Adenovirus-mediated p16 gene transfer changes the sensitivity to taxanes and vinca alkaloids of human ovarian cancer cells

Anticancer Research

Volumn 21, Issue 4 A, 2001, Pages 2537-2546

  Kawakami, Y ^a   Hama, S ^a   Hiura, M ^a   Nogawa, T ^a   Chiba, T ^a   Yokoyama, T ^a   Takashima, S ^a   Tajiri, H ^a   Eguchi, K ^a   Nagai, N ^a   Shigemasa, K ^a   Ohama, K ^a   Kurisu, K ^a   Heike, Y ^a  

^a NATIONAL HOSPITAL ORGANIZATION SHIKOKU CANCER CENTER   (Japan)

Author keywords

Chemoresistance; Growth inhibition; MAP4; Ovarian cancer; P16

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; MICROTUBULE ASSOCIATED PROTEIN 4; PACLITAXEL; PROTEIN P16; TAXANE DERIVATIVE; VINCA ALKALOID; VINDESINE;

ADENOVIRUS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL CYCLE G1 PHASE; CELL DEATH; DRUG EFFECT; DRUG RESISTANCE; DRUG SENSITIVITY; FLOW CYTOMETRY; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; ONCOGENE; OVARY CANCER; PRIORITY JOURNAL; VIRUS INFECTION; WESTERN BLOTTING;

ADENOVIRIDAE; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL DIVISION; COMBINED MODALITY THERAPY; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; GENES, P16; GENETIC VECTORS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; OVARIAN NEOPLASMS; PACLITAXEL; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED; VINDESINE;

EID: 0035157892     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer
2. Exploratory phaseÖ study of paclitaxel and cisplatin versus paclitaxel and carboplatin in advanced ovarian cancer
3. Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status
4. An adenovirus encoding proapoptotic Bax induces apoptosis and enhances the radiation effect in human ovarian cancer
5. Thymidine kinase gene therapy with concomitant topotecan chemotherapy for recurrent ovarian cancer
6. Modification of tumor-suppressor-gene expression and induction of apoptosis in non-small-cell lung cancer (NSCLC) with an adenovirus vector expressing wild-type p 53 and cisplatin
7. Adenovirus-mediated p16 transfer to glioma cells induces G1 arrest and protects from paclitaxel and topotecan: Implications for therapy
8. Adenovirus-mediated p16 gene transfer prevents drug-induced cell death through G1 arrest in human glioma cells
9. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
10. A cell cycle regulator potentially involved in genesis of many tumor types
11. Detailed deletion mapping of chromosome 9p and p16 gene alternations in human borderline and invasive epithelial ovarian tumors
12. Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribosome
13. Kip1 correlates inversely with anchorage-independent growth of human cancer cell lines
14. Rates of p16 (MTS1) mutations in primary tumors with 9p loss
15. p16/MTS1 inactivation in ovarian carcinonas: High frequency of reduced protein expression associated with hyper-methylation or mutation in endometrioid and mucinous tumors
16. Lack of mutation at p161NK4A gene but expression of aberrant p16INK4A RNA transcripts in human ovarian carcinoma
17. Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase
18. Interleukin-2 gene transduction into freshly isolated lung adenocarcinoma cells with adenoviral vectors
19. A model for microtuble-associated protein 4 structure
20. Proteins of the mammalian mitotic spindle: Phosphorylation/dephosphorylation of MAP-4 during mitosis
21. Wild-type p53 negatively regulates the expression of a microtubule-associated protein
22. The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells