Appetitive instrumental learning is impaired by inhibition of cAMP-dependent protein kinase within the nucleus accumbens

Neurobiology of Learning and Memory

Volumn 77, Issue 1, 2002, Pages 44-62

  Baldwin, Anne E ^a   Sadeghian, Kenneth ^b   Holahan, Matthew R ^b   Kelley, Ann E ^a,b  

^a Neuroscience Training Program   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Appetitive learning; cAMP dependent protein kinase; D1; Dopamine; Nucleus accumbens; PKA, striatum

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; ADENOSINE 3',5' CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ACTIVATOR; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ENZYME ACTIVATOR; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ADAPTIVE BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; FEEDING; LEARNING; MALE; MOTOR ACTIVITY; NONHUMAN; NUCLEUS ACCUMBENS; PROTEIN FUNCTION; RAT; TASK PERFORMANCE;

EID: 0036353486     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1006/nlme.2000.4002     Document Type: Article

References (58)

1. Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory
2. Distinct interactions between Ca2+/calmodulin and neurotransmitter stimulation of adenylate cyclase in striatum and hippocampus
3. Late and prolonged post-training memory modulation in entorhinal and parietal cortex by drugs acting on the cAMP/protein kinase A signaling pathway
4. Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons
5. N-methyl-D-aspartate receptor-dependent plasticity within a distributed corticostriatal network mediates appetitive instrumental learning
6. Stimulators of the cAMP cascade reverse amnesia induced by intra-amygdala but not intrahippocampal KN-62 administration
7. Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats
8. Hippocampal cGMP and cAMP are differentially involved in memory processing of inhibitory avoidance learning
9. Food reward: Brain substrates of wanting and liking
10. Agents that affect cAMP levels or protein kinase A activity modulate memory consolidation when injected into rat hippocampus but not amygdala
11. Drugs acting upon the cyclic adenosine monophosphate/protein kinase A signalling pathway modulate memory consolidation when given late after training into rat hippocampus but not amygdala
12. Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA
13. The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported fluoro-gold
14. Protein kinase inhibitors: Probes for the functions of protein phosphorylation
15. Neuromodulatory actions of dopamine in the neostriatum are dependent upon the excitatory amino acid receptor subtypes activated
16. Dopamine and N-methyl-D-aspartate receptor interactions in the neostriatum
17. Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum
18. The role of dopamine in drug abuse viewed from the perspective of its role in motivation
19. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons
20. Elements of the intrinsic organization and information processing in the neostriatum
21. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C
22. Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus
23. Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB- dependent transcription and ERK nuclear translocation
24. Memory formation: The sequence of biochemical events in the hippocampus and its connection to activity in other brain structures
25. Blockade of neurotensin-induced motor activity by inhibition of protein kinase
26. Genes, nerve cells and the remembrance of things past
27. Response-reinforcement learning is dependent on NMDA receptor activation in the nucleus accumbens core
28. Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium
29. Postsynaptic integration of glutamatergic and dopaminergic signals in the striatum
30. Synaptic plasticity in the hippocampus: LTP and LTD
31. NMDA-receptor-dependent synaptic plasticity: Multiple forms and mechanisms
32. Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis
33. Protein phosphorylation and the regulation of neuronal function
34. Opposite modulation of opiate withdrawal behaviors on microinfusion of a protein kinase A inhibitor versus activator into the locus coeruleus or periaqueductal gray
35. Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase
36. Involvement of mechanisms dependent on NMDA receptors, nitric oxide and protein kinase A in the hippocampus but not in the caudate nucleus in memory
37. Neurobehavioural mechanisms of reward and motivation
38. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3′,5′-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase
39. The involvement of nucleus accumbens dopamine in appetitive and aversive motivation
40. Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase
41. Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior
42. CREB and memory
43. The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones
44. Synaptic relationships between dopaminergic afferents and cortical or thalamic input in the sensorimotor territory of the striatum in monkey
45. Coincident activation of NMDA and dopamine D1 receptors within the nucleus accumbens core is required for appetitive instrumental learning
46. A dopamine/D1 receptor/protein kinase A/dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor
47. Excitatory interactions between glutamate receptors and protein kinases
48. Injection of the protein kinase inhibitor H7 into the A10 dopamine region blocks the acute responses to cocaine: Behavioral and in vivo microdialysis studies
49. Conditioned locomotion in rats following amphetamine infusion into the nucleus accumbens: Blockade by coincident inhibition of protein kinase A
50. Activation of cAMP-depenendent protein kinase A in prefrontal cortex impairs working memory performance
51. Possible involvement of protein kinases in physical dependence on opioids: Studies using protein kinase inhibitors, H-7 and H-8
52. Excitatory amino acids and drugs of abuse: A role for N-methyl-D-aspartate receptors in drug tolerance, sensitization and physical dependence
53. Cellular models of reinforcement
54. Dopamine reverses the depression of rat corticostriatal synapses which normally follows high-frequency stimulation of cortex in vitro
55. Modulation of memory fields by dopamine D1 receptors in prefrontal cortex
56. A psychomotor stimulant theory of addiction
57. On the significance of subterritories in the "accumbens" part of the rat ventral striatum