Downregulation of aryl hydrocarbon receptor function and cytochrome p450 1A1 induction by expression of Ha-ras oncogenes

Molecular Carcinogenesis

Volumn 19, Issue 2, 1997, Pages 91-100

  Reiners Jr , John J ^a   Jones, Carol L ^a   Hong, Nancy ^a   Clift, Russell E ^a   Elferink, Cornelis ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

2,3,7,8 tetrachlorodibenzo p dioxin; Cytochrome P450; Mammary gland

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450; PROTEIN P21;

ARTICLE; BREAST CELL; CELL TRANSFORMATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE H RAS; PRIORITY JOURNAL;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; BREAST; CELL LINE; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DOWN-REGULATION; GENES, RAS; HUMANS; KERATINOCYTES; MICE; MICE, TRANSGENIC; QUINONE REDUCTASES; RECEPTORS, ARYL HYDROCARBON; SKIN NEOPLASMS; TETRACHLORODIBENZODIOXIN; TRANSFECTION;

MUS MUSCULUS;

EID: 0030754559     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199707)19:2<91::AID-MC4>3.0.CO;2-O     Document Type: Article

References (55)

1. Whitlock Jr JP. Mechanistic aspects of dioxin action. Chem Res Toxicol 6:754-763, 1993.
2. Hankinson O. The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35:307-340, 1995.
3. Holsapple MP, Morris DL, Wood SC, Snyder NK. 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: Possible mechanisms. Annu Rev Pharmacol Toxicol 31:73-100, 1991.
4. Nebert DW. Drug-metabolizing enzymes in ligand-modulated transcription. Biochem Pharmacol 47:25-37, 1994.
5. Sutter TR, Tang YM, Hayes CL, et al. Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2. J Biol Chem 269:13092-13099, 1994.
6. Chen H-S, Perdew GH. Subunit composition of the heteromeric cytosolic aryl hydrocarbon receptor complex. J Biol Chem 269:27554-27558, 1994.
7. Denison MS, Fisher JM, Whitlock Jr JP. Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex. J Biol Chem 264:16478-16482, 1989.
8. Hohne M, Becker-Rabbenstein B, Kahl GF, Taniguchi H. Regulation of cytochrome P-450 CYP1A1 gene expression and protooncogene expression by growth factors in primary hepatocytes. FEBS Lett 273:219-222, 1990.
9. Guo JF, Brown R, Rothwell CE, Bernstein IA. Levels of cytochrome P-450-mediated aryl hydrocarbon hydroxylase (AHH) are higher in differentiated than germinative cutaneous keratinocytes. J Invest Dermatol 94:86-93, 1990.
10. Reiners JJ Jr, Cantu AR, Thai G, Scholler A. Differential expression of basal and hydrocarbon-induced cytochrome P-450 monooxygenase and quinone reductase activities in subpopulations of murine epidermal cells differing in their stages of differentiation. Drug Metab Dispos 20:360-366, 1992.
11. Green MR, Couchman JR. Differences in human skin between the epidermal growth factor receptor distribution detected by EGF binding and monoclonal antibody recognition. J Invest Dermatol 85:239-245, 1985.
12. Filvaroff E, Calautti E, McCormick F, Dotto GP. Specific changes of ras GTPase-activating protein (GAP) and a GAP-associated p62 protein during calcium-induced keratinocyte differentiation. Mol Cell Biol 12:5319-5328, 1992.
13. Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322:78-80, 1986.
14. 2 in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol. Carcinogenesis 13:1113-1120, 1992.
15. Soule HD, Maloney TM, Wolman SR, et al. Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10. Cancer Res 50:6075-6086, 1990.
16. Basolo F, Elliott J, Tait L, et al. Transformation of human breast epithelial cells by c-Ha-ras oncogene. Mol Carcinog 4:25-35, 1991.
17. Basolo F, Serra C, Ciardiello F, et al. Regulation of surface-differentiation molecules by epidermal growth factor, transforming growth factor alpha, and hydrocortisone in human mammary epithelial cells transformed by an activated c-Ha-ras proto-oncogene. Int J Cancer 51:634-640, 1992.
18. Ha to the epidermis of transgenic mice induces hyperplasia, hyperkeratosis, and papillomas. Mol Carcinog 7:99-110, 1993.
19. Scholler A, Hong NJ, Bischer P, Reiners JJ Jr. Short and long term effects of cytoskeleton-disrupting drugs on P450 Cyp1a1 induction in murine hepatoma 1c1c7 cells: Suppression by the microtubule inhibitor nocodazole. Mol Pharmacol 45:944-954, 1994.
20. Reiners JJ Jr, Cantu AR, Rupp TA. Coordinate modulation of murine hepatic xanthine oxidase activity and the cytochrome P-450 system by interferons. J Interferon Res 10:109-118, 1990.
21. Reiners JJ Jr, Cantu AR, Pavone A, Smith SC, Gardner CR, Laskin DL. Fluorescence assay for per-cell estimation of cytochrome P-450-dependent monooxygenase activities in keratinocyte suspensions and cultures. Anal Biochem 188:317-324, 1990.
22. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987.
23. Feinberg AP, Vogelstein B. A technique for radiolabeling DMA restriction endonuclease fragments to high specific activity. Anal Biochem 137:266-267, 1984.
24. Krieg P, Finch J, Fustenberger G, Melber K, Matrisian LM, Bowden GT. Tumor promoters induce a transient expression of tumor-associated genes in both basal and differentiated cells of the mouse epidermis. Carcinogenesis 9:95-100, 1988.
25. Elferink CJ, Reiners JJ Jr. Quantitative RT-PCR on CYP1A1 heterogeneous nuclear RNA: A surrogate for the in vitro transcription run-on-assay. BioTechniques 20:470-477, 1996.
26. Pollenz RS, Sattler CA, Poland A. The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy. Mol Pharmacol 45:428-438, 1994.
27. Shen ES, Elferink CJ, Whitlock Jr JP. Use of gel retardation to analyze protein-DNA interactions upstream of CYP1A1 gene. Methods Enzymol 206:403-408, 1991.
28. Lusska A, Shen E, Whitlock Jr JP. Protein-DNA interactions at a dioxin responsive enhancer. J Biol Chem 268:6575-6580, 1993.
29. Pan SS, Forrest GL, Akman SA, Hu L-T. NAD(P)H:quinone oxidoreductase expression and mitomycin C resistance developed by human colon cancer HTC 116 cells. Cancer Res 55:330-335, 1995.
30. Bank PA, Yao EF, Phelps CL, Harper PA, Denison MS. Species-specific binding of transformed Ah receptor to a dioxin responsive transcriptional enhancer. Eur J Pharmacol 228:85-94, 1992.
31. Stauber KL, Laskin JD, Yurkow EJ, Thomas PE, Laskin DL, Conney AH. Flow cytometry reveals subpopulations of murine epidermal cells that are refractory to induction of cytochrome P-4501A1 by β-naphthoflavone. J Pharmacol Exp Ther 273:967-975, 1995.
32. Ichikawa T, Hayashi S-l, Noshiro M, Takada K, Okuda K. Purification and characterization of cytochrome P-450 induced by benz[a]anthracene in mouse skin microsomes. Cancer Res 49:806-809, 1989.
33. Agerwal R, Khan SG, Athar M, Zaidi SI, Bickers DR, Mukhtar H. Protein p21 processing enzyme farnesyltransferase in chemical carcinogen-induced murine skin tumors. Mol Carcinog 8:290-298, 1993.
34. Walsh AA, Tullis K, Rice RH, Denison MS, Identification of a novel cis-acting negative regulatory element affecting expression of CYP1A1 gene in rat epidermal cells. J Biol Chem, 271:22746-22753, 1996.
35. Stanley LA. Molecular aspects of chemical carcinogenesis: The roles of oncogenes and tumour suppressor genes. Toxicology 96:174-194, 1995.
36. Forkert PG, Parkinson A, Thaete LG, Malkinson AM. Resistance of murine lung tumors to xenobiotic-induced cytotoxicity. Cancer Res 52:6797-6803, 1992.
37. Forkert PG, Jackson AC, Parkinson A, Chen S. Diminished expression of CYP1A1 in urethane-induced lung tumors in strain A/J mice: Analysis by in situ hybridization and immunohistochemical methods. Am J Respir Cell Mol Biol 14:444-453, 1996.
38. Barbacid M. ras genes. Ann Rev Biochem 56:779-827, 1987.
39. Reiners JJ Jr, Cantu AR, Pavone A. Distribution of constitutive and polycyclic aromatic hydrocarbon-induced cytochrome P-450 activities in murine epidermal cells that differ in their stages of differentiation. Prog Clin Biol Res 369:123-135, 1991.
40. Rizzino A, Kazakoff P, Ruff E, Kuszynski C, Nebelsick J. Regulatory effects of cell density on the binding of transforming growth factor beta, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor. Cancer Res 48:4266-4271, 1988.
41. 1 cell cycle arrest. Abstract. Proceedings of the American Association for Cancer Research 37:4, 1996.
42. Weib C, Kolluri SK, Kiefer F, Gottlicher M. Complementation of Ah receptor deficiency in hepatoma cells: Negative feedback regulation and cell cycle control by the Ah receptor. Exp Cell Res 226:154-163, 1996.
43. Ma Q, Whitlock Jr JP. The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. J Mol Cell Biol 16:2144-2150, 1996.
44. Mahon MJ, Gasiewicz TA. Ah receptor phosphorylation: Localization of phosphorylation sites to the C-terminal half of the protein. Arch Biochem Biophys 318:166-174, 1995.
45. Berghard A, Gradin K, Pongratz I, Whitelaw M, Poellinger L. Cross-coupling of signal transduction pathways: The dioxin receptor mediated induction of cytochrome P-4501A1 expression via a protein kinase C-dependent mechanism. Mol Cell Biol 13:677-689, 1993.
46. Denison MS, Vella LM, Okey AB. Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver: Lack of sensitivity to alkaline phosphatase when compared with that of glucocorticoid receptor. Arch Biochem Biophys 273:458-465, 1989.
47. Cai H, Szeberenyi J, Cooper GM. Effects of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells. Mol Cell Biol 10:5314-5323, 1990.
48. Grand RJA, Owen D. The biochemistry of ras p21. Biochem J 278:609-631, 1991.
49. Schafer MW, Madhukar BV, Swanson HI, Tullis K, Denison MS. Protein kinase C is not involved in Ah receptor transformation and DNA binding. Arch Biochem Biophys 307:267-271, 1993.
50. Chen Y-H, Tukey RH. Protein kinase C modulates regulation of the CYP1A1 gene by the aryl hydrocarbon receptor. J Biol Chem 271:26261-26266, 1996.
51. Cano E, Mahadevan LC. Parallel signal processing among mammalian MAPKs. Trends Biochem Sci 20:117-122, 1995.
52. Derijard B, Raingeaud J, Barrett T, et al. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685, 1995.
53. Okino ST, Pendurthi UR, Tukey RH. Phorbol esters inhibit the dioxin receptor-mediated transcriptional activation of the mouse Cyp1a-1 and Cyp1a-2 genes by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 267:6991-6998, 1992.
54. Reiners JJ Jr, Cantu AR, Scholler A. Phorbol ester-mediated suppression of cytochrome P450 Cyp1a-1 induction in murine skin: Involvement of protein kinase C. Biochem Biophys Res Commun 186:970-976, 1992.
55. Troppmair J, Bruder JT, Munoz H. Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activated by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires raf and is necessary for transformation. J Biol Chem 268:7030-7035, 1994.