Fatty acid binding protein-2 gene variants and insulin resistance: Gene and gene-environment interaction effects

Physiological Genomics

Volumn 2002, Issue 10, 2002, Pages 145-157

  Weiss, Edward P ^a   Brown, Michael D ^a   Shuldiner, Alan R ^b,c   Hagberg, James M ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c BALTIMORE VA MEDICAL CENTER   (United States)

Author keywords

Aging; Body composition; Diet; Insulin responsiveness; Insulin sensitivity; Physical activity

Indexed keywords

CARRIER PROTEIN; FABP2 PROTEIN, HUMAN; FABP2 PROTEIN, MOUSE; FABP7 PROTEIN, HUMAN; FATTY ACID BINDING PROTEIN; TUMOR PROTEIN; TUMOR SUPPRESSOR PROTEIN;

AMINO ACID SUBSTITUTION; BODY COMPOSITION; CHEMISTRY; DIET; GENETIC VARIABILITY; GENETICS; GENOTYPE; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RESISTANCE; MOTOR ACTIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN CONFORMATION; REVIEW;

AMINO ACID SUBSTITUTION; BODY COMPOSITION; CARRIER PROTEINS; DIABETES MELLITUS, TYPE 2; DIET; FATTY ACID-BINDING PROTEINS; GENOTYPE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; MOTOR ACTIVITY; NEOPLASM PROTEINS; PROTEIN CONFORMATION; TUMOR SUPPRESSOR PROTEINS; VARIATION (GENETICS);

EID: 0346739933     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00070.2001     Document Type: Review

References (62)

1. Almind K, Doria A, and Kahn CR. Putting the genes for type II diabetes on the map. Nat Med 7: 277-279, 2001.
2. Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, and Landers ES. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26: 76-80, 2000.
3. Baier LJ, Bogardus C, and Sacchettini JC. A polymorphism in the human intestinal fatty acid binding protein alters fatty acid transport across Caco-2 cells. J Biol Chem 271: 10892-10896, 1996.
4. Baier LJ, Sacchettini JC, Knowler WC, Eads J, Paolisso G, Tataranni PA, Mochizuki H, Bennett PH, Bogardus C, and Prochazka M. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance. J Clin Invest 95: 1281-1287, 1995.
5. Beck-Nielsen H and Groop LC. Metabolic and genetic characterization of prediabetic states. Sequence of events leading to non insulin dependent diabetes mellitus. J Clin Invest 94: 1714-1721, 1994.
6. Bernlohr DA, Simpson MA, Hertzel AV, and Banaszak LJ. Intracellular lipid-binding proteins and their genes. Annu Rev Nutr 17: 277-303, 1997.
7. Bogardus C, Lillioja S, Ward R, Degregrorio M, Mott D, Ferraro R, Myomba B, Saad M, Pettitt D, Knowler W, and Bennett P. Association and linkage between insulin resistance and MNS red cell antigens in Pima Indians (Abstract). Diabetes 40: 297A, 1991.
8. Boullu-Sanchis S, Lepretre F, Hedelin G, Donnet JP, Schaffer P, Froguel P, and Pinget M. Type 2 diabetes mellitus: association study of five candidate genes in an Indian population of Guadeloupe, genetic contribution of FABP2 polymorphism. Diabetes Metab 25: 150-156, 1999.
9. Brown MD, Korytkowski MT, Zmuda JM, McCole SD, Moore GE, and Hagberg JM. Insulin sensitivity in postmenopausal women: Independent and combined effects of hormone replacement, cardiovascular fitness, and body composition. Diabetes Care 23: 1731-1736, 2000.
10. Brown MD, Shuldiner AR, Ferrell RE, Weiss EP, Korytkowski MT, Zmuda JM, McCole SD, Moore GE, and Hagberg JM. FABP2 genotype is associated with insulin sensitivity in older women. Metabolism 50: 1102-1105, 2001.
11. Chen KW, Boyko EJ, Bergstrom RW, Leonetti DL, Newell-Morris L, Wahl PW, and Fujimoto WY. Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5 year follow-up of initially nondiabetic Japanese-American men. Diabetes Care 18: 747-753, 1995.
12. Chiu KC, Chuang LM, Chu A, and Yoon C. Fatty acid binding protein 2 and insulin resistance. Eur J Clin Invest 31: 521-527, 2001.
13. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346: 393-403, 2002.
14. Editorial. Freely associating. Nat Genet 22: 1-2, 1999.
15. Elbein SC. The genetics of human noninsulin-dependent (type 2) diabetes mellitus. J Nutr 127: 1891S-1896S, 1997.
16. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 25: S5-S20, 2002.
17. Forouhi NG, Jenkinson G, Thomas EL, Mullick S, Mierisova S, Bhonsle U, McKeigue PM, and Bell JD. Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men. Diabetologia 42: 932-935, 1999.
18. Galluzzi JR, Cupples LA, Meigs JB, Wilson PW, Schaefer EJ, and Ordovas JM. Association of the Ala54-Thr polymorphism in the intestinal fatty acid-binding protein with 2-h post-challenge insulin levels in the Framingham Offspring Study. Diabetes Care 24: 1161-1166, 2001.
19. Guyton AC. Textbook of Medical Physiology. Philadelphia, PA: Saunders, 1986.
20. Hamman RF. Genetic and environmental determinants of non-insulin-dependent diabetes mellitus. Diabetes Metab Rev 8: 287-338, 1992.
21. Hayakawa T, Nagai Y, Nohara E, Yamashita H, Takamura T, Abe T, Nomura G, and Kobayashi K. Variation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects. Metabolism 48: 655-657, 1999.
22. Hegele RA, Harris SB, Hanley AJ, Sadikian S, Connelly PW, and Zinman B. Genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal Canadians. J Clin Endocrinol Metab 12: 4334-4337, 1996.
23. Hegele RA, Young TK, and Connelly PW. Are Canadian Inuit at increased genetic risk for coronary heart disease? J Mol Med 75: 364-370, 1997.
24. Humphreys P, McCarthy M, Tuomilehto J, Tuomilehto-Wolf E, Stratton I, Morgan R, Rees A, Owens D, Stengard J, and Nissinen A. Chromosome 4q locus associated with insulin resistance in Pima Indians: studies in three European NIDDM populations.. Diabetes 43: 800-804, 1994.
25. Ishii T, Hirose H, Kawai T, Hayashi K, Maruyama H, Saito I, and Saruta T. Effects of intestinal fatty acid-binding protein gene Ala54Thr polymorphism and β3-adrenergic receptor gene Trp64Arg polymorphism on insulin resistance and fasting plasma glucose in young to older Japanese men. Metabolism 50: 1301-1307, 2001.
26. Ito K, Nakatani K, Fujii M, Katsuki A, Tsuchihashi K, Murata K, Goto H, Yano Y, Gabazza EC, Sumida Y, and Adachi Y. Codon 54 polymorphism of the fatty acid binding protein gene and insulin resistance in the Japanese population. Diabet Med 16: 119-124, 1999.
27. Ivy JL, Zderic TW, and Fogt DL. Prevention and treatment of non-insulin-dependent diabetes mellitus. Exerc Sport Sci Rev 27: 1-36, 1999.
28. Kahn RC. Insulin resistance, insulin insensitivity, and insulin unresponsiveness: a necessary distinction. Metabolism 12: 1893-1902, 1978.
29. Kahn RC, Vincent D, and Doria A. Genetics of non-insulin dependent (type-II) diabetes mellitus. Annu Rev Med 47: 509-531, 1996.
30. Kim CH, Yun SK, Byun DW, Yoo MH, Lee KU, and Suh KI. Codon 54 polymorphism of the fatty acid binding protein 2 gene is associated with increased fat oxidation and hyperinsulinemia, but not with intestinal fatty acid absorption in Korean men. Metabolism 50: 473-476, 2001.
31. Kraulis PJ. Molescript: a program to produce both detailed and schematic plots of protein structures. J Appl Crystallography 24: 946-950, 1991.
32. Lei HH, Coresh J, Shuldiner AR, Boerwinkle E, and Brancati FL. Variants of the insulin receptor substrate-1 and fatty acid binding protein 2 genes and the risk of type 2 diabetes, obesity, and hyperinsulinemia in African-Americans: the Atherosclerosis Risk in Communities Study. Diabetes 48: 1868-1872, 1999.
33. Lopez-Miranda J, Galluzzi JR, Marin C, Bravo D, Paz E, Perez-Martinez P, Fernandez de la Puebla RA, Ordovas JM, and Perez-Jiminez F. The Ala54Thr polymorphism at the fatty acid binding protein-2 locus is associated with insulin sensitivity in response to dietary fat (Abstract). Circulation 102: II701-II702, 2002.
34. Manco M, Mingron G, Greco AV, Capristo E, Gniuli D, DeGaitano A, and Gasbarrini G. Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides. Metabolism 49: 220-224, 2000.
35. Matsuda M and Defronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470, 1999.
36. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, and Turner R. Homeostasis model assessment insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
37. Merrit EA and Bacon DJ. Raster 3D: photorealistic molecular graphics. Methods Enzymol 277: 505-524, 1997.
38. Mitchell BD, Kammerer CM, O'Connell P, Harrison CR, Manire M, Shipman P, Moyer MP, Stern MP, and Frazier ML. Evidence for linkage of postchallenge insulin levels with intestinal fatty acid-binding protein (FABP2) in Mexican-Americans. Diabetes 44: 1046-1053, 1995.
39. Pan DA, Lilloja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenlans AB, and Storlien LH. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46: 983-988, 1997.
40. Pan XT, Li GW, Hu YH, Wang JX, Yang WY, An ZX, Hu ZX, Lin J, Xiao JZ, Cao HB, Liu PA, Jiang XG, Wang JP, Zheng H, Zhang H, Bennett PH, and Howard BV. Effects of diet and exercise in prevention NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20: 537-544, 1997.
41. Pihlajamaki J, Rissanen J, Heikkinen S, Karjalainen L, and Laakso M. Codon 54 polymorphism of the human intestinal fatty acid binding protein 2 gene is associated with dyslipidemias but not with insulin resistance in patients with familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 17: 1039-1044, 1997.
42. Pratley RE, Baier L, Pan DA, Salbe AD, Storlien L, Ravussin E, and Bogardus C. Effects of an Ala54Thr polymorphism in the intestinal fatty acid-binding protein on responses to dietary fat in humans. J Lipid Res 41: 2002-2008, 2000.
43. Prochazka M, Lillioja S, Tait JF, Knowler WC, Mott DM, Spraul M, Bennett PH, and Bogardus C. Linkage of chromosomal markers on 4q with a putative gene determining maximal insulin action in Pima Indians. Diabetes 42: 514-519, 1993.
44. Randle PJ, Garland PB, Hales CN, and Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 785-789, 1963.
45. Richieri GV, Low PJ, Ogata RT, and Kleinfeld AM. Thermodynamics of fatty acid binding to engineered mutants of the adipocyte and intestinal fatty acid-binding proteins. J Biol Chem 273: 7397-7405, 1998.
46. Rissanen J, Pihlajamaki J, Heikkinen S, Kekalaien P, Kumsisto J, and Laakso M. The Ala54Thr polymorphism of the fatty acid binding protein 2 gene does not influence insulin sensitivity in Finnish nondiabetic and NIDDM subjects. Diabetes 46: 711-712, 1997.
47. Ryan AS. Insulin resistance with aging: effects of diet and exercise. Sports Med 30: 327-346, 2000.
48. Shuldiner AR and Sabra M. Trp64Arg β3-adrenoceptor: when does a candidate gene become a disease-susceptibility gene? Obesity Res 9: 741-745, 2001.
49. Silver K and Shuldiner AR. Candidate genes for type 2 diabetes mellitus. In: Diabetes Mellitus: a Fundamental and Clinical Text, edited by LeRoith D, Olefsky JM, and Taylor SI. Philadelphia: Lippincott, 2000.
50. Sipilainen R, Uusitupa M, Heikkinen S, Rissanen A, and Laakso M. Variants in the human intestinal fatty acid binding protein 2 gene in obese subjects. J Clin Endocrinol Metab 82: 2629-2632, 1997.
51. Snustad PD and Simmons MJ. Principles of Genetics. New York: Wiley, 2000.
52. Stevens T and Caspersen CJ. The demography of physical activity. In: Physical Activity, Fitness, and Health, edited by Bouchard C, Shepard RJ, Stephens T. Champaign, IL: Human Kinetics, 1994, p. 204-213.
53. Stumvoll M, Mitrakou A, Pimenta W, Jenssen T, Yki-Jarvinen H, VanHaeften TRW, and Gerich J. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care 23: 295-301, 2000.
54. Sweetser DA, Birkenmeier EH, Klisak IJ, Zollman S, Sparkes RS, Mohandas T, Lusis AJ, and Gordon JL. The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. J Biol Chem 262: 16060-16071, 1987.
55. Tahvanainen E, Molin M, Vainio S, Tiret L, Nicaud V, Farinaro E, Masana L, and Ehnholm C. Intestinal fatty acid binding protein polymorphism at codon 54 is not associated with postprandial responses to fat and glucose tolerance tests in healthy young Europeans. Results from EARS II participants. Atherosclerosis 152: 317-325, 2000.
56. Tuomilehto J, Lindstrom J, Eriksson JG, Timo TV, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaaniemi S, Laakson M, Louheranta A, Rastas M, Salminen V, and Uusitupa M. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344: 1343-1350, 2001.
57. Vionnet N, Hani EH, Lesage S, Philippi A, Hager J, Varret M, Stoffel M, Tanizawa Y, Chiu KC, Glaser B, Permutt MA, Passa P, Demenais F, and Froguel P. Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs. Diabetes 46: 1062-1068, 1997.
58. Weiss ST, Silverman EK, and Palmer LJ. Case control association studies in pharmacogenetics. Pharmacogenomics J 1: 157-158, 2001.
59. Xiang K, Zheng T, Jia W, Sun D, Ding W, Lu J, and Tang J. The impact of codon 54 variation in intestinal fatty acid binding protein gene on the pathogenesis of diabetes mellitus in Chinese. Chin Med J (Engl) 112: 99-102, 1999.
60. Yagi T, Nishi S, Hinata S, Murakami M, and Yoshimi T. A population association study of four candidate genes (hexokinase II, glucagon-like peptide-1 receptor, fatty acid binding protein-2, and apolipoprotein C-II) with type 2 diabetes and impaired glucose tolerance in Japanese subjects. Diabet Med 13: 902-907, 1996.
61. Yamada K, Yuan X, Ishiyama S, Koyama K, Ichikawa F, Koyanagi A, Koyama W, and Nonaka K. Association between Ala54Thr substitution of the fatty acid-binding protein 2 gene with insulin resistance and intra-abdominal fat thickness in Japanese men. Diabetologia 40: 706-710, 1997.
62. Zhang F, Lücke C, Baier LJ, Sacchettini JC, and Hamilton JA. Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. J Biomol NMR 9: 28-213, 1997.