The mechanism of epidermal hyperpigmentation in dermatofibroma is associated with stem cell factor and hepatocyte growth factor expression

Journal of Investigative Dermatology

Volumn 117, Issue 3, 2001, Pages 627-633

  Shishido, Etsuko ^a   Kadono, Satsuki ^a   Manaka, Izumi ^a   Kawashima, Makoto ^a   Imokawa, Genji ^a,b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b Kao Biological Science Laboratories   (Japan)

Author keywords

Cytokines; Fibroblasts; Mast cell; Melanocytes

Indexed keywords

CYTOKINE; ENDOTHELIN 1; FIBROBLAST GROWTH FACTOR; MESSENGER RNA; MONOPHENOL MONOOXYGENASE; PROTEIN; PROTEIN ANTIBODY; SCATTER FACTOR; STEM CELL FACTOR; TOLONIUM CHLORIDE;

ADULT; ARTICLE; CELL COUNT; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOFIBROMA; EPIDERMIS; FEMALE; FIBROBLAST; GENETIC CODE; HUMAN; HUMAN TISSUE; HYPERPIGMENTATION; IMMUNOHISTOCHEMISTRY; MALE; MAST CELL; MELANOCYTE; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; SKIN; TUMOR CELL;

EID: 0034790851     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202X.2001.01440.x     Document Type: Article

References (25)

1. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides
2. Production and release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: Regulation by UVB
3. Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo
4. Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients
5. The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet B-induced pigmentation
6. Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes
7. Tumors of the fibrous tissue involving the skin
8. Characterization of keratinocyte- and fibroblast-derived mitogens for human melanocyte - Their roles in stimulated cutaneous pigmentation
9. Endothelins secreted from human keratinocytes are intrinsic mitogens for human melanocytes
10. Endothelin-1 as a new melanogen: Coordinated expression of its gene and the tyrosinase gene in UVB-exposed human epidermis
11. Signaling mechanisms of endothelin-induced mitogenesis and melanogenesis in human melanocytes
12. Granulocyte/macrophage colony-stimulating factor is an intrinsic keratinocyte-derived growth factor for human melanocytes in UVA-induced melanosis
13. The role of endothelin-1 in epidermal hyperpigmentation and signaling mechanisms of mitogenesis and melanogenesis
14. Purification and characterization of an allergy-induced melanogenic stimulating factor in brownish guinea pig skin
15. Biological characterization of human fibroblast-derived mitogenic factors for human melanocytes
16. Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes: Cross-talk via trans-activation of the tyrosine kinase C-kit receptor
17. The role of the epidermal endothelin cascade in the hyperpigmentation mechanism of lentigo senilis
18. Multiple dermatofibromas and systemic lupus erythematosus
19. Altered metabolism of mast-cell growth factor (c-kit ligand) in cutaneous mastocytosis
20. Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth
21. Multiple dermatofibromas in patients with systemic lupus erythematosus on immunosuppressive therapy
22. Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes
23. Hepatocyte growth factor and c-met/hepatocyte growth factor receptor in pulmonary adenocarcinomas: An evaluation of their expression as prognostic markers
24. Role of endothelin-1 in hyperpigmentation in seborrhoeic keratosis
25. Abnormal distribution of intestinal pacemaker (C-Kit-positive) cells in an infant with chronic idiopathic intestinal pseudoobstruction