gavioli, R.2    Ebensen, T.3    Canella, A.4    Reinhard, E.5    Guzman, C.A.6
  • 13
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho, I., T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot. 2003. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197: 403-411.
    • (2003) J. Exp. Med. , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 14
    • 0031950056 scopus 로고    scopus 로고
    • Expression level of a transgenic λ2 chain results in isotype exclusion and commitment to B1 cells
    • Engel, H., B. Bogen, U. Muller, J. Andersson, A. Rolink, and S. Weiss. 1998. Expression level of a transgenic λ2 chain results in isotype exclusion and commitment to B1 cells. Eur. J. Immunol. 28: 2289-2299.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 2289-2299
    • Engel, H.1    Bogen, B.2    Muller, U.3    Andersson, J.4    Rolink, A.5    Weiss, S.6
  • 15
    • 0033229798 scopus 로고    scopus 로고
    • Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65
    • Jumaa, H., B. Wollscheid, M. Mitterer, J. Wienands, M. Reth, and P. J. Nielsen. 1999. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 11: 547-554.
    • (1999) Immunity , vol.11 , pp. 547-554
    • Jumaa, H.1    Wollscheid, B.2    Mitterer, M.3    Wienands, J.4    Reth, M.5    Nielsen, P.J.6
  • 16
    • 0037234971 scopus 로고    scopus 로고
    • The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion
    • Flemming, A., T. Brummer, M. Reth, and H. Jumaa. 2003. The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nat. Immunol. 4: 38-43.
    • (2003) Nat. Immunol. , vol.4 , pp. 38-43
    • Flemming, A.1    Brummer, T.2    Reth, M.3    Jumaa, H.4
  • 17
    • 0037100435 scopus 로고    scopus 로고
    • B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-α and Ig-β
    • Pelanda, R., U. Braun, E. Hobeika, M. C. Nussenzweig, and M. Reth. 2002. B cell progenitors are arrested in maturation but have intact VDJ recombination in the absence of Ig-α and Ig-β. J. Immunol. 169: 865-872.
    • (2002) J. Immunol. , vol.169 , pp. 865-872
    • Pelanda, R.1    Braun, U.2    Hobeika, E.3    Nussenzweig, M.C.4    Reth, M.5
  • 18
    • 0042346235 scopus 로고    scopus 로고
    • Antibody repertoire and gene expression profile: Implications for different developmental and functional traits of splenic and peritoneal B-1 lymphocytes
    • Kretschmer, K., A. Jungebloud, J. Stopkowicz, B. Stoermann, R. Hoffmann, and S. Weiss. 2003. Antibody repertoire and gene expression profile: implications for different developmental and functional traits of splenic and peritoneal B-1 lymphocytes. J. Immunol. 171: 1192-1201.
    • (2003) J. Immunol. , vol.171 , pp. 1192-1201
    • Kretschmer, K.1    Jungebloud, A.2    Stopkowicz, J.3    Stoermann, B.4    Hoffmann, R.5    Weiss, S.6
  • 19
    • 0345671672 scopus 로고    scopus 로고
    • Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration
    • Mühlradt, P. F., M. Kiess, H. Meyer, R. Süssmuth, and G. Jung. 1997. Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J. Exp. Med. 185: 1951-1958.
    • (1997) J. Exp. Med. , vol.185 , pp. 1951-1958
    • Mühlradt, P.F.1    Kiess, M.2    Meyer, H.3    Süssmuth, R.4    Jung, G.5
  • 20
    • 0016733262 scopus 로고
    • The lipoprotein of the outer membrane of Escherichia coli: A B-lymphocyte mitogen
    • Melchers, F., V. Braun, and C. Galanos. 1975. The lipoprotein of the outer membrane of Escherichia coli: a B-lymphocyte mitogen. J. Exp. Med. 142: 473-482.
    • (1975) J. Exp. Med. , vol.142 , pp. 473-482
    • Melchers, F.1    Braun, V.2    Galanos, C.3
  • 21
    • 0036176053 scopus 로고    scopus 로고
    • Site-specific proteolysis of the MALP-404 lipoprotein determines the release of a soluble selective lipoprotein-associated motif-containing fragment and alteration of the surface phenotype of Mycoplasma fermentans
    • Davis, K. L., and K. S. Wise. 2002. Site-specific proteolysis of the MALP-404 lipoprotein determines the release of a soluble selective lipoprotein-associated motif-containing fragment and alteration of the surface phenotype of Mycoplasma fermentans. Infect. Immun. 70: 1129-1135.
    • (2002) Infect. Immun. , vol.70 , pp. 1129-1135
    • Davis, K.L.1    Wise, K.S.2
  • 22
    • 0005484870 scopus 로고    scopus 로고
    • Genetic mechanisms of surface variation
    • R. Herrmann, ed. Kluwer Academic/Plenum, New York, Boston, Dordrecht. London, Moscow
    • Yogev, D., G. F. Browning, and K. Wise. 2002. Genetic mechanisms of surface variation. In Molecular Biology and Pathogenesis of Mycoplasmas. R. Herrmann, ed. Kluwer Academic/Plenum, New York, Boston, Dordrecht. London, Moscow, p. 417-444.
    • (2002) Molecular Biology and Pathogenesis of Mycoplasmas , pp. 417-444
    • Yogev, D.1    Browning, G.F.2    Wise, K.3
  • 23
    • 0038189845 scopus 로고    scopus 로고
    • Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells
    • Weigt, H., P. F. Mühlradt, A. Emmendorffer, N. Krug, and A. Braun. 2003. Synthetic mycoplasma-derived lipopeptide MALP-2 induces maturation and function of dendritic cells, Immunobiology 207: 223-233.
    • (2003) Immunobiology , vol.207 , pp. 223-233
    • Weigt, H.1    Mühlradt, P.F.2    Emmendorffer, A.3    Krug, N.4    Braun, A.5
  • 24
    • 0028863448 scopus 로고
    • Bacterial lipoproteins may substitute for cytokines in the humoral immune response to T cell-independent type 11 antigens
    • Snapper, C. M., F. R. Rosas, L. Jin, C. Wortham, M. R. Kehry, and J. J. Mond. 1995. Bacterial lipoproteins may substitute for cytokines in the humoral immune response to T cell-independent type 11 antigens. J. Immunol. 155: 5582-5589.
    • (1995) J. Immunol. , vol.155 , pp. 5582-5589
    • Snapper, C.M.1    Rosas, F.R.2    Jin, L.3    Wortham, C.4    Kehry, M.R.5    Mond, J.J.6
  • 25
    • 0021931094 scopus 로고
    • Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes
    • Lowenthal, J. W., R. H. Zubler, M. Nabholz, and H. R. MacDonald. 1985. Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. Nature 315: 669-672.
    • (1985) Nature , vol.315 , pp. 669-672
    • Lowenthal, J.W.1    Zubler, R.H.2    Nabholz, M.3    MacDonald, H.R.4
  • 26
    • 0027394657 scopus 로고
    • The IL-2/IL-2 receptor system: A current overview
    • Taniguchi, T., and Y. Minami. 1993. The IL-2/IL-2 receptor system: a current overview. Cell 73: 5-8.
    • (1993) Cell , vol.73 , pp. 5-8
    • Taniguchi, T.1    Minami, Y.2
  • 27
    • 0026587743 scopus 로고
    • CD19: Lowering the threshold for antigen receptor stimulation of B lymphocytes
    • Carter, R. H., and D. T. Fearon. 1992. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256: 105-107.
    • (1992) Science , vol.256 , pp. 105-107
    • Carter, R.H.1    Fearon, D.T.2
  • 28
    • 0029558617 scopus 로고
    • The CD 19 signal transduction molecule is a response regulator of B-lymphocyte differentiation
    • Sato, S., D. A. Steeber, and T. F. Tedder. 1995. The CD 19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc. Natl. Acad. Sci. USA 92: 11558-11562.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11558-11562
    • Sato, S.1    Steeber, D.A.2    Tedder, T.F.3
  • 29
    • 0023930695 scopus 로고
    • The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice
    • Kurt-Jones, E. A., D. Liano, K. A. HayGlass, B. Benacerraf, M. S. Sy, and A. K. Abbas. 1988. The role of antigen-presenting B cells in T cell priming in vivo. Studies of B cell-deficient mice. J. Immunol. 140: 3773-3778.
    • (1988) J. Immunol. , vol.140 , pp. 3773-3778
    • Kurt-Jones, E.A.1    Liano, D.2    HayGlass, K.A.3    Benacerraf, B.4    Sy, M.S.5    Abbas, A.K.6
  • 30
    • 0028261578 scopus 로고
    • In vivo activation of naive T cells by antigen-presenting B cells
    • Morris, S. C., A. Lees, and F. D. Finkelman. 1994. In vivo activation of naive T cells by antigen-presenting B cells. J. Immunol 152: 3777-3785.
    • (1994) J. Immunol. , vol.152 , pp. 3777-3785
    • Morris, S.C.1    Lees, A.2    Finkelman, F.D.3
  • 31
    • 0033563084 scopus 로고    scopus 로고
    • + T cell priming in vivo
    • + T cell priming in vivo. J. Immunol. 162: 5695-5703.
    • (1999) J. Immunol. , vol.162 , pp. 5695-5703
    • Constant, S.L.1
  • 32
    • 0033821991 scopus 로고    scopus 로고
    • A two-phase model of B-cell activation
    • Baumgarth, N. 2000. A two-phase model of B-cell activation, Immunol. Rev. 176: 171-180.
    • (2000) Immunol. Rev. , vol.176 , pp. 171-180
    • Baumgarth, N.1
  • 33
    • 0032525007 scopus 로고    scopus 로고
    • Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM
    • Boes, M., C. Esau, M. B. Fischer, T. Schmidt, M. Carroll, and J. Chen. 1998. Enhanced B-1 cell development, but impaired IgG antibody responses in mice deficient in secreted IgM. J. Immunol. 160: 4776-4787.
    • (1998) J. Immunol. , vol.160 , pp. 4776-4787
    • Boes, M.1    Esau, C.2    Fischer, M.B.3    Schmidt, T.4    Carroll, M.5    Chen, J.6
  • 34
    • 0032544110 scopus 로고    scopus 로고
    • Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response
    • Ehrenstein, M. R., T. L. O'Keefe, S. L. Davies, and M. S. Neuberger. 1998. Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response. Proc. Natl. Acad. Sci. USA 95: 10089-10093.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10089-10093
    • Ehrenstein, M.R.1    O'Keefe, T.L.2    Davies, S.L.3    Neuberger, M.S.4
  • 35
    • 0014307334 scopus 로고
    • Competition of 19S and 7S antigen receptors in the regulation of the primary immune response
    • Henry, C., and N. K. Jerne. 1968. Competition of 19S and 7S antigen receptors in the regulation of the primary immune response. J. Exp. Med. 128: 133-152.
    • (1968) J. Exp. Med. , vol.128 , pp. 133-152
    • Henry, C.1    Jerne, N.K.2
  • 36
    • 0020035069 scopus 로고
    • Antigen-dependent IgM-mediated enhancement of the sheep erythrocyte response in mice: Evidence for induction of B cells with specificities other than that of the injected antibodies
    • Heyman, B., G, Andrighetto, and H. Wigzell. 1982. Antigen-dependent IgM-mediated enhancement of the sheep erythrocyte response in mice: evidence for induction of B cells with specificities other than that of the injected antibodies. J. Exp. Med. 155: 994-1009.
    • (1982) J. Exp. Med. , vol.155 , pp. 994-1009
    • Heyman, B.1    Andrighetto, G.2    Wigzell, H.3
  • 37
    • 0020511441 scopus 로고
    • II. IgM-mediated enhancement: Dependency on antigen dose, T-cell requirement and lack of evidence for an idiotype-related mechanism
    • Lehner, P., P. Hutchings, P. M. Lydyard, and A. Cooke. 1983. II. IgM-mediated enhancement: dependency on antigen dose, T-cell requirement and lack of evidence for an idiotype-related mechanism. Immunology 50: 503-509.
    • (1983) Immunology , vol.50 , pp. 503-509
    • Lehner, P.1    Hutchings, P.2    Lydyard, P.M.3    Cooke, A.4
  • 38
    • 0021894435 scopus 로고
    • The classical complement pathway: Activation and regulation of the first complement component
    • Cooper, N. R. 1985. The classical complement pathway: activation and regulation of the first complement component. Adv. Immunol 37: 151-216.
    • (1985) Adv. Immunol. , vol.37 , pp. 151-216
    • Cooper, N.R.1
  • 40
    • 0018135592 scopus 로고
    • Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells
    • Chen L. L., A. M. Frank, J. C. Adams, and R. M. Steinman. 1978. Distribution of horseradish peroxidase (HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells. J. Cell Biol. 79: 184-189.
    • (1978) J. Cell Biol. , vol.79 , pp. 184-189
    • Chen, L.L.1    Frank, A.M.2    Adams, J.C.3    Steinman, R.M.4
  • 41
    • 0021272471 scopus 로고
    • Follicular trapping of hapten-erythrocyte-antibody complexes in mouse spleen
    • Enriquez-Rincon, F., and G. G. Klaus. 1984. Follicular trapping of hapten-erythrocyte-antibody complexes in mouse spleen. Immunology 52: 107-116.
    • (1984) Immunology , vol.52 , pp. 107-116
    • Enriquez-Rincon, F.1    Klaus, G.G.2
  • 42
    • 0030593030 scopus 로고    scopus 로고
    • C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
    • Dempsey, P. W., M. E. Allison, S. Akkaraju, C. C. Goodnow, and D. T. Fearon. 1996. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271: 348-350.
    • (1996) Science , vol.271 , pp. 348-350
    • Dempsey, P.W.1    Allison, M.E.2    Akkaraju, S.3    Goodnow, C.C.4    Fearon, D.T.5
  • 43
    • 0029064680 scopus 로고
    • Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
    • Rickert, R. C., K. Rajewsky. and J. Roes. 1995. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Nature 376: 352-355.
    • (1995) Nature , vol.376 , pp. 352-355
    • Rickert, R.C.1    Rajewsky, K.2    Roes, J.3
  • 44
    • 0029916530 scopus 로고    scopus 로고
    • Antibody response to a T-dependent antigen requires B cell expression of complement receptors
    • Croix, D. A., J. M. Ahearn, A. M. Rosengard, S. Han, G. Kelsoe, M. Ma, and M. C. Carroll. 1996. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J. Exp. Med. 183: 1857-1864.
    • (1996) J. Exp. Med. , vol.183 , pp. 1857-1864
    • Croix, D.A.1    Ahearn, J.M.2    Rosengard, A.M.3    Han, S.4    Kelsoe, G.5    Ma, M.6    Carroll, M.C.7
  • 45
    • 15844412034 scopus 로고    scopus 로고
    • Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen
    • Aheam, J. M., M. B. Fischer, D. Croix, S. Goerg, M. Ma, J. Xia, X. Zhou, R. G. Howard, T. L. Rothstein, and M. C. Carroll. 1996. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 4: 251-262.
    • (1996) Immunity , vol.4 , pp. 251-262
    • Aheam, J.M.1    Fischer, M.B.2    Croix, D.3    Goerg, S.4    Ma, M.5    Xia, J.6    Zhou, X.7    Howard, R.G.8    Rothstein, T.L.9    Carroll, M.C.10
  • 47
    • 0021273088 scopus 로고
    • Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins
    • Brandtzaeg, P., and H. Prydz. 1984. Direct evidence for an integrated function of J chain and secretory component in epithelial transport of immunoglobulins. Nature 311: 71-73.
    • (1984) Nature , vol.311 , pp. 71-73
    • Brandtzaeg, P.1    Prydz, H.2
  • 49
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi. O., S. Sato, T. Horiuchi, K. Hoshino, K. Takeda, Z. Dong, R. L. Modlin, and S. Akira. 2002. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169: 10-14.
    • (2002) J. Immunol. , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3    Hoshino, K.4    Takeda, K.5    Dong, Z.6    Modlin, R.L.7    Akira, S.8
  • 50
    • 0037083638 scopus 로고    scopus 로고
    • Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent
    • Massari, P., P. Henneke, Y. Ho, E. Latz, D. T. Golenbock, and L. M. Wetzler. 2002. Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J. Immunol. 168: 1533-1537.
    • (2002) J. Immunol. , vol.168 , pp. 1533-1537
    • Massari, P.1    Henneke, P.2    Ho, Y.3    Latz, E.4    Golenbock, D.T.5    Wetzler, L.M.6
  • 51
    • 0034669965 scopus 로고    scopus 로고
    • Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848
    • Bishop, G. A., Y. Hsing, B. S. Hostager, S. V. Jalukar, L. M. Ramirez, and M. A. Tomai. 2000. Molecular mechanisms of B lymphocyte activation by the immune response modifier R-848. J. Immunol, 165: 5552-5557.
    • (2000) J. Immunol. , vol.165 , pp. 5552-5557
    • Bishop, G.A.1    Hsing, Y.2    Hostager, B.S.3    Jalukar, S.V.4    Ramirez, L.M.5    Tomai, M.A.6
  • 53
    • 0034631779 scopus 로고    scopus 로고
    • The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes
    • Tomai, M. A., L. M. Imbertson, T. L. Stanczak, L. T. Tygrett, and T. J. Waldschmidt. 2000. The immune response modifiers imiquimod and R-848 are potent activators of B lymphocytes. Cell Immunol. 203: 55-65.
    • (2000) Cell Immunol. , vol.203 , pp. 55-65
    • Tomai, M.A.1    Imbertson, L.M.2    Stanczak, T.L.3    Tygrett, L.T.4    Waldschmidt, T.J.5
  • 55
    • 0035340404 scopus 로고    scopus 로고
    • Enhancement of antigen-presenting ability of B lymphoma cells by immunostimulatory CpG-oligonucleotides and anti-CD40 antibody
    • Chen, W., Y. Yu, C. Shao, M. Zhang, W. Wang, L. Zhang, and X. Cao. 2001. Enhancement of antigen-presenting ability of B lymphoma cells by immunostimulatory CpG-oligonucleotides and anti-CD40 antibody. Immunol. Lett. 77: 17-23.
    • (2001) Immunol. Lett. , vol.77 , pp. 17-23
    • Chen, W.1    Yu, Y.2    Shao, C.3    Zhang, M.4    Wang, W.5    Zhang, L.6    Cao, X.7
  • 56
    • 0031171377 scopus 로고    scopus 로고
    • OspA lipoprotein of Borrelia burgdorferi is a mucosal immunogen and adjuvant
    • Erdile, L. F., and B. Guy. 1997. OspA lipoprotein of Borrelia burgdorferi is a mucosal immunogen and adjuvant. Vaccine 15: 988-996.
    • (1997) Vaccine , vol.15 , pp. 988-996
    • Erdile, L.F.1    Guy, B.2
  • 57
    • 0024441168 scopus 로고
    • Enhancement of protection against Salmonella infection in mice mediated by a synthetic lipopeptide analogue of bacterial lipoprotein in S. typhimurium vaccines
    • Schlecht, S., K. H. Wiesmuller, G. Jung, and W. G. Bessler. 1989. Enhancement of protection against Salmonella infection in mice mediated by a synthetic lipopeptide analogue of bacterial lipoprotein in S. typhimurium vaccines. Zentralbl Bakteriol. 271: 493-500.
    • (1989) Zentralbl Bakteriol. , vol.271 , pp. 493-500
    • Schlecht, S.1    Wiesmuller, K.H.2    Jung, G.3    Bessler, W.G.4
  • 59
    • 0032210729 scopus 로고    scopus 로고
    • Preclinical studies on a recombinant group B meningococcal porin as a carrier for a novel Haemophilus influenzae type b conjugate vaccine
    • Fusco, P. C., F. Michon, M. Laude-Sharp, C. A. Minetti, C. H. Huang. I. Heron, and M. S. Blake. 1998. Preclinical studies on a recombinant group B meningococcal porin as a carrier for a novel Haemophilus influenzae type b conjugate vaccine. Vaccine 16: 1842-1849.
    • (1998) Vaccine , vol.16 , pp. 1842-1849
    • Fusco, P.C.1    Michon, F.2    Laude-Sharp, M.3    Minetti, C.A.4    Huang, C.H.5    Heron, I.6    Blake, M.S.7
  • 60
    • 0031800888 scopus 로고    scopus 로고
    • CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
    • Moldoveanu, Z., L. Love-Homan, W. Q. Huang, and A. M. Krieg. 1998. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 16: 1216-1224.
    • (1998) Vaccine , vol.16 , pp. 1216-1224
    • Moldoveanu, Z.1    Love-Homan, L.2    Huang, W.Q.3    Krieg, A.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.