The mechanism of epidermal hyperpigmentation in café-au-lait macules of neurofibromatosis type 1 (von Recklinghausen's disease) may be associated with dermal fibroblast-derived stem cell factor and hepatocyte growth factor

British Journal of Dermatology

Volumn 148, Issue 4, 2003, Pages 689-697

  Okazaki, M ^a   Yoshimura, K ^a   Suzuki, Y ^a   Uchida, G ^a   Kitano, Y ^a   Harii, K ^a   Imokawa, Genji ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b KAO CORPORATION   (Japan)

Author keywords

Caf au lait macules; Fibroblasts; Hepatocyte growth factor; Neurofibromatosis type 1; Stem cell factor; Von Recklinghausen's disease

Indexed keywords

CYTOKINE; ENDOTHELIN 1; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; SCATTER FACTOR; STEM CELL FACTOR;

ADULT; ARTICLE; CAFE AU LAIT SPOT; CLINICAL ARTICLE; CONTROLLED STUDY; DERMIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIBROBLAST; HUMAN; HUMAN TISSUE; HYPERPIGMENTATION; KERATINOCYTE; MALE; NEUROFIBROMATOSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; CAFE-AU-LAIT SPOTS; CELLS, CULTURED; CHILD, PRESCHOOL; CULTURE MEDIA, CONDITIONED; CYTOKINES; FEMALE; FIBROBLASTS; HEPATOCYTE GROWTH FACTOR; HUMANS; MALE; MIDDLE AGED; NEUROFIBROMATOSIS 1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELL FACTOR;

EID: 0037903285     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2003.05283.x     Document Type: Article

References (29)

1. Kang S, Sorber AJ. Disturbances of melanin pigmentation. In: Dermatology (Moschella SL, Hurley HJ. eds, 3rd edn, Vol. 2. Philadelphia: W.B.Saunders Co., 1992; 1446-7.
2. Moscher DB, Fitzpatrick TB, Hori Y et al. Disorders of pigmentation. In: Dermatology in General Medicine (Fitzpatrick TB, Eisen AZ, Wolff K, Freedberg IM. Austen KF, eds), 4th edn, Vol. 1. New York: McGraw-Hill, 1993; 967-9.
3. Benedict PH, Szabo G, Fitzpatrick TB et al. Melanotic macules in Albright's syndrome and in neurofibromatosis. JAMA 1968; 205: 618-26.
4. Frenk E, Marazzi A. Neurofibromatosis of von Recklinghausen: quantitative study of the epidermal keratinocyte and melanocyte populations. J Invest Dermatol 1984; 83: 23-5.
5. Barker D, Wright E, Nguyen K et al. Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science 1987; 236: 1100-2.
6. Cawthorn RM, Weiss R, Xu G et al. A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure and point mutations. Cell 1990; 62: 193-201.
7. Viskochil D, Buchberg AM, Xu G et al. Deletions or translocation interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell 1990; 62: 187-92.
8. Wallance MR, Marchuk DA, Anderson LB et al. Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science 1990; 249: 181-6.
9. Griesser J, Kaufmann D, Eisenbarth I et al. Ras-GTP regulation is not altered in cultured melanocytes with reduced levels of neurofibromin derived from patients with neurofibromatosis 1 (NF1). Biol Chem Hoppe Seyler 1995; 376: 91-101.
10. Yada Y, Higuchi K, Imokawa G. Effect of endothelins on signal transduction and proliferation in human melanocytes. J Biol Chem 1991; 266: 18352-7.
11. Imokawa G, Yada Y, Miyagishi M. Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes. J Biol Chem 1992; 267: 24675-80.
12. Imokawa G, Miyagishi M, Yada Y. Endothelin-1 as a new melanogen: coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis. J Invest Dermatol 1995; 105: 32-7.
13. Imokawa G, Yada Y, Kimura N et al. Granulocyte/macrophage colony-stimulating factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis. Biochem J 1996; 313: 625-31.
14. Kadono S, Manaka I, Kawashima M et al. The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis. J Invest Dermatol 2001; 116: 571-7.
15. Matsumoto K, Tajima H, Nakamura T. Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth. Biochem Biophys Res Commun 1991; 176: 45-51.
16. Imokawa G, Yada Y, Morisaki N. Melanogenesis and malignant melanoma. In: Biochemistry, Cell Biology, Molecular Biology. Pathophysiology, Diagnosis and Treatment (Hori Y, Hearing VJ, Nakayama J, eds). Amsterdam: Elsevier Science BV, 1996: 35-48.
17. Imokawa G, Yada Y, Kimura M. Signaling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes. Biochem J 1996; 314: 305-12.
18. Imokawa G, Yada Y, Morisaki N et al. Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes. Biochem J 1998; 330: 1235-19.
19. Halaban R, Langdon R, Birchall N et al. Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes. J Cell Biol 1988; 107: 1611-19.
20. Grabbe J, Welker P, Dippel E et al. Stem cell factor, a novel cutaneous growth factor for mast cells and melanocytes. Arch Dermatol Res 1994; 161: 78-84.
21. Puri N, van der Weel MB, de Wit FS et al. Basic fibroblast growth factor promotes melanin synthesis by melanocytes. Arch Dermatol Res 1996; 288: 633-5.
22. Costa JJ, Demetri GD, Harrist TJ et al. Recombinant human stem cell factor (Kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J Exp Med 1996; 183: 2681-6.
23. Grichnik JM, Crawford J, Jimenez F et al. Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients. J Am Acad Dermatol 1995; 33: 577-83.
24. Shishido E, Kadono S, Manaka I et al. The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression. J Invest Dermato; 2001; 117: 627-33.
25. Conference Statement. National Institutes of Health Consensus Development Conference. Neurofibromatosis. Arch Neurol 1988; 45: 575-8.
26. Tsunenaga M, Kohno Y, Horii I et al. Growth and differentiation properties of normal and transformed keratinocytes in organo-typic culture. Jpn J Cancer Res 1994; 85: 238-44.
27. Shimokawa T, Kato M, Ezaki O, Hashimoto S. Transcriptional regulation of muscle-specific genes during myoblast differentiation. Biochem Biophys Res Cornmun 1998; 246: 287-92.
28. Eder M, Battmer K, Kafert S et al. Monitoring of BCR-ABL expression using real-time RT-PCR in CML after bone marrow or peripheral blood stem cell transplantation. Leukemia 1999; 13: 1383-9.
29. Nurnberger M, Moll I. Semiquantitative aspects of mast cells in normal skin and in neurofibromas of neurofibromatosis type 1 and 5. Dermatology 1994; 188: 296-9.