Evidence that [Phe1 ψ(CH2-NH)Gly2]nociceptin-(1-13)-NH2, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord

British Journal of Pharmacology

Volumn 125, Issue 5, 1998, Pages 949-952

  Carpenter, Kate J ^a   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antinociception; Nociceptin; ORL 1 receptor; Spinal cord

Indexed keywords

ANTINOCICEPTIVE AGENT; NOCICEPTIN; OPIATE AGONIST; OPIATE ANTAGONIST; OPIATE RECEPTOR; ANALGESIC AGENT; NOCICEPTIN (1 13) NH2, PHE(1) PSI(CH2 NH) GLY(2); NOCICEPTIN (1-13)-NH2, PHE(1)-PSI(CH2-NH)-GLY(2)-; NOCICEPTIN RECEPTOR; OPIATE PEPTIDE; PEPTIDE; PEPTIDE FRAGMENT;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; SPINAL CORD DORSAL HORN; ANESTHESIA; ANIMAL; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; HAMSTER; HUMAN; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT;

ANALGESICS; ANESTHESIA; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; MALE; NEURONS; OPIOID PEPTIDES; PEPTIDE FRAGMENTS; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; SPINAL CORD;

EID: 0031593492     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702188     Document Type: Article

References (11)

1. ANTON, B., FEIN, J., TO, T., LI, X., SILBERSTEIN, L. & EVANS, C.J. (1996). Immunohistochemical localization of ORL-1 in the central nervous system of the rat. J. Comp. Neurol., 368, 229-251.
2. 2 is an agonist of the nociceptin (ORL-1) receptor. Eur. J. Pharmacol., In press.
3. DICKENSON, A.H., SULLIVAN, A., KNOX, R., ROQUES, B.P. & ZAJAC, J. (1987). Opioid receptor subtypes in the rat spinal cord: electrophysiological evidence for a role of mu and delta opioid receptor antagonists in the control of nociception. Brain Res., 413, 44-46.
4. GUERRINI, R., CALO, G., RIZZI, A., BIGONI, R., BIANCHI, C., SALVADORI, S. & REGOLI, D. (1998). A new selective antagonist of the nociceptin receptor. Br. J. Pharmacol., 123, 163-165.
5. MATHIS, J.P., RYAN-MORO, J., CHANG, A., HOM, J.S., SCHEINBERG, D.A. & PASTERNAK, G.W. (1997). Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain. Biochem. Biophys. Res. Commun., 230, 462-465.
6. MEUNIER, J.-C. (1997). Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor. Eur. J. Pharmacol., 340, 1-15.
7. PELUSO, J., LAFORGE, K.S., MATTHES, H.W., KREEK, M.J., KIEFFER, B.L. & GAVÉRIAUX-RUFF, C. (1998). Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells. J. Neuroimmunol., 81, 184-192.
8. REINSCHEID, R.K., NOTHAKER, H.-P., BOURSON, A., ARDATI, A., HENNINGSEN, R.A., BUNZOW, J.R., GRANDY, D.K., LANGEN, H., MONSMA JR, F.R. & CIVELLI, O. (1995). Orphanin FQ: A neuropeptide that activates an opioid-like G protein-coupled receptor. Science, 270, 792-794.
9. STANFA, L.C., CHAPMAN, V., KERR, N. & DICKENSON, A.H. (1996). Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo. Br. J. Pharmacol,. 118, 1875-1877.
10. WICK, M.J., MINNERATH, S.R., LIN, X., ELDE, R., LAW, P.-Y. & LOH, H.H. (1994). Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ and κ opioid receptors. Mol. Brain Res., 27, 37-44.
11. WILLIAMS, C.A., WU, S.Y., COOK, J. & DUN, N.J. (1998). Release of nociceptin-like substance from the rat spinal cord dorsal horn. Neurosci. Lett., 244, 141-144.