The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis

Journal of Investigative Dermatology

Volumn 116, Issue 4, 2001, Pages 571-577

  Kadono, Satsuki ^a   Manaka, Izumi ^a   Kawashima, Makoto ^a   Kobayashi, Takashi ^b   Imokawa, Genji ^b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b KAO CORPORATION   (Japan)

Author keywords

Endothelin B receptor; Interleukin 1 ; Tumor necrosis factor

Indexed keywords

CYTOKINE; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; ENDOTHELIN CONVERTING ENZYME; INTERLEUKIN 1ALPHA; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; EPIDERMIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPIGMENTATION; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; LENTIGO; MALE; MELANOCYTE; MELANOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENILE LENTIGO;

EID: 0035046659     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01296.x     Document Type: Article

References (16)

1. Ontogeny of endothelins-1 and -3, their receptors, and endothelin converting enzyme-1 in the early human embryo
2. Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes
3. Endothelln-1 as a new melanogen: Coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis
4. Signaling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes
5. Granulocyte/macrophage colony-stimulating factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis
6. The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis
7. Purification and characterization of an allergy-induced melanogenic stimulating factor in brownish guinea pig skin
8. Intracellular signaling mechanisms leading to synergastic effects of endothehn-1 and stem cell factor on proliferation of cultured human melanocytes: Cross-talk via trans-activation of the tyrosine kinase c-kit receptor
9. Autoregulation of endothelin-1 secretion by cultured human keratinocytes via the endothelin B receptor
10. Regulation of endothelin-B receptor mRNA expression in human endothelial cells by cytokines and growth factors
11. Endothelin-1 participates in their responses to ultraviolet radiation
12. Role of endothelin-1 in hyperpigmentation in seborrhoeic keratosis
13. Endothelin-1 acts as an autocrine growth factor for normal keratinocytes
14. ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
15. Effects of endothelins on signal transduction and proliferation in human melanocytes
16. A novel potent vasoconstrictor peptide produced by vascular endothelial cells