Autocrine and Paracrine Regulation of Melanocytes in Human Skin and in Pigmentary Disorders

Pigment Cell Research

Volumn 17, Issue 2, 2004, Pages 96-110

  Imokawa, Genji ^a,b  

^a Kao Biological Science Laboratories   (Japan)

^b KAO CORPORATION   (Japan)

Author keywords

Cyotokines; Epidermal hyperpigmentary disorders; Fibroblasts; Keratinocytes; Melanocytes; Paracrine network; Receptors; Ultraviolet light

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MELANOMA GROWTH STIMULATORY ACTIVITY FACTOR; SCATTER FACTOR; SPHINGOSYLPHOSPHORYLCHOLINE; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR;

ATOPIC DERMATITIS; AUTOCRINE EFFECT; CAFE AU LAIT SPOT; CELL INTERACTION; DERMATOFIBROMA; FIBROBLAST; HUMAN; HYPERPIGMENTATION; HYPOPIGMENTATION; KERATINOCYTE; LENTIGO; MELANOCYTE; MELANOSIS; ONCOGENE; PARACRINE SIGNALING; PIGMENT DISORDER; REVIEW; SEBORRHEIC KERATOSIS; TOXIC MELANODERMATITIS; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; VITILIGO;

DOWN-REGULATION; FIBROBLASTS; HUMANS; KERATINOCYTES; MELANOCYTES; MODELS, BIOLOGICAL; PIGMENTATION; PROTO-ONCOGENE PROTEINS C-KIT; SKIN; STEM CELL FACTOR; ULTRAVIOLET RAYS; UP-REGULATION;

EID: 1842473620     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0749.2003.00126.x     Document Type: Review

References (106)

1. Yada Y, Higuchi K, Imokawa G. Effects of endothelins on signal transduction and proliferation in human melanocytes. J Biol Chem 1991;266:18352-18357
2. Imokawa G, Yada Y, Miyagishi M. Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes. J Biol Chem 1992;267:24675-24680
3. Imokawa G, Yada Y, Morisaki N, Kimura M. Granulocyte/macrophage-colony-stimulatory factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis. Biochem J 1996;313:625-631
4. Imokawa G, Yada Y, Higuchi K. Purification and characterization of an allergy-induced melanogenic stimulating factor in brownish guinea pig skin. J Biol Chem 1998;273:1605-1612
5. Imokawa G, Yada Y, Morisaki N, Kimura M. Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes. Biochem J 1998;330:1235-1239
6. Halaban R, Langdon R, Birchall N, Cuono C, Baurd A, Scott G, Moellmann G, McGuire J. Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. J Cell Biol 1988;107:1611-1619
7. Gordon PR, Mansur CP, Gilchrest BA. Regulation of human melanocyte growth, densricity, and melanization by keratinocyte derived factors. J Invest Dermatol 1989;92:565-572
8. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988;332:411-415
9. Imokawa G, Miyagishi M, Yada Y. Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis. J Invest Dermatol 1995;105:32-37
10. Imokawa G, Kobayashi T, Miyagishi M, Higashi K, Yada Y. The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis. Pigment Cell Res 1997;10:218-228
11. Imokawa G, Yada Y, Kimura M. Signaling mechanisms of endothelin-induced mitogenesis in human melanocytes. Biochem J 1996;314:305-312
12. Grichnik JM, Burch JA, Burchette J, Shea CR. The SCF/KIT pathway plays a critical role in the control of normal human melanocyte homeostasis. J Invest Dermatol 1998;111:233-238
13. Hachiya A, Kobayashi A, Ohuchi A, Takema Y, Imokawa G. The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet B-induced pigmentation. J Invest Dermatol 2001;116:578-586
14. Imokawa G, Kawai M, Mishima Y, Motegi I. Differential analysis of experimental hypermelanosis induced by UVB, PUVA and allergic contact dermatitis using brownish guinea pig model. Arch Dermatol Res 1986;278:352-362
15. Abdel-Malek ZA, Swope VB, Suzuki I, Akcali C, Harriger MD, Boyce ST, Urabe K, Hearing VJ. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proc Natl Acad Sci USA 1995;92:1789-1793
16. Chakraborty AK, Funasaka Y, Slominski A, Ermak G, Hwang J, Pawelek J, Ichihashi M. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: regulation by UVB. Biochim Biophys Acta 1996;1313:130-138
17. Imokawa G, Yada Y, Morisaki N, Kimura M. Characterization of keratinocyte-and fibroblast-derived mitogens for human melanocyte - their roles in stimulated cutaneous pigmentation. In: Hori Y, Hearing VJ, Nakayama J, ed. Melanogenesis and Malignant Melanoma. London: Elsevier Science B.V.; 1996. pp. 35-48
18. Wakamatu K, Graham A, Cook D, Thody AJ. Characterisation of ACTH peptides in human skin and their activation of the melanocortin-1 receptor. Pigment Cell Res 1997;10:288-297
19. Hachiya A, Kobayashi T, Takema Y, Imokawa G. Biochemical characterization of endothlein-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis. J Biol Chem 2002;277:5395-5403
20. Xu D, Emoto N, Giaid A, Slaughter C, Kaw S, deWit D, Yanagisawa M. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 1994;78:473-485
21. Tada A, Suzuki I, Im S, Davis MB, Cornelius J, Babcock G, Nordlund JJ, Abdel-Malek ZA. Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation. Cell Growth Differ 1998;9:575-584
22. Brand M, Moullec J-ML, Corvol P, Gasc J-M. Ontogeny of endothelins-1 and -3, their receptors, and endothelin converting enzyme-1 in the early human embryo. J Clin Invest 1998;101:549-59
23. Imokawa G, Kobayashi T, Miyagishi M. Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes: cross-talk via trans-activation of the tyrosine kinase c-kit receptor. J Biol Chem 2000;275:33321-33328
24. Kadono S, Manaka I, Kawashima M, Kobayashi T, Imokawa G. The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis. J Invest Dermatol 2001;116:571-577
25. Hattori H, Kawashima M, Ichikawa Y, Imokawa G. The epidermal stem cell factor is over-expressed in lentigo senilis: implication for the mechanism of hyperpigmentation. J Invest Dermatol in press
26. Shishido E, Kadono S, Manaka I, Kawashima M, Imokawa G. The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression. J Invest Dermatol 2001;117:627-633
27. Okazaki M, Yoshimura K, Suzuki Y, Uchid G, Kitano Y, Harii K, Imokawa G. The mechanism of epidermal hyhperpigmentation in café-au-lait macules of neurofibromatosis type-1 (von Recklinghausen's disease) may be associated with dermal fibroblast-derived stem cell factor and hepatocyte growth factor. Br J Dermatol 2003;148:689-697
28. Longley BJ Jr, Morganroth GS, Tyrrell L, Ding TG, Anderson DM, Williams DE, Halaban R. Altered metabolism of mast-cell growth factor (c-kit ligand) in cutaneous mastocytosis. N Engl J Med 1993;328:1302-1307
29. Kunisada T, Lu SZ, Yoshida H, Nishikawa S, Nishikawa S, Mizoguchi M, Hayashi S, Tyrrell L, Williams DA, Wang X, Longley BJ. Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor. J Exp Med 1998;187:1565-1573
30. Imokawa G, Kawai M. Differential hypermelanosis induced by allergic contact dermatitis. J Invest Dermatol 1987;789:540-546
31. Imokawa G, Yada Y, Okuda M. Allergic contact dermatitis releases soluble factors that stimulate melanogenesis through activation of protein kinase C-related signal-transduction pathway. J Invest Dermatol 1992;99:482-488
32. Castor CW, Miller JW, Walz DA. Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor. Proc Natl Acad Sci USA 1983;80:765-769
33. Luster AD Unkeless JC, Ravetch JV. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 1985;315:672-676
34. Walz A, Peveri P, Aschauer H, Baggioline M. Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem Biophys Res Commun 1987;149:755-761
35. Wen DZ, Rowland A, Derynck R. Expression and secretion of gro/ MGSA by stimulated human endothelial cells. EMBO J 1989;8:1761-1766
36. Moser B, Schumacher C, von Tscharner V, Clark-Lewis I, Baggiolline M. Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophils. J Biol Chem 1991;266:10666-10671
37. Richmond A, Lawson DH, Nixon DW, DStevens S, Chawla RK. Extraction of a melanoma growth-stimulatory activity from culture medium conditioned by the Hs0294 human melanoma cell line. Cancer Res 1983;43:2106-2112
38. Venner TJ, Sauder DN, Feliciani C, Mckenzie RC. Interleukin-8 and melanoma growth-stimulating activity (GRO) are induced by ultra-violet B radiation in human keratinocyte cell lines. Exp Dermatol 1995;4:138-145
39. Kojima T, Cromie MA, Fisher GJ, Voorhees JJ, Elder JT. GRO-alpha mRNA is selectively overexpressed in psoriatic epidermis and is reduced by cyclosporin A in vivo, but not in cultured keratinocytes. J Invest Dermatol 1993;101:767-772
40. Anisowicz A, Zajchowski D, Stenman G, Sager R. Functional diversity of gro gene expression in human fibroblasts and mammary epithelial cells. Proc Natl Acad Sci USA 1988;85:9645-9649
41. Groves RW, Rauschemayr T, Nakamura K, Sarkar S, Williams IR, Kupper TS. Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes. Evidence that IL-1-inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease. J Clin Invest 1996;98:336-344
42. Murata Y, Ogata J, Higaki Y, Kawashima M, Yada Y, Higuchi K, Tsuchiya T, Kawaminami S, Imokawa G. Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? J Invest Dermatol 1996;106:1242-1249
43. Hara J, Higuchi K, Okamoto R, Kawashima M, Imokawa G. High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. J Invest Dermatol 2000;115:406-413
44. Higuchi K, Hara J, Okamoto R, Kawashima M, Imokawa G. The skin of atopic dermatitis patients contains a novel enzyme, glucosylceramide sphingomyelin deacylase, which cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. Biochem J 2000;350:747-756
45. Imokawa G., Abe A., Jin K., Higaki Y., Kawashima M., Hidano A. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin?. J Invest Dermatol 1991;96:523-526
46. Okamoto R, Arikawa J, Ishibashi M, Kawashima M, Takagi Y, Imokawa G. Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. J Lipid Res 2003;44:93-102
47. Sun L, Xu L, Henry FA, Spiegel S, Nielsen TB. A new wound healing agent-sphingosylphosphorylcholine. J Invest Dermatol 1996;106:232-237
48. Imokawa G, Takagi Y, Higuchi K, Kondo H, Yada Y. Sphingosylphosphorylcholine is a potent inducer of intercellular adhesion molecule-1 expression in human keratinocytes. J Invest Dermatol 1999;112:91-96
49. Higuchi K, Kawashima M, Takagi Y, Kondo H, Yada Y, Ichikawa Y, Imokawa G. Sphingosylphosphorylcholine is an activator of transglutaminase activity in human keratinocytes. J Lipid Res 2001;42:1562-1570
50. Boguslawski G, Lyons D, Harvey KA, Kovala AT, English D. Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. Biochem Biophys Res Commun 2000;272:603-609
51. Higuchi K, Kawashima M, Ichikawa Y, Imokawa G. Sphingosylphosphorylcholine is a melanogenic stimulator for human melanocytes. Pigment Cell Res 2003;16:670-678
52. Colver GB, Mortimer PS, Millard PR, Dawber RPR, Ryan TJ. The 'Dirty Neck' - a reticulate pigmentation in atopics. Clin Exp Dermatol 1987;12:1-4
53. Manabe T, Inagaki Y, Nakagawa S, Miyoshi K, Ueki H. Ripple pigmentation of the neck in atopic dermatitis. Am J Dermatopathol 1987;9:301-307
54. Ruzicka T, Gluck S. Cutaneous histamine levels and histamine releasability from the skin in atopic dermatitis and hyper-IgE-syndrome. Arch Dermatol Res 1983;275:41-44
55. Yoshida M, Takahashi Y, Inoue S. Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H2 receptors in human normal melanocytes. J Invest Dermatol 2000;114:334-342
56. Teraki E, Tajima S, Manaka, I., Kawashima M, Miyagishi M, Imokawa G. Role of endothelin-1 in hyperpigmentation in seborrhoeic keratosis. Br J Dermatol 1996;135:918-923
57. Manaka I, Kadono S, Kawashima M, Kobayashi T, Imokawa G. The mechanim of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1α and TNFα, which stimulate secretion of endothelin-1. Br J Dermatol 2001;145:895-903
58. Matsumoto K, Tajima H, Nakamura T. Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth. Biochem Biophys Res Commun 1991;176:45-51
59. Heenan PJ. Tumors of the fibrous tissue involving the skin. In: Elder D, Elenltsas R, Jaworsky C, Johnson B Jr. Lever's Histopathology of the Skin, 8th edn. Philadelphia: Lippincott-Raven; 1997. pp. 685-746.
60. Newman DM, Walter JB. Multiple dermatofibromas in patients with systemic lupus erythematosus on immunosuppressive therapy. N Engl J Med 1973;289:842-843
61. Lin RY. Multiple dermatofibromas and systemic lupus erythematosus. Cutis 1986;32:45-49
62. Grichnik JM, Crawford J, Jimenez F, Kurtzberg J. Buchanan M, Blackwell S, Clark RE, Hitchcock MG. Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. J Am Acad Dermatol 1995;33:577-583
63. Costa JJ, Demetri GD, Harrist TJ, Dvorak AM, Hayes DF, Merica EA, Menchaca DM, Gringeri AJ, Schwartz LB, Galli SJ. Recombinant human stem cell factor(Kit Ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J Exp Med 1996;183:2681-2686
64. Longley BJ, Morganroth GS, Tyrrell L, Ding TG, Anderson DM, Williams DE, Halaban R. Altered metabolism of mast-cell growth factor (c-kit ligand) in cutaneous mastocytosis. N Engl J Med 1993;328:1302-1307
65. Kang S, Sorber AJ. Disturbances of Melanin Pigmentation. In: Moschella SL, Hurley HJ, eds. Dermatology, 3rd edn, vol. 2. Philadelphia, PA: W.B. Saunders Co.; 1992, pp. 1446-1447
66. Moscher DB, Fitzpatrick TB, Hori Y. Disorders of Pigmentation. In: Fritzpatrick TB, Eisen AZ, Wolff K, Freedberg IM, Austen KF, eds. Dermatology in General Medicine, vol. 1. New York: McGraw-Hill Inc.; 1993. pp. 967-969
67. Benedict PH, Szabo G, Fitzpatrick TB, Sinesi SJ. Melanotic macules in Albright's syndrome and in neurofibromatosis. J Amer Med Assoc 1968;205:618-626
68. Frenk E, Marazzi A. Neurofibromatosis of von Recklinghausen: quantitative study of the epidermal keratinocyte and melanocyte populations. J Invest Dermatol 1984;83:23-25
69. Barker D, Wright E, Nguyen K, Cannon L, Fain P, Goldgar D, Bishop DT, Carey J, Baty B, Kivlin J. Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science 1987;236:1100-1102
70. Cawthon RM, Weiss R, Xu G, Viskochil D, Culver M, Stevens J, Robertson M, Dunn D, Gesteland R, O'Connell P. A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure and point mutations. Cell 1990;62:193-201
71. Viskochil D, Buchberg AM, Xu G, Cawthon RM, Stevens J, Wolff RK, Culver M, Carey JC, Copeland NG, Jenkins NA. Deletions or translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell 1990;62:187-192
72. Wallance MR, Marchuk DA, Anderson LB, Letcher R, Odeh HM, Saulino AM, Fountain JW, Brereton A, Nicholson J, Mitchell AL. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science 1990;249:181-186
73. Griesser J, Kaufmann D, Eisenbarth I, Bauerle C, Krone W. Ras-GTP regulation is not altered in cultured melanocytes with reduced levels of neurofibromin derived from patients with neurofibromatosis 1 (NF1). Biol Chem Hoppe Seyler 1995;376:91-101
74. Grabbe J, Welker P, Dippel E, Czarnetzki BM. Stem cell factor, a novel cutaneous growth factor for mast cells and melanocytes. Arch Dermatol Res 1994;161:78-84
75. Puri N, van der Weel MB, de Wit FS, Asghar SS, Das PK, Ramaiah A, Westerhof W. Basic fibroblast growth factor promotes melanin synthesis by melanocytes. Arch Dermatol Res 1996;288:633-635
76. Numberger M, Moll I. Semiquantitative aspects of mast cells in normal skin and in neurofibromas of neurofibromatosis type 1 and 5. Dermatology 1994;188:296-299
77. Nordlund JJ, Ortonne JP. Vitiligo vulgaris. In: Nordlund JJ, Boissy RE, Hearing VJ, King RA, Ortonne JP, eds. The Pigmentary System. Physiology and Pathophysiology. New York: Oxford University Press; 1998. pp. 513-551
78. Tobin DJ, Swanson NN, Pittelkow MR, Peters EM, Schallreuter KU. Melanocytes are not absent in lesional skin of long duration vitiligo. J Pathol 2000;191:407-416
79. Gauthier Y, CarioAndre M, Taieb A. A critical appraisal of vitiligo etiologic theories. Is melanocyte loss a melanocytorrhgy? Pigment Cell Res 2003;16:322-332
80. van den Wijngaard R, Wankowicz-Kalinska A, Pals S, Weening J, Dad P. Autoimmune melanocyte destruction in vitiligo. Lab Invest 2001;81:1061-1067
81. Alkhteeb A, Fain PR, Thody A, Bennett DC, Spritz RA. Epidemiology of vitiligo and associated autoimmune disease in caucasian probands and their families. Pigment Cell Res 2003;16:208-214
82. Wankowicz-Kalinska A, Le Poole C, van der Wijngaard R, Storkus WJ, Das PK. Melanocyte-specific immune response in melanoma and vitiligo: two faces of the same coin? Pigment Cell Res 2003;16:254-260
83. Schallreuter KU, Wood JM, Berger J. Low catalase levels in the epidermis of patients with vitiligo. J Invest Dermatol 1991;97:1081-1085
84. Maresca V, Roccella M, Roccella F, Camera E, Del Porto G, Passi S, Grammatico P, Picardo M. Increased sensitivity to peroxidative agents as a possible pathogenic factor of melanocyte damage in vitiligo. J Invest Dermatol 1997;109:310-313
85. Passi S, Grandinetti M, Maggio F, Stancato A, De Luca C. Epidermal oxidative stress in vitiligo. Pigment Cell Res 1998;11:81-85
86. Cario-Andre M, Gauthier Y, Pain C, Taieb A. SP-21 ex vivo vitiligo vs control melanocytes susceptibility to catecholamines and hydrogen peroxide. Pigment Cell Res 2003;16:587-588
87. Moretti S, Giovannelli L, Bellandi S, Dolara P, Fabbri P. PP-29 DNA damage in vitiligo. Pigment Cell Res 2003;16:602-603
88. Moretti S, Spallanzani A, Amato L, Hautmann G, Gallerani I, Fabiani M, Fabbri P. New insights into the pathogenesis of vitiligo: imbalance of epidermal cytokines at sites of lesions. Pigment Cell Res 2002;15:87-92
89. Giebel LB, Spritz RA. Mutation of the KIT (mast/stem-cell growth factor receptor) protooncogene in human piebaldism. Proc Natl Acad Sci USA 1991;88:8696-8699
90. Ezoe K, Holmes SA, Ho L, Bennett CP, Bolognia JL, Brueton L, Burn J, Falabella R, Gatto EM, Ishii N, Moss C, Pittelkow MR, Thompson E, Ward KA, Spritz RA. Novel mutations and deletions of the KIT (steel factor receptor) gene in human piebaldism. Am J Hum Genet 1995;56:58-66
91. Baynash AG, Hosoda K, Giaid A, Richardson JA, Emoto N, Hammer RE, Yanagisawa M. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 1994;79:1277-1285
92. Puffenberger EG, Hosoda K, Washington SS, Nakao K, deWit D, Yanagisawa M, Chakravart A. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell 1994;79:1257-1266
93. Williams DE, Eisenman J, Baird A, Rauch C, Van Ness K, March CJ, Park LS, Martin U, Mochizuki DY, Boswell HS. Identification of a ligand for the c-kit proto-oncogene. Cell 1990;63:167-174
94. Flanfan JG, Leder P. The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell 1990;63:185-194
95. Zsebo KM, Williams DA, Geissler EN, Broudy VC, Martin FH, Atkins HL, Hsu RY, Birkett NC, Okino KH, Murdock DC, Jacobsen FW, Langley KE, Smith KA, Takeishi T, Cattanach BM, Galli SJ, Suggs SJ. Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor. Cell 1990;63:213-224
96. Kitamura R, Tsukamoto K, Harada K, Shimizu A, Shimada S, Kobayashi T, Imokawa G. Mechanims underlying the dysfunction of melanocytes in vitiligo epidermis: Role of SCF/KIT protein interactions and its downstream effector, MITF-M. J Pathol in press
97. Norris A, Todd C, Graham A, Quinn AG, Thody AJ. The expression of the c-kit receptor by epidermal melanocytes may be reduced in vitiligo. Br J Dermatol 1996;134:299-306
98. Hemesath TJ, Price ER, Takemoto C, Badalian T, Fisher DE. MAP kinase links the transcription factor microphthalmia to c-Kit signalling in melanocytes. Nature 1998;391:298-301
99. Tachibana M, Takeda K, Nobukuni Y, Urabe K, Long JE, Meyers KA, Aaronson SA, Miki T. Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics. Nat Genet 1996;14:50-54
100. Wu M, Hemesath TJ, Takemoto CM, Horstmann MA, Wells AG, Price ER, Fisher DZ, Fisher DE. c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev 2000;14:301-312
101. Xu W, Gong L, Haddad MM, Bischof O, Campisi J, Yeh ET, Medrano EE. Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the ubiquitin hUBC9. Exp Cell Res 2000;255:135-143
102. McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S, Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 2002;109:707-718
103. Hou L, Panthier JJ, Arnheiter H. Signaling and transcriptional regulation in the neural crest-derived melanocyte lineage: interactions between KIT and MITF. Development 2000;127:5379-5389
104. Tsujimura T, Morii E, Nozaki M, Hashimoto K, Moriyama Y, Takebayashi K, Kondo T, Kanakura Y, Kitamura Y. Involvement of transcription factor encoded by the mi locus in the expression of c-kit receptor tyrosine kinase in cultured mast cells of mice. Blood 1996;88:1225-1233
105. Feng HL, Sandlow JI, Sparks AE, Sandra A, Zheng LJ. Decreased expression of the c-kit receptor is associated with increased apoptosis in subfertile human testes. Fertil Steril 1999;71:85-89
106. Jimenez-Cervantes C, Martinez-Esparza M, Perez C, Daum N, Solano F, Garcia-Borron JC. Inhibition of melanogenesis in response to oxidative stress: Transient downregulation of melanocyte differentiation markers and possible involvement of microphthalmia transcription factor. J Cell Sci 2001;114:2335-2344