Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells

Cancer Research

Volumn 63, Issue 4, 2003, Pages 760-765

  Zhang, Xinqiao ^a   Multani, Asha S ^a   Zhou, Jain Hua ^a   Shay, Jerry W ^b   McConkey, David ^a   Dong, Li ^a   Kim, Chang Soo ^a   Rosser, Charles J ^a   Pathak, Sen ^a   Benedict, William F ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CASPASE; TELOMERASE;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL IMMORTALIZATION; CHROMOSOME ABERRATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; HUMAN; HUMAN CELL; POLYPLOIDY; PRIORITY JOURNAL; RETINOBLASTOMA 110 GENE; RETINOBLASTOMA 94 GENE; TELOMERE; TUMOR SUPPRESSOR GENE; UROTHELIUM;

ADENOVIRIDAE; APOPTOSIS; CASPASES; CHROMOSOME ABERRATIONS; GENE THERAPY; GENETIC VECTORS; HUMANS; PEPTIDE FRAGMENTS; RETINOBLASTOMA PROTEIN; TELOMERE; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 0037442425     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Xu, H-J., Xu, K., Zhou, Y., Li, J., Benedict, W. F., and Hu, S. X. Enhanced tumor cell growth suppression by an internal AUG codon initiated retinoblastoma protein. Proc. Natl. Acad. Sci. USA, 91: 9837-9841, 1994.
2. Xu, H-J., Zhou, Y., Seigne, J., Perng, G-S., Mixon, M., Zhang, C., Li, J., Benedict, W. F., and Hu, S-X. Enhanced tumor suppressor gene therapy via replication-deficient adenovirus vectors expressing an N-terminal truncated retinoblastoma protein. Cancer Res., 56: 2245-2249, 1996.
3. Reznikoff, C. A., Yeager, T. R., Belair, C. D., Savelieva, E., Puthenveettil, J. A., and Stadler, W. M. Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed uroepithelial cells. Cancer Res., 56: 2886-2890, 1996.
4. Belair, C. D., Yeager, T. R., Lopez, P. A., and Reznikoff, C. A. Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc. Natl. Acad. Sci. USA, 94: 13677-13682, 1997.
5. Bryan, T. M., Englezou, A., Gupta, J., Bacchetti, S., and Reddel, R. R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J., 14: 4240-4248, 1995.
6. Liebert, M., Wedemeyer, G., Chang, J. H., Stein, J. A., McKeever, P. E., Carey, T. E., Flint, A., Steplewski, Z., Buchsbaum, D. J., Wahl, R. L., and Grossman, H. B. Comparison of antigen expression on normal urothelial cells in tissue section and tissue culture. J. Urol., 144: 1288-1292, 1990.
7. Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., and Riccardi, C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry, J. Immunol. Methods. 139: 271-279, 1991.
8. McConkey, D. J., Goodrich, D., Bucana, C., and Klostergaard, J. The human retinoblastoma gene product suppresses ceramide-induced apoptosis in human bladder tumor cells. Oncogene, 13: 1693-1700, 1996.
9. Pathak, S. Chromosome banding techniques, J. Reprod. Med., 17: 25-28, 1976.
10. Multani, A. S., Ozen, M., Furlong, C. L., Zhao, Y. J., Hsu, T. C., and Pathak, S. Heterochromatin and interstitial telomeric DNA homology. Chromosoma (Berl.), 110: 214-220, 2001.
11. Henson, J. D., Neumann, A. A., Yeager, T. R., and Reddel, R. R. Alternative lengthening of telomeres in mammalian cells. Oncogene, 21: 598-610, 2002.
12. Multani, A. S., Ozen, M., Narayan, S., Kumar, V., Chandra, J., McConkey, D. J., Newman, R. A., and Pathak, S. Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss. Neoplasia, 2: 339-345, 2000.
13. Sherr, C. J., and DePinho, R. A. Cellular senescence: mitotic clock or culture shock? Cell, 102: 407-410, 2000.
14. Multani, A. S., Li, C., Ozen, M., Imam, A. S., Wallace, S., and Pathak, S. Cell-killing by paclitaxel in a metastatic murine melanoma cell line is mediated by extensive telomere erosion with no decrease in telomerase activity. Oncol. Rep., 6: 39-44, 1999.
15. Li, D., Day, K. V., Yu, S., Shi, G., Liu, S., Guo, M., Xu, Y., Sreedharan, S., and O'Malley, B. W. The role of adenovirus-mediated retinoblastoma 94 in the treatment of head and neck cancer. Cancer Res., 62: 4637-4644, 2002.
16. Czerniak, B., Li, L., Chaturvedi, V., Johnston, D. A., and Benedict, W. F. Genetic modeling of urinary bladder carcinogenesis. Genes Chromosomes Cancer, 27: 392-402, 2000.