-
1
-
-
0029166509
-
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
-
Meunier JC, Mollereau C, Toll L, Suaudeau C, Moisand C, Alivinerie P, Butour JL, Guillemot JC, Ferrara P, Monsarrat B, Mazarguil H, Vassart G, Parmentier M, Costentin J. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature 1995; 377: 532-535.
-
(1995)
Nature
, vol.377
, pp. 532-535
-
-
Meunier, J.C.1
Mollereau, C.2
Toll, L.3
Suaudeau, C.4
Moisand, C.5
Alivinerie, P.6
Butour, J.L.7
Guillemot, J.C.8
Ferrara, P.9
Monsarrat, B.10
Mazarguil, H.11
Vassart, G.12
Parmentier, M.13
Costentin, J.14
-
2
-
-
0028971215
-
Orphanin FQ: A neuropeptide that activates an opioid like G protein-coupled receptor
-
Reinscheid RK, Nothacker HP, Bourson A, Ardati A, Henningsen RA, Bunzow JR, Grandy DK, Langen H, Monsma FJ, Civelli O. Orphanin FQ: a neuropeptide that activates an opioid like G protein-coupled receptor. Science 1995; 270: 792-794.
-
(1995)
Science
, vol.270
, pp. 792-794
-
-
Reinscheid, R.K.1
Nothacker, H.P.2
Bourson, A.3
Ardati, A.4
Henningsen, R.A.5
Bunzow, J.R.6
Grandy, D.K.7
Langen, H.8
Monsma, F.J.9
Civelli, O.10
-
4
-
-
0032104547
-
Anti-hyperalgesic and anti-allodynic effects of intrathecal nociceptin/orphanin FQ in rats after spinal cord injury, peripheral nerve injury and inflammation
-
Hao JX, Xu IS, Wiesenfeld-Hallin Z, Xu XJ. Anti-hyperalgesic and anti-allodynic effects of intrathecal nociceptin/orphanin FQ in rats after spinal cord injury, peripheral nerve injury and inflammation. Pain 1998; 76: 385-393.
-
(1998)
Pain
, vol.76
, pp. 385-393
-
-
Hao, J.X.1
Xu, I.S.2
Wiesenfeld-Hallin, Z.3
Xu, X.J.4
-
5
-
-
0031553387
-
Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor
-
Meunier JC. Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor. Eur. J. Pharmacol. 1997; 340: 1-15.
-
(1997)
Eur. J. Pharmacol
, vol.340
, pp. 1-15
-
-
Meunier, J.C.1
-
6
-
-
0031050078
-
Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats
-
Sandin J, Georgieva J, Schott PA, Ogren SO, Terenius L. Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats. Eur. J. Neurosci. 1997; 9: 194-197.
-
(1997)
Eur. J. Neurosci
, vol.9
, pp. 194-197
-
-
Sandin, J.1
Georgieva, J.2
Schott, P.A.3
Ogren, S.O.4
Terenius, L.5
-
7
-
-
17944390583
-
Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors
-
Manabe T, Noda Y, Mamiya T, Katagiri H, Houtani T, Nishi M, Nada T, Takahashi T, Sugimoto T, Nabeshima T, Takeshima H. Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. Nature 1998; 394: 577-581.
-
(1998)
Nature
, vol.394
, pp. 577-581
-
-
Manabe, T.1
Noda, Y.2
Mamiya, T.3
Katagiri, H.4
Houtani, T.5
Nishi, M.6
Nada, T.7
Takahashi, T.8
Sugimoto, T.9
Nabeshima, T.10
Takeshima, H.11
-
8
-
-
0031912743
-
Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice
-
Mamiya T, Noda Y, Nishi M, Takeshima H, Nabeshima T. Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice. Brain Res. 1998; 783: 236-240.
-
(1998)
Brain Res
, vol.783
, pp. 236-240
-
-
Mamiya, T.1
Noda, Y.2
Nishi, M.3
Takeshima, H.4
Nabeshima, T.5
-
9
-
-
0034687553
-
Highly potent nociceptin analog containing the Arg-Lys triple repeat
-
Okada K, Sujaku T, Chuman Y, Nakashima R, Nose T, Costa T, Yamada Y, Yokoyama M, Nagahisa A, Shimohigashi Y. Highly potent nociceptin analog containing the Arg-Lys triple repeat. Biochem. Biophys. Res. Commun. 2000; 278: 493-498.
-
(2000)
Biochem. Biophys. Res. Commun
, vol.278
, pp. 493-498
-
-
Okada, K.1
Sujaku, T.2
Chuman, Y.3
Nakashima, R.4
Nose, T.5
Costa, T.6
Yamada, Y.7
Yokoyama, M.8
Nagahisa, A.9
Shimohigashi, Y.10
-
10
-
-
0033556437
-
Desensitization of G-protein-coupled receptors
-
Xiao Z, Yao Y, Long Y, Devreotes P. Desensitization of G-protein-coupled receptors. J. Biol. Chem. 1999; 274: 1440-1448.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 1440-1448
-
-
Xiao, Z.1
Yao, Y.2
Long, Y.3
Devreotes, P.4
-
11
-
-
0034736150
-
4-Aminoquinolines: Novel nociceptin antagonists with analgesic activity
-
Shinkai H, Ito T, Iida T, Kitao Y, Yamada H, Uchida I. 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J. Med. Chem. 2000; 43: 4667-4677.
-
(2000)
J. Med. Chem
, vol.43
, pp. 4667-4677
-
-
Shinkai, H.1
Ito, T.2
Iida, T.3
Kitao, Y.4
Yamada, H.5
Uchida, I.6
-
12
-
-
0036177296
-
Pharmacological profiles of a novel opioid receptor-like 1 (ORL1) receptor antagonist, JTC-801
-
Yamada H, Nakamoto H, Suzuki Y, Ito T, Aisaka K. Pharmacological profiles of a novel opioid receptor-like 1 (ORL1) receptor antagonist, JTC-801. Br. J. Pharmacol. 2002; 135: 323-332.
-
(2002)
Br. J. Pharmacol
, vol.135
, pp. 323-332
-
-
Yamada, H.1
Nakamoto, H.2
Suzuki, Y.3
Ito, T.4
Aisaka, K.5
-
13
-
-
0033576679
-
Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl] -3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397)
-
Kawamoto H, Ozaki S, Itoh Y, Miyaji M, Arai S, Nakashima H, Kato T, Ohta H, Iwasawa Y. Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl] -3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397). J. Med. Chem. 1999; 42: 5061-5063.
-
(1999)
J. Med. Chem
, vol.42
, pp. 5061-5063
-
-
Kawamoto, H.1
Ozaki, S.2
Itoh, Y.3
Miyaji, M.4
Arai, S.5
Nakashima, H.6
Kato, T.7
Ohta, H.8
Iwasawa, Y.9
-
14
-
-
0033969588
-
A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist: J-113397
-
Ozaki S, Kawamoto H, Itoh Y, Miyaji M, Iwasawa Y, Ohta H. A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist: J-113397. Eur. J. Pharmacol. 2000; 387: R17-R18.
-
(2000)
Eur. J. Pharmacol
, vol.387
-
-
Ozaki, S.1
Kawamoto, H.2
Itoh, Y.3
Miyaji, M.4
Iwasawa, Y.5
Ohta, H.6
-
15
-
-
0034683206
-
In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist
-
Ozaki S, Kawamoto H, Itoh Y, Miyaji M, Azuma T, Ichikawa D, Nambu H, Iguchi T, Iwasawa Y, Ohta H. In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur. J. Pharmacol. 2000; 402: 45-53.
-
(2000)
Eur. J. Pharmacol
, vol.402
, pp. 45-53
-
-
Ozaki, S.1
Kawamoto, H.2
Itoh, Y.3
Miyaji, M.4
Azuma, T.5
Ichikawa, D.6
Nambu, H.7
Iguchi, T.8
Iwasawa, Y.9
Ohta, H.10
-
16
-
-
0031593492
-
2, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord
-
2, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord. Br. J. Pharmacol. 1998; 125: 949-951.
-
(1998)
Br. J. Pharmacol
, vol.125
, pp. 949-951
-
-
Carpenter, K.J.1
Dickenson, A.H.2
-
17
-
-
0031974718
-
A new selective antagonist of the nociceptin receptor
-
Guerrini R, Calo G, Rizzi A, Bigoni R, Bianchi C, Salvadori S, Regoli D. A new selective antagonist of the nociceptin receptor. Br. J. Pharmacol. 1998; 123: 163-165.
-
(1998)
Br. J. Pharmacol
, vol.123
, pp. 163-165
-
-
Guerrini, R.1
Calo, G.2
Rizzi, A.3
Bigoni, R.4
Bianchi, C.5
Salvadori, S.6
Regoli, D.7
-
18
-
-
0031690094
-
Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway
-
Shah S, Page CP, Spina D. Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway. Br. J. Pharmacol. 1998; 125: 510-516.
-
(1998)
Br. J. Pharmacol
, vol.125
, pp. 510-516
-
-
Shah, S.1
Page, C.P.2
Spina, D.3
-
19
-
-
0032588075
-
2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors
-
2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors. Br. J. Pharmacol. 1999; 127: 123-130.
-
(1999)
Br. J. Pharmacol
, vol.127
, pp. 123-130
-
-
Okawa, H.1
Nicol, B.2
Bigoni, R.3
Hirst, R.A.4
Calo, G.5
Guerrini, R.6
Rowbotham, D.J.7
Smart, D.8
McKnight, A.T.9
Lambert, D.G.10
-
22
-
-
0034101842
-
2, a new selective nociceptin receptor antagonist
-
2, a new selective nociceptin receptor antagonist. Br. J. Pharmacol. 2000; 129: 1183-1193.
-
(2000)
Br. J. Pharmacol
, vol.129
, pp. 1183-1193
-
-
Calo', G.1
Guerrini, R.2
Bigoni, R.3
Rizzi, A.4
Marzola, G.5
Okawa, H.6
Bianchi, C.7
Lambert, D.G.8
Salvadori, S.9
Regoli, D.10
-
23
-
-
0033560133
-
Orphanin-FQ/nociceptin (OFQ/N) modulates the activity of suprachiasmatic nucleus neurons
-
Allen CN, Jiang ZG, Teshima K, Darland T, Ikeda M, Nelson CS, Quigley DI, Yoshioka T, Allen RG, Rea MA, Grandy DK. Orphanin-FQ/nociceptin (OFQ/N) modulates the activity of suprachiasmatic nucleus neurons. J. Neurosci. 1999; 19: 2152-2160.
-
(1999)
J. Neurosci
, vol.19
, pp. 2152-2160
-
-
Allen, C.N.1
Jiang, Z.G.2
Teshima, K.3
Darland, T.4
Ikeda, M.5
Nelson, C.S.6
Quigley, D.I.7
Yoshioka, T.8
Allen, R.G.9
Rea, M.A.10
Grandy, D.K.11
-
24
-
-
0032589310
-
gray
-
2 activation of an inward rectifier as a partial agonist of ORL1 receptors in rat periaqueductal gray. Br. J. Pharmacol. 1999; 128: 103-107.
-
(1999)
Br. J. Pharmacol
, vol.128
, pp. 103-107
-
-
Chiou, L.C.1
-
25
-
-
0033153291
-
Pre- and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro
-
Emmerson PJ, Miller RJ. Pre- and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro. J. Physiol. 1999: 517: 431-445.
-
(1999)
J. Physiol
, vol.517
, pp. 431-445
-
-
Emmerson, P.J.1
Miller, R.J.2
-
26
-
-
0032589558
-
2 on tonic activity of rat hypothalamic neurons
-
2 on tonic activity of rat hypothalamic neurons. Neurosci. Lett. 1999; 274: 87-90.
-
(1999)
Neurosci. Lett
, vol.274
, pp. 87-90
-
-
Yakimova, K.S.1
Pierau, F.K.2
-
27
-
-
0030831767
-
Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1
-
Dooley CT, Spaeth CG, Berzetei-Gurske IP, Craymer K, Adapa ID, Brandt SR, Houghten RA, Toll L. Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J. Pharmacol. Exp. Ther. 1997; 283: 735-741.
-
(1997)
J. Pharmacol. Exp. Ther
, vol.283
, pp. 735-741
-
-
Dooley, C.T.1
Spaeth, C.G.2
Berzetei-Gurske, I.P.3
Craymer, K.4
Adapa, I.D.5
Brandt, S.R.6
Houghten, R.A.7
Toll, L.8
-
28
-
-
0032982315
-
2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ
-
2 of G protein activation in rat brain preparations and of chronotropic effect on rat cardiomyocytes evoked by nociceptin/orphanin FQ. Br. J. Pharmacol. 1999; 126: 555-558.
-
(1999)
Br. J. Pharmacol
, vol.126
, pp. 555-558
-
-
Berger, H.1
Albrecht, E.2
Wallukat, G.3
Bienert, M.4
-
29
-
-
0033821760
-
The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties
-
Berger H, Bigoni R, Albrecht E, Richter RM, Krause E, Bienert M, Calo' G. The nociceptin/orphanin FQ receptor ligand acetyl-RYYRIK-amide exhibits antagonistic and agonistic properties. Peptide 2000; 21: 1131-1139.
-
(2000)
Peptide
, vol.21
, pp. 1131-1139
-
-
Berger, H.1
Bigoni, R.2
Albrecht, E.3
Richter, R.M.4
Krause, E.5
Bienert, M.6
Calo', G.7
-
30
-
-
0021100710
-
High efficiency polyoma DNA transfection of chloroquine treated cells
-
Luthman H, Magnusson G. High efficiency polyoma DNA transfection of chloroquine treated cells. Nucleic Acids Res. 1983; 11: 1295-1308.
-
(1983)
Nucleic Acids Res
, vol.11
, pp. 1295-1308
-
-
Luthman, H.1
Magnusson, G.2
-
31
-
-
0018001339
-
Simultaneous analysis of families of sigmoidal curves: Application to bioassay, radioligand assay, and physiological dose-response curves
-
DeLean A, Munson PJ, Rodbard D. Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. Am. J. Physiol. 1978; 235: E97-E102.
-
(1978)
Am. J. Physiol
, vol.235
-
-
DeLean, A.1
Munson, P.J.2
Rodbard, D.3
-
32
-
-
0032793461
-
Effects of substitution of hydrophobic amino acids by tryptophan on receptor binding and biological activity of neuropeptide nociceptin
-
Okada K, Sujaku T, Nakashima R, Nose T, Yamada Y, Yokoyama M, Nagahisa A, Shimohigashi Y. Effects of substitution of hydrophobic amino acids by tryptophan on receptor binding and biological activity of neuropeptide nociceptin. Bull. Chem. Soc. Jpn. 1999; 72: 1899-1904.
-
(1999)
Bull. Chem. Soc. Jpn
, vol.72
, pp. 1899-1904
-
-
Okada, K.1
Sujaku, T.2
Nakashima, R.3
Nose, T.4
Yamada, Y.5
Yokoyama, M.6
Nagahisa, A.7
Shimohigashi, Y.8
-
33
-
-
0032496406
-
Different domains of the ORL1 and κ-opioid receptors are involved in recognition of nociceptin and dynorphin A
-
Lapalu S, Moisand C, Butour JL, Mollereau C, Meunier JC. Different domains of the ORL1 and κ-opioid receptors are involved in recognition of nociceptin and dynorphin A. FEBS Lett. 1998; 427: 296-300.
-
(1998)
FEBS Lett
, vol.427
, pp. 296-300
-
-
Lapalu, S.1
Moisand, C.2
Butour, J.L.3
Mollereau, C.4
Meunier, J.C.5
-
34
-
-
0033023897
-
Distinct mechanisms for activation of the opioid receptor-like 1 and κ-opioid receptors by nociceptin and dynorphin A
-
Mollereau C, Mouledous L, Lapalu S, Cambois G, Moisand C, Butour JL, Meunier JC. Distinct mechanisms for activation of the opioid receptor-like 1 and κ-opioid receptors by nociceptin and dynorphin A. Mol. Pharmacol. 1999: 55: 324-331.
-
(1999)
Mol. Pharmacol
, vol.55
, pp. 324-331
-
-
Mollereau, C.1
Mouledous, L.2
Lapalu, S.3
Cambois, G.4
Moisand, C.5
Butour, J.L.6
Meunier, J.C.7
-
35
-
-
0034072698
-
The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics
-
Barlocco D, Cignarella G, Giardina GAM, Toma L. The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics. Eur. J. Med. Chem. 2000; 35: 275-282.
-
(2000)
Eur. J. Med. Chem
, vol.35
, pp. 275-282
-
-
Barlocco, D.1
Cignarella, G.2
Giardina, G.A.M.3
Toma, L.4
-
36
-
-
0029796366
-
Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide
-
Shimohigashi Y, Hatano R, Fujita T, Nakashima R, Nose T, Sujaku T, Saigo A, Shinjo K, Nagahisa A. Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide. J. Biol. Chem. 1996; 271: 23642-23645.
-
(1996)
J. Biol. Chem
, vol.271
, pp. 23642-23645
-
-
Shimohigashi, Y.1
Hatano, R.2
Fujita, T.3
Nakashima, R.4
Nose, T.5
Sujaku, T.6
Saigo, A.7
Shinjo, K.8
Nagahisa, A.9
|