Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: Lipoma

Cancer Genetics and Cytogenetics

Volumn 150, Issue 2, 2004, Pages 93-115

  Sandberg, Avery A ^a  

^a ST JOSEPH'S HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP A PROTEIN; LIM PROTEIN;

ADIPOCYTE; ANGIOLIPOMA; ANGIOMYOLIPOMA; BENIGN TUMOR; BONE TUMOR; CHOROID; CHROMOSOME ANALYSIS; EDITORIAL; HIBERNOMA; HUMAN; KARYOTYPE; LIPOBLASTOMA; LIPOMA; MOLECULAR DYNAMICS; PLEOMORPHIC ADENOMA; PRIORITY JOURNAL; SKELETAL MUSCLE; SOFT TISSUE TUMOR; SPINDLE CELL;

EID: 1842454080     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2003.12.018     Document Type: Article

References (261)

1. Sandberg A.A., Gibas Z., Saren E., Li F.P., Limon J., Tebbi C.K. Chromosome abnormalities in two benign adipose tumors. Cancer Genet Cytogenet. 22:1986;55-61.
2. Turc-Carel C., Dal Cin P., Rao U., Karakousis C., Sandberg A.A. Cytogenetic studies of adipose tissue tumors I. A benign lipoma with reciprocal translocation t(3;12)(q28;q14). Cancer Genet Cytogenet. 23:1986;283-289.
3. Heim S., Mandahl N., Kristoffersson U., Mitelman F., Rööser B., Rydholm A., Willén H. Reciprocal translocation t(3;12)(q27;q13) in lipoma. Cancer Genet Cytogenet. 23:1986;301-304.
4. Sreekantaiah C., Sandberg A.A. Clustering of aberrations to specific chromosome regions in benign neoplasms. Int J Cancer. 48:1991;194-198.
5. Hess J.L., Kossev P. Molecular genetics of benign tumors. Cancer Invest. 20:2002;362-372.
6. Nielsen G.P., Lipoma Mandahl N. Fletcher C.D.M., Unni K.K., Mertens F. Pathology and genetics of tumours of soft tissue and bone. World Health Organization Classification of Tumours. 2002;20-22 IARC Press, Lyon.
7. Weiss S.W., Goldblum J.R. Enzinger and Weiss's soft tissue tumors. 4th edition:2001;Mosby, St. Louis.
8. Kawashima A., Magid D., Fishman E.K., Hruban R.H., Ney D.R. Parosteal ossifying lipoma: CT and MR findings. J Comput Assist Tomogr. 17:1993;147-150.
9. Rodríguez-Peralto J.L., Lòpez-Barea F., González-Lòpez J., Lamas-Lorenzo M. Case report 821: parosteal ossifying lipoma of femur. Skeletal Radiol. 23:1994;67-69.
10. Kindblom L.G., Angervall L., Stener B., Wickbom I. Intermuscular and intramuscular lipomas and hibernomas: a clinical, roentgenologic, histologic, and prognostic study of 46 cases. Cancer. 33:1974;754-762.
11. Fletcher C.D., Martin-Bates E. Intramuscular and intermuscular lipoma: neglected diagnoses. Histopathology. 12:1988;275-287.
12. Hallel T., Lew S., Bansal M. Villous lipomatous proliferation of the synovial membrane (lipoma arborescens). J Bone Joint Surg Am. 70:1988;264-270.
13. Martinez D., Millner P.A., Coral A., Newman R.J., Hardy G.J., Butt W.P. Case report 745: synovial lipoma arborescens. Skeletal Radiol. 21:1992;393-395.
14. Grieten M., Buckwalter K.A., Cardinal E., Rougraff B. Case report 873: lipoma arborescens (villous lipomatous proliferation of the synovial membrane). Skeletal Radiol. 23:1994;654-655.
15. Chaljub G., Johnson P.R. In vivo MRI characteristics of lipoma arborescens utilizing fat suppression and contrast administration. J Comput Assist Tomogr. 20:1996;85-87.
16. Layfield L.J. Cytopathology of bone and soft tissue tumors. 2002;Oxford University Press, Oxford.
17. Knipping G., Popper H. Composition of fat in different types of liposarcomas in comparison with lipomas. Cancer Lett. 46:1989;51-56.
18. Oliveira A.M., Nascimento A.G., Lloyd R.V. Leptin and leptin receptor mRNA are widely expressed in tumors of adipocytic differentiation. Mod Pathol. 14:2001;549-555.
19. Sandberg A.A., Bridge J.A. The cytogenetics of bone and soft tissue tumors. 1994;R.G. Landes, Austin.
20. Willén H., Åkerman M., Dal Cin P., De Wever I., Fletcher C.D.M., Mandahl N., Mertens F., Mitelman F., Rosai J., Rydholm A., Sciot R., Tallini G., Van den Berghe H., Vanni R. Comparison of chromosomal patterns with clinical features of 165 lipomas: a report of the CHAMP study group. Cancer Genet Cytogenet. 102:1998;46-49.
21. Nilbert M., Heim S. Uterine leiomyoma cytogenetics. Genes Chromosomes Cancer. 2:1990;3-13.
22. Rein M.S., Friedman A.J., Barbieri R.L., Pavelka K., Fletcher J.A., Morton C.C. Cytogenetic abnormalities in uterine leiomyomata. Obstet Gynecol. 77:1991;923-926.
23. Dal Cin P., Kools P., De Jonge I., Moerman P., Van de Ven W., Van den Berghe H. Rearrangements of 12q14-15 in pulmonary chondroid hamartoma. Genes Chromosomes Cancer. 8:1993;131-133.
24. Mandahl N., Örndal C., Heim S., Willén H., Rydholm A., Bauer H.C., Mitelman F. Aberrations of chromosome segment 12q13-15 characterize a subgroup of hemangiopericytomas. Cancer. 71:1993;3009-3013.
25. Fletcher J.A., Longtine J., Wallace K., Mentzer S.J., Sugarbaker D.J. Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: evidence for a pathogenetic relationship with lipomas and leiomyomas. Genes Chromosomes Cancer. 12:1995;220-223.
26. Schoenberg Fejzo M., Yoon S.-J., Montgomery K.T., Rein M.S., Weremowicz S., Krauter K.S., Dorman T.E., Fletcher J.A., Mao J.-I., Moir D.T., Kucherlapati R.S., Morton C.C. Identification of a YAC spanning the translocation breakpoints in uterine leiomyomata, pulmonary chondroid hamartoma, and lipoma: physical mapping of the 12q14-q15 breakpoint region in uterine leiomyomata. Genomics. 26:1995;265-271.
27. Kazmierczak B., Rosigkeit J., Wanschura S., Meyer-Bolte K., Van de Ven W., Kayser K., Krieghoff B., Kastendiek H., Bartnitzke S., Bullerdiek J. HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors. Oncogene. 12:1996;515-521.
28. Klotzbucher M., Wasserfall A., Fuhrmann U. Misexpression of wild-type and truncated isoforms of the high-mobility group I proteins HMGI-C and HMGI(Y) in uterine leiomyomas. Am J Pathol. 155:1999;1535-1542.
29. Kurose K., Mine N., Doi D., Ota Y., Yoneyama K., Konishi H., Araki T., Emi M. Novel gene fusion of COX6C at 8q22-23 to HMGIC at 12q15 in a uterine leiomyoma. Genes Chromosomes Cancer. 27:2000;303-307.
30. Fletcher C.D.M., Åkerman M., Dal Cin P., De Wever I., Mandahl N., Mertens F., Mitelman F., Rosai J., Rydholm A., Sciot R., Tallini G., Van den Berghe H., Van de Ven W., Vanni R., Willén H. Correlation between clinicopathological features and karyotype in lipomatous tumors: a report of 178 cases from the Chromosomes and Morphology (CHAMP) Collaborative Study Group. Am J Pathol. 148:1996;623-630.
31. Mandahl N., Mertens F., Willén H., Rydholm A., Brosjö O., Mitelman F. A new cytogenetic subgroup in lipomas: loss of chromosome 16 material in spindle cell and pleomorphic lipomas. J Cancer Res Clin Oncol. 120:1994;707-711.
32. Mandahl N., Mertens F., Willén H., Rydholm A., Kreicbergs A., Mitelman F. Nonrandom pattern of telomeric associations in atypical lipomatous tumors with ring and giant marker chromosomes. Cancer Genet Cytogenet. 103:1998;25-34.
33. Mandahl N., Heim S., Arheden K., Rydholm A., Willén H., Mitelman F. Three major cytogenetic subgroups can be identified among chromosomally abnormal solitary lipomas. Hum Genet. 79:1988;203-208.
34. Gisselsson D., Höglund M., Mertens F., Johansson B., Dal Cin P., Van den Berghe H., Earnshaw W.C., Mitelman F., Mandahl N. The structure and dynamics of ring chromosomes in human neoplastic and non-neoplastic cells. Hum Genet. 104:1999;315-325.
35. Dahlén A., Debiec-Rychter M., Pedeutour F., Domanski H.A., Höglund M., Bauer H.C.F., Rydholm A., Sciot R., Mandahl N., Mertens F. Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. Int J Cancer. 103:2003;616-623.
36. Szymanska J., Virolainen M., Tarkkanen M., Wiklund T., Asko-Seljavaara S., Tukiainen E., Elomaa I., Blomqvist C., Knuutila S. Overrepresentation of 1q21-23 and 12q13-21 in lipoma-like liposarcomas but not in benign lipomas: a comparative genomic hybridization study. Cancer Genet Cytogenet. 99:1997;14-18.
37. Tomoda R., Seto M., Tsumuki H., Iida K., Yamazaki T., Sonoda J., Matsumine A., Uchida A. Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. Cancer. 95:2002;1127-1133.
38. Alho A., Skjeldal S., Pettersen E.O., Melvik J.E., Larsen T.E. Aneuploidy in benign tumors and nonneoplastic lesions of musculoskeletal tissues. Cancer. 73:1994;1200-1205.
39. Pedeutour F., Forus A., Coindre J.-M., Berner J.-M., Nicolo G., Michiels J.-F., Terrier P., Ranchere-Vince D., Collin F., Myklebost O., Turc-Carel C. Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors. Genes Chromosomes Cancer. 24:1999;30-41.
40. Mitelman F, Johansson B, Mertens F, editors. Mitelman database of chromosome aberrations in cancer [Internet]. Updated August 2003. Available from http://cgap.nci.nih.gov/Chromosomes/Mitelman.
41. Sreekantaiah C., Leong S.P., Karakousis C.P., McGee D.L., Rappaport W.D., Villar H.V., Neal D., Fleming S., Wankel A., Harrington P.N., Carmona R., Sandberg A.A. Cytogenetic profile of 109 lipomas. Cancer Res. 51:1991;422-433.
42. Mandahl N., Höglund M., Mertens F., Rydholm A., Willén H., Brosjö O. Cytogenetic aberrations in 188 benign and borderline adipose tissue tumors. Genes Chromosomes Cancer. 9:1994;207-215.
43. Mitchell E.L.D., Kelsey A., Armstrong G., Dickson A. Ring chromosomes in a retroperitoneal lipoma of childhood. Genes Chromosomes Cancer. 4:1992;89-91.
44. Foa C., Mainguené C., Dupré F., Coindre J.-M., Huguet C., Kober C., Pedeutour F. Rearrangement involving chromosomes 1 and 8 in a retroperitoneal lipoma. Cancer Genet Cytogenet. 133:2002;156-159.
45. Weiss S.W. Soft tissue tumors. Monogr Pathol. 38:1996;207-239.
46. Mertens F., Rydholm A., Brosjö O., Willén H., Mitelman F., Mandahl N. Hibernomas are characterized by rearrangements of chromosome bands 11q13-21. Int J Cancer. 58:1994;503-505.
47. Nilbert M., Rydholm A., Mitelman F., Meltzer P.S., Mandahl N. Characterization of the 12q13-15 amplicon in soft tissue tumors. Cancer Genet Cytogenet. 83:1995;32-36.
48. Nakayama T., Toguchida J., Wadayama B., Kanoe H., Kotoura Y., Sasaki M.S. MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors. Int J Cancer. 64:1995;342-346.
49. Nilbert M., Rydholm A., Willén H., Mitelman F., Mandahl N. MDM2 gene amplification correlates with ring chromosomes in soft tissue tumors. Genes Chromosomes Cancer. 9:1994;261-265.
50. Pilotti S., Della Torre G., Mezzelani A., Tamborini E., Azzarelli A., Sozzi G., Pierotti M.A. The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma. Br J Cancer. 82:2000;1271-1275.
51. Logan P.M., Janzen D.L., O'Connell J.X., Munk P.L., Connell D.G. Chondroid lipoma: MRI appearances with clinical and histologic correlation. Skeletal Radiol. 25:1996;592-595.
52. Ashar H.R., Schoenberg Fejzo M., Tkachenko A., Zhou X., Fletcher J.A., Weremowicz S., Morton C.C., Chada K. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell. 82:1995;57-65.
53. Schoenmakers E.F.P.M., Wanschura S., Bullerdiek J., Van den Berghe H., Van de Ven W.J.M. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet. 10:1995;436-443.
54. Wanschura S., Kazmierczak B., Schoenmakers E., Meyen E., Bartnitzke S., Van de Ven W., Bullerdiek J., Schloot W. Regional fine mapping of the multiple-aberration region involved in uterine leiomyoma, lipoma, and pleomorphic adenoma of the salivary gland to 12q15. Genes Chromosomes Cancer. 14:1995;68-70.
55. Wanschura S., Belge G., Stenman G., Kools P., Dal Cin P., Schoenmakers E., Huysmans C., Van den Berghe H., Bartnitzke S., Van de Ven W.J.M., Bullerdiek J. Mapping of the translocation breakpoints of primary pleomorphic adenomas and lipomas within a common region of chromosome 12. Cancer Genet Cytogenet. 86:1996;39-45.
56. Tallini G., Dal Cin P., Rhoden K.J., Chiapetta G., Manfioletti G., Giancotti V., Fusco A., Van den Berghe H., Sciot R. Expression of HMGI-C and HMGI(Y) in ordinary lipoma and atypical lipomatous tumors. Immunohistochemical reactivity correlates with karyotypic alterations. Am J Pathol. 151:1997;37-43.
57. Tkachenko A., Ashar H.R., Meloni A.M., Sandberg A.A., Chada K.K. Misexpression of disrupted HMGI architectural factors activates alternative pathways of tumorigenesis. Cancer Res. 57:1997;2276-2280.
58. Ashar H.R., Tkachenko A., Shah P., Chada K. HMGA2 is expressed in an allele-specific manner in human lipomas. Cancer Genet Cytogenet. 143:2003;160-168.
59. Zhou X., Benson K.F., Ashar H.R., Chada K. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature. 376:1995;771-774.
60. Ashar H.R., Cherath L., Przybysz K.M., Chada K. Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas. Genomics. 31:1996;207-214.
61. Zhou X., Chada K. HMGI family proteins: architectural transcription factors in mammalian development and cancer. Keio J Med. 47:1998;73-77.
62. Petit M.M.R., Mols R., Schoenmakers E.F.P.M., Mandahl N., Van de Ven W.J.M. LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics. 36:1996;118-129.
63. Petit M.M.R., Schoenmakers E.F.P.M., Huysmans C., Geurts J.M.W., Mandahl N., Van de Ven W.J.M. LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes. Genomics. 57:1999;438-441.
64. Kazmierczak B., Hennig Y., Wanschura S., Rogalla P., Bartnitzke S., Van de Ven W., Bullerdiek J. Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial aldehyde dehydrogenase gene. Cancer Res. 55:1995;6038-6039.
65. Reeves R., Nissen M.S. The AT-DNA-binding domain of mammalian high mobility group I chromosomal proteins: a novel peptide motif for recognizing DNA structure. J Biol Chem. 265:1990;8573-8582.
66. Du W., Thanos D., Maniatis T. Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell. 74:1993;887-898.
67. Falvo J.V., Thanos D., Maniatis T. Reversal of intrinsic DNA bends in the IFNβ gene enhancer by transcription factors and the architectural protein HMG I(Y). Cell. 82:1995;1101-1111.
68. Thanos D., Maniatis T. Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome. Cell. 83:1995;1091-1100.
69. Friedmann M., Holth L.T., Zoghbi H.Y., Reeves R. Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. Nucleic Acids Res. 21:1993;4259-4267.
70. Patel U.A., Bandiera A., Manfioletti G., Giancotti V., Chau K.-Y., Crane-Robinson C. Expression and cDNA cloning of human HMGI-C phosphoprotein. Biochem Biophys Res Commun. 201:1994;63-70.
71. Liu J., Schiltz J.F., Shah P.C., Benson K.F., Chada K.K. Genomic structure and expression of the murine HMGA1 gene. Gene. 246:2000;197-207.
72. Ishwad C.S., Shriver M.D., Lassige D.M., Ferrell R.E. The high mobility group I-C gene (HMGI-C); polymorphism and genetic localization. Hum Genet. 99:1997;103-105.
73. Hirning-Folz U., Wilda M., Rippe V., Bullerdiek J., Hameister H. The expression pattern of the HMGIC gene during development. Genes Chromosomes Cancer. 23:1998;350-357.
74. Ram T.G., Reeves R., Hosick H.L. Elevated high mobility group-I(Y) gene expression is associated with progressive transformation of mouse mammary epithelial cells. Cancer Res. 53:1993;2655-2660.
75. Berlingieri M.T., Manfioletti G., Santoro M., Bandiera A., Visconti R., Giancotti V., Fusco A. Inhibition of HMGI-C protein synthesis suppresses retrovirally induced neoplastic transformation of rat thyroid cells. Mol Cell Biol. 15:1995;1545-1553.
76. Rogalla P., Drechsler K., Frey G., Hennig Y., Helmke B., Bonk U., Bullerdiek J. HMGI-C expression patterns in human tissues: implications for the genesis of frequent mesenchymal tumors. Am J Pathol. 149:1996;775-779.
77. Arlotta P., Tai A.K., Manfioletti G., Clifford C., Jay G., Ono S.J. Transgenic mice expressing a truncated form of the high mobility group I-C protein develop adiposity and an abnormally high prevalence of lipomas. J Biol Chem. 275:2000;14394-14400.
78. Schoenberg Fejzo M., Ashar H.R., Krauter K.S., Powell W.L., Rein M.S., Weremowicz S., Yoom S.-J., Kucherlapati R.S., Chada K., Morton C.C. Translocation breakpoints upstream of the HMGIC gene in uterine leiomyomata suggest dysregulation of this gene by a mechanism different from that in lipomas. Genes Chromosomes Cancer. 17:1996;1-6.
79. Berner J.M., Meza-Zepeda L.A., Kools P.F., Forus A., Schoenmakers E.F., Van de Ven W.J., Fodstad O., Myklebost O. HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas. Oncogene. 14:1997;2935-2941.
80. Battista S., Fidanza V., Fedele M., Klein-Szanto A.J.P., Outwater E., Brunner H., Santoro M., Croce C.M., Fusco A. The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. Cancer Res. 59:1999;4793-4797.
81. Petit M.M.R., Swarts S., Bridge J.A., Van de Ven W.J.M. Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. Cancer Genet Cytogenet. 106:1998;18-23.
82. Rogalla P., Kazmierczak B., Meyer-Bolte K., Tran K.H., Bullerdiek J. The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype. Genes Chromosomes Cancer. 22:1998;100-104.
83. Lovell-Badge R. Developmental genetics: living with bad architecture. Nature. 376:1995;725-726.
84. Prasad R., Leshkowitz D., Gu Y., Alder H., Nakamura T., Saito H., Huebner K., Berger R., Croce C.M., Canaani E. Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. Proc Natl Acad Sci U S A. 91:1994;8107-8111.
85. Fedele M., Berlingieri M.T., Scala S., Chiariotti L., Viglietto G., Rippel V., Bullerdiek J., Santoro M., Fusco A. Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts. Oncogene. 17:1998;413-418.
86. Geurts J.M., Schoenmakers E.F., Van de Ven W.J. Molecular characterization of a complex chromosomal rearrangement in a pleomorphic salivary gland adenoma involving the 3′-UTR of HMGIC. Cancer Genet Cytogenet. 95:1997;198-205.
87. Mitchell P.J., Tjian R. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science. 245:1989;371-378.
88. Sait S.N.J., Dal Cin P., Sandberg A.A., Leong S., Karakousis C., Rao U., Harris K. Involvement of 6p in benign lipomas: a new cytogenetic entity? Cancer Genet Cytogenet. 37:1989;281-283.
89. Kazmierczak B., Pohnke Y., Bullerdiek J. Fusion transcripts between the HMGIC gene and RTVL-H-related sequences in mesenchymal tumors without cytogenetic aberrations. Genomics. 38:1996;223-226.
90. Rogalla P., Blank C., Helbig R., Wosniok W., Bullerdiek J. Significant correlation between the breakpoints of rare clonal aberrations in benign solid tumors and the assignment of HMGIY retropseudogenes. Cancer Genet Cytogenet. 130:2001;51-56.
91. Bussemakers M.J.G., van de Ven W.J.M., Debruyne F.M.J., Schalken J.A. Identification of high mobility group protein I(Y) as potential progression marker for prostate cancer by differential hybridization analysis. Cancer Res. 51:1991;606-611.
92. Broberg K., Zhang M., Strombeck B., Isaksson M., Nilsson M., Mertens F., Mandahl N., Panagopoulos I. Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15. Int J Oncol. 21:2002;321-326.
93. Wood L.J., Maher J.F., Bunton T.E., Resar L.M.S. The oncogenic properties of the HMG-I gene family. Cancer Res. 60:2000;4256-4261.
94. Wood L.J., Mukherjee M., Dolde C.E., Xu Y., Maher J.F., Bunton T.E., Williams J.B., Resar L.M.S. HIG-I/Y: a new c-Myc target gene and potential oncogene. Mol Cell Biol. 20:2000;5490-5502.
95. Ayoubi T.A.Y., Van de Ven W.J.M. Regulation of gene expression by alternative promoters. FASEB J. 10:1996;453-460.
96. Sachs A.B. Messenger RNA degradation in eukaryotes. Cell. 74:1993;413-421.
97. Freyd G., Kim S.K., Horvitz H.R. Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11. Nature. 344:1990;876-879.
98. Sanchez-García I., Rabbitts T.H. The LIM domain: a new structural motif found in zinc-finger-like proteins. Trends Genet. 10:1994;315-320.
99. Dawid I.B., Toyama R., Taira M. LIM domain proteins. C R Acad Sci III. 318:1995;295-306.
100. Taira M., Evrard J.-L., Steinmetz A., Dawid I.B. Classification of LIM domains. Trends Genet. 11:1995;431-432.
101. Schmeichel K.L., Beckerle M.C. The LIM domain is a modular protein-binding interface. Cell. 79:1994;211-219.
102. Sadler I., Crawford A.W., Michelsen J.W., Beckerle M.C. Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol. 119:1992;1573-1587.
103. Petit M.M.R., Fradelizi J., Golsteyn R.M., Ayoubi T.A.Y., Menichi B., Louvard D., Van de Ven W.J.M., Friederich E. LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity. Mol Biol Cell. 11:2000;117-129.
104. Lemke I., Rogalla P., Bullerdiek J. Large deletion of part of the HMGIC locus accompanying a t(3;12)(q27∼q28;q14∼q15) in a lipoma. Cancer Genet Cytogenet. 129:2001;161-164.
105. Rogalla P., Lemke I., Bullerdiek J. Absence of the HMGIC-LHFP fusion in pulmonary chondroid hamartomas with aberrations involving chromosomal regions 12q13-15 and 13q12-14. Cancer Genet Cytogenet. 133:2002;90-93.
106. Van de Ven W.J.M., Schoenmakers E.F.P.M., Wanschura S., Kazmierczak B., Kools P.F.J., Geurts J.M.W., Bartnitzke S., Van den Berghe H., Bullerdiek J. Molecular characterization of MAR, a multiple aberration region on human chromosome segment 12q13-q15 implicated in various solid tumors. Genes Chromosomes Cancer. 12:1995;296-303.
107. Turc-Carel C., Pedeutour F., Durieux E. Characteristic chromosome abnormalities and karyotype profiles in soft tissue tumors. Harms D., Schmidt D. Soft tissue tumors. Current Topics in Pathology. 1995;73-94 Springer-Verlag, Berlin/Heidelberg.
108. Turc-Carel C., Dal Cin P., Boghosian L., Leong S.P., Sandberg A.A. Breakpoints in benign lipoma may be at 12q13 or 12q14. Cancer Genet Cytogenet. 36:1988;131-135.
109. Merscher S., Marondel I., Pedeutour F., Gaudray P., Kucherlapati R., Turc-Carel C. Identification of new translocation breakpoints at 12q13 in lipomas. Genomics. 46:1997;70-77.
110. Pedeutour F., Merscher S., Durieux E., Montgomery K., Krauter K., Clevy J.P., Barcelo G., Kucherlapati R., Gaudray P., Turc-Carel C. Mapping of the 12q12-q22 region with respect to tumor translocation breakpoints. Genomics. 22:1994;512-518.
111. Raynaud S.D., Bekri S., Leroux D., Grosgeorge J., Klein B., Battard C., Gaudray P., Simon M.P. Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies. Genes Chromosomes Cancer. 8:1993;80-87.
112. Manfioletti G., Giancotti V., Bandiera A., Buratti E., Sautiere P., Cary P., Crane-Robinson C., Coles B., Goodwin G.H. cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes. Nucleic Acids Res. 19:1991;6793-6797.
113. Bridge J.A., DeBoer J., Walker C.W., Neff J.R. Translocation t(3;12)(q28;q14) in parosteal lipoma. Genes Chromosomes Cancer. 12:1995;70-72.
114. Kindblom LG, Meis-Kindblom JM, Mandahl N. Chondroid lipoma. In: Fletcher CDM, Unni KK, Mertens F, editors. Pathology and genetics of tumours of soft tissue and bone. World Health Organization Classification of Tumours.
115. Kindblom L.G., Meis-Kindblom J.M. Chondroid lipoma: an ultrastructural and immunohistochemical analysis with further observations regarding its differentiation. Hum Pathol. 26:1995;706-715.
116. Meis J.M., Enzinger F.M. Chondroid lipoma: a unique tumor simulating liposarcoma and myxoid chondrosarcoma. Am J Surg Pathol. 17:1993;1103-1112.
117. Logan P.M., Janzen D.L., O'Connell J.X., Munk P.L., Connell D.G. Chondroid lipoma: MRI appearances with clinical and histologic correlation. Skeletal Radiol. 25:1996;592-595.
118. Yang Y.J., Damron T.A., Ambrose J.L. Diagnosis of chondroid lipoma by fine-needle aspiration biopsy. Arch Pathol Lab Med. 125:2001;1224-1226.
119. Gisselsson D., Domanski H.A., Höglund M., Carlén B., Mertens F., Willén H., Mandahl N. Unique cytologic features and chromosome aberrations in chondroid lipoma: a case report based on fine-needle aspiration cytology, histopathology, electron microscopy, chromosome banding, and molecular cytogenetics. Am J Surg Pathol. 23:1999;1300-1304.
120. Thomson T.A., Horsman D., Bainbridge T.C. Cytogenetic and cytologic features of chondroid lipoma of soft tissue. Mod Pathol. 12:1999;88-91.
121. Micci F., Teixeira M.R., Dietrich C.U., Saeter G., Bjerkehagen B., Heim S. Combined RxFISH/G-banding allows refined karyotyping of solid tumors. Hum Genet. 104:1999;370-375.
122. Thomson T.A., Bainbridge T.C., Horsman D. Unique cytologic and chromosome aberrations in chondroid lipoma. Am J Surg Pathol. 24:2000;1035.
123. Dal Cin P., Van Damme B., Hoogmartens M., Van den Berghe H. Chromosome changes in a case of hibernoma. Genes Chromosomes Cancer. 5:1992;178-180.
124. Meloni A.M., Spanier S.S., Bush C.H., Stone J.F., Sandberg A.A. Involvement of 10q22 and 11q13 in hibernoma. Cancer Genet Cytogenet. 72:1994;59-64.
125. Dixon A.Y., McGregor D.H., Lee S.H. Angiolipomas: an ultrastructural and clinicopathological study. Hum Pathol. 12:1981;739-747.
126. Sciot R., Mandahl N. Angiolipoma. Fletcher C.D.M., Unni K.K., Mertens F. Pathology and genetics of tumours of soft tissue and bone. World Health Organization Classification of Tumours. 2002;28 IARC Press, Lyon.
127. Howard W.R., Helwig E.B. Angiolipoma. Arch Dermatol. 82:1960;924-931.
128. Lee S.P., Nicholson G.I., Hitchcock G. Familial abdominal chemodectomas with associated cutaneous angiolipomas. Pathology. 9:1977;173-177.
129. Heymann W.R., Fiorillo A., Simons J. Eruptive familial angiolipomas occurring during pregnancy. Cutis. 42:1988;525-526.
130. Kanter W.R., Wolfort F.G. Multiple familial angiolipomatosis: treatment of liposuction. Ann Plast Surg. 20:1988;277-279.
131. Bordet R., Ghawche F., Destee A. Epidural angiolipoma and multiple familial lipomatosis. [in French] Rev Neurol (Paris). 147:1991;740-742.
132. Cina S.J., Radentz S.S., Smialek J.E. A case of familial angiolipomatosis with Lisch nodules. Arch Pathol Lab Med. 123:1999;946-948.
133. Turgut M. Spinal angiolipomas: report of a case and review of the cases published since the discovery of the tumour in 1890. Br J Neurosurg. 13:1999;30-40.
134. Hamakawa H., Hino H., Sumida T., Tanioka H. Infiltrating angiolipoma of the cheek: a case report and a review of the literature. J Oral Maxillofac Surg. 58:2000;674-677.
135. Sciot R., Åkerman M., Dal Cin P., De Wever I., Fletcher C.D.M., Mandahl N., Mertens F., Mitelman F., Rosai J., Rydholm A., Tallini G., Van den Berghe H., Vanni R., Willén H. Cytogenetic analysis of subcutaneous angiolipoma: further evidence supporting its difference from ordinary pure lipomas: a report of the CHAMP study group. Am J Surg Pathol. 21:1997;441-444.
136. Miettinen M.M., Mandahl N. Spindle cell lipoma/pleomorphic lipoma. Fletcher C.D.M., Unni K.K., Mertens F. Pathology and genetics of tumours of soft tissue and bone. World Health Organization Classification of Tumours. 2002;31-32 IARC Press, Lyon.
137. Dal Cin P., Sciot R., Polito P., Stas M., De Wever I., Cornelis A., Van den Berghe H. Lesions of 13q may occur independently of deletion of 16q in spindle cell/pleomorphic lipomas. Histopathology. 31:1997;222-225.
138. Sciot R., Mandahl N. Lipoblastoma/lipoblastomatosis. Fletcher C.D.M., Unni K.K., Mertens F. Pathology and genetics of tumours of soft tissue and bone. World Health Organization Classification of Tumours. 2002;26-27 IARC Press, Lyon.
139. Coffin C.M. Lipoblastoma: an embryonal tumor of soft tissue related to organogenesis. Semin Diagn Pathol. 11:1994;98-103.
140. Vellios F., Baez J., Shumacker H.B. Lipoblastomatosis: a tumor of fetal fat different from hibernoma. Report of a case, with observations on the embryogenesis of human adipose tissue. Am J Pathol. 34:1958;1149-1159.
141. Chung E.B., Enzinger F.M. Benign liopblastomatosis: an analysis of 35 cases. Cancer. 32:1973;482-492.
142. Mentzel T., Calonje E., Fletcher C.D. Lipoblastoma and lipoblastomatosis: a clinicopathological study of 14 cases. Histopathology. 23:1993;527-533.
143. Collins M.H., Chatten J. Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 25 tumors. Am J Surg Pathol. 21:1997;1131-1137.
144. Mahour G.H., Bryan B.J., Isaacs H. Lipoblastomatosis: a report of six cases. Surgery. 104:1988;577-579.
145. Krempl G.A., McGuff H.S., Pulitzer D.R., Otto R.A. Lipoblastoma in the parotid gland of an infant. Otolaryngol Head Neck Surg. 117:1997;S234-S237.
146. Rasmussen I.S., Kirkegaard J., Kaasbol M. Intermittent airway obstruction in a child caused by a cervical lipoblastoma. Acta Anaesthesiol Scand. 41:1997;945-946.
147. Tsai H., Whitney K., Kogan S.J. Perineal lipoblastoma in a neonate. J Urol. 158:1997;2272-2273.
148. Demircan M., Sayan A., Erikci V., Bayol U., Arikan A. An hourglass type of intrathoracic lipoblastoma manifested by edema in right upper limb. J Pak Med Assoc. 48:1998;108-110.
149. Irgau I., McNicholas K.W. Mediastinal lipoblastoma involving the left innominate vein and the left phrenic nerve. J Pediatr Surg. 33:1998;1540-1542.
150. Miller G.G., Yanchar N.L., Magee J.F., Blair G.K. Lipoblastoma and liposarcoma in children: an analysis of 9 cases and review of the literature. Can J Surg. 41:1998;455-458.
151. Posey Y., Valdivia E., Persons D.L., Ally S., Smith D.L., Pantazis C.G., Smith S.D. Lipoblastoma presenting as a mesenteric mass in an infant. J Pediatr Hematol Oncol. 20:1998;580-582.
152. Turner D.T., Shah S.M., Jones R. Intrascrotal lipoblastoma. Br J Urol. 81:1998;166-167.
153. Ilhan H., Tokar B., Isiksoy S., Koku N., Passaoglu O. Giant mesenteric lipoma. J Pediatr Surg. 34:1999;639-640.
154. Kwak J.Y., Ha D.H., Kim Y.A., Shim J.Y. Lipoblastoma of the parietal pleura in a 7-month-old infant. J Comput Assist Tomogr. 23:1999;952-954.
155. Pollono D.G., Tomarchio S., Drut R., Zaritzky M., Otero L., Vazquez A.J., Ripoll M.C. Retroperitoneal and deep-seated lipoblastoma: diagnosis by CT scan and fine-needle aspiration biopsy. Diagn Cytopathol. 20:1999;295-297.
156. Broeders A., Smet M.H., Breysem L., Marchal G. Lipoblastoma: a rare mediastinal tumour in a child. Pediatr Radiol. 30:2000;580.
157. Park C.H., Kim K.I., Lim Y.T., Chung S.W., Lee C.H. Ruptured giant intrathoracic lipoblastoma in a 4-month-old infant. CT and MR findings. Pediatr Radiol. 30:2000;38-40.
158. Dishop M.K., O'Connor W.N., Abraham S., Cottrill C.M. Primary cardiac lipoblastoma. Pediatr Dev Pathol. 4:2001;276-280.
159. Mathew J., Sen S., Chandi S.M., Kumar N.K., Zachariah N., Chacko J., Thomas G. Pulmonary lipoblastoma: a case report. Pediatr Surg Int. 17:2001;543-544.
160. Bolen J.W., Thorning D. Benign lipoblastoma and myxoid liposarcoma: a comparative light- and electron-microscopic study. Am J Surg Pathol. 4:1980;163-174.
161. Fetsch J.F., Miettinen M., Laskin W.B., Michal M., Enzinger F.M. A clinicopathologic study of 45 pediatric soft tissue tumors with an admixture of adipose tissue and fibroblastic elements, and a proposal for classification as lipofibromatosis. Am J Surg Pathol. 24:2000;1491-1500.
162. Miller G.G., Yanchar N.L., Magee J.F., Blair G.K. Tumor karyotype differentiates lipoblastoma from liposarcoma. J Pediatr Surg. 32:1997;1771-1772.
163. Chen Z., Coffin C.M., Scott S., Meloni-Ehrig A., Shepard R., Issa B., Forsyth D.R., Sandberg A.A., Brothman A.R., Lowichik A. Evidence by spectral karyotyping that 8q11.2 is nonrandomly involved in lipoblastoma. J Mol Diagn. 2:2000;73-77.
164. Hibbard M.K., Kozakewich H.P., Dal Cin P., Sciot R., Tan X., Xiao S., Fletcher J.A. PLAG1 fusion oncogenes in lipoblastoma. Cancer Res. 60:2000;4869-4872.
165. Fletcher J.A., Kozakewich H.P., Schoenberg M.L., Morton C.C. Cytogenetic findings in pediatric adipose tumors: consistent rearrangement of chromosome 8 in lipoblastoma. Genes Chromosomes Cancer. 6:1993;24-29.
166. Kas K., Voz M.L., Roijer E., Astrom A.K., Meyen E., Stenman G., Van de Ven W.J. Promoter swapping between the genes for a novel zinc finger protein and β-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat Genet. 15:1997;170-174.
167. Gisselsson D., Hibbard M.K., Dal Cin P., Sciot R., Hsi B.-L., Kozakewich H.P., Fletcher J.A. PLAG1 alterations in lipoblastoma: involvement in varied mesenchymal cell types and evidence for alternative oncogenic mechanisms. Am J Pathol. 159:2001;955-962.
168. Åström A.-K., D'Amore E.S.G., Sainati L., Panarello C., Morerio C., Mark J., Stenman G. Evidence of involvement of the PLAG1 gene in lipoblastomas. Int J Oncol. 16:2000;1107-1110.
169. O'Donnell K.A., Caty M.G., Allen J.E., Fisher J.E. Lipoblastoma: better termed infantile lipoma? Pediatr Surg Int. 16:2000;458-461.
170. Gaffney E.F., Hargreaves H.K., Semple E., Vellios F. Hibernoma: distinctive light and electron microscopic features and relationship to brown adipose tissue. Hum Pathol. 14:1983;677-687.
171. Kransdorf M.J., Moser R.J. Jr., Meis J.M., Meyer C.A. Fat-containing soft-tissue masses of the extremities. Radiographics. 11:1991;81-106.
172. Lemos M.M., Kindblom L.-G., Meis-Kindblom J.M., Remotti F., Ryd W., Gunterberg B., Willén H. Fine-needle aspiration characteristics of hibernoma. Cancer. 93:2001;206-210.
173. Miettinen M.M., Fanburg-Smith J.C., Mandahl N. Hibernoma. Fletcher C.D.M., Unni K.K., Mertens F. Pathology and genetics of tumours of soft tissue and bone. World Health Organization Classification of Tumours. 2002;33-35 IARC Press, Lyon.
174. Furlong M.A., Fanburg-Smith J.C., Miettinen M. The morphologic spectrum of hibernoma: a clinicopathologic study of 170 cases. Am J Surg Pathol. 25:2001;809-814.
175. Ahn C., Harvey J.C. Mediastinal hibernoma, a rare tumor. Ann Thorac Surg. 50:1990;828-830.
176. Gisselsson D., Höglund M., Mertens F., Dal Cin P., Mandahl N. Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics. Am J Surg Pathol. 155:1999;61-66.
177. Haldmeier G., Hoffmann K. Melatonin stimulates the growth of brown adipose tissue. Nature. 247:1974;224-225.
178. Zennaro M.-C., Le Menuet D., Viengchareun S., Walker F., Ricquier D., Lombés M. Hibernoma development in transgenic mice identifies brown adipose tissue as a novel target of aldosterone action. J Clin Invest. 101:1998;1254-1260.
179. Allegra S.R., Gmuer C., O'Leary G.P. Endocrine activity in a large hibernoma. Hum Pathol. 14:1983;1044-1052.
180. Darling T.N., Skarulis M.C., Steinberg S.M., Marx S.J., Spiegel A.M., Turner M. Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1. Arch Dermatol. 133:1997;853-857.
181. Miller J.A., Norton J.A. Multiple endocrine neoplasia. Pollock R.E. Surgical oncology. 1997;213-225 Kluwer Academic Publishers, Dordrecht.
182. Maire G., Forus A., Foa C., Bjerkehagen B., Mainguene C., Kresse S.H., Myklebost O., Pedeutour F. 11q13 alterations in two cases of hibernoma: large heterozygous deletions and rearrangement breakpoints near GARP in 11q13.5. Genes Chromosomes Cancer. 37:2003;389-395.
183. Pea M., Bonetti F., Zamboni G., Mortignoni G., Riva M., Colombari R., Mombello A., Bonzanini M., Scarpa A., Ghimenton C. Melanocytic-marker-HMB-45 is regularly expressed in angiomyolipoma of the kidney. Pathology. 23:1991;185-188.
184. Sturtz C.L., Dabbs D.J. Angiomyolipomas: the nature and expression of the HMB45 antigen. Mod Pathol. 7:1994;842-845.
185. Chau K.-Y., Patel U.A., Lee K.-L.D., Lam H.-Y.P., Crane-Robinson C. The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element. Nucleic Acids Res. 23:1995;4262-4266.
186. Busam K.J., Iversen K., Coplan K.A., Old L.J., Stockert E., Chen Y.-T., McGregor D., Jungbluth A. Immunoreactivity for A103, an antibody to Melan-A (Mart-1), in adrenocortical and other steroid tumors. Am J Surg Pathol. 22:1998;57-63.
187. Fetsch P.A., Fetsch J.F., Marincola F.M., Marincola F.M., Travis W., Batts K.P., Abati A. Comparison of melanoma antigen recognized by T cells (MART-1) to HMB-45: additional evidence to support a common lineage for angiomyolipoma, lymphangiomyomatosis, and clear cell sugar tumor. Mod Pathol. 11:1998;699-703.
188. Stone C.H., Lee M.W., Amin M.B., Yaziji H., Gown A.M., Ro J.Y., Têtu B., Paraf F., Zarbo R.J. Renal angiomyolipoma: further immunophenotypic characterization of an expanding morphologic spectrum. Arch Pathol Lab Med. 125:2001;751-758.
189. Miettinen M. Benign fatty tumors. Miettinen M. Diagnostic soft tissue pathology. 2003;207-225 Churchill Livingstone, New York.
190. Jungbluth A.A., Busam K.J., Gerald W.L., Stockert E., Coplan K.A., Iversen K., MacGregor D.P., Old L.J., Chen Y.T. A103, an anti-Melan-A monoclonal antibody for the detection of malignant melanoma in paraffin embedded tissues. Am J Surg Pathol. 22:1998;595-602.
191. Jungbluth A.A., Iversen K., Coplan K., Williamson B., Chen Y.T., Stockert E., Old L.J., Busam K.J. Expression of melanocyte-associated markers gp-100 and Melan-A/MART-1 in angiomyolipomas: an immunohistochemical and rt-PCR analysis. Virchows Arch. 434:1999;429-435.
192. Jungbluth A.A., King R., Fisher D.E., Iversen K., Coplan K., Kolb D., Williamson B., Chen Y.-T., Stockert E., Old L.J., Busam K.J. Immunohistochemical and reverse transcription-polymerase chain reaction expression analysis of tyrosinase and microphthalmia-associated transcription factor in angiomyolipomas. Appl Immunohistochem Mol Morphol. 9:2001;29-34.
193. Desai S., Hejmadi R., Krishnamurthy S., Chinoy R.F. Renal angiomyolipoma: a clinicopathologic, immunohistochemical, and follow-up study of 46 cases. Am J Surg Pathol. 25:2001;972-973.
194. Panizo-Santos A., Sola I., de Alava E., Lozano M.D., Idoate M.A., Pardo F.J. Angiomyolipoma and PEComa are immunoreactive for MyoD1 in cell cytoplasmic staining pattern. Appl Immunohistochem Mol Morphol. 11:2003;156-160.
195. Makhlouf H.R., Remotti H.E., Ishak K.G. Expression of KIT (CD117) in angiomyolipoma. Am J Surg Pathol. 26:2002;493-497.
196. Tong Y.C., Chieng P.U., Tsai T.C., Lin S.N. Renal angiomyolipoma: report of 24 cases. Br J Urol. 66:1990;585-589.
197. L'Hostis H., Deminiere C., Ferriere J.-M., Coindre J.-M. Renal angiomyolipoma: a clinicopathologic, immunohistochemical, and follow-up study of 46 cases. Am J Surg Pathol. 23:1999;1011-1020.
198. De Jong B., Castedo S.M.M.J., Oosterhuis J.W., Dam A. Trisomy 7 in a case of angiomyolipoma. Cancer Genet Cytogenet. 34:1988;219-222.
199. Debiec-Rychter M., Saryusz-Wolska H., Salagierski M. Cytogenetic analysis of renal angiomyolipoma. Genes Chromosomes Cancer. 4:1992;101-103.
200. Wullich B., Henn W., Siemer S., Seitz G., Freiler A., Zang K.-D. Clonal chromosome aberrations in three of five sporadic angiomyolipomas of the kidney. Cancer Genet Cytogenet. 96:1997;42-45.
201. Dal Cin P., Sciot R., Van Poppel H., Baert L., Van Damme B., Van den Berghe H. Chromosome analysis in angiomyolipoma. Cancer Genet Cytogenet. 99:1997;132-134.
202. Dal Cin P., Gutierrez N.C., Hernandez J.M., Van den Berghe H. Molecular cytogenetics of angiomyolipomas. Cancer Genet Cytogenet. 106:1998;182.
203. Stöckle M., Störkel S., Mielke R., Steinbach F., El-Damanhoury H., Voges G., Hohenfellner R. Characterization of conservatively resected renal tumors using automated image analysis DNA cytometry. Cancer. 68:1991;1926-1931.
204. Abdulla M., Bui H.X., del Rosario A.D., Wolf B.C., Ross J.S. Renal angiomyolipoma: DNA content and immunohistochemical study of classic and multicentric variants. Arch Pathol Lab Med. 118:1994;735-739.
205. Kattar M.M., Grignon D.J., Eble J.N., Hurley P.M., Lewis P.E., Sakr W.E., Cher M.L. Chromosomal analysis of renal angiomyolipoma by comparative genomic hybridization: evidence for clonal origin. Hum Pathol. 30:1999;295-299.
206. Green A.J., Sepp T., Yates J.R.W. Clonality of tuberous sclerosis hamartomas shown by non-random X-chromosome inactivation. Hum Genet. 97:1996;240-243.
207. Paradis V., Laurendeau I., Vieillefond A., Blanchet P., Eschwege P., Benoît G., Vidaud M., Jardin A., Bedosa P. Clonal analysis of renal sporadic angiomyolipomas. Hum Pathol. 29:1998;1063-1067.
208. Saxena A., Alport E.C., Custead S., Skinnider L.F. Molecular analysis of clonality of sporadic angiomyolipoma. J Pathol. 189:1999;79-84.
209. Pea M., Martignoni G., Zamboni G., Bonetti F. Perivascular epithelioid cell. Am J Surg Pathol. 20:1996;1149-1153.
210. Mai K.T., Yazdi H.M., Perkins D.G., Thijssen A. Fine needle aspiration biopsy of epithelioid angiomyolipoma: a case report. Acta Cytol. 45:2001;233-236.
211. Cheng L., Gu J., Eble J.N., Bostwick D.G., Younger C., MacLennan G.T., Abdul-Karim F.W., Geary W.A., Koch M.O., Zhang S., Ulbright T.M. Molecular genetic evidence for different clonal origin of components of human renal angiomyolipomas. Am J Surg Pathol. 25:2001;1231-1236.
212. Gomez M.R. Phenotypes of the tuberous sclerosis complex with a revision of diagnostic criteria. Ann N Y Acad Sci. 615:1991;1-7.
213. Neumann H., Bruggen V., Wetterauer U., Kruse R., Blankenhorn V., Riegler P. Angiomyolipomas of the kidney and tuberous sclerosis. Am J Hum Genet. 51:1992;A104.
214. Green A.J., Johnson P.H., Yates J.R. The tuberous sclerosis gene on chromosome 9q34 acts as a growth suppressor. Hum Mol Genet. 3:1994;1833-1834.
215. Green A.J., Smith M., Yates J.R.W. Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nat Genet. 6:1994;193-196.
216. Povey S, Burley MW, Attwood J, Benham F, Hunt D, Jeremiah SJ, Franklin D, Gillett G, Malas S, Robson EB, Tippett P, Edwards JH, Kwiatkowski DJ, Super M, Mueller R, Fryer A, Clarke A, Webb D, Osborne J. Two loci for tuberous sclerosis: one on 9q34 and one on 16p13. 1994;58:107-27.
217. European Chromosome 16 Tuberous Sclerosis Consortium. Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell. 75:1993;1305-1315.
218. Henske E.P., Neumann H.P.H., Scheithauer B.W., Herbst E.W., Short M.P., Kwiatkowski D.J. Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas. Genes Chromosomes Cancer. 13:1995;295-298.
219. Carbonara C., Longa L., Grosso E., Mazzucco G., Borrone C., Garrè M.L., Brisigotti M., Filippi G., Scabar A., Giannotti A., Falzoni P., Monga G., Garini G., Gabrielli M., Riegler P., Danesino C., Ruggieri M., Magro G., Migone N. Apparent preferential loss of heterozygosity at TSC2 over TSC1 chromosomal region in tuberous sclerosis hamartomas. Genes Chromosomes Cancer. 15:1996;18-25.
220. Martignoni G., Pea M., Rigaud G., Manfrin E., Colato C., Zamboni G., Scarpa A., Tardanico R., Roncalli M., Bonetti F. Renal angiomyolipoma with epithelioid sarcomatous transformation and metastases: demonstration of the same genetic defects in the primary and metastatic lesions. Am J Surg Pathol. 24:2000;889-894.
221. Smolarek T.A., Wessner L.L., McCormack F.X., Mylet J.C., Menon A.G., Henske E.P. Evidence that lymphangiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis. Am J Hum Genet. 62:1998;810-815.
222. Plank T.L., Logginidou H., Klein-Szanto A., Henske E.P. The expression of hamartin, the product of the TSC1 gene, in normal human tissues and in TSC1- and TSC2-linked angiomyolipomas. Mod Pathol. 12:1999;539-545.
223. Kawaguchi K., Oda Y., Nakanishi K., Saito T., Tamiya S., Nakahara K., Matsuoka H., Tsuneyoshi M. Malignant transformation of renal angiomyolipoma: a case report. Am J Surg Pathol. 26:2002;523-529.
224. Mai K.T., Hossein M., Collins J.P. Vascular myxolipoma (angiomyxolipoma) of the spermatic cord. Am J Surg Pathol. 20:1996;1145-1148.
225. Zamecnik M. Vascular myxolipoma (angiomyxolipoma) of subcutaneous tissue. Histopathology. 34:1999;180-181.
226. Sciot R., Debiec-Rychter M., De Wever I., Hagemeijer A. Angiomyxolipoma shares cytogenetic changes with lipoma, spindle cell/pleomorphic lipoma and myxoma. Virchows Arch. 438:2001;66-69.
227. Spalding J.E. Adenolipoma and lipoma of the breast. Guys Hosp Rep. 94:1945;80-84.
228. Fechner R.E. Fibroadenoma and related lesions. Page D.L., Anderson T.J. Diagnostic histopathology of the breast. 1st edition:1987;72-85 Churchill Livingstone, Edinburgh.
229. Gadd M.A., Souba W.W. Evaluation and treatment of benign breast disorders. Bland K.I., Copeland E.M. III. The breast: comprehensive management of benign and malignant diseases. 2nd edition:1998;W.B. Saunders, Philadelphia.
230. Dietrich C.U., Pandis N., Andersen J.A., Heim S. Chromosome abnormalities in adenolipomas of the breast: karyotypic evidence that the mesenchymal component constitutes the neoplastic parenchyma. Cancer Genet Cytogenet. 72:1994;146-150.
231. Tayyeb M.T., Neff J.R., Bridge J.A. A case report of fibrolipoma with t(12;16)(q13;q24). Cancer Genet Cytogenet. 67:1993;145-146.
232. Morelli A., Falchetti A., Weinstein L., Fabiani S., Tomassetti P., Enzi G., Carraro R., Bordi C., Tonelli F., Brandi M.L. RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis and multiple endocrine neoplasia type 1-associated lipomas. Biochem Biophys Res Commun. 207:1995;363-368.
233. Sandberg A.A. The chromosomes in human cancer and leukemia. 2nd edition:1990;Elsevier, New York.
234. Schoenmakers E.F.P.M., Van de Ven W.J.M. From chromosome aberrations to the high mobility group protein gene family: evidence for a common genetic denominator in benign solid tumor development. Cancer Genet Cytogenet. 95:1997;51-58.
235. Peulve P., Thomine E., Hemet J. Cytogenetic analysis of a rare case of pediatric myxolipoma. Ann Genet. 33:1990;222-224.
236. Åman P., Ron D., Mandahl N., Fioretos T., Heim S., Arheden K., Willén H., Rydholm A., Mitelman F. Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). Genes Chromosomes Cancer. 5:1992;278-285.
237. Holme E., Larsson N.G., Oldfors A., Tulinius M., Sahlin P., Stenman G. Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys)A→G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am J Hum Genet. 52:1993;551-556.
238. Mrózek K., Karakousis C.P., Bloomfield C.D. Chromosome 12 breakpoints are cytogenetically different in benign and malignant lipogenic tumors: localization of breakpoints in lipoma to 12q15 and in myxoid liposarcoma to 12q13.3. Cancer Res. 53:1993;1670-1675.
239. Örndal C., Rydholm A., Willén H., Mitelman F., Mandahl N. Cytogenetic intratumor heterogeneity in soft tissue tumors. Cancer Genet Cytogenet. 78:1994;127-137.
240. Mandahl N., Åkerman M., Åman P., Dal Cin P., De Wever I., Fletcher C.D.M., Mertens F., Mitelman F., Rosai J., Rydholm A., Sciot R., Tallini G., Van den Berghe H., Van de Ven W., Vanni R., Willén H. Duplication of chromosome segment 12q15-24 is associated with atypical lipomatous tumors: a report of the CHAMP Collaborative Study Group. Int J Cancer. 67:1996;632-635.
241. Wanschura S., Kazmierczak B., Bartnitzke S., Bullerdiek J., Schloot W. Molecular cytogenetic assignment of the chromosome 12 breakpoints in many benign tumors to 12q15 affecting the HMGIC gene. Genes Chromosomes Cancer. 15:1996;195-196.
242. Dal Cin P., Van den Berghe H., Sciot R., De Wever I. Deletion of the long arm of chromosome 7 in lipoma. Cancer Genet Cytogenet. 96:1997;85-86.
243. Bridge J.A., Roberts C.A., Degenhardt J., Walker C., Lackner R., Linder J. Low-level chromosome 12 amplification in a primary lipoma of the lung. Arch Pathol Lab Med. 122:1998;187-190.
244. Dong S.-Y., Morgan R., Stone J., Meloni-Ehrig A.M., Chen Z., Malawer M.M., Sandberg A.A. Translocation (12;14) in lipoma: a case report and review of the literature. Cancer Genet Cytogenet. 103:1998;59-61.
245. Gisselsson D., Höglund M., Mertens F., Mitelman F., Mandahl N. Chromosomal organization of amplified chromosome 12 sequences in mesenchymal tumors detected by fluorescence in situ hybridization. Genes Chromosomes Cancer. 23:1998;203-212.
246. Kazmierczak B., Dal Cin P., Wanschura S., Bartnitzke S., Van den Berghe H., Bullerdiek J. Cloning and molecular characterization of part of a new gene fused to HMGIC in mesenchymal tumors. Am J Pathol. 152:1998;431-435.
247. Kazmierczak B., Dal Cin P., Wanschura S., Borrmann L., Fusco A., Van den Berghe H., Bullerdiek J. HMGIY is the target of 6p21.3 rearrangements in various benign mesenchymal tumors. Genes Chromosomes Cancer. 23:1998;279-285.
248. Rieder H., Lohmann D., Poensgen B., Fritz B., Aslan M., Drohm D., Strombach Angersbach F.J., Rehder H. Loss of heterozygosity of the retinoblastoma (RB1) gene in lipomas from a retinoblastoma patient. J Natl Cancer Inst. 90:1998;324-326.
249. Kazmierczak B., Dal Cin P., Meyer-Bolte K., Van den Berghe H., Bullerdiek J. HMG1 is not rearranged by 13q12 aberrations in lipomas. Genes Chromosomes Cancer. 24:1999;290-292.
250. Vaughan C.J., Weremowicz S., Goldstein M.M., Casey M., Hart M., Hahn R.T., Devereux R.B., Girardi L., Schoen F.J., Fletcher J.A., Morton C.C., Basson C.T. A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis. Genes Chromosomes Cancer. 28:2000;133-137.
251. Domanski H.A., Carlén B., Jonsson K., Mertens F., Åkerman M. Distinct cytologic features of spindle cell lipoma: a cytologic-histologic study with clinical, radiologic, electron microscopic, and cytogenetic correlations. Cancer. 93:2001;381-389.
252. Dumollard J.-M., Ranchère-Vince D., Burel F., Coindre J.-M., Tallini G., Ligon A.H., Mayaud R., Turc-Carel C., Martin C., Mosnier J.-F., Pedeutour F. Spindle cell lipoma and 13q deletion: diagnostic utility of cytogenetic analysis. [in French] Ann Pathol. 21:2001;303-310.
253. Mrózek K., Karakousis C.P., Bloomfield C.D. Band 11q13 is nonrandomly rearranged in hibernomas. Genes Chromosomes Cancer. 9:1994;145-147.
254. Ohjimi Y., Iwasaki H., Kaneko Y., Ishiguro M., Ohgami A., Kikuchi M. A case of lipoblastoma with t(3;8)(q12;q11.2). Cancer Genet Cytogenet. 62:1992;103-105.
255. Dal Cin P., Sciot R., De Wever I., Van Damme B., Van den Berghe H. New discriminative chromosomal marker in adipose tissue tumors. The chromosome 8q11-q13 region in lipoblastoma. Cancer Genet Cytogenet. 78:1994;232-235.
256. Sawyer J.R., Parsons E.A., Crowson M.L., Smith S., Erickson S., Bell J.M. Potential diagnostic implications of breakpoints in the long arm of chromosome 8 in lipoblastoma. Cancer Genet Cytogenet. 76:1994;39-42.
257. Francois A., Bodenant C., Rives N., Bachy B., Mitrofanoff P., Mace B., Hemet J. Mesenteric lipoblastoma with changes in chromosome 8: use of cytogenetics in the diagnosis of adipocytic tumors in children. [in French] Ann Pathol. 17:1997;406-411.
258. Kanazawa C., Mitsui T., Shimizu Y., Saitoh E., Kawakami T., Shiihara T., Yokoyama S., Yamagiwa I., Hayasaka K. Chromosomal aberration in lipoblastoma: a case with 46,XX, ins(8;6)(q11.2;q13q27). Cancer Genet Cytogenet. 95:1997;163-165.
259. Panarello C., Rosanda C., Morerio C., Russo I., Dallorso S., Gambini C., Ricco A.S., Storlazzi T., Archidiacono N., Rocchi M. Lipoblastoma: a case with t(7;8)(q31;q13). Cancer Genet Cytogenet. 102:1998;12-14.
260. Morerio C., Panarello C., Russo I., Rosanda C., Gambini C., Rizzo A. A further case of chromosome 8q rearrangement in lipoblastoma. J Pediatr Hematol Oncol. 22:2000;484-485.
261. Batanian J.R., Brink D.S., Thorpe C.M., Haddad B.R. Case of lipoblastoma with two derivative chromosomes 8 containing homogeneously staining-like regions and review of the literature: lipoblastoma and chromosome 8. Cancer Genet Cytogenet. 125:2001;10-13.