The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1α and TNF-α, which stimulate secretion of endothelin 1

British Journal of Dermatology

Volumn 145, Issue 6, 2001, Pages 895-903

  Manaka, I ^a   Kadono, S ^a   Kawashima, M ^a   Kobayashi, T ^a   Imokawa, Genji ^a  

^a KAO CORPORATION   (Japan)

Author keywords

Endothelin; Endothelin converting enzyme 1 ; Hyperpigmentation; Interleukin 1 ; Seborrhoeic keratosis; Tumour necrosis factor

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN CONVERTING ENZYME; ENDOTHELIN CONVERTING ENZYME 1ALPHA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 1ALPHA; MESSENGER RNA; MONOPHENOL MONOOXYGENASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BASAL CELL; CONTROLLED STUDY; DOWN REGULATION; EPIDERMIS; GENE EXPRESSION; HUMAN; HUMAN TISSUE; HYPERPIGMENTATION; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEBORRHEIC KERATOSIS; ULTRAVIOLET B RADIATION;

CELL CULTURE TECHNIQUES; ENDOTHELIN-1; GENE EXPRESSION; HUMANS; HYPERPIGMENTATION; IMMUNOENZYME TECHNIQUES; KERATINOCYTES; KERATOSIS, SEBORRHEIC; METALLOENDOPEPTIDASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035724283     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2001.04521.x     Document Type: Article

References (15)

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14. The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression