Preparation and evaluation of chitosan microspheres containing bisphosphonates

Journal of Drug Targeting

Volumn 4, Issue 6, 1997, Pages 371-380

  Patashnik, Shulamit ^a   Rabinovich, Laura ^a   Golomb, Gershon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Bisphosphonates; Calcium related disorders; Chitosan; Controlled release; Drug delivery systems; Drug implants; Implantable; Osteolysis

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CHITOSAN; MICROSPHERE; PAMIDRONIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; BONE DESTRUCTION; CALCIFICATION; CELL CULTURE; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISPOSITION; DRUG FORMULATION; DRUG IMPLANT; DRUG RELEASE; DRUG TISSUE LEVEL; ENDOTHELIUM CELL; FEMUR; INTRADERMAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TIBIA; TIBIALIS ANTERIOR MUSCLE;

EID: 0030747547     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869709017894     Document Type: Article

References (48)

1. Akbuga. J. and Durmaz, G. (1994) Preparation and evaluation of cross-linked chitosan microspheres containing furosemide. Int. J. Pharm., 111, 217-222.
2. Averbuch, S. D. (1993) New bisphosphonates in the treatment of bone metastases. Cancer, 72, 3443-3452.
3. Brunner, K. W., Fleisch, H. and Senn, H.-J. (1989) Bisphosphonates and tumor osteolysis. Recent results in cancer research, Vol. 116 (Berlin-Heidelberg: Springer-Verlag), pp. 79.
4. Chandy, T. and Sharma, C. (1993) Chitosan matrix for oral sustained delivery of ampicllin. Biomaterials, 14, 939-944.
5. Chandy, T. and Sharma, C. P. (1990) Chitosan as a biomaterial. Biomat. Art. Cells. Art. Org., 18, 1-24.
6. Chithambara, T. B., Sunny, M. C. and Jayakrishnan, A. (1992) Cross-linked chitosan microspheres: preparations and evaluation as a matrix for the controlled release of pharmaceuticals. J. Pharm. Pharmacol., 44, 283-286.
7. Curotto, E. and Aros, F. (1993) Quantitative determination of chitosan and the percentage of free amino groups. Analytical Biochemistry, 211, 240-241.
8. Demssen, H., van Beek, E., Lowik, C., Papapoulos, S. and van den Hooff, A. (1994) Ceramic hydroxyapatite implants for the release of bisphosphonate. Bone and Min., 25, 123-134.
9. Emerich, D. F., Frydel, B. R., Flanagan, T. R., Palmatier, M., Win, S, R. and Christenson, L. (1993) Transplantation of polymer encapsulated PC 12 cells: Use of chitosan as an immobilization matrix. Cell Transplantation, 2, 241-249.
10. Fleisch, H. (1993) Bisphosphonates: Mechanism of action and clinical use. In Mundy, G. R. and Martin, T. J. (eds). Physiology and Pharmacology of Bone (Heidelberg: Springer-Verlag).
11. Fleisch, H. (1995) Bisphosphonates in bone disease: From the laboratory to the patient. (2nd edn) (NY and London: The Parthenon Publishing Group).
12. Francis, R. M. (1995) Oral bisphosphonates in the treatment of osteoporosis: a review. Current Therapeutic Research, 56, 831-851.
13. Garret, I. R. (1993) Bone destruction in cancer. Sem. Oncol., 20, 4-9.
14. Geddes, A. D., D'Souza, S. M., Ebetino. F. H. and Ibbotson, K. J. (1994) Bisphosphonates: structure-activity relationships and therapeutic implications. In Heersche. J. N. M. and Kanis, J. A. (eds), Bone and Mineral Research. 8. pp. 265-306.
15. Golomb, C. (1987) Controlled-release of diphosphonate from synthetic polymers to inhibit calcification. J. Biomaierials Applications, 2, 266-288.
16. Golomb, G., Dixon, M, Smith, M., Schoen, F. J. and Levy, R, J. (1986a) Inhibition of bioprosthetic heart valve calcification by sustained local delivery of Ca and Na diphosphonate via controlled release matrices. Trans. Am. Soc. Artif. Intern. Organs, XXXII, 587-590.
17. Golomb, G., Dixon, M., Smith, M. S., Schoen, F. J and Levy, R. J. (1987) Controlled-release drug delivery of diphosphonates to inhibit bioprosthetic heart valve calcification: release rate modulation with silicone matrices via drug solubility and membrane coating. J. Pharm. Sci., 76, 271-276.
18. 3H]tetracycline kinetics and indices of kidney function facilitate study of the activity and toxic effects of bisphosphonates in bone resorption. Pharm. Res., 9, 1022-1027.
19. Golomb, G., Langer, R., Schoen, F. J., Smith. S. M., Choi, Y. and Levy, R J. (1986b) Controlled release of diphosphonate to inhibit bioprosthetic heart valve calcification: Dose-response and mechanistic studies. J. Controlled Rel., 4, 181-194.
20. Golomb, G., Levi, M. and Van Gelder, J. M, (1992b) Controlled release of bisphosphonates from a biodegradable implant: Evaluation of release kinetics and anticalcification effect. J. Appl. Biomater., 3, 23-28.
21. Golomb, G., Schlossman, A., Saadeh, H., Levi, M., Van Gelder, J. M. and Breuer, E. (1992c) Bisacylphosphonates inhibit hydroxyapatite formation and dissolution in vitro and dystrophic calcification in vivo. Pharm. Res., 9, 143-148.
22. Golomb, G. and Wagner, D. (1992) Characterization and anticalcification effects of implantable polyurethane matrices containing amorphous dispersion of bisphosphonic acid. Clinical Materials, 8, 33-42.
23. Henriksen, I., Smistad, G. and Karlsen, J. (1994) Interactions between liposomes and chitosan. Int. J. Pharm., 101, 227-236.
24. Illum, L., Farraj, N. F. and Davis, S. S. (1994) Chitosan as a novel nasal delivery system for peptide drugs. Pharm. Res., 11(8), 1186-1189.
25. Jameela, S. R. and Jayakrishnan, A. (1995) Glutaraldehyde cross-linked chitosan microspheres as a long acting biodegradable drug delivery vehicle: studies on the in vitro release of mitoxantrone and in vivo degradation of microspheres in rat muscle. Biomaterials, 16, 769-775.
26. Jameela, S. R., Misra, A. and Jayakrishnan, A. ( 1994) Cross-linked chitosan microspheres as carriers for prolonged delivery of macromolecular drugs. J. Biomater. Sci. Polymer Edn., 6, 621-632.
27. Kinirons, M. T. (1993) Newer agents for the treatment of malignant hypercalcemia. Am, J. Med, Sci., 305, 403-406.
28. Levy, R. J., Schoen, F. J., Anderson, H. C., Harasaki, H., Koch, T. H., Brown, W, Lian, J. B., Gumming, R. and Gavin, J. B. (1991) Cardiovascular implant calcification: a survey and update. Biomaterials, 12, 707-714.
29. Levy, R. J., Schoen, F. J., Langer, R., Levy, J. T., Wolfrum. J., Hawley, M. A., Lund. S. A. and Carens, D. L. (1985a) Bioprosthetic heart valve calcification. In Butler, W. T. (ed.). The chemistry and biology of mineralized tissues (Birmingham) pp. 375-380.
30. Levy, R. J., Wolfrum, J., Schoen, F. J., Hawley, M. A., Lund, S. and Langer, R. (1985b) Inhibition of calcification of bioprosthetic heart valve calcification by local controlled release of diphosphonate Science, 228, 190-192.
31. Lower, S. E. (1984) Polymers from the sea chitin and chitosan. Manufact. Chemist, 47-52.
32. Miyazaki, S., Ishii. K. and Nadai, T. (1981) The use of chitin and chitosan as drug carriers. Chem, Pharm. Bull., 29, 3067-3069.
33. Moore, S. and Stein, W. H. (1954) A modified ninhydrin regent for the photometric determination of amino acids and releated compounds. J. Biol. Chem., 211, 907-913.
34. Muzzarelli, R., Baldassarre, V., Conti, F., Ferrara, P., Biagini, G., Gazzanelli, G. and Vasi, V. (1988) Biological activity of chitosan: ultrastnictural study. Biomaterials, 9, 247-252.
35. Muzzarelli, R., Jeuniaux, C. and Gooday, G. W. (1986) Chitin in nature and technology (NY: Plenum Press), pp. 583.
36. Muzzarelli, R. A. A., Biagini, G., Bellardini, M., Simonelli, L., CastaJdini, C. and Fratto, G. (1993) Osteoconduction exerted by methylpynolidinone chitosan used in dental surgery. Biomaterials, 14, 39-43.
37. Muzzarelli. R. A. A., Mattioli-Belmome, M., Tietz, C., Biagini. R., Ferioli, G., Brunelli, M. A., Fini, M.? Giardino, R., Ilari, P. and Biagini, G. (1994) Stimulatory effect on bone formation exerted by a modified chitosan. Biomaterials, 15, 1075-1081.
38. Nishioka, Y., Kyotani, S., Masui, H., Okamura, M., Miyazaki, M., Okazaki. K., Ohnishi, S., Yamamoto, Y. and Ito, K. (1989) Preparation and release characteristics of cisplatin albumin microspheres containing chitin and treated with chitosan. Chem. Pharm. Bull., 37, 3074-3077.
39. Otsuka, M., Matsuda, Y., Suwa, Y., Fox, J. L. and Higuchi, W. I. (1994a) A novel skeletal drug delivery system using a self-setting calcium phosphate cement. 5. Drug release behavior from beterogenous drug-loaded cement containing an anticancer drug. J. Pharm. Sci., 83, 1565-1568.
40. Otsuka, M., Matsuda, Y., Suwa, Y., Fox, J. L. and Higuchi, W. I. (1994b) A novel skeletal drug delivery system using a self-setting calcium phosphate cement. 7. Effect of biological factors on indomethacin release from the cement loaded on bovine bone. J. Pharm. Sci., 83, 1569-1573.
41. Ouchi, T., Takei, T., Kobayashi, H. and Ohya, Y. (1991) Controlled release of 5fu from chitosan gel microspheres coated with polysaccharide chains recognizing tumor cells. Proceed. Inter. Symp. Control. Rel. Bioact. Mater., 18, 271-272.
42. Pantaleone, D., Yalpani, M. and Scollar, M. (1992) Unusual susceptibility of chitosan to enzymic hydrolysis. Carbohydr. Res., 237, 325-332.
43. Sawayanagi, Y., Nambu, N. and Nagai, T. (1982a) Permeation of drugs through chitosan membranes. Chem. Pharm. Bull., 30, 3297-3301.
44. Sawayanagi, Y., Nambu, N. and Nagai, T. (1982b) Use of chitosan for sustained-release preparations of water-soluble drugs. Chem. Pharm. Bull. 30, 4213-4215.
45. Schoen, F. J. and Levy, R. J. (1984) Bioprosthetic heart valve failure: pathology and pathogenesis. Cardiology Clinics, 2, 717-739.
46. Thanoo, B, C., Sunny, M. C. and Jayakrishnan, A. (1992) Cross-linked chitosan microspheres: Preparation and evaluation as a matrix for the controlled release of pharmaceuticals. J. Pharm. Pharmacol., 44, 283-286.
47. Van Gelder, J. M., Breuer, E., Ornoy, A., Schlossman, A., N. Patlas and Golomb, G. (1995) Anticalcification and antiresorption effects of bisacylphosphonates. Bone, 16, 511-520.
48. Van Gelder, J. M. and Golomb, G. (1995) The evaluation of bisphosphonates as potential drugs for calcium-related disorders. In Ornoy, A. (ed), Animal models of human related calcium metabolic disorders (Boca Raton: CRC Press), pp. 181-206.