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Volumn 274, Issue 1-2, 2004, Pages 1-33

Chitosan microspheres as a potential carrier for drugs

Author keywords

Chitosan; Microspheres

Indexed keywords

ACICLOVIR; ALGINIC ACID; ANTIBIOTIC AGENT; ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTITHROMBOCYTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARBOXYMETHYLCELLULOSE; CARRAGEENAN; CENTRAL NERVOUS SYSTEM AGENTS; CHITOSAN; CHLORPHENIRAMINE MALEATE; CORTICOSTEROID; DIURETIC AGENT; DOCUSATE SODIUM; DRUG CARRIER; ETIDRONIC ACID; GASTROINTESTINAL AGENT; MACROGOL; MELATONIN; MICROSPHERE; NANOPARTICLE; PAMIDRONIC ACID; PREDNISOLONE SODIUM PHOSPHATE; STEROID; TRANSFORMING GROWTH FACTOR BETA1; TRIPOLYPHOSPHATE; UNINDEXED DRUG; XANTHAN;

EID: 1842452953     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.12.026     Document Type: Review
Times cited : (1053)

References (205)
  • 1
    • 0028918769 scopus 로고
    • Chitosan microspheres of diclofenac sodium. II: In vitro and in vivo evaluation
    • Acikgoz M., Kas H.S., Hascelik Z., Milli U., Hincal A.A. Chitosan microspheres of diclofenac sodium. II: In vitro and in vivo evaluation. Pharmazie. 50:1995;275-277.
    • (1995) Pharmazie , vol.50 , pp. 275-277
    • Acikgoz, M.1    Kas, H.S.2    Hascelik, Z.3    Milli, U.4    Hincal, A.A.5
  • 2
    • 0029925250 scopus 로고    scopus 로고
    • Chitosan microspheres of diclofenac sodium: I. Application of factorial design and evaluation of release kinetics
    • Acikgoz M., Kas H.S., Orman M., Hincal A.A. Chitosan microspheres of diclofenac sodium: I. Application of factorial design and evaluation of release kinetics. J. Microencapsul. 13:1996;141-159.
    • (1996) J. Microencapsul. , vol.13 , pp. 141-159
    • Acikgoz, M.1    Kas, H.S.2    Orman, M.3    Hincal, A.A.4
  • 3
    • 0034772028 scopus 로고    scopus 로고
    • Chitosan microspheres prepared by an aqueous process: Release of indomethacin
    • Aggarwal A., Kaur S., Tiwary A.K., Gupta S. Chitosan microspheres prepared by an aqueous process: release of indomethacin. J. Microencapsul. 18:2001;819-823.
    • (2001) J. Microencapsul. , vol.18 , pp. 819-823
    • Aggarwal, A.1    Kaur, S.2    Tiwary, A.K.3    Gupta, S.4
  • 4
    • 0030799947 scopus 로고    scopus 로고
    • Chitosan microcapsules as controlled release systems for insulin
    • Aiedeh K., Gianasi E., Orienti E., Zecchi V. Chitosan microcapsules as controlled release systems for insulin. J. Microencapsul. 14:1997;567-576.
    • (1997) J. Microencapsul. , vol.14 , pp. 567-576
    • Aiedeh, K.1    Gianasi, E.2    Orienti, E.3    Zecchi, V.4
  • 5
    • 0027437851 scopus 로고
    • Effect of the physicochemical properties of a drug on its release from chitosan malate matrix tablets
    • Akbuga J. Effect of the physicochemical properties of a drug on its release from chitosan malate matrix tablets. Int. J. Pharm. 100:1993;257-261.
    • (1993) Int. J. Pharm. , vol.100 , pp. 257-261
    • Akbuga, J.1
  • 6
    • 0030007271 scopus 로고    scopus 로고
    • 5-Fluorouracil-loaded chitosan microspheres: Preparation and release characteristics
    • Akbuga J., Bergisadi N. 5-Fluorouracil-loaded chitosan microspheres: preparation and release characteristics. J. Microencapsul. 13:1996;161-168.
    • (1996) J. Microencapsul. , vol.13 , pp. 161-168
    • Akbuga, J.1    Bergisadi, N.2
  • 7
    • 0345466363 scopus 로고    scopus 로고
    • Effect of formulation variables on cis-platin loaded chitosan microsphere properties
    • Akbuga J., Bergisadi N. Effect of formulation variables on cis-platin loaded chitosan microsphere properties. J. Microencapsul. 16:1999;697-703.
    • (1999) J. Microencapsul. , vol.16 , pp. 697-703
    • Akbuga, J.1    Bergisadi, N.2
  • 8
    • 0028108163 scopus 로고
    • Preparation and evaluation of cross-linked chitosan microspheres containing furosemide
    • Akbuga J., Durmaz G. Preparation and evaluation of cross-linked chitosan microspheres containing furosemide. Int. J. Pharm. 111:1994;217-222.
    • (1994) Int. J. Pharm. , vol.111 , pp. 217-222
    • Akbuga, J.1    Durmaz, G.2
  • 10
    • 0031943155 scopus 로고    scopus 로고
    • Preparation and evaluation of sustained release cross-linked chitosan microspheres containing phenobarbitone
    • Al-Helw A.A., Al-Angary A.A., Mahrous G.M., Al-Dardari M.M. Preparation and evaluation of sustained release cross-linked chitosan microspheres containing phenobarbitone. J. Microencapsul. 15:1998;373-382.
    • (1998) J. Microencapsul. , vol.15 , pp. 373-382
    • Al-Helw, A.A.1    Al-Angary, A.A.2    Mahrous, G.M.3    Al-Dardari, M.M.4
  • 11
    • 0345118196 scopus 로고    scopus 로고
    • In vitro-in vivo evaluation of tableted caseinchitosan microspheres containing diltiazem hydrochloride
    • al-Suwayeh S.A., el-Helw A.R., al-Mesned A.F., Bayomi M.A., el-Gorashi A.S. In vitro-in vivo evaluation of tableted caseinchitosan microspheres containing diltiazem hydrochloride. Boll. Chim. Farm. 142:2003;14-20.
    • (2003) Boll. Chim. Farm. , vol.142 , pp. 14-20
    • Al-Suwayeh, S.A.1    El-Helw, A.R.2    Al-Mesned, A.F.3    Bayomi, M.A.4    El-Gorashi, A.S.5
  • 12
    • 0029064359 scopus 로고
    • Permeability and blood compatibility properties of chitosan- poly(ethylene oxide) blend membranes for haemodialysis
    • Amiji M.M. Permeability and blood compatibility properties of chitosan-poly(ethylene oxide) blend membranes for haemodialysis. Biomaterials. 16:1995;593-599.
    • (1995) Biomaterials , vol.16 , pp. 593-599
    • Amiji, M.M.1
  • 13
    • 0034001582 scopus 로고    scopus 로고
    • Studies of effective factors of plasmid DNA-loaded chitosan microspheres. Part 1: Plasmid size, chitosan concentration & plasmid addition techniques
    • Aral C., Ozbas-Turan S., Kabasakal L., Keyer-Uysal M., Akbuga J. Studies of effective factors of plasmid DNA-loaded chitosan microspheres. Part 1: Plasmid size, chitosan concentration & plasmid addition techniques. STP Pharm. Sci. 10:2000;83-88.
    • (2000) STP Pharm. Sci. , vol.10 , pp. 83-88
    • Aral, C.1    Ozbas-Turan, S.2    Kabasakal, L.3    Keyer-Uysal, M.4    Akbuga, J.5
  • 14
    • 0029977566 scopus 로고    scopus 로고
    • Chitosan beads for the delivery of salmon calcitonin: Preparation and release characteristics
    • Aydin Z., Akbuga J. Chitosan beads for the delivery of salmon calcitonin: preparation and release characteristics. Int. J. Pharm. 131:1996;101-103.
    • (1996) Int. J. Pharm. , vol.131 , pp. 101-103
    • Aydin, Z.1    Akbuga, J.2
  • 15
    • 0032403648 scopus 로고    scopus 로고
    • Preparation of casein-chitosan microspheres containing diltiazem hydrochloride by an aqueous coacervation technique
    • Bayomi M.A., al-Suwayeh S.A., el-Helw A.M., Mesnad A.F. Preparation of casein-chitosan microspheres containing diltiazem hydrochloride by an aqueous coacervation technique. Pharm. Acta Helv. 73:1998;187-192.
    • (1998) Pharm. Acta Helv. , vol.73 , pp. 187-192
    • Bayomi, M.A.1    Al-Suwayeh, S.A.2    El-Helw, A.M.3    Mesnad, A.F.4
  • 16
    • 0028410752 scopus 로고
    • Phenyl alanine, tryptophan immobilized chitosan beads as adsorbents for selective removal of immunoproteins
    • Beena M.S., Chandy T., Sharma C.P. Phenyl alanine, tryptophan immobilized chitosan beads as adsorbents for selective removal of immunoproteins. J. Biomater. Appl. 8:1994;385-403.
    • (1994) J. Biomater. Appl. , vol.8 , pp. 385-403
    • Beena, M.S.1    Chandy, T.2    Sharma, C.P.3
  • 17
    • 0028306824 scopus 로고
    • Incorporation of basic fibroblast growth factor into methylpyrrolidinone chitosan fleeces and determination of the in vitro release characteristics
    • Berscht P.C., Nies B., Liebendorfer A., Kreuter J. Incorporation of basic fibroblast growth factor into methylpyrrolidinone chitosan fleeces and determination of the in vitro release characteristics. Biomaterials. 15:1994;593-600.
    • (1994) Biomaterials , vol.15 , pp. 593-600
    • Berscht, P.C.1    Nies, B.2    Liebendorfer, A.3    Kreuter, J.4
  • 18
    • 0029969540 scopus 로고    scopus 로고
    • Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs
    • Berthold A., Cremer K., Kreuter J. Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs. J. Control Rel. 39:1996a;17-25.
    • (1996) J. Control Rel. , vol.39 , pp. 17-25
    • Berthold, A.1    Cremer, K.2    Kreuter, J.3
  • 19
    • 0029830736 scopus 로고    scopus 로고
    • Influence of crosslinking on the acid stability and physicochemical properties of chitosan microspheres
    • Berthold A., Cremer K., Kreuter J. Influence of crosslinking on the acid stability and physicochemical properties of chitosan microspheres. STP Pharm. Sci. 6:1996b;358-364.
    • (1996) STP Pharm. Sci. , vol.6 , pp. 358-364
    • Berthold, A.1    Cremer, K.2    Kreuter, J.3
  • 20
    • 0343603531 scopus 로고    scopus 로고
    • Chitosan microspheres in PLG films as devices for cytarabine release
    • Blanco M.D., Gomez C., Olmo R., Muniz E., Teijon J.M. Chitosan microspheres in PLG films as devices for cytarabine release. Int. J. Pharm. 202:2000;29-39.
    • (2000) Int. J. Pharm. , vol.202 , pp. 29-39
    • Blanco, M.D.1    Gomez, C.2    Olmo, R.3    Muniz, E.4    Teijon, J.M.5
  • 21
    • 0000532356 scopus 로고
    • Preparation and evaluation of drug-containing chitosan beads
    • Bodmeier R., Oh K.H., Pramar Y. Preparation and evaluation of drug-containing chitosan beads. Drug Dev. Ind. Pharm. 15:1989a;1475-1494.
    • (1989) Drug Dev. Ind. Pharm. , vol.15 , pp. 1475-1494
    • Bodmeier, R.1    Oh, K.H.2    Pramar, Y.3
  • 22
    • 0024371139 scopus 로고
    • A novel approach to the oral delivery of micro-or nanoparticles
    • Bodmeier R., Chen H.G., Paeratakul O. A novel approach to the oral delivery of micro-or nanoparticles. Pharm. Res. 6:1989b;413-417.
    • (1989) Pharm. Res. , vol.6 , pp. 413-417
    • Bodmeier, R.1    Chen, H.G.2    Paeratakul, O.3
  • 23
    • 0024893223 scopus 로고
    • Spherical agglomerates of water-insoluble drugs
    • Bodmeier R., Paeratakul O. Spherical agglomerates of water-insoluble drugs. J. Pharm. Sci. 78:1989;964-967.
    • (1989) J. Pharm. Sci. , vol.78 , pp. 964-967
    • Bodmeier, R.1    Paeratakul, O.2
  • 25
    • 0035860004 scopus 로고    scopus 로고
    • The study of drug release from microspheres adhered on pig vesical mucosa
    • Burjak M., Bogataj M., Velnar M., Grabnar I., Mrhar A. The study of drug release from microspheres adhered on pig vesical mucosa. Int. J. Pharm. 224:2001;123-130.
    • (2001) Int. J. Pharm. , vol.224 , pp. 123-130
    • Burjak, M.1    Bogataj, M.2    Velnar, M.3    Grabnar, I.4    Mrhar, A.5
  • 26
    • 0033832154 scopus 로고    scopus 로고
    • 5-Fluorouracil-loaded chitosan coated polylactic acid microspheres as biodegradable drug carriers for cerebral tumours
    • Chandy T., Das G.S., Rao G.H. 5-Fluorouracil-loaded chitosan coated polylactic acid microspheres as biodegradable drug carriers for cerebral tumours. J. Microencapsul. 17:2000;625-638.
    • (2000) J. Microencapsul. , vol.17 , pp. 625-638
    • Chandy, T.1    Das, G.S.2    Rao, G.H.3
  • 27
    • 0034980564 scopus 로고    scopus 로고
    • Development of poly(lactic acid)/chitosan co-matrix microspheres: Controlled release of taxol-heparin for preventing restenosis
    • Chandy T., Rao G.H., Wilson R.F., Das G.S. Development of poly(lactic acid)/chitosan co-matrix microspheres: controlled release of taxol-heparin for preventing restenosis. Drug Deliv. 8:2001;77-86.
    • (2001) Drug Deliv. , vol.8 , pp. 77-86
    • Chandy, T.1    Rao, G.H.2    Wilson, R.F.3    Das, G.S.4
  • 29
    • 0026331146 scopus 로고
    • Biodegradable chitosan matrix for the controlled release of steroids
    • Chandy T., Sharma C.P. Biodegradable chitosan matrix for the controlled release of steroids. Biomater. Artif. Cells Immob. Biotechnol. 19:1991;745-760.
    • (1991) Biomater. Artif. Cells Immob. Biotechnol. , vol.19 , pp. 745-760
    • Chandy, T.1    Sharma, C.P.2
  • 30
    • 0027102970 scopus 로고
    • Polylysine-immobilized chitosan beads as adsorbents for bilirubin
    • Chandy T., Sharma C.P. Polylysine-immobilized chitosan beads as adsorbents for bilirubin. Artif. Organs. 16:1992;568-576.
    • (1992) Artif. Organs , vol.16 , pp. 568-576
    • Chandy, T.1    Sharma, C.P.2
  • 31
    • 0027496885 scopus 로고
    • Chitosan matrix for oral sustained delivery of ampicillin
    • Chandy T., Sharma C.P. Chitosan matrix for oral sustained delivery of ampicillin. Biomaterials. 14:1993;939-944.
    • (1993) Biomaterials , vol.14 , pp. 939-944
    • Chandy, T.1    Sharma, C.P.2
  • 32
    • 0036525575 scopus 로고    scopus 로고
    • Changes in cisplatin delivery due to surface-coated poly(lactic acid)-poly(epsilon-caprolactone) microspheres
    • Chandy T., Wilson R.F., Rao G.H., Das G.S. Changes in cisplatin delivery due to surface-coated poly(lactic acid)-poly(epsilon-caprolactone) microspheres. J. Biomater. Appl. 16:2002;275-291.
    • (2002) J. Biomater. Appl. , vol.16 , pp. 275-291
    • Chandy, T.1    Wilson, R.F.2    Rao, G.H.3    Das, G.S.4
  • 33
  • 34
    • 0035216777 scopus 로고    scopus 로고
    • Effects of the characteristics of chitosan on controlling drug release of chitosan coated PLLA microspheres
    • Chiou S.H., Wu W.T., Huang Y.Y., Chung T.W. Effects of the characteristics of chitosan on controlling drug release of chitosan coated PLLA microspheres. J. Microencapsul. 18:2001;613-625.
    • (2001) J. Microencapsul. , vol.18 , pp. 613-625
    • Chiou, S.H.1    Wu, W.T.2    Huang, Y.Y.3    Chung, T.W.4
  • 35
    • 0024034580 scopus 로고
    • Chitosan-alginate coacervate capsule: Effect of calcium chloride Plastcizers and polyelectrolytes on mechanical stability
    • Daly M.M., Knorr D. Chitosan-alginate coacervate capsule: effect of calcium chloride Plastcizers and polyelectrolytes on mechanical stability. Biotechnol. Progr. 4:1988;76.
    • (1988) Biotechnol. Progr. , vol.4 , pp. 76
    • Daly, M.M.1    Knorr, D.2
  • 36
    • 0035675361 scopus 로고    scopus 로고
    • Preparation of chitosan gel beads by ionotropic molybdate gelation
    • Dambies L., Vincent T., Domard A., Guibal E. Preparation of chitosan gel beads by ionotropic molybdate gelation. Biomacromolecules. 2:2001;1198-1205.
    • (2001) Biomacromolecules , vol.2 , pp. 1198-1205
    • Dambies, L.1    Vincent, T.2    Domard, A.3    Guibal, E.4
  • 37
    • 0037437096 scopus 로고    scopus 로고
    • Polymer relationships during preparation of chitosan-alginate and poly-L-lysine-alginate nanospheres
    • De S., Robinson D. Polymer relationships during preparation of chitosan-alginate and poly-L-lysine-alginate nanospheres. J. Control Rel. 89:2003;101-112.
    • (2003) J. Control Rel. , vol.89 , pp. 101-112
    • De, S.1    Robinson, D.2
  • 38
    • 1842518611 scopus 로고
    • New properties of chitosan in lipid dispersions
    • Chitin World, Karnicki, Z.S., Wojtaso Pajak, A., Breziski, M.M., Bylowski, P.J. (Eds.), Germany
    • Demarger-Andre, S., Domard, A., 1994. New properties of chitosan in lipid dispersions. In: Chitin World, Karnicki, Z.S., Wojtaso Pajak, A., Breziski, M.M., Bylowski, P.J. (Eds.), Bremerhauser, Germany, pp. 153-158.
    • (1994) Bremerhauser , pp. 153-158
    • Demarger-Andre, S.1    Domard, A.2
  • 39
    • 0032831579 scopus 로고    scopus 로고
    • 5-Fluorouracil loaded chitosan microspheres for chemoembolization
    • Denkbas E.B., Seyyal M., Piskin E. 5-Fluorouracil loaded chitosan microspheres for chemoembolization. J. Microencapsul. 16:1999;741-749.
    • (1999) J. Microencapsul. , vol.16 , pp. 741-749
    • Denkbas, E.B.1    Seyyal, M.2    Piskin, E.3
  • 40
    • 1142287456 scopus 로고    scopus 로고
    • Nifedipine loaded chitosan microspheres prepared by emulsification phase separation
    • Dhawan S., Singla A.K. Nifedipine loaded chitosan microspheres prepared by emulsification phase separation. Biotech. Histochem. 78:2003;243-254.
    • (2003) Biotech. Histochem. , vol.78 , pp. 243-254
    • Dhawan, S.1    Singla, A.K.2
  • 41
    • 0038107399 scopus 로고    scopus 로고
    • Synthesis and characterization of cross-linked chitosan microspheres for drug delivery applications
    • Dini E., Alexandridou S., Kiparissides C. Synthesis and characterization of cross-linked chitosan microspheres for drug delivery applications. J. Microencapsul. 20:2003;375-385.
    • (2003) J. Microencapsul. , vol.20 , pp. 375-385
    • Dini, E.1    Alexandridou, S.2    Kiparissides, C.3
  • 42
    • 0032917517 scopus 로고    scopus 로고
    • Effect of chitosan on epithelial permeability and structure
    • Dodane V., Khan M.A., Merwin J.R. Effect of chitosan on epithelial permeability and structure. Int. J. Pharm. 182:1999;21-32.
    • (1999) Int. J. Pharm. , vol.182 , pp. 21-32
    • Dodane, V.1    Khan, M.A.2    Merwin, J.R.3
  • 43
    • 0029931232 scopus 로고    scopus 로고
    • Controlled release of endothelial cell growth factor from chitosan-albumin microspheres for localized angiogenesis: In vitro and in vivo studies
    • Elcin Y.M., Dixit V., Gitnick G. Controlled release of endothelial cell growth factor from chitosan-albumin microspheres for localized angiogenesis: in vitro and in vivo studies. Artif. Cells Blood Substit. Immobil. Biotechnol. 24:1996;257-271.
    • (1996) Artif. Cells Blood Substit. Immobil. Biotechnol. , vol.24 , pp. 257-271
    • Elcin, Y.M.1    Dixit, V.2    Gitnick, G.3
  • 44
    • 0037027837 scopus 로고    scopus 로고
    • Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: Comparison with non-floating chitosan microspheres
    • El-Gibaly I. Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: comparison with non-floating chitosan microspheres. Int. J. Pharm. 249:2002;7-21.
    • (2002) Int. J. Pharm. , vol.249 , pp. 7-21
    • El-Gibaly, I.1
  • 45
    • 0034056836 scopus 로고    scopus 로고
    • Improved nasal bioavailability of FITC-dextran (Mw 4300) from mucoadhesive microspheres in rabbits
    • El-Shafy M.A., Kellaway I.W., Taylor G., Dickinson P.A. Improved nasal bioavailability of FITC-dextran (Mw 4300) from mucoadhesive microspheres in rabbits. J. Drug Target. 7:2000;355-361.
    • (2000) J. Drug Target , vol.7 , pp. 355-361
    • El-Shafy, M.A.1    Kellaway, I.W.2    Taylor, G.3    Dickinson, P.A.4
  • 46
    • 1842466449 scopus 로고
    • Isosorbide-5-mononitrate microspheres: Formulation and evaluation of in vitro release profiles by application of factorial design
    • Farivar M., Kas H.S., Oner L., Hincal A.A. Isosorbide-5-mononitrate microspheres: formulation and evaluation of in vitro release profiles by application of factorial design. HU Ecz. Der. 13:1993;25-37.
    • (1993) HU Ecz. Der. , vol.13 , pp. 25-37
    • Farivar, M.1    Kas, H.S.2    Oner, L.3    Hincal, A.A.4
  • 47
    • 0031714427 scopus 로고    scopus 로고
    • Chitosan: A unique polysaccharide for drug delivery
    • Felt O., Buri P., Gurny R. Chitosan: a unique polysaccharide for drug delivery. Drug Dev. Ind. Pharm. 24:1998;979-993.
    • (1998) Drug Dev. Ind. Pharm. , vol.24 , pp. 979-993
    • Felt, O.1    Buri, P.2    Gurny, R.3
  • 48
    • 0032964520 scopus 로고    scopus 로고
    • Topical use of chitosan in ophthalmology: Tolerance assessment and evaluation of precorneal retention
    • Felt O., Furrer P., Mayer J.M., Plazonnet B., Buri P., Gurny R. Topical use of chitosan in ophthalmology: tolerance assessment and evaluation of precorneal retention. Int. J. Pharm. 180:1999;185-193.
    • (1999) Int. J. Pharm. , vol.180 , pp. 185-193
    • Felt, O.1    Furrer, P.2    Mayer, J.M.3    Plazonnet, B.4    Buri, P.5    Gurny, R.6
  • 50
    • 0030591403 scopus 로고    scopus 로고
    • Chitosan microspheres of nifedipine and nifedipine-cyclodextrin inclusion complexes
    • Filipovic-Grcic J., Becirevic-Lacan M., Skalko N., Jalsenjak I. Chitosan microspheres of nifedipine and nifedipine-cyclodextrin inclusion complexes. Int. J. Pharm. 135:1996;183-190.
    • (1996) Int. J. Pharm. , vol.135 , pp. 183-190
    • Filipovic-Grcic, J.1    Becirevic-Lacan, M.2    Skalko, N.3    Jalsenjak, I.4
  • 51
    • 0028837084 scopus 로고
    • Macromolecular prodrugs. Part 4. Alginate-chitosan microspheres of PHEA-L-dopa adduct
    • Filipovic-Grcic J., Maysinger D., Zorc B., Jalsenjak I. Macromolecular prodrugs. Part 4. Alginate-chitosan microspheres of PHEA-L-dopa adduct. Int. J. Pharm. 116:1995;39-44.
    • (1995) Int. J. Pharm. , vol.116 , pp. 39-44
    • Filipovic-Grcic, J.1    Maysinger, D.2    Zorc, B.3    Jalsenjak, I.4
  • 53
    • 0019000065 scopus 로고
    • Polyelectrolyte complexes of chitosan carboxymethyl cellulose
    • Fukuda H. Polyelectrolyte complexes of chitosan carboxymethyl cellulose. Bull. Chem. Soc. Jpn. 53:1980;837-840.
    • (1980) Bull. Chem. Soc. Jpn. , vol.53 , pp. 837-840
    • Fukuda, H.1
  • 54
    • 1842623076 scopus 로고
    • Nonabsorbable lipid binder. US Patent 4,223,023.
    • Furda, I., 1980. Nonabsorbable lipid binder. US Patent 4,223,023.
    • (1980)
    • Furda, I.1
  • 55
    • 0023921066 scopus 로고
    • Receptor-mediated magnetic carriers: Basis for targeting
    • Gallo J.M., Hassan E.E. Receptor-mediated magnetic carriers: basis for targeting. Pharm. Res. 5:1988;300-304.
    • (1988) Pharm. Res. , vol.5 , pp. 300-304
    • Gallo, J.M.1    Hassan, E.E.2
  • 58
    • 0029039321 scopus 로고
    • Improvement of dexamethasone dissolution rate from spray-dried chitosan microspheres
    • Genta I., Pavanetto F., Conti B., Gunchedi P., Conte U. Improvement of dexamethasone dissolution rate from spray-dried chitosan microspheres. STP Pharm. Sci. 5:1995;202-207.
    • (1995) STP Pharm. Sci. , vol.5 , pp. 202-207
    • Genta, I.1    Pavanetto, F.2    Conti, B.3    Gunchedi, P.4    Conte, U.5
  • 59
    • 0031845277 scopus 로고    scopus 로고
    • Different molecular weight chitosan microspheres: Influence on drug loading and drug release
    • Genta I., Perugini P., Pavanetto F. Different molecular weight chitosan microspheres: influence on drug loading and drug release. Drug Dev. Ind. Pharm. 24:1998;779-784.
    • (1998) Drug Dev. Ind. Pharm. , vol.24 , pp. 779-784
    • Genta, I.1    Perugini, P.2    Pavanetto, F.3
  • 60
    • 0031840056 scopus 로고    scopus 로고
    • Preparation and characterization of ampicillin loaded methylpyrrolidinone chitosan and chitosan microspheres
    • Giunchedi P., Genta I., Conti B., Muzzarelli R.A., Conte U. Preparation and characterization of ampicillin loaded methylpyrrolidinone chitosan and chitosan microspheres. Biomaterials. 19:1998;157-161.
    • (1998) Biomaterials , vol.19 , pp. 157-161
    • Giunchedi, P.1    Genta, I.2    Conti, B.3    Muzzarelli, R.A.4    Conte, U.5
  • 61
    • 0036191263 scopus 로고    scopus 로고
    • Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres
    • Giunchedi P., Juliano C., Gavini E., Cossu M., Sorrenti M. Formulation and in vivo evaluation of chlorhexidine buccal tablets prepared using drug-loaded chitosan microspheres. Eur. J. Pharm. Biopharm. 53:2002;233-239.
    • (2002) Eur. J. Pharm. Biopharm. , vol.53 , pp. 233-239
    • Giunchedi, P.1    Juliano, C.2    Gavini, E.3    Cossu, M.4    Sorrenti, M.5
  • 64
    • 0027516917 scopus 로고
    • Avicel RC-591/chitosan beads by extrusion spheronization technology
    • Goskonda S.R., Upadrashta S.M. Avicel RC-591/chitosan beads by extrusion spheronization technology. Drug Dev. Ind. Pharm. 19:1993;915-927.
    • (1993) Drug Dev. Ind. Pharm. , vol.19 , pp. 915-927
    • Goskonda, S.R.1    Upadrashta, S.M.2
  • 65
    • 0029944486 scopus 로고    scopus 로고
    • Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin
    • Hari P.R., Chandy T., Sharma C.P. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. J. Microencapsul. 13:1996;319-329.
    • (1996) J. Microencapsul. , vol.13 , pp. 319-329
    • Hari, P.R.1    Chandy, T.2    Sharma, C.P.3
  • 66
    • 0027870537 scopus 로고
    • Targeting anticancer drugs to the brain. I: Enhanced brain delivery of oxantrazole following administration in magnetic cationic microspheres
    • Hassan E.E., Gallo J.M. Targeting anticancer drugs to the brain. I: Enhanced brain delivery of oxantrazole following administration in magnetic cationic microspheres. J. Drug Target. 1:1993;7-14.
    • (1993) J. Drug Target , vol.1 , pp. 7-14
    • Hassan, E.E.1    Gallo, J.M.2
  • 67
    • 0026543192 scopus 로고
    • Optimized formulation of magnetic chitosan microspheres containing the anticancer agent, oxantrazole
    • Hassan E.E., Parish R.C., Gallo J.M. Optimized formulation of magnetic chitosan microspheres containing the anticancer agent, oxantrazole. Pharm. Res. 9:1992;390-397.
    • (1992) Pharm. Res. , vol.9 , pp. 390-397
    • Hassan, E.E.1    Parish, R.C.2    Gallo, J.M.3
  • 68
    • 0032507738 scopus 로고    scopus 로고
    • In vitro evaluation of the mucoadhesive properties of chitosan microspheres
    • He P., Davis S.S., Illum L. In vitro evaluation of the mucoadhesive properties of chitosan microspheres. Int. J. Pharm. 166:1998;75-88.
    • (1998) Int. J. Pharm. , vol.166 , pp. 75-88
    • He, P.1    Davis, S.S.2    Illum, L.3
  • 69
    • 0032881548 scopus 로고    scopus 로고
    • Chitosan microspheres prepared by spray drying
    • He P., Davis S.S., Illum L. Chitosan microspheres prepared by spray drying. Int. J. Pharm. 187:1999a;53-65.
    • (1999) Int. J. Pharm. , vol.187 , pp. 53-65
    • He, P.1    Davis, S.S.2    Illum, L.3
  • 70
    • 0032928411 scopus 로고    scopus 로고
    • Sustained release chitosan microspheres prepared by novel spray drying methods
    • He P., Davis S.S., Illum L. Sustained release chitosan microspheres prepared by novel spray drying methods. J. Microencapsul. 16:1999b;343-355.
    • (1999) J. Microencapsul. , vol.16 , pp. 343-355
    • He, P.1    Davis, S.S.2    Illum, L.3
  • 71
    • 0037139358 scopus 로고    scopus 로고
    • Stomach-specific anti-H. pylori therapy. I: Preparation and characterization of tetracyline-loaded chitosan microspheres
    • Hejazi R., Amiji M. Stomach-specific anti-H. pylori therapy. I: preparation and characterization of tetracyline-loaded chitosan microspheres. Int. J. Pharm. 235:2002;87-94.
    • (2002) Int. J. Pharm. , vol.235 , pp. 87-94
    • Hejazi, R.1    Amiji, M.2
  • 72
    • 0041843840 scopus 로고    scopus 로고
    • Stomach-specific anti-H. pylori therapy. II. Gastric residence studies of tetracycline-loaded chitosan microspheres in gerbils
    • Hejazi R., Amiji M. Stomach-specific anti-H. pylori therapy. II. Gastric residence studies of tetracycline-loaded chitosan microspheres in gerbils. Pharm. Dev. Technol. 8:2003;253-262.
    • (2003) Pharm. Dev. Technol. , vol.8 , pp. 253-262
    • Hejazi, R.1    Amiji, M.2
  • 74
    • 0035443504 scopus 로고    scopus 로고
    • Hypoglycemic effect of chitosan-microcapsulated insulin on the blood glucose level of streptozotocin-diabetic Wistar rats
    • Huang H., Tian, H., Li, X., Zhao, G., 2001. Hypoglycemic effect of chitosan-microcapsulated insulin on the blood glucose level of streptozotocin-diabetic Wistar rats. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 18, 425-427, 460.
    • (2001) Sheng Wu Yi Xue Gong Cheng Xue Za Zhi , vol.18 , pp. 425-427
    • Huang, H.1    Tian, H.2    Li, X.3    Zhao, G.4
  • 75
    • 0037820592 scopus 로고    scopus 로고
    • The characteristics of betamethasone-loaded chitosan microparticles by spray-drying method
    • Huang Y.C., Yeh M.K., Cheng S.N., Chiang C.H. The characteristics of betamethasone-loaded chitosan microparticles by spray-drying method. J. Microencapsul. 20:2003a;459-472.
    • (2003) J. Microencapsul. , vol.20 , pp. 459-472
    • Huang, Y.C.1    Yeh, M.K.2    Cheng, S.N.3    Chiang, C.H.4
  • 76
    • 0037372407 scopus 로고    scopus 로고
    • Optimizing formulation factors in preparing chitosan microparticles by spray-drying method
    • Huang Y.C., Chiang C.H., Yeh M.K. Optimizing formulation factors in preparing chitosan microparticles by spray-drying method. J. Microencapsul. 20:2003b;247-260.
    • (2003) J. Microencapsul. , vol.20 , pp. 247-260
    • Huang, Y.C.1    Chiang, C.H.2    Yeh, M.K.3
  • 77
    • 0033004905 scopus 로고    scopus 로고
    • Microencapsulation of chlorpheniramine maleate-resin particles with crosslinked chitosan for sustained release
    • Huang R.G., Schwartz J.B., Ofner C.M. III Microencapsulation of chlorpheniramine maleate-resin particles with crosslinked chitosan for sustained release. Pharm. Dev. Technol. 4:1999;107-115.
    • (1999) Pharm. Dev. Technol. , vol.4 , pp. 107-115
    • Huang, R.G.1    Schwartz, J.B.2    Ofner III, C.M.3
  • 78
    • 0037151427 scopus 로고    scopus 로고
    • Formulation factors in preparing BTM-chitosan microspheres by spray drying method
    • Huang Y., Yeh M., Chiang C. Formulation factors in preparing BTM-chitosan microspheres by spray drying method. Int. J. Pharm. 242:2002;239-242.
    • (2002) Int. J. Pharm. , vol.242 , pp. 239-242
    • Huang, Y.1    Yeh, M.2    Chiang, C.3
  • 81
    • 0028124642 scopus 로고
    • Chitosan as a novel nasal delivery system for peptide drugs
    • Illum L., Farraj N.F., Davis S.S. Chitosan as a novel nasal delivery system for peptide drugs. Pharm. Res. 11:1994;1186-1189.
    • (1994) Pharm. Res. , vol.11 , pp. 1186-1189
    • Illum, L.1    Farraj, N.F.2    Davis, S.S.3
  • 82
    • 0031783879 scopus 로고    scopus 로고
    • Chitosan and its use as a pharmaceutical excipient
    • Illum L. Chitosan and its use as a pharmaceutical excipient. Pharm. Res. 15:1998;1326-1331.
    • (1998) Pharm. Res. , vol.15 , pp. 1326-1331
    • Illum, L.1
  • 85
    • 0034087210 scopus 로고    scopus 로고
    • Anti-ulcer effects of chitin and chitosan, healthy foods, in rats
    • Ito M., Ban A., Ishihara M. Anti-ulcer effects of chitin and chitosan, healthy foods, in rats. Jpn. J. Pharmacol. 82:2000;218-225.
    • (2000) Jpn. J. Pharmacol. , vol.82 , pp. 218-225
    • Ito, M.1    Ban, A.2    Ishihara, M.3
  • 86
    • 0028384710 scopus 로고
    • Lipoprotein lipase immobilization onto porous chitosan beads
    • Itoyama K., Tokura S., Hayashi T. Lipoprotein lipase immobilization onto porous chitosan beads. Biotechnol. Progr. 10:1994;225-229.
    • (1994) Biotechnol. Progr. , vol.10 , pp. 225-229
    • Itoyama, K.1    Tokura, S.2    Hayashi, T.3
  • 87
    • 0029329224 scopus 로고
    • Glutaraldehyde cross-linked chitosan microspheres as a long acting biodegradable drug delivery vehicle: Studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle
    • Jameela S.R., Jayakrishnan A. Glutaraldehyde cross-linked chitosan microspheres as a long acting biodegradable drug delivery vehicle: studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle. Biomaterials. 16:1995;769-775.
    • (1995) Biomaterials , vol.16 , pp. 769-775
    • Jameela, S.R.1    Jayakrishnan, A.2
  • 88
    • 0032473536 scopus 로고    scopus 로고
    • Progesterone-loaded chitosan microspheres: A long acting biodegradable controlled delivery system
    • Jameela S.R., Kumary T.V., Lal A.V., Jayakrishnan A. Progesterone-loaded chitosan microspheres: a long acting biodegradable controlled delivery system. J. Control Rel. 52:1998;17-24.
    • (1998) J. Control Rel. , vol.52 , pp. 17-24
    • Jameela, S.R.1    Kumary, T.V.2    Lal, A.V.3    Jayakrishnan, A.4
  • 89
    • 0029789042 scopus 로고    scopus 로고
    • Antitumour activity of mitoxantrone-loaded chitosan microspheres against Ehrlich ascites carcinoma
    • Jameela S.R., Latha P.G., Subramoniam A., Jayakrishnan A. Antitumour activity of mitoxantrone-loaded chitosan microspheres against Ehrlich ascites carcinoma. J. Pharm. Pharmacol. 48:1996;685-688.
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 685-688
    • Jameela, S.R.1    Latha, P.G.2    Subramoniam, A.3    Jayakrishnan, A.4
  • 90
    • 84895289445 scopus 로고
    • Cross-linked chitosan microspheres as carriers for prolonged delivery of macromolecular drugs
    • Jameela S.R., Misra A., Jayakrishnan A. Cross-linked chitosan microspheres as carriers for prolonged delivery of macromolecular drugs. J. Biomater. Sci. Polym. Ed. 6:1994;621-632.
    • (1994) J. Biomater. Sci. Polym. Ed. , vol.6 , pp. 621-632
    • Jameela, S.R.1    Misra, A.2    Jayakrishnan, A.3
  • 91
    • 0030830841 scopus 로고    scopus 로고
    • Chitosan: Properties, preparation and application to microparticulate systems
    • Kas H.S. Chitosan: properties, preparation and application to microparticulate systems. J. Microencapsul. 14:1997;689-711.
    • (1997) J. Microencapsul. , vol.14 , pp. 689-711
    • Kas, H.S.1
  • 92
    • 0141504461 scopus 로고    scopus 로고
    • Application of chitin and chitosan derivatives in the pharmaceutical field
    • Kato Y., Onishi H., Machida Y. Application of chitin and chitosan derivatives in the pharmaceutical field. Curr. Pharm. Biotechnol. 4:2003;303-309.
    • (2003) Curr. Pharm. Biotechnol. , vol.4 , pp. 303-309
    • Kato, Y.1    Onishi, H.2    MacHida, Y.3
  • 93
    • 0021832523 scopus 로고
    • The effects of thickness and hardness of the coating film on the drug release rate of theophylline granules coated with chitosan-sodium tripolyphosphate complex
    • Kawashima Y., Handa T., Kasai A., Takenaka H., Lin S.Y. The effects of thickness and hardness of the coating film on the drug release rate of theophylline granules coated with chitosan-sodium tripolyphosphate complex. Chem. Pharm. Bull. (Tokyo). 33:1985a;2469-2474.
    • (1985) Chem. Pharm. Bull. (Tokyo) , vol.33 , pp. 2469-2474
    • Kawashima, Y.1    Handa, T.2    Kasai, A.3    Takenaka, H.4    Lin, S.Y.5
  • 94
    • 0022002711 scopus 로고
    • Novel method for the preparation of controlled-release theophylline granules coated with a polyelectrolyte complex of sodium polyphosphate-chitosan
    • Kawashima Y., Handa T., Kasai A., Takenaka H., Lin S.Y., Ando Y. Novel method for the preparation of controlled-release theophylline granules coated with a polyelectrolyte complex of sodium polyphosphate-chitosan. J. Pharm. Sci. 74:1985b;264-268.
    • (1985) J. Pharm. Sci. , vol.74 , pp. 264-268
    • Kawashima, Y.1    Handa, T.2    Kasai, A.3    Takenaka, H.4    Lin, S.Y.5    Ando, Y.6
  • 95
    • 0033969945 scopus 로고    scopus 로고
    • Mucoadhesive DL-lactide/glycolide copolymer nanospheres coated with chitosan to improve oral delivery of elcatonin
    • Kawashima Y., Yamamoto H., Takeuchi H., Kuno Y. Mucoadhesive DL-lactide/glycolide copolymer nanospheres coated with chitosan to improve oral delivery of elcatonin. Pharm. Dev. Technol. 5:2000;77-85.
    • (2000) Pharm. Dev. Technol. , vol.5 , pp. 77-85
    • Kawashima, Y.1    Yamamoto, H.2    Takeuchi, H.3    Kuno, Y.4
  • 97
    • 1842623077 scopus 로고
    • Transdermal permeation of proteins in chitosan capsules
    • Skjak-Braek, G., Anthonen, T., Sanford, P. (Eds.), Elsevier, London
    • Kim, S.K., Rha, C., 1989b. Transdermal permeation of proteins in chitosan capsules. In: Skjak-Braek, G., Anthonen, T., Sanford, P. (Eds.), Chitin and Chitosan-Sources, Chemistry, Physical Properties and Application. Elsevier, London, pp. 365-642.
    • (1989) Chitin and Chitosan-Sources, Chemistry, Physical Properties and Application , pp. 365-642
    • Kim, S.K.1    Rha, C.2
  • 98
    • 0042658021 scopus 로고    scopus 로고
    • Porous chitosan scaffold containing microspheres loaded with transforming growth factor-beta1: Implications for cartilage tissue engineering
    • Kim S.E., Park J.H., Cho Y.W., Chung H., Jeong S.Y., Lee E.B., Kwon I.C. Porous chitosan scaffold containing microspheres loaded with transforming growth factor-beta1: implications for cartilage tissue engineering. J. Control Rel. 91:2003;365-374.
    • (2003) J. Control Rel. , vol.91 , pp. 365-374
    • Kim, S.E.1    Park, J.H.2    Cho, Y.W.3    Chung, H.4    Jeong, S.Y.5    Lee, E.B.6    Kwon, I.C.7
  • 99
    • 0037027849 scopus 로고    scopus 로고
    • Preparation and characterization of chitosan microparticles intended for controlled drug delivery
    • Ko J.A., Park H.J., Hwang S.J., Park J.B., Lee J.S. Preparation and characterization of chitosan microparticles intended for controlled drug delivery. Int. J. Pharm. 249:2002;165-174.
    • (2002) Int. J. Pharm. , vol.249 , pp. 165-174
    • Ko, J.A.1    Park, H.J.2    Hwang, S.J.3    Park, J.B.4    Lee, J.S.5
  • 100
    • 0043212012 scopus 로고    scopus 로고
    • Polymeric microspheres for drug delivery to the oral cavity: An in vitro evaluation of mucoadhesive potential
    • Kockisch S., Rees G.D., Young S.A., Tsibouklis J., Smart J.D. Polymeric microspheres for drug delivery to the oral cavity: an in vitro evaluation of mucoadhesive potential. J. Pharm. Sci. 92:2003;1614-1623.
    • (2003) J. Pharm. Sci. , vol.92 , pp. 1614-1623
    • Kockisch, S.1    Rees, G.D.2    Young, S.A.3    Tsibouklis, J.4    Smart, J.D.5
  • 101
    • 0034097317 scopus 로고    scopus 로고
    • The controlled release of a drug from biodegradable chitosan gel beads
    • Kofuji K., Ito T., Murata Y., Kawashima S. The controlled release of a drug from biodegradable chitosan gel beads. Chem. Pharm. Bull. (Tokyo). 48:2000;579-581.
    • (2000) Chem. Pharm. Bull. (Tokyo) , vol.48 , pp. 579-581
    • Kofuji, K.1    Ito, T.2    Murata, Y.3    Kawashima, S.4
  • 103
    • 0345055299 scopus 로고    scopus 로고
    • Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
    • Kotze A.F., Lueβen H.L., de Leeuw B.J., de Boer A.G., Verhoef J.C., Junginger H.E. Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J. Control Rel. 51:1998;35-46.
    • (1998) J. Control Rel. , vol.51 , pp. 35-46
    • Kotze, A.F.1    Lueen, H.L.2    De Leeuw, B.J.3    De Boer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 107
    • 0036153895 scopus 로고    scopus 로고
    • Crosslinked chitosan microspheres for encapsulation of diclofenac sodium: Effect of crosslinking agent
    • Kumbar S.G., Kulkarni A.R., Aminabhavi M. Crosslinked chitosan microspheres for encapsulation of diclofenac sodium: effect of crosslinking agent. J. Microencapsul. 19:2002;173-180.
    • (2002) J. Microencapsul. , vol.19 , pp. 173-180
    • Kumbar, S.G.1    Kulkarni, A.R.2    Aminabhavi, M.3
  • 108
    • 0026478522 scopus 로고
    • A study of embolizing materials for chemo-embolization therapy of hepatocellular carcinoma: Antitumor effect of cis-diamminedichloroplatinum(II) albumin microspheres, containing chitin and treated with chitosan on rabbits with VX2 hepatic tumors
    • Kyotani S., Nishioka Y., Okamura M., Tanaka T., Miyazaki M., Ohnishi S., Yamamoto Y., Ito K., Ogiso T., Tanada S. A study of embolizing materials for chemo-embolization therapy of hepatocellular carcinoma: antitumor effect of cis-diamminedichloroplatinum(II) albumin microspheres, containing chitin and treated with chitosan on rabbits with VX2 hepatic tumors. Chem. Pharm. Bull. (Tokyo). 40:1992;2814-2816.
    • (1992) Chem. Pharm. Bull. (Tokyo) , vol.40 , pp. 2814-2816
    • Kyotani, S.1    Nishioka, Y.2    Okamura, M.3    Tanaka, T.4    Miyazaki, M.5    Ohnishi, S.6    Yamamoto, Y.7    Ito, K.8    Ogiso, T.9    Tanada, S.10
  • 109
    • 0031782990 scopus 로고    scopus 로고
    • Preparation and characterization of melatonin-loaded stearyl alcohol microspheres
    • Lee B.J., Choe J.S., Kim C.K. Preparation and characterization of melatonin-loaded stearyl alcohol microspheres. J. Microencapsul. 15:1998;775-787.
    • (1998) J. Microencapsul. , vol.15 , pp. 775-787
    • Lee, B.J.1    Choe, J.S.2    Kim, C.K.3
  • 110
    • 0026800237 scopus 로고
    • In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
    • Lehr C.M., Bouwstra J.A., Schacht E.H., Junginger H.E. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm. 78:1992;43-48.
    • (1992) Int. J. Pharm. , vol.78 , pp. 43-48
    • Lehr, C.M.1    Bouwstra, J.A.2    Schacht, E.H.3    Junginger, H.E.4
  • 111
    • 0029888801 scopus 로고    scopus 로고
    • The use of chitosan to increase the stability of calcium alginate beads with entrapped yeast cells
    • Li X. The use of chitosan to increase the stability of calcium alginate beads with entrapped yeast cells. Biotechnol. Appl. Biochem. 23:1996;269-272.
    • (1996) Biotechnol. Appl. Biochem. , vol.23 , pp. 269-272
    • Li, X.1
  • 112
    • 0026038678 scopus 로고
    • Preparation of chitosan microspheres containing fluorouracil using the 'dry-in-oil' method and its release characteristics
    • Li Y.P., Machida T.Y., Sannan T., Nagai T. Preparation of chitosan microspheres containing fluorouracil using the 'dry-in-oil' method and its release characteristics. STP Pharm. Sci. 1:1991;363-368.
    • (1991) STP Pharm. Sci. , vol.1 , pp. 363-368
    • Li, Y.P.1    MacHida, T.Y.2    Sannan, T.3    Nagai, T.4
  • 113
    • 0031918689 scopus 로고    scopus 로고
    • Effect of magnesium stearate on chitosan microspheres prepared by an emulsification-coacervation technique
    • Lim L.Y., Wan L.S. Effect of magnesium stearate on chitosan microspheres prepared by an emulsification-coacervation technique. J. Microencapsul. 15:1998;319-333.
    • (1998) J. Microencapsul. , vol.15 , pp. 319-333
    • Lim, L.Y.1    Wan, L.S.2
  • 114
    • 0030827319 scopus 로고    scopus 로고
    • Chitosan microspheres prepared by emulsification and ionotropic gelation
    • Lim L.Y., Wan L.S., Thai P.Y. Chitosan microspheres prepared by emulsification and ionotropic gelation. Drug Dev. Ind. Pharm. 23:1997;981-985.
    • (1997) Drug Dev. Ind. Pharm. , vol.23 , pp. 981-985
    • Lim, L.Y.1    Wan, L.S.2    Thai, P.Y.3
  • 115
    • 0034658305 scopus 로고    scopus 로고
    • Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan
    • Lim S.T., Martin G.P., Berry D.J., Brown M.B. Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan. J. Control Rel. 66:2000;281-292.
    • (2000) J. Control Rel. , vol.66 , pp. 281-292
    • Lim, S.T.1    Martin, G.P.2    Berry, D.J.3    Brown, M.B.4
  • 116
    • 0027080597 scopus 로고
    • Influence of sodium bicarbonate and sodium tripolyphosphate and the adding sequence on the formation and dissolution of theophylline chitosan microcapsules
    • Lin S.Y., Lin P.C. Influence of sodium bicarbonate and sodium tripolyphosphate and the adding sequence on the formation and dissolution of theophylline chitosan microcapsules. STP Pharm. Sci. 2:1992;500-505.
    • (1992) STP Pharm. Sci. , vol.2 , pp. 500-505
    • Lin, S.Y.1    Lin, P.C.2
  • 117
    • 0037370856 scopus 로고    scopus 로고
    • Comparison of chitosan and gelatin coated microparticles: Prepared by hot-melt method
    • Lin W.J., Kang W.W. Comparison of chitosan and gelatin coated microparticles: prepared by hot-melt method. J. Microencapsul. 20:2003;169-177.
    • (2003) J. Microencapsul. , vol.20 , pp. 169-177
    • Lin, W.J.1    Kang, W.W.2
  • 118
    • 0031060250 scopus 로고    scopus 로고
    • Controlled release of interleukin 2 for tumor immunotherapy using alginate/chitosan porous microspheres
    • Liu L.S., Liu S.Q., Ng S.Y., Froix M., Heller J. Controlled release of interleukin 2 for tumor immunotherapy using alginate/chitosan porous microspheres. J. Control Rel. 43:1997;65-74.
    • (1997) J. Control Rel. , vol.43 , pp. 65-74
    • Liu, L.S.1    Liu, S.Q.2    Ng, S.Y.3    Froix, M.4    Heller, J.5
  • 120
    • 0037369421 scopus 로고    scopus 로고
    • Microspheres of alginate-chitosan containing isoniazid
    • Lucinda-Silva R.M., Evangelista R.C. Microspheres of alginate-chitosan containing isoniazid. J. Microencapsul. 20:2003;145-152.
    • (2003) J. Microencapsul. , vol.20 , pp. 145-152
    • Lucinda-Silva, R.M.1    Evangelista, R.C.2
  • 122
    • 0031056799 scopus 로고    scopus 로고
    • Formation of positively charged microcapsules based on chitosan-lecithin interactions
    • Magdassi S., Bach U., Mumcuoglu K.Y. Formation of positively charged microcapsules based on chitosan-lecithin interactions. J. Microencapsul. 14:1997;189-195.
    • (1997) J. Microencapsul. , vol.14 , pp. 189-195
    • Magdassi, S.1    Bach, U.2    Mumcuoglu, K.Y.3
  • 125
    • 0027511618 scopus 로고
    • Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behavior of chlorpromazine HCl
    • Meshali M.M., Gabr K.E. Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behavior of chlorpromazine HCl. Int. J. Pharm. 89:1993;177-181.
    • (1993) Int. J. Pharm. , vol.89 , pp. 177-181
    • Meshali, M.M.1    Gabr, K.E.2
  • 126
    • 0033197952 scopus 로고    scopus 로고
    • Porous chitosan microsphere for controlling the antigen release of Newcastle disease vaccine: Preparation of antigen-adsorbed microsphere and in vitro release
    • Mi F.L., Shyu S.S., Chen C.T., Schoung J.Y. Porous chitosan microsphere for controlling the antigen release of Newcastle disease vaccine: preparation of antigen-adsorbed microsphere and in vitro release. Biomaterials. 20:1999;1603-1612.
    • (1999) Biomaterials , vol.20 , pp. 1603-1612
    • Mi, F.L.1    Shyu, S.S.2    Chen, C.T.3    Schoung, J.Y.4
  • 127
    • 15644383204 scopus 로고    scopus 로고
    • Sustained-release of oxytetracycline from chitosan microspheres prepared by interfacial acylation and spray hardening methods
    • Mi F.L., Wong T.B., Shyu S.S. Sustained-release of oxytetracycline from chitosan microspheres prepared by interfacial acylation and spray hardening methods. J. Microencapsul. 14:1997;577-591.
    • (1997) J. Microencapsul. , vol.14 , pp. 577-591
    • Mi, F.L.1    Wong, T.B.2    Shyu, S.S.3
  • 128
    • 0036027616 scopus 로고    scopus 로고
    • In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant
    • Mi F.L., Tan Y.C., Liang H.F., Sung H.W. In vivo biocompatibility and degradability of a novel injectable-chitosan-based implant. Biomaterials. 23:2002;181-191.
    • (2002) Biomaterials , vol.23 , pp. 181-191
    • Mi, F.L.1    Tan, Y.C.2    Liang, H.F.3    Sung, H.W.4
  • 130
    • 0030864524 scopus 로고    scopus 로고
    • Preparation and scanning electronic microscopy study of chitosan/polyvinyl (alcohol)-encapsulated crude urease extract
    • Miguez M.J., Rodrigues B.C., Sanchez Mde N., Laranjeira M.C. Preparation and scanning electronic microscopy study of chitosan/polyvinyl (alcohol)-encapsulated crude urease extract. J. Microencapsul. 14:1997;639-646.
    • (1997) J. Microencapsul. , vol.14 , pp. 639-646
    • Miguez, M.J.1    Rodrigues, B.C.2    Sanchez Mde, N.3    Laranjeira, M.C.4
  • 131
    • 85007752510 scopus 로고
    • Adsorption of benzoic acid and its derivatives to swollen chitson beads
    • Mitani T., Tamashita T., Okaumura C., Ishii H. Adsorption of benzoic acid and its derivatives to swollen chitson beads. Biosci. Biotech. Biochem. 59:1995;927-928.
    • (1995) Biosci. Biotech. Biochem. , vol.59 , pp. 927-928
    • Mitani, T.1    Tamashita, T.2    Okaumura, C.3    Ishii, H.4
  • 132
    • 0028556843 scopus 로고
    • In vitro effects of brain derived neurotrophic factor released from microspheres
    • Mittal S., Cohen A., Maysinger D. In vitro effects of brain derived neurotrophic factor released from microspheres. Neuroreport. 5:1994;2577-2582.
    • (1994) Neuroreport , vol.5 , pp. 2577-2582
    • Mittal, S.1    Cohen, A.2    Maysinger, D.3
  • 133
    • 0019817431 scopus 로고
    • Use of chitin and chitosan as drug carriers
    • Miyazaki S., Ishii K., Nadai T. Use of chitin and chitosan as drug carriers. Chem. Pharm. Bull. 29:1981;3067-3069.
    • (1981) Chem. Pharm. Bull. , vol.29 , pp. 3067-3069
    • Miyazaki, S.1    Ishii, K.2    Nadai, T.3
  • 134
    • 0025651471 scopus 로고
    • Use of chitosan as a pharmaceutical material effectiveness as an additional additive of sodium alginate
    • Miyazaki T., Komuro T., Yomota C., Okada S. Use of chitosan as a pharmaceutical material effectiveness as an additional additive of sodium alginate. Eisei Shikenjo Hokoku. 108:1990;95-97.
    • (1990) Eisei Shikenjo Hokoku , vol.108 , pp. 95-97
    • Miyazaki, T.1    Komuro, T.2    Yomota, C.3    Okada, S.4
  • 135
    • 0031939288 scopus 로고    scopus 로고
    • Influence of chitosan microspheres on the transport of prednisolone sodium phosphate across HT-29 cell monolayers
    • Mooren F.C., Berthold A., Domschke W., Kreuter J. Influence of chitosan microspheres on the transport of prednisolone sodium phosphate across HT-29 cell monolayers. Pharm. Res. 15:1998;58-65.
    • (1998) Pharm. Res. , vol.15 , pp. 58-65
    • Mooren, F.C.1    Berthold, A.2    Domschke, W.3    Kreuter, J.4
  • 136
    • 0027178518 scopus 로고
    • Preparation of chitosan-reinforced alginate gel beads - Effects of chitosan on gel matrix erosion
    • Murata Y., Maeda T., Miyamoto E., Kawashima S. Preparation of chitosan-reinforced alginate gel beads - effects of chitosan on gel matrix erosion. Int. J. Pharm. 96:1993;139-145.
    • (1993) Int. J. Pharm. , vol.96 , pp. 139-145
    • Murata, Y.1    Maeda, T.2    Miyamoto, E.3    Kawashima, S.4
  • 137
    • 0029968402 scopus 로고    scopus 로고
    • Additive effect of chondroitin sulfate and chitosan on drug release from calcium-induced alginate gel beads
    • Murata Y., Miyamoto E., Kawashima S. Additive effect of chondroitin sulfate and chitosan on drug release from calcium-induced alginate gel beads. J. Control Rel. 38:1996;101-108.
    • (1996) J. Control Rel. , vol.38 , pp. 101-108
    • Murata, Y.1    Miyamoto, E.2    Kawashima, S.3
  • 138
    • 15144340539 scopus 로고
    • Morophogenetic action of chitosan and growth factors-fibroblast encapsulation in chitosan gel
    • Italy.
    • Muzzarelli, R.A.A., 1994. Morophogenetic action of chitosan and growth factors-fibroblast encapsulation in chitosan gel. In: Proceedings of Workshop on Cell Cultures, Italy.
    • (1994) Proceedings of Workshop on Cell Cultures
    • Muzzarelli, R.A.A.1
  • 139
    • 0004184147 scopus 로고
    • Pergamon Press, New York
    • Muzzarelli, R.A.A., 1977. Chitin. Pergamon Press, New York, pp. 1-37.
    • (1977) Chitin , pp. 1-37
    • Muzzarelli, R.A.A.1
  • 140
    • 1842623072 scopus 로고
    • Treating hyperbilirubinemia. US Patent 4,363,801.
    • Nagyuvary, J.J., 1982. Treating hyperbilirubinemia. US Patent 4,363,801.
    • (1982)
    • Nagyuvary, J.J.1
  • 141
    • 0035217005 scopus 로고    scopus 로고
    • Impregnation and release of aspirin from chitosan/poly(acrylic acid) graft copolymer microspheres
    • Nascimento A., Laranjeira M.C., Favere V.T., Josue A. Impregnation and release of aspirin from chitosan/poly(acrylic acid) graft copolymer microspheres. J. Microencapsul. 18:2001;679-684.
    • (2001) J. Microencapsul. , vol.18 , pp. 679-684
    • Nascimento, A.1    Laranjeira, M.C.2    Favere, V.T.3    Josue, A.4
  • 142
    • 0025174935 scopus 로고
    • Investigation of prolonged drug release from matrix formulations of chitosan
    • Nigalaye A.G., Adusumilli P., Bolton S. Investigation of prolonged drug release from matrix formulations of chitosan. Drug Dev. Ind. Pharm. 16:1990;449-467.
    • (1990) Drug Dev. Ind. Pharm. , vol.16 , pp. 449-467
    • Nigalaye, A.G.1    Adusumilli, P.2    Bolton, S.3
  • 143
    • 0029049604 scopus 로고
    • In vitro assessment of bioadhesion for periodontal and buccal drug delivery
    • Needleman I.G., Smales F.C. In vitro assessment of bioadhesion for periodontal and buccal drug delivery. Biomaterials. 16:1995;617-624.
    • (1995) Biomaterials , vol.16 , pp. 617-624
    • Needleman, I.G.1    Smales, F.C.2
  • 144
    • 0022816347 scopus 로고
    • Macrophage attraction with multiporous beads prepared from practically deacetylated chitin
    • Nishimura K., Nishimura S., Seo H., Nishi N.M., Tokura I. Macrophage attraction with multiporous beads prepared from practically deacetylated chitin. J. Biomed. Mater. Res. 20:1986;1359-1372.
    • (1986) J. Biomed. Mater. Res. , vol.20 , pp. 1359-1372
    • Nishimura, K.1    Nishimura, S.2    Seo, H.3    Nishi, N.M.4    Tokura, I.5
  • 147
    • 0036236114 scopus 로고    scopus 로고
    • Localized delivery of paclitaxel in solid tumors from biodegradable chitin microparticle formulations
    • Nsereko S., Amiji M. Localized delivery of paclitaxel in solid tumors from biodegradable chitin microparticle formulations. Biomaterials. 23:2002;2723-2731.
    • (2002) Biomaterials , vol.23 , pp. 2723-2731
    • Nsereko, S.1    Amiji, M.2
  • 148
    • 1842570983 scopus 로고
    • Immobilization of alphagalactosidase and glucoamylases on crosslined chitosan beads
    • Chitin and Chitosan-Source, Chemistry.
    • Ohtakara, A., Mukerjee, G., Mitsutomi, M., 1989a. Immobilization of alphagalactosidase and glucoamylases on crosslined chitosan beads. In: Chitin and Chitosan-Source, Chemistry. Biomed. Mater Res. 20, 1359-1375.
    • (1989) Biomed. Mater Res. , vol.20 , pp. 1359-1375
    • Ohtakara, A.1    Mukerjee, G.2    Mitsutomi, M.3
  • 150
    • 0027468519 scopus 로고
    • Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition
    • Ohya Y., Takei T., Kobayashi H., Ouchi T. Release behaviour of 5-fluorouracil from chitosan-gel microspheres immobilizing 5-fluorouracil derivative coated with polysaccharides and their cell specific recognition. J. Microencapsul. 10:1993;1-9.
    • (1993) J. Microencapsul. , vol.10 , pp. 1-9
    • Ohya, Y.1    Takei, T.2    Kobayashi, H.3    Ouchi, T.4
  • 152
    • 0030035685 scopus 로고    scopus 로고
    • Indomethacin loaded chitosan microspheres. Correlation between the erosion process and release kinetics
    • Orienti I., Aiedeh K., Gianasi E., Bertasi V., Zecchi V. Indomethacin loaded chitosan microspheres. Correlation between the erosion process and release kinetics. J. Microencapsul. 13:1996;463-472.
    • (1996) J. Microencapsul. , vol.13 , pp. 463-472
    • Orienti, I.1    Aiedeh, K.2    Gianasi, E.3    Bertasi, V.4    Zecchi, V.5
  • 153
    • 0036560435 scopus 로고    scopus 로고
    • Controlled release of interleukin-2 from chitosan microspheres
    • Ozbas-Turan S., Akbuga J., Aral C. Controlled release of interleukin-2 from chitosan microspheres. J. Pharm. Sci. 91:2002;1245-1251.
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1245-1251
    • Ozbas-Turan, S.1    Akbuga, J.2    Aral, C.3
  • 154
    • 0038725718 scopus 로고    scopus 로고
    • Co-encapsulation of two plasmids in chitosan microspheres as a non-viral gene delivery vehicle
    • Ozbas-Turan S., Aral C., Kabasakal L., Keyer-Uysal M., Akbuga J. Co-encapsulation of two plasmids in chitosan microspheres as a non-viral gene delivery vehicle. J. Pharm. Pharm. Sci. 6:2003;27-32.
    • (2003) J. Pharm. Pharm. Sci. , vol.6 , pp. 27-32
    • Ozbas-Turan, S.1    Aral, C.2    Kabasakal, L.3    Keyer-Uysal, M.4    Akbuga, J.5
  • 155
    • 0002545341 scopus 로고
    • Diffusion characteristics and properties of chitosan coacervate capsules
    • Pandya Y., Knorr D. Diffusion characteristics and properties of chitosan coacervate capsules. Proc. Biochem. 26:1991;75-81.
    • (1991) Proc. Biochem. , vol.26 , pp. 75-81
    • Pandya, Y.1    Knorr, D.2
  • 156
    • 0030747547 scopus 로고    scopus 로고
    • Preparation and evaluation of chitosan microspheres containing bisphosphonates
    • Patashnik S., Rabinovich L., Golomb G. Preparation and evaluation of chitosan microspheres containing bisphosphonates. J. Drug Target. 4:1997;371-380.
    • (1997) J. Drug Target , vol.4 , pp. 371-380
    • Patashnik, S.1    Rabinovich, L.2    Golomb, G.3
  • 157
    • 0029951322 scopus 로고    scopus 로고
    • Evaluation of process parameters involved in chitosan microsphere preparation by the o/w/o multiple emulsion method
    • Pavanetto F., Perugini P., Conti B., Modena T., Genta I. Evaluation of process parameters involved in chitosan microsphere preparation by the o/w/o multiple emulsion method. J. Microencapsul. 13:1996;679-688.
    • (1996) J. Microencapsul. , vol.13 , pp. 679-688
    • Pavanetto, F.1    Perugini, P.2    Conti, B.3    Modena, T.4    Genta, I.5
  • 158
    • 0028225381 scopus 로고
    • Controlled release of albumin from chitosan-alginate microcapsules
    • Polk A., Amsden B., De Yao K., Peng T., Goosen M.F. Controlled release of albumin from chitosan-alginate microcapsules. J. Pharm. Sci. 83:1994;178-185.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 178-185
    • Polk, A.1    Amsden, B.2    De Yao, K.3    Peng, T.4    Goosen, M.F.5
  • 159
    • 0036827501 scopus 로고    scopus 로고
    • Reacetylated chitosan microspheres for controlled delivery of anti-microbial agents to the gastric mucosa
    • Portero A., Remunan-Lopez C., Criado M.T., Alonso M.J. Reacetylated chitosan microspheres for controlled delivery of anti-microbial agents to the gastric mucosa. J. Microencapsul. 19:2002;797-809.
    • (2002) J. Microencapsul. , vol.19 , pp. 797-809
    • Portero, A.1    Remunan-Lopez, C.2    Criado, M.T.3    Alonso, M.J.4
  • 160
    • 0034004164 scopus 로고    scopus 로고
    • Surface & blood interaction properties of polyethylene oxide modified chitosan microspheres
    • Queen M.C., Silvia C., Lai A., Amiji P.M.C. Surface & blood interaction properties of polyethylene oxide modified chitosan microspheres. STP Pharm. Sci. 10:2000;95-100.
    • (2000) STP Pharm. Sci. , vol.10 , pp. 95-100
    • Queen, M.C.1    Silvia, C.2    Lai, A.3    Amiji, P.M.C.4
  • 161
    • 0032586798 scopus 로고    scopus 로고
    • Alginate encapsulated bioadhesive chitosan microspheres for intestinal drug delivery
    • Ramdas M., Dileep K.J., Anitha Y., Paul W., Sharma C.P. Alginate encapsulated bioadhesive chitosan microspheres for intestinal drug delivery. J. Biomater. Appl. 13:1999;290-296.
    • (1999) J. Biomater. Appl. , vol.13 , pp. 290-296
    • Ramdas, M.1    Dileep, K.J.2    Anitha, Y.3    Paul, W.4    Sharma, C.P.5
  • 163
    • 0032857897 scopus 로고    scopus 로고
    • Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres
    • Ribeiro A.J., Neufeld R.J., Arnaud P., Chaumeil J.C. Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres. Int. J. Pharm. 187:1999;115-123.
    • (1999) Int. J. Pharm. , vol.187 , pp. 115-123
    • Ribeiro, A.J.1    Neufeld, R.J.2    Arnaud, P.3    Chaumeil, J.C.4
  • 164
    • 0029012511 scopus 로고
    • Modelling mucoadhesion by use of surface energy terms obtained from the Lewis acid-Lewis base approach. II. Studies on anionic, cationic and unionisable polymers
    • Rillosi M., Buckton G. Modelling mucoadhesion by use of surface energy terms obtained from the Lewis acid-Lewis base approach. II. Studies on anionic, cationic and unionisable polymers. Pharm. Res. 12:1995;669-675.
    • (1995) Pharm. Res. , vol.12 , pp. 669-675
    • Rillosi, M.1    Buckton, G.2
  • 165
    • 0004169627 scopus 로고
    • Mac Millian Press, Houndmills
    • Roberts, G.A.F., 1992. Chitin Chemistry. Mac Millian Press, Houndmills, pp. 1-50.
    • (1992) Chitin Chemistry , pp. 1-50
    • Roberts, G.A.F.1
  • 166
    • 0031390929 scopus 로고    scopus 로고
    • Use of chitosan in compressed tablets of diclofenac sodium: Inhibition of drug release in an acidic environment
    • Sabnis S., Rege P., Block L.H. Use of chitosan in compressed tablets of diclofenac sodium: inhibition of drug release in an acidic environment. Pharm. Dev. Technol. 2:1997;243-255.
    • (1997) Pharm. Dev. Technol. , vol.2 , pp. 243-255
    • Sabnis, S.1    Rege, P.2    Block, L.H.3
  • 167
    • 0035098467 scopus 로고    scopus 로고
    • Chitosan based pentazocine microspheres for intranasal systemic delivery: Development and biopharmaceutical evaluation
    • Sankar C., Rani M., Srivastava A.K., Mishra B. Chitosan based pentazocine microspheres for intranasal systemic delivery: development and biopharmaceutical evaluation. Pharmazie. 56:2001;223-226.
    • (2001) Pharmazie , vol.56 , pp. 223-226
    • Sankar, C.1    Rani, M.2    Srivastava, A.K.3    Mishra, B.4
  • 168
    • 0020449039 scopus 로고
    • Enhancement of dissolution properties of griseofulvin from ground mixtures with chitin and chitosan
    • Sawayanagi Y., Nambu N., Nagai T. Enhancement of dissolution properties of griseofulvin from ground mixtures with chitin and chitosan. Chem. Pharm. Bull. 30:1982a;4464-4467.
    • (1982) Chem. Pharm. Bull. , vol.30 , pp. 4464-4467
    • Sawayanagi, Y.1    Nambu, N.2    Nagai, T.3
  • 169
    • 0020364684 scopus 로고
    • Permeation of drugs through chitosan membranes
    • Sawayanagi Y., Nambu N., Nagai T. Permeation of drugs through chitosan membranes. Chem. Pharm. Bull. 30:1982b;3297-3301.
    • (1982) Chem. Pharm. Bull. , vol.30 , pp. 3297-3301
    • Sawayanagi, Y.1    Nambu, N.2    Nagai, T.3
  • 170
    • 0020561577 scopus 로고
    • Dissolution properties and bioavailability of phenytoin from ground mixtures with chitin or chitosan
    • Sawayanagi Y., Nambu N., Nagai T. Dissolution properties and bioavailability of phenytoin from ground mixtures with chitin or chitosan. Chem. Pharm. Bull. (Tokyo). 31:1983;2064-2068.
    • (1983) Chem. Pharm. Bull. (Tokyo) , vol.31 , pp. 2064-2068
    • Sawayanagi, Y.1    Nambu, N.2    Nagai, T.3
  • 171
    • 0030455292 scopus 로고    scopus 로고
    • Chitosan as absorption enhancers for poorly absorbable drugs. 1: Influence of molecular weight and degree of acetylation on drug transport across human epithelial (Caco-2) cells
    • Schipper N.G.M., Varum K.M., Artursson P. Chitosan as absorption enhancers for poorly absorbable drugs. 1: Influence of molecular weight and degree of acetylation on drug transport across human epithelial (Caco-2) cells. Pharm. Res. 13:1996;1686-1692.
    • (1996) Pharm. Res. , vol.13 , pp. 1686-1692
    • Schipper, N.G.M.1    Varum, K.M.2    Artursson, P.3
  • 172
    • 0030787377 scopus 로고    scopus 로고
    • Chitosans as absorption enhancers for poorly absorbable drugs. 2: Mechanism of absorption enhancement
    • Schipper N.G.M., Olsson S., Hoogstraate J.A., de Boer A.G., Varum K.M., Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs. 2: Mechanism of absorption enhancement. Pharm. Res. 14:1997;923-929.
    • (1997) Pharm. Res. , vol.14 , pp. 923-929
    • Schipper, N.G.M.1    Olsson, S.2    Hoogstraate, J.A.3    De Boer, A.G.4    Varum, K.M.5    Artursson, P.6
  • 173
    • 0029073777 scopus 로고
    • Controlled release of piroxicam from chitosan beads
    • Sezer A.D., Akbuga J. Controlled release of piroxicam from chitosan beads. Int. J. Pharm. 121:1995;113-116.
    • (1995) Int. J. Pharm. , vol.121 , pp. 113-116
    • Sezer, A.D.1    Akbuga, J.2
  • 174
    • 0032768423 scopus 로고    scopus 로고
    • Evaluation of the factors influencing stomach-specific delivery of antibacterial agents for Helicobacter pylori infection
    • Shah S., Qaqish R., Patel V., Amiji M. Evaluation of the factors influencing stomach-specific delivery of antibacterial agents for Helicobacter pylori infection. J. Pharm. Pharmacol. 51:1999;667-672.
    • (1999) J. Pharm. Pharmacol. , vol.51 , pp. 667-672
    • Shah, S.1    Qaqish, R.2    Patel, V.3    Amiji, M.4
  • 175
    • 0034862390 scopus 로고    scopus 로고
    • Bioadhesive characteristics of chitosan microspheres to the mucosa of rat small intestine
    • Shimoda J., Onishi H., Machida Y. Bioadhesive characteristics of chitosan microspheres to the mucosa of rat small intestine. Drug Dev Ind. Pharm. 27:2001;567-576.
    • (2001) Drug Dev Ind. Pharm. , vol.27 , pp. 567-576
    • Shimoda, J.1    Onishi, H.2    MacHida, Y.3
  • 176
    • 0002724879 scopus 로고
    • Tramsmembrane permeability of chitosan/carboxymethyl cellulose capsules
    • Skjak-Braek, G., Anthonsen, T., Sanford, P. (Eds.), Elsevier, London
    • Shioya, T., Rha, C., 1989. Tramsmembrane permeability of chitosan/carboxymethyl cellulose capsules. In: Skjak-Braek, G., Anthonsen, T., Sanford, P. (Eds.), Chitin and Chitosan-Source, Chemistry, Biochemistry, Physical Properties and Application. Elsevier, London, pp. 627-634.
    • (1989) Chitin and Chitosan-Source, Chemistry, Biochemistry, Physical Properties and Application , pp. 627-634
    • Shioya, T.1    Rha, C.2
  • 177
    • 0025215648 scopus 로고
    • Enhancement of dissolution rates of several drugs by low-molecular weight chitosan and alginate
    • Shiraishi S., Arahira M., Imai T., Otagiri M. Enhancement of dissolution rates of several drugs by low-molecular weight chitosan and alginate. Chem. Pharm. Bull. 38:1990;185-187.
    • (1990) Chem. Pharm. Bull. , vol.38 , pp. 185-187
    • Shiraishi, S.1    Arahira, M.2    Imai, T.3    Otagiri, M.4
  • 178
    • 0027258318 scopus 로고
    • Controlled release of indomethacin by chitosan-polyelectrolyte complex: Optimization and in vivo/in vitro evaluation
    • Shiraishi S., Imai T., Otagiri M. Controlled release of indomethacin by chitosan-polyelectrolyte complex: optimization and in vivo/in vitro evaluation. J. Control Rel. 25:1993;217-225.
    • (1993) J. Control Rel. , vol.25 , pp. 217-225
    • Shiraishi, S.1    Imai, T.2    Otagiri, M.3
  • 179
    • 0035117746 scopus 로고    scopus 로고
    • Chitosan/gelatin microspheres prepared by modified emulsification and ionotropic gelation
    • Shu X.Z., Zhu K.J. Chitosan/gelatin microspheres prepared by modified emulsification and ionotropic gelation. J. Microencapsul. 18:2001;237-245.
    • (2001) J. Microencapsul. , vol.18 , pp. 237-245
    • Shu, X.Z.1    Zhu, K.J.2
  • 180
    • 0037148687 scopus 로고    scopus 로고
    • Controlled drug release properties of ionically cross-linked chitosan beads: The influence of anion structure
    • Shu X.Z., Zhu K.J. Controlled drug release properties of ionically cross-linked chitosan beads: the influence of anion structure. Int. J. Pharm. 233:2002a;217-225.
    • (2002) Int. J. Pharm. , vol.233 , pp. 217-225
    • Shu, X.Z.1    Zhu, K.J.2
  • 181
    • 0036191261 scopus 로고    scopus 로고
    • The release behavior of brilliant blue from calcium-alginate gel beads coated by chitosan: The preparation method effect
    • Shu X.Z., Zhu K.J. The release behavior of brilliant blue from calcium-alginate gel beads coated by chitosan: the preparation method effect. Eur. J. Pharm. Biopharm. 53:2002b;193-201.
    • (2002) Eur. J. Pharm. Biopharm. , vol.53 , pp. 193-201
    • Shu, X.Z.1    Zhu, K.J.2
  • 182
    • 0031710698 scopus 로고    scopus 로고
    • Methotrexate loaded chitosan and chitin microspheres - In vitro characterization and pharmacokinetics in mice bearing Ehrlich ascites carcinoma
    • Singh U.V., Udupa N. Methotrexate loaded chitosan and chitin microspheres - in vitro characterization and pharmacokinetics in mice bearing Ehrlich ascites carcinoma. J. Microencapsul. 15:1998;581-594.
    • (1998) J. Microencapsul. , vol.15 , pp. 581-594
    • Singh, U.V.1    Udupa, N.2
  • 183
    • 0035179501 scopus 로고    scopus 로고
    • Nifedipine loaded chitosan microspheres: Characterization of internal structure
    • Singla A.K., Sharma M.L., Dhawan S. Nifedipine loaded chitosan microspheres: characterization of internal structure. Biotech. Histochem. 76:2001;165-171.
    • (2001) Biotech. Histochem. , vol.76 , pp. 165-171
    • Singla, A.K.1    Sharma, M.L.2    Dhawan, S.3
  • 184
    • 0034879035 scopus 로고    scopus 로고
    • Chitosan: Some pharmaceutical and biological aspects - An update
    • Singla A.K., Chawla M. Chitosan: some pharmaceutical and biological aspects - an update. J. Pharm. Pharmacol. 53:2001;1047-1067.
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 1047-1067
    • Singla, A.K.1    Chawla, M.2
  • 185
    • 0004078794 scopus 로고
    • Chitosan - New biopolymer for cosmetics and drugs
    • Skaugrud O. Chitosan - new biopolymer for cosmetics and drugs. Drug Cosmetic Ind. 148:1991;24-29.
    • (1991) Drug Cosmetic Ind. , vol.148 , pp. 24-29
    • Skaugrud, O.1
  • 187
    • 0032815654 scopus 로고    scopus 로고
    • Microspheres of chitosan/poly(vinylalcohol) incorporating tetrasulphonated copper (II) phthalocyanine: Preparation and characterization
    • Stolberg J., Laranjeira M.C., Sanchez M.N., Klug M., Favere V.T. Microspheres of chitosan/poly(vinylalcohol) incorporating tetrasulphonated copper (II) phthalocyanine: preparation and characterization. J. Microencapsul. 16:1999;431-438.
    • (1999) J. Microencapsul. , vol.16 , pp. 431-438
    • Stolberg, J.1    Laranjeira, M.C.2    Sanchez, M.N.3    Klug, M.4    Favere, V.T.5
  • 188
    • 0009915005 scopus 로고
    • Biodegradation of chitosan
    • Karnicki, Z.S., Wojtascpajak, A., Breziski, M.M., Bylowsky, P.J. (Eds.), Brenerhaven Wirtschaftsverlag
    • Struszczyk, H., Niekraszewicz, A., Owczarek, K., Wishiewska-Wrona, M., 1994. Biodegradation of chitosan. In: Karnicki, Z.S., Wojtascpajak, A., Breziski, M.M., Bylowsky, P.J. (Eds.), Chitin World. Brenerhaven Wirtschaftsverlag, pp. 555-561.
    • (1994) Chitin World , pp. 555-561
    • Struszczyk, H.1    Niekraszewicz, A.2    Owczarek, K.3    Wishiewska-Wrona, M.4
  • 189
    • 0037788529 scopus 로고    scopus 로고
    • Preparation of silver sulfadiazine-containing spongy membranes of chitosan and chitin-chitosan mixture and their evaluation as burn wound dressings
    • Tachihara K., Onishi H., Machida Y. Preparation of silver sulfadiazine-containing spongy membranes of chitosan and chitin-chitosan mixture and their evaluation as burn wound dressings. Arch. Practical Pharm. 57:1997;159-167.
    • (1997) Arch. Practical Pharm. , vol.57 , pp. 159-167
    • Tachihara, K.1    Onishi, H.2    MacHida, Y.3
  • 190
    • 0025316768 scopus 로고
    • Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate
    • Takahashi T., Takayama K., Machida Y., Nagai T. Characteristics of polyion complexes of chitosan with sodium alginate and sodium polyacrylate. Int. J. Pharm. 61:1990;35-41.
    • (1990) Int. J. Pharm. , vol.61 , pp. 35-41
    • Takahashi, T.1    Takayama, K.2    MacHida, Y.3    Nagai, T.4
  • 191
    • 1842518606 scopus 로고    scopus 로고
    • Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats
    • Takishima J., Onishi H., Machida Y. Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats. Biol. Pharm. Bull. 25:2002;1498-1502.
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 1498-1502
    • Takishima, J.1    Onishi, H.2    MacHida, Y.3
  • 192
    • 0027300501 scopus 로고
    • Factors influencing the mechanism of release from sustained release matrix pellets, produced by extrusion/spheronization
    • Tapia C., Buckton G., Newton J.M. Factors influencing the mechanism of release from sustained release matrix pellets, produced by extrusion/ spheronization. Int. J. Pharm. 92:1993;211-218.
    • (1993) Int. J. Pharm. , vol.92 , pp. 211-218
    • Tapia, C.1    Buckton, G.2    Newton, J.M.3
  • 193
    • 0026530398 scopus 로고
    • Cross-linked chitosan microspheres: Preparation and evaluation as a matrix for the controlled release of pharmaceuticals
    • Thanoo B.C., Sunny M.C., Jayakrishnan A. Cross-linked chitosan microspheres: preparation and evaluation as a matrix for the controlled release of pharmaceuticals. J. Pharm. Pharmacol. 44:1992;283-286.
    • (1992) J. Pharm. Pharmacol. , vol.44 , pp. 283-286
    • Thanoo, B.C.1    Sunny, M.C.2    Jayakrishnan, A.3
  • 194
    • 0033017771 scopus 로고    scopus 로고
    • Preparation of gadopentetic acid-loaded chitosan microparticles for gadolinium neutron-capture therapy of cancer by a novel emulsion-droplet coalescence technique
    • Tokumitsu H., Ichikawa H., Fukumori Y., Block L.H. Preparation of gadopentetic acid-loaded chitosan microparticles for gadolinium neutron-capture therapy of cancer by a novel emulsion-droplet coalescence technique. Chem. Pharm. Bull. (Tokyo). 47:1999;838-842.
    • (1999) Chem. Pharm. Bull. (Tokyo) , vol.47 , pp. 838-842
    • Tokumitsu, H.1    Ichikawa, H.2    Fukumori, Y.3    Block, L.H.4
  • 197
    • 0342589407 scopus 로고
    • Indomethacin microspheres. I. Formulation and in vitro evaluation
    • Vural I., Kao H.S., Hincali A.A. Indomethacin microspheres. I. Formulation and in vitro evaluation. Chimica Oggi. 9:1991;49-52.
    • (1991) Chimica Oggi. , vol.9 , pp. 49-52
    • Vural, I.1    Kao, H.S.2    Hincali, A.A.3
  • 198
    • 1842518604 scopus 로고
    • Chitosan-treated albumin microspheres of sulfasalazine. Part 1. Formulation and in vitro release profiles
    • Vural I., Kas H.S., Hincal A.A. Chitosan-treated albumin microspheres of sulfasalazine. Part 1. Formulation and in vitro release profiles. Hacettepe Universitesi Eczacilik Fakultesi Dergisi. 14:1994;57-65.
    • (1994) Hacettepe Universitesi Eczacilik Fakultesi Dergisi , vol.14 , pp. 57-65
    • Vural, I.1    Kas, H.S.2    Hincal, A.A.3
  • 199
  • 200
    • 0030325890 scopus 로고    scopus 로고
    • Studies on preparation and characteristics of cisplatin chitosan microspheres
    • Wang Y.M., Shi T.S., Pu Y.L., Zhu J.G., Zhao Y.L. Studies on preparation and characteristics of cisplatin chitosan microspheres. Yao Xue Xue Bao. 31:1996a;300-305.
    • (1996) Yao Xue Xue Bao , vol.31 , pp. 300-305
    • Wang, Y.M.1    Shi, T.S.2    Pu, Y.L.3    Zhu, J.G.4    Zhao, Y.L.5
  • 201
    • 0000440228 scopus 로고    scopus 로고
    • Optimization of the formulation design of chitosan microspheres containing cisplatin
    • Wang Y.M., Sato H., Adachi I., Horikoshi I. Optimization of the formulation design of chitosan microspheres containing cisplatin. J. Pharm. Sci. 85:1996b;1204-1210.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1204-1210
    • Wang, Y.M.1    Sato, H.2    Adachi, I.3    Horikoshi, I.4
  • 202
    • 0037028008 scopus 로고    scopus 로고
    • Design of controlled-release solid dosage forms of alginate and chitosan using microwave
    • Wong T.W., Chan L.W., Kho S.B., Sia Heng P.W. Design of controlled-release solid dosage forms of alginate and chitosan using microwave. J. Control Rel. 84:2002;99-114.
    • (2002) J. Control Rel. , vol.84 , pp. 99-114
    • Wong, T.W.1    Chan, L.W.2    Kho, S.B.3    Sia Heng, P.W.4
  • 203
    • 0141501329 scopus 로고    scopus 로고
    • Preparation of genistein-loaded chitosan microspheres
    • Wu W.Y., Li Y.G. Preparation of genistein-loaded chitosan microspheres. Zhongguo Zhong Yao Za Zhi. 27:2002;353-355.
    • (2002) Zhongguo Zhong Yao Za Zhi , vol.27 , pp. 353-355
    • Wu, W.Y.1    Li, Y.G.2
  • 204
    • 0035082959 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of sustained release chitosan-coated ketoprofen microparticles
    • Yamada T., Onishi H., Machida Y. In vitro and in vivo evaluation of sustained release chitosan-coated ketoprofen microparticles. Yakugaku Zasshi. 121:2001;239-245.
    • (2001) Yakugaku Zasshi , vol.121 , pp. 239-245
    • Yamada, T.1    Onishi, H.2    MacHida, Y.3
  • 205
    • 0038641842 scopus 로고    scopus 로고
    • Preparation and characterization of chitosan microspheres containing doxifluridine
    • Yoshino T., Machida Y., Onishi H., Nagai T. Preparation and characterization of chitosan microspheres containing doxifluridine. Drug Dev. Ind. Pharm. 29:2003;417-427.
    • (2003) Drug Dev. Ind. Pharm. , vol.29 , pp. 417-427
    • Yoshino, T.1    MacHida, Y.2    Onishi, H.3    Nagai, T.4


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