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Volumn 11, Issue 3, 2004, Pages 408-417

Increases in fibrosis-related gene transcripts in livers of dimethylnitrosamine-intoxicated rats

Author keywords

Smooth muscle actin; Connective tissue growth factor; Dimethylnitrosamine; Fibrosis; Tissue inhibitor of metalloproteinase 1; Transforming growth factor 1

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; ALANINE AMINOTRANSFERASE; ALPHA ACTIN; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; COLLAGEN; DIMETHYLNITROSAMINE; PROCOLLAGEN; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

EID: 1842635414     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000077110     Document Type: Article
Times cited : (28)

References (61)
  • 1
    • 0023196358 scopus 로고
    • Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat
    • Ala-Kokko L, Pihlajaniemi T, Myers JC, Kivirikko KI, Savolainen ER. Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat. Biochem J 244:75-79;1987.
    • (1987) Biochem J , vol.244 , pp. 75-79
    • Ala-Kokko, L.1    Pihlajaniemi, T.2    Myers, J.C.3    Kivirikko, K.I.4    Savolainen, E.R.5
  • 2
    • 0034767501 scopus 로고    scopus 로고
    • Transforming growth factor β and the liver
    • Bissell DM, Roulot D, George J. Transforming growth factor β and the liver. Hepatology 34:859-867;2001.
    • (2001) Hepatology , vol.34 , pp. 859-867
    • Bissell, D.M.1    Roulot, D.2    George, J.3
  • 3
    • 0034604110 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human disease
    • Blobe GC, Schiemann WP, Lodish, HF. Role of transforming growth factor beta in human disease. N Engl J Med 342:1350-1358;2000.
    • (2000) N Engl J Med , vol.342 , pp. 1350-1358
    • Blobe, G.C.1    Schiemann, W.P.2    Lodish, H.F.3
  • 5
    • 0025855367 scopus 로고
    • Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy
    • Castilla A, Prieto J, Fausto N. Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy. N Engl J Med 324:933-940;1991.
    • (1991) N Engl J Med , vol.324 , pp. 933-940
    • Castilla, A.1    Prieto, J.2    Fausto, N.3
  • 6
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159;1987.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 7
    • 0001877933 scopus 로고
    • Animal models of portal hypertension
    • Holstege A, Scholmerich J, Hahn E.G., eds. Dordrecht, Kluwer Academic Publishers
    • Colombato LA, Robin M, Pomier-Layrargues G, Huet P-M. Animal models of portal hypertension. In: Holstege A, Scholmerich J, Hahn E.G., eds. Portal Hypertension. Dordrecht, Kluwer Academic Publishers, 3-14;1995.
    • (1995) Portal Hypertension , pp. 3-14
    • Colombato, L.A.1    Robin, M.2    Pomier-Layrargues, G.3    Huet, P.-M.4
  • 8
    • 0033607653 scopus 로고    scopus 로고
    • Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells
    • De Bleser PJ, Xu G, Rombouts K, Rogiers V, Geerts A. Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J Biol Chem 274:33881-33887;1999.
    • (1999) J Biol Chem , vol.274 , pp. 33881-33887
    • De Bleser, P.J.1    Xu, G.2    Rombouts, K.3    Rogiers, V.4    Geerts, A.5
  • 9
    • 0032873465 scopus 로고    scopus 로고
    • Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
    • Duncan MR, Frazier KS, Abramson S, Williams S, Klapper H, Huang X, Grotendorst GR. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J 13:1774-1786;1999.
    • (1999) FASEB J , vol.13 , pp. 1774-1786
    • Duncan, M.R.1    Frazier, K.S.2    Abramson, S.3    Williams, S.4    Klapper, H.5    Huang, X.6    Grotendorst, G.R.7
  • 10
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275:2247-2250;2000.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 11
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis-from bench to bedside
    • Friedman SL. Liver fibrosis-from bench to bedside. J Hepatol 38:S38-S53;2003.
    • (2003) J Hepatol , vol.38
    • Friedman, S.L.1
  • 12
    • 0033053458 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells
    • Garcia-Trevijano ER, Iraburu MJ, Fontana L, Dominguez-Rosales JA, Auster A, Covarrubias-Pinedo A, Rojkind M. Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta- dependent mechanism in rat hepatic stellate cells. Hepatology 29:960-970;1999.
    • (1999) Hepatology , vol.29 , pp. 960-970
    • Garcia-Trevijano, E.R.1    Iraburu, M.J.2    Fontana, L.3    Dominguez-Rosales, J.A.4    Auster, A.5    Covarrubias-Pinedo, A.6    Rojkind, M.7
  • 13
    • 0036257518 scopus 로고    scopus 로고
    • Oxidative stress, plant-derived antioxidants and liver fibrosis
    • Gebhardt R. Oxidative stress, plant-derived antioxidants and liver fibrosis. Planta Med 68:289-296;2002.
    • (2002) Planta Med , vol.68 , pp. 289-296
    • Gebhardt, R.1
  • 14
    • 0242419301 scopus 로고    scopus 로고
    • The biology of portal hypertension
    • Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Shafritz, DA, eds. Philadelphia, Lippincott Williams & Wilkins
    • Groszmann RJ, Loureiro-Silva MR, Tsai M-H. The biology of portal hypertension. In: Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Shafritz, DA, eds. The Liver: Biology and Pathobiology, ed 4. Philadelphia, Lippincott Williams & Wilkins, 801-830;2001.
    • (2001) The Liver: Biology and Pathobiology, Ed 4 , pp. 801-830
    • Groszmann, R.J.1    Loureiro-Silva, M.R.2    Tsai, M.-H.3
  • 15
    • 0029808645 scopus 로고    scopus 로고
    • A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene
    • Grotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 7:469-480;1996.
    • (1996) Cell Growth Differ , vol.7 , pp. 469-480
    • Grotendorst, G.R.1    Okochi, H.2    Hayashi, N.3
  • 17
    • 0036866389 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor mRNA in rat liver cirrhosis induced by N-nitrosodimethylamine as evidenced by in situ RT-PCR
    • Hata J, Ikeda E, Uno H, Asano S. Expression of hepatocyte growth factor mRNA in rat liver cirrhosis induced by N-nitrosodimethylamine as evidenced by in situ RT-PCR. J Histochem Cytochem 50:1461-1468;2002.
    • (2002) J Histochem Cytochem , vol.50 , pp. 1461-1468
    • Hata, J.1    Ikeda, E.2    Uno, H.3    Asano, S.4
  • 21
    • 0032102881 scopus 로고    scopus 로고
    • Vascular hyporeactivity persists despite increased contractility after longterm administration of isosorbide dinitrate in portal hypertensive rats
    • Huang Y-T, Lin H-C, Tsai J-F, Hou M-C, Lee S-D, Hong C-Y. Vascular hyporeactivity persists despite increased contractility after longterm administration of isosorbide dinitrate in portal hypertensive rats. J Hepatol 28:1037-1044;1998.
    • (1998) J Hepatol , vol.28 , pp. 1037-1044
    • Huang, Y.-T.1    Lin, H.-C.2    Tsai, J.-F.3    Hou, M.-C.4    Lee, S.-D.5    Hong, C.-Y.6
  • 22
    • 0037221231 scopus 로고    scopus 로고
    • Oxidative-stress-related changes in the livers of bile-duct-ligated rats
    • Huang Y-T, Hsu Y-C, Chen C-J, Liu C-T, Wei Y-H. Oxidative-stress-related changes in the livers of bile-duct-ligated rats. J Biomed Sci 10:170-178;2003.
    • (2003) J Biomed Sci , vol.10 , pp. 170-178
    • Huang, Y.-T.1    Hsu, Y.-C.2    Chen, C.-J.3    Liu, C.-T.4    Wei, Y.-H.5
  • 24
    • 0035122655 scopus 로고    scopus 로고
    • Expression patterns of cell cycle-related proteins in a rat cirrhotic model induced by CCl4 or thioacetamide
    • Jeong DH, Jang JJ, Lee SJ, Lee JH, Lim IK, Lee MJ, Lee YS. Expression patterns of cell cycle-related proteins in a rat cirrhotic model induced by CCl4 or thioacetamide. J Gastroenterol 36:24-32;2001.
    • (2001) J Gastroenterol , vol.36 , pp. 24-32
    • Jeong, D.H.1    Jang, J.J.2    Lee, S.J.3    Lee, J.H.4    Lim, I.K.5    Lee, M.J.6    Lee, Y.S.7
  • 25
    • 0023425909 scopus 로고
    • A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat
    • Jezequel AM, Mancini R, Rinaldesi ML, Macarri G, Venturini C, Orlandi F. A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat. J Hepatol 5:174-181;1987.
    • (1987) J Hepatol , vol.5 , pp. 174-181
    • Jezequel, A.M.1    Mancini, R.2    Rinaldesi, M.L.3    Macarri, G.4    Venturini, C.5    Orlandi, F.6
  • 26
    • 0037154380 scopus 로고    scopus 로고
    • Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in rats: Suppression of transforming growth factor-beta1 and tumor necrosis factor-alpha expression
    • Kang KW, Choi SH, Ha JR, Kim CW, Kim SG. Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2- dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-beta1 and tumor necrosis factor-alpha expression. Chem Biol Interact 139:61-77;2002.
    • (2002) Chem Biol Interact , vol.139 , pp. 61-77
    • Kang, K.W.1    Choi, S.H.2    Ha, J.R.3    Kim, C.W.4    Kim, S.G.5
  • 27
    • 0032952079 scopus 로고    scopus 로고
    • Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: Regulation by TNF-alpha and TGF-beta1
    • Knittel T, Mehde M, Kobold D, Saile B, Dinter C, Ramadori G. Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1. J Hepatol 30:48-60;1999.
    • (1999) J Hepatol , vol.30 , pp. 48-60
    • Knittel, T.1    Mehde, M.2    Kobold, D.3    Saile, B.4    Dinter, C.5    Ramadori, G.6
  • 28
    • 0021238490 scopus 로고
    • Prolonged bile duct ligation: A new experimental model for cirrhosis in the rat
    • Kountouras J, Billing BH, Scheuer PJ. Prolonged bile duct ligation: a new experimental model for cirrhosis in the rat. Br J Exp Pathol 65:305-311;1981.
    • (1981) Br J Exp Pathol , vol.65 , pp. 305-311
    • Kountouras, J.1    Billing, B.H.2    Scheuer, P.J.3
  • 29
    • 0028838193 scopus 로고
    • Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression
    • Lee KS, Buck M, Houglum K, Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96:2461-2468;1995.
    • (1995) J Clin Invest , vol.96 , pp. 2461-2468
    • Lee, K.S.1    Buck, M.2    Houglum, K.3    Chojkier, M.4
  • 30
    • 0022362862 scopus 로고
    • A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections
    • Lopez-De Leon A, Rojkind M. A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 33:737-743;1985.
    • (1985) J Histochem Cytochem , vol.33 , pp. 737-743
    • Lopez-De Leon, A.1    Rojkind, M.2
  • 31
    • 1842775148 scopus 로고    scopus 로고
    • Role of hepatic sinusoidal endothelium injury in hepatic fibrogenesis induced by dimethylnitrosamine in rats
    • Lu X, Liu P, Liu C, Xu G, Wang X, Chen W, Li F. Role of hepatic sinusoidal endothelium injury in hepatic fibrogenesis induced by dimethylnitrosamine in rats (in Chinese). Zhonghua Gan Zang Bing Za Zhi 10:441-444;2002.
    • (2002) Zhonghua Gan Zang Bing Za Zhi , vol.10 , pp. 441-444
    • Lu, X.1    Liu, P.2    Liu, C.3    Xu, G.4    Wang, X.5    Chen, W.6    Li, F.7
  • 32
    • 0034659145 scopus 로고    scopus 로고
    • Indices of lipid peroxidation in vivo: Strengths and limitations
    • Meagher EA, FitzGerald GA. Indices of lipid peroxidation in vivo: strengths and limitations. Free Radic Biol Med 28:1745-1750;2000.
    • (2000) Free Radic Biol Med , vol.28 , pp. 1745-1750
    • Meagher, E.A.1    Fitzgerald, G.A.2
  • 33
    • 0035694910 scopus 로고    scopus 로고
    • Smad regulation in TGF-beta signal transduction
    • Moustakas A, Souchelnytskyi S, Heldin CH. Smad regulation in TGF-beta signal transduction. J Cell Sci 114:4359-4369;2001.
    • (2001) J Cell Sci , vol.114 , pp. 4359-4369
    • Moustakas, A.1    Souchelnytskyi, S.2    Heldin, C.H.3
  • 34
    • 0037192866 scopus 로고    scopus 로고
    • Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: Implications for reversibility of liver fibrosis
    • Murphy FR, Issa R, Zhou X, Ratnarajah S, Nagase H, Arthur MJ, Benyon C, Iredale JP. Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. J Biol Chem 277:11069-11076;2002.
    • (2002) J Biol Chem , vol.277 , pp. 11069-11076
    • Murphy, F.R.1    Issa, R.2    Zhou, X.3    Ratnarajah, S.4    Nagase, H.5    Arthur, M.J.6    Benyon, C.7    Iredale, J.P.8
  • 35
    • 0033854016 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine- treated rats
    • Nakamura T, Sakata R, Ueno T, Sata M, Ueno H. Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatology 32:247-254;2000.
    • (2000) Hepatology , vol.32 , pp. 247-254
    • Nakamura, T.1    Sakata, R.2    Ueno, T.3    Sata, M.4    Ueno, H.5
  • 36
    • 0030881019 scopus 로고    scopus 로고
    • Sequential increases in the intrahepatic expression of epidermal growth factor, basic fibroblast growth factor, and transforming growth factor beta in a bile duct ligated rat model of cirrhosis
    • Napoli J, Prentice D, Niinami C, Bishop GA, Desmond P, McCaughan GW. Sequential increases in the intrahepatic expression of epidermal growth factor, basic fibroblast growth factor, and transforming growth factor beta in a bile duct ligated rat model of cirrhosis. Hepatology 26:624-633;1997.
    • (1997) Hepatology , vol.26 , pp. 624-633
    • Napoli, J.1    Prentice, D.2    Niinami, C.3    Bishop, G.A.4    Desmond, P.5    McCaughan, G.W.6
  • 37
    • 0036139102 scopus 로고    scopus 로고
    • Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived oxygen species
    • Nieto N, Friedman SL, Cederbaum AI. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived oxygen species. Hepatology 35:62-73;2002.
    • (2002) Hepatology , vol.35 , pp. 62-73
    • Nieto, N.1    Friedman, S.L.2    Cederbaum, A.I.3
  • 38
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358;1979.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 40
    • 0036281460 scopus 로고    scopus 로고
    • Effects and regulation of connective tissue growth factor on hepatic stellate cells
    • Paradis V, Dargere D, Bonvoust F, Vidaud M, Segarini P, Bedossa P. Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest 82:767-774;2002.
    • (2002) Lab Invest , vol.82 , pp. 767-774
    • Paradis, V.1    Dargere, D.2    Bonvoust, F.3    Vidaud, M.4    Segarini, P.5    Bedossa, P.6
  • 41
    • 0027226140 scopus 로고
    • Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (I) gene expression in human liver fat-storing cells
    • Parola M, Pinzani M, Casini A, Albano E, Poli G, Gentilini A, Gentilini P, Dianzani MU. Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (I) gene expression in human liver fat-storing cells. Biochem Biophys Res Commun 194:1044-1050;1993.
    • (1993) Biochem Biophys Res Commun , vol.194 , pp. 1044-1050
    • Parola, M.1    Pinzani, M.2    Casini, A.3    Albano, E.4    Poli, G.5    Gentilini, A.6    Gentilini, P.7    Dianzani, M.U.8
  • 42
    • 0033450924 scopus 로고    scopus 로고
    • Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis
    • Pinzani M, Gentilini P. Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis. Semin Liver Dis 19:397-410;1999.
    • (1999) Semin Liver Dis , vol.19 , pp. 397-410
    • Pinzani, M.1    Gentilini, P.2
  • 43
    • 0033869778 scopus 로고    scopus 로고
    • Pathogenesis of liver fibrosis: Role of oxidative stress
    • Poli G. Pathogenesis of liver fibrosis: role of oxidative stress. Mol Aspects Med 21:49-98;2000.
    • (2000) Mol Aspects Med , vol.21 , pp. 49-98
    • Poli, G.1
  • 44
    • 0012119538 scopus 로고    scopus 로고
    • Pathophysiology of liver fibrosis
    • Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Shafritz, DA, eds. Philadelphia, Lippincott Williams & Wilkins
    • Rojkind M, Greenwel P. Pathophysiology of liver fibrosis. In: Arias IM, Boyer JL, Chisari FV, Fausto N, Schachter D, Shafritz, DA, eds. The Liver: Biology and Pathobiology. ed 4. Philadelphia, Lippincott Williams & Wilkins, 721-738;2001.
    • (2001) The Liver: Biology and Pathobiology. Ed 4 , pp. 721-738
    • Rojkind, M.1    Greenwel, P.2
  • 45
    • 0032030879 scopus 로고    scopus 로고
    • Interferon gamma treatment prevents procollagen gene expression without affecting transforming growth factor-β1 expression in pig serum-induced rat liver fibrosis
    • Sakaida I, Uchida K, Matsumura Y, Okita K. Interferon gamma treatment prevents procollagen gene expression without affecting transforming growth factor-β1 expression in pig serum-induced rat liver fibrosis. J Hepatol 28:471-479;1998.
    • (1998) J Hepatol , vol.28 , pp. 471-479
    • Sakaida, I.1    Uchida, K.2    Matsumura, Y.3    Okita, K.4
  • 46
    • 0037427796 scopus 로고    scopus 로고
    • Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells
    • Sakaida I, Hironaka K, Terai S, Okita K. Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells. Life Sci 72:943-959;2003.
    • (2003) Life Sci , vol.72 , pp. 943-959
    • Sakaida, I.1    Hironaka, K.2    Terai, S.3    Okita, K.4
  • 48
    • 0026072529 scopus 로고
    • Classification of chronic viral hepatitis: A need for reassessment
    • Scheuer PJ. Classification of chronic viral hepatitis: a need for reassessment. J Hepatol 13:372-374;1991.
    • (1991) J Hepatol , vol.13 , pp. 372-374
    • Scheuer, P.J.1
  • 49
    • 0035066961 scopus 로고    scopus 로고
    • Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis
    • Sedlaczek N, Jia JD, Bauer M, Herbst H, Ruehl M, Hahn EG, Schuppan D. Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am J Pathol 158:1239-1244;2001.
    • (2001) Am J Pathol , vol.158 , pp. 1239-1244
    • Sedlaczek, N.1    Jia, J.D.2    Bauer, M.3    Herbst, H.4    Ruehl, M.5    Hahn, E.G.6    Schuppan, D.7
  • 50
    • 0031816836 scopus 로고    scopus 로고
    • Expression of type I and type III collagens during the course of dimethylnitrosamine-induced hepatic fibrosis in rats
    • Shiba M, Shimizu I, Yasuda M, Ii K, Ito S. Expression of type I and type III collagens during the course of dimethylnitrosamine-induced hepatic fibrosis in rats. Liver 18:196-204;1998.
    • (1998) Liver , vol.18 , pp. 196-204
    • Shiba, M.1    Shimizu, I.2    Yasuda, M.3    Ii, K.4    Ito, S.5
  • 52
    • 0035059634 scopus 로고    scopus 로고
    • A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats
    • Tada S, Iwamoto H, Nakamuta M, Sugimoto R, Enjoji M, Nakashima Y, Nawata H. A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats. J Hepatol 34:529-536;2001.
    • (2001) J Hepatol , vol.34 , pp. 529-536
    • Tada, S.1    Iwamoto, H.2    Nakamuta, M.3    Sugimoto, R.4    Enjoji, M.5    Nakashima, Y.6    Nawata, H.7
  • 54
    • 0037219276 scopus 로고    scopus 로고
    • Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis
    • Taimr P, Higuchi H, Kocova E, Rippe RA, Friedman SL, Gores GJ. Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology 37:87-95;2003.
    • (2003) Hepatology , vol.37 , pp. 87-95
    • Taimr, P.1    Higuchi, H.2    Kocova, E.3    Rippe, R.A.4    Friedman, S.L.5    Gores, G.J.6
  • 55
  • 57
    • 0018119866 scopus 로고
    • 2+ uptake coupled to electron transport in rat heart mitochondria
    • 2+ uptake coupled to electron transport in rat heart mitochondria. J Biol Chem 253:6379-6385;1978.
    • (1978) J Biol Chem , vol.253 , pp. 6379-6385
    • Vercesi, A.1    Reynafarje, B.2    Lehninger, A.L.3
  • 58
    • 0032212753 scopus 로고    scopus 로고
    • Salvia miltiorrhiza reduced experimentally-induced hepatic fibrosis in rats
    • Wasser S, Ho JMS, Ang HK, Tan CEL. Salvia miltiorrhiza reduced experimentally-induced hepatic fibrosis in rats. J Hepatol 29:760-771;1998.
    • (1998) J Hepatol , vol.29 , pp. 760-771
    • Wasser, S.1    Ho, J.M.S.2    Ang, H.K.3    Tan, C.E.L.4
  • 60
    • 0342264463 scopus 로고    scopus 로고
    • Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells
    • Williams EJ, Gaca MDA, Brigstock DR, Arthur MJP, Benyon RC. Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J Hepatol 32:754-761;2000.
    • (2000) J Hepatol , vol.32 , pp. 754-761
    • Williams, E.J.1    Gaca, M.D.A.2    Brigstock, D.R.3    Arthur, M.J.P.4    Benyon, R.C.5


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