Cloning and molecular characterization of part of a new gene fused to HMGIC in mesenchymal tumors

American Journal of Pathology

Volumn 152, Issue 2, 1998, Pages 431-435

  Kazmierczak, Bernd ^a   Dal Cin, Paola ^b   Wanschura, Sylke ^a   Bartnitzke, Sabine ^a   Van Den Berghe, Herman ^b   Bullerdiek, Jörn ^a  

^a UNIVERSITY OF BREMEN   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ARTICLE; CHROMOSOME 12; CYTOGENETICS; EXON; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; HAMARTOMA; HUMAN; HUMAN TISSUE; LIPOMA; MESENCHYME; MOLECULAR CLONING; PERICENTRIC CHROMOSOME INVERSION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERUS MYOMA;

AMINO ACID SEQUENCE; ARTIFICIAL GENE FUSION; BASE SEQUENCE; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN, PAIR 12; CLONING, MOLECULAR; HAMARTOMA; HIGH MOBILITY GROUP PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIPOMA; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; MYXOMA;

EID: 2642645427     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Heim S, Mandahl N, Kristoffersson U, Mitelman F, Rööser B, Rydholm A, Willen H: Reciprocal translocation t(3;12)(q27;q13) in lipoma. Cancer Genet Cytogenet 1986, 23:301-304
2. Turc-Carel C, Dal Cin P, Rao U, Karakousis C, Sandberg AA: Cytogenetic studies of adipose tissue tumors. I. A benign lipoma with reciprocal translocation t(3;12)(q28;q14). Cancer Genet Cytogenet 1986, 23:283-289
3. Mandahl N, Heim S, Arheden K, Rydholm A, Willen H, Mitelman F: Three major cytogenetic subgroups can be identified among chromosomally abnormal solitary lipomas. Hum Genet 1988, 79:203-208
4. Heim S, Nilbert M, Vanni R, Floderus U-M, Mandahl N, Liedgren S, Lecca U, Mitelman F: A specific translocation, t(12;14)(q14-q15; q23-q24), characterizes a subgroup of uterine leiomyomas. Cancer Genet Cytogenet 1988, 32:13-17
5. Turc-Carel C, Dal Cin P, Boghosian J, Terk-Zakarian J, Sandberg AA: Consistent breakpoints in region 14q22-q24 in uterine leiomyoma. Cancer Genet Cytogenet 1988, 32:25-31
6. Vanni R, Lecca U: Involvement of the long arm of chromosome 12 in chromosome rearrangement of uterine leiomyoma. Cancer Genet Cytogenet 1988, 32:33-34
7. Walter TA, Fan SX, Medchill MT, Berger CS, Decker HJH, Sandberg AA: Inv(12)(p11.2q13) in an endometrial polyp. Cancer Genet Cytogenet 1989, 41: 99-103
8. Vanni R, Dal Cin P, Marras S, Moerman Ph, Andria M, Valdes E, Deprest J, Van den Berghe H: Endometrial polyp: another benign tumor characterized by 12q13-15 changes. Cancer Genet Cytogenet 1993, 68:32-33
9. Bol S, Wanschura S, Thode B, Deichert U, Van de Ven WJM, Bartnitzke S, Bullerdiek J: An endometrial polyp with a rearrangement of HMGI-C underlying a complex cytogenetic rearrangement involving chromosomes 2 and 12. Cancer Genet Cytogenet 1996, 81:1-3
10. Johansson M, Heim S, Mandahl N, Johansson L, Hambraeus G, Mitelman F: t(3;6;14)(p21;p21;q24) as the sole clonal chromosome abnormality in a hamartoma of the lung. Cancer Genet Cytogenet 1992, 60:219-220
11. Fletcher AF, Longtine J, Wallace K, Mentzer SJ, Sugarbaker DJ: Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: evidence for a pathogenetic relationship with lipomas and leiomyomas. Genes Chromosomes & Cancer 1995, 12:220-223
12. Kazmierczak B, Wanschura S, Rosigkeit J, Meyer-Bolte K, Uschinsky K, Haupt R, Schoenmakers EFPM, Bartnitzke S, Van de Ven WJM, Bullerdiek J: Molecular characterization of 12q14-15 rearrangements in three pulmonary chondroid hamartomas. Cancer Res 1995, 55: 2497-2499
13. Mark J, Dahlenfors R, Ekedahl C, Stenman G: The mixed salivary gland tumor: a normally benign human neoplasm frequently showing specific chromosomal abnormalities. Cancer Genet Cytogenet 1980, 2:231-241
14. Bullerdiek J, Bartnitzke S, Weinberg M, Chilla R, Haubrich J, Schloot W: Rearrangements of chromosome 12q13-15 in pleomorphic adenomas of the human salivary gland (PSA). Cytogenet Cell Genet 1987, 45:187-190
15. Kazmierczak B, Wanschura S, Meyer-Bolte K, Schoenmakers E, Caselitz J, Meister P, Bartnitzke S, Van de Ven W, Bullerdiek J: Cytogenetic and molecular analysis of an aggressive angiomyxoma. Am J Pathol 1995, 147: 580-585
16. Schoenmakers EFPM, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJM: Recurrent rearrangements in the high mobility group protein gene HMGI-C, in benign mesenchymal tumours. Nature Genet 1995, 10:436-444
17. Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K: Disruption of the architectural factor HMGI-C: DNA binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 1995, 82:57-65
18. Kazmierczak B, Rosigkeit J, Wanschura S, Meyer-Bolte K, Van de Ven WJM, Kayser K, Krieghoff B, Kastendiek H, Bartnitzke S, Bullerdiek J: HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors. Oncogene 1996, 12:515-521
19. Wanschura S: Molekulargenetische Untersuchungen von Chromosom 12-Aberrationen in soliden Tumoren ed 1. Hamburg, Dr. Kovac, 1996
20. Petit NMR, Mols R, Schoenmakers EFPM, Mandahl N, Van de Ven WJM: LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 1996, 36:118-129
21. Kazmierczak B, Hennig Y, Wanschura S, Rogalla P, Bartnitzke S, Van de Ven W, Bullerdiek J: Description of a novel fusion transcript between HMGI-C, a gene encoding for a member of the high mobility group proteins, and the mitochondrial alcohol dehydrogenase gene. Cancer Res 1995, 55:6038-6039
22. Kievits T, Dauwerse JG, Wiegant J, Devilee P, Breuning MH, Cornelisse CJ, Van Ommen G-JB, Pearson PL: Rapid subchromosomal localization of cosmids by non radioactive in situ hybridization. Cytogenet Cell Genet 1990, 53:134-136
23. Krizman DB, Berget, SM: Efficient selection of 3′-terminal exons from vertebrate DNA. Nucleic Acid Res 1993, 22:5198-5202
24. Mitelman F: Catalog of Chromosome Aberrations in Cancer, ed 5. New York, Wiley-Liss, 1994
25. Williams AJ, Powell WL, Collins T, Morton CC: HMGI(Y) expression in human uterine leiomyomata. Am J Pathol 1997, 3:911-918
26. Xiao S, Lux ML, Reeves R, Hudson TJ, Fletcher JA: HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma. Am J Pathol 1997, 3:901-910
27. Geurts JM, Schoenmakers EF, Roijer E, Stenman G, Van de Ven WJ: Expression of reciprocal hybrid transcripts of HMGIC and FHIT in a pleomorphic adenoma of the parotid gland. Cancer Res 1997, 57: 13-17
28. Wlodarska I, Marynen P, La Starza R, Mecucci C, Van den Berghe H: The ETV6, CDKN1B and D12S178 loci are involved in a segment commonly deleted in various 12p aberrations in different hematologic malignancies. Cytogenet Cell Genet 1996, 72:229-235