Interferon gamma treatment prevents procollagen gene expression without affecting transforming growth factor-β1 expression in pig serum-induced rat liver fibrosis in vivo

Journal of Hepatology

Volumn 28, Issue 3, 1998, Pages 471-479

  Sakaida, Isao ^a   Uchida, Koichi ^a   Matsumura, Yasuhiro ^a   Okita, Kiwamu ^a  

^a YAMAGUCHI UNIVERSITY   (Japan)

Author keywords

Interferon gamma; Stellate cell; TGF 1; Smooth muscle actin

Indexed keywords

ALANINE AMINOTRANSFERASE; GAMMA INTERFERON; HYDROXYPROLINE; PROCOLLAGEN; RECOMBINANT GAMMA INTERFERON; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER CIRRHOSIS; LIVER FIBROSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; SERUM; STELLATE CELL; SWINE;

EID: 0032030879     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(98)80322-X     Document Type: Article

References (48)

1. Rojkind M, Giambrone M-A, Biempica L. Collagen types in normal and cirrhotic liver. Gastroenterology. 76:1979;710-719.
2. Friedman SL. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med. 328:1993;1828-1835.
3. Pinzani M. Hepatic stellate (ITO) cells: expanding roles for a liver-specific pericyte. J Hepatol. 22:1995;700-706.
4. Dusheiko G, Dibisceglie A, Bowyer S, Sachs E, Ritchie M, Schoub B, et al. Recombinant leukocyte interferon treatment of chronic hepatitis B. Hepatology. 5:1985;556-560.
5. Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner J, et al. Recombinant interferon alpha therapy for chronic hepatitis C: a randomized, doubleblind, placebo-controlled trial. N Engl J Med. 321:1989;1506-1510.
6. Jimemex SA, Freundlich B, Rosenbloom J. Selective inhibition of human diploid fibroblast collagen synthesis by interferons. J Clin Invest. 74:1984;1112-1116.
7. Duncan MR, Berman B. r-interferon is the lymphokine and β interferon the monokine responsible for inhibition of fibroblast collagen production and late but not early fibroblast proliferation. J Exp Med. 162:1985;516-527.
8. Stephenson ML, Krane SM, Amento EP, McCraskery PR, Byrne M. Immune interferon inhibits collagen synthesis by rheumatoid synovial cells associated with decreased levels of the procollagen mRNAs. FEBS Lett. 180:1985;43-50.
9. Goldring MB, Sandell LJ, Stephenson ML, Krane SM. Immune interferon suppresses levels of procollagen mRNA and type II collagen synthesis in cultured human articular and costal chondrocytes. J Biol Chem. 261:1986;9049-9056.
10. Mallat A, Preaux AM, Blazejewski S, Rosenbaum J, Dhumeaux D, Mavier P. Interferon alfa and gamma inhibit proliferation and collagen synthesis of human Ito cells in culture. Hepatology. 21:1995;1003-1010.
11. Czaja MJ, Weiner FR, Takahashi S, Giambrone M-A, Van Der Meide PH, Schllekens H, et al. r-Interferon treatment inhibits collagen deposition in murine schistosomiasis. Hepatology. 10:1989;795-800.
12. Baroni GS, D'Ambrosio L, Curto P, Casini A, Mancini R, Jezequel AM, Benedetti A. Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis. Hepatology. 23:1996;1189-1199.
13. Matsumura Y, Sakaida I, Uchida K, Kimura T, Ishihara T, Okita K. Prolyl 4-hydroxylase inhibitor (HOE 077) inhibits pig serum-induced rat liver fibrosis by preventing stellate cell activation. J Hepatol. 27:1997;185-192.
14. Nakabayashi H, Takamatsu S, Tsujii H, Okamoto Y, Nakano H, Yamada E, et al. Collagen content of liver biopsy specimen in patients with chronic hepatitis. Int Hepatol Commun. 4:1996;311-315.
15. Sakaida I, Kubota M, Kayano K, Takenaka K, Mori K, Okita K. Prevention of fibrosis reduces enzyme-altered lesions in the rat liver. Carcinogenesis. 15:1994;2201-2206.
16. Sakaida I, Matsumura Y, Kubota M, Kayano K, Takenaka K, Okita K. Prolyl 4-hydroxylase inhibitor (HOE 077) prevents activation of Ito cells, reducing procollagen gene expression in rat liver fibrosis by choline deficient L-amino acid defined diet. Hepatology. 23:1996;755-763.
17. Kivirikko KI, Laitinen O, Prockop DJ. Modifications of a specific assay for hydroproline in urine. Anal Biochem. 19:1967;249-255.
18. Inayama S, Shibata T, Ohtsuki J, Saito S. A new microanalytical method for determination of hydroxyproline in connective tissue. Keio J Med. 27:1978;43-46.
19. 1 (III) collagen. J Biol Chem. 260:1985;4357-4363.
20. Tso JY, Sun XH, Kao TH, Reece KS, Wu R. Isolation and characterization of rat and human glyceraldehyde-3 phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 13:1985;2485-2502.
21. Derynck R, Jarrett JA, Chen EY, Eaton DH, Bell JR, Associan RK, et al. Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature. 316:1985;701-705.
22. Lin HY, Wang X-F, Ng-Eaton E, Winberg RA, Lodish HF. Expression of cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase. Cell. 68:1992;775-785.
23. Schweizer J, Goerttler K. Synthesis in vivo of keratin polypeptides directed by mRNA isolation from newborn and adult mouse epidermis. Eur J Biochem. 112:1980;243-249.
24. Aviv H, Leder P. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci USA. 69:1972;1408-1412.
25. Sambrook J, Fritsch EF, Maniatis T. Transfer of denatured RNA to nitrocellulose filters. Sambrook J, Frisch EF, Maniatis T. Molecular Cloning. 1:1989;46 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
26. Sambrook J, Fritsch EF, Maniatis T. Transfer of denatured RNA to nitrocellulose filters. Sambrook J, Frisch EF, Maniatis T. Molecular Cloning. 7:1989;46 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
27. Danielpour D. Improved sandwich enzyme-linked immunosorbent assays for transforming growth factor beta. J Immunol Meth. 158:1993;17-25.
28. Chen W, Gendrault JL, Steffan AM. Isolation, culture and main characteristics of mouse fat-storing cells: interaction with viruses. Hepatology. 9:1989;352-362.
29. Milani S, Herbst H, Schuppan D, Surrenti C, Riecken EO, Stein H. Cellular localization of type I, III, and IV procollagen gene transcripts in normal and fibrotic human liver. Am J Pathol. 137:1990;59-70.
30. Pietrangelo A, Gualdi R, Casalgrandi G, Geerts A, De Bleser P, Montosi G, et al. Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis. Hepatology. 19:1994;714-721.
31. 1 (I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology. 19:1994;1262-1271.
32. Bhunchet E, Wake K. Role of mesenchymal cell populations in porcine serum-induced rat liver fibrosis. Hepatology. 16:1992;1452-1473.
33. vivo and in culture. J Submicrosc Cytol Pathol. 24:1992;193-203.
34. Rockey DC, Maher JJ, Jarnagin WR, Gabbiani G, Friedman SL. Inhibition of rat hepatic lipocyte activation in culture by interferon-γ Hepatology. 16:1992;776-784.
35. Gurujeyalakshmi G, Giri SN. Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-β and procollagen I and III gene expression. Exp Lung Res. 21:1995;791-808.
36. 1 and α in chronic liver disease. N Engl J Med. 324:1991;933-940.
37. Bhunchet E, Eishi Y, Wake K. Contribution of immune response to the hepatic fibrosis induced by porcine serum. Hepatology. 23:1996;811-817.
38. Friedman SL, Arthur MJP. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium: direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest. 84:1989;150-158.
39. Murray HW, Spitalny GL, Nathan CF. Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-γ J Immunol. 134:1885;1619-1622.
40. Nathan CF, Horowitz CR, de la Harpe J, Vadhan-Raj S, Sherwin SA, Oettgen HF, et al. Administration of recombinant interferon γ to cancer patients enhances monocyte secretion of hydrogen peroxide. Proc Natl Acad Sci USA. 82:1985;8686-8690.
41. Tiggelman AM, Boers W, Linthorst C, Sala M, Chamuleau RAFM. Collagen synthesis by human liver (myo)fibroblasts in culture: evidence for a regulatory role of IL-1β, IL-4, TGF-β and IFN gamma. J Hepatol. 23:1995;307-317.
42. Bachem MG, Meyer D, Melchior R, Sell KM, Gressner AM. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells. J Clin Invest. 89:1992;19-27.
43. Lyons RM, Keski-Oja J, Moses HL. Proteolytic activation of latent transforming growth factor-β from fibroblast-conditioned medium. J Cell Biol. 106:1988;1659-1665.
44. Friedman SL, Yamasaki G, Wong L. Modulation of transforming growth factor β receptors of rat lipocytes during the hepatic wound healing response. J Biol Chem. 269:1994;10551-10558.
45. Yingling JM, Wang X.-F, Bassing CH. Signaling by the transforming growth factor-β receptors. Biochem Biophys Acta. 1242:1995;115-136.
46. Niederau C, Fischer R, Sonnenberg A, Stremmel W, Trampisch HJ, Strohmeyer G. Survival and causes of death in cirrhotic and in noncirrhotic patients with primary hemochromatosis. N Engl J Med. 313:1985;1256-1262.
47. Fargion S, Mandelli C, Piperno A, Ceasana B, Fracanzani AL, Fraquelli M, et al. Survival and prognostic factors in 212 Italian patients with genetic hemochromatosis. Hepatology. 15:1992;655-659.
48. Sakaida I, Matsumura Y, Akiyama S, Hayashi K, Ishige A, Okita K. Herbal medicine Sho-saiko-to (TJ-9) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient-L-amino-acid-defined diet. J Hepatol. 28:1998;298-306.