메뉴 건너뛰기




Volumn 14, Issue 1, 2004, Pages 172-182

The role of M cells and the long QT syndrome in cardiac arrhythmias: Simulation studies of reentrant excitations using a detailed electrophysiological model

Author keywords

[No Author keywords available]

Indexed keywords


EID: 1842430979     PISSN: 10541500     EISSN: None     Source Type: Journal    
DOI: 10.1063/1.1636272     Document Type: Article
Times cited : (24)

References (45)
  • 1
    • 0034601749 scopus 로고    scopus 로고
    • Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue
    • Z. Qu, A. Garflnkel, P. S. Chen, and J. N. Weiss, "Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue," Circulation 102, 1664-1670 (2000).
    • (2000) Circulation , vol.102 , pp. 1664-1670
    • Qu, Z.1    Garflnkel, A.2    Chen, P.S.3    Weiss, J.N.4
  • 3
    • 0037155052 scopus 로고    scopus 로고
    • Spatiotemporal transition to conduction block in canine ventricle
    • J. J. Fox, M. L. Riccio, F. Hua, E. Bodenschatz, and R. F. Gilmour, "Spatiotemporal transition to conduction block in canine ventricle," Circ. Res. 90, 289-296 (2002).
    • (2002) Circ. Res. , vol.90 , pp. 289-296
    • Fox, J.J.1    Riccio, M.L.2    Hua, F.3    Bodenschatz, E.4    Gilmour, R.F.5
  • 4
    • 0025829410 scopus 로고
    • A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell
    • S. Sicouri and C. Antzelevitch, "A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell," Circ. Res. 68, 1729-1741 (1991).
    • (1991) Circ. Res. , vol.68 , pp. 1729-1741
    • Sicouri, S.1    Antzelevitch, C.2
  • 5
    • 0025748631 scopus 로고
    • Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells
    • C. Antzelevitch, S. Sicouri, S. H. Litovsky, A. Lukas, S. C. Krishnan, J. M. D. Diego, G. A. Gintant, and D. W. Liu, "Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells," Circ. Res. 69, 1427-1449 (1991).
    • (1991) Circ. Res. , vol.69 , pp. 1427-1449
    • Antzelevitch, C.1    Sicouri, S.2    Litovsky, S.H.3    Lukas, A.4    Krishnan, S.C.5    Diego, J.M.D.6    Gintant, G.A.7    Liu, D.W.8
  • 6
    • 0029922712 scopus 로고    scopus 로고
    • Evidence for the presence of M cells in the guinea pig ventricle
    • S. Sicouri, M. Quist, and C. Antzelevitch, "Evidence for the presence of M cells in the guinea pig ventricle," J. Cardiovasc. Electrophysiol. 7, 503-511 (1996).
    • (1996) J. Cardiovasc. Electrophysiol. , vol.7 , pp. 503-511
    • Sicouri, S.1    Quist, M.2    Antzelevitch, C.3
  • 7
    • 0029023244 scopus 로고
    • Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: Evidence for presence of M cells
    • E. Drouin, F. Charpentier, C. Gauthier, K. Laurent, and H. L. Marec, "Electrophysiologic characteristics of cells spanning the left ventricular wall of human heart: Evidence for presence of M cells," J. Am. Coll. Cardiol. 26, 185-192 (1995).
    • (1995) J. Am. Coll. Cardiol. , vol.26 , pp. 185-192
    • Drouin, E.1    Charpentier, F.2    Gauthier, C.3    Laurent, K.4    Marec, H.L.5
  • 8
    • 0032480753 scopus 로고    scopus 로고
    • Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations
    • G. X. Van, W. Shimizu, and C. Antzelevitch, "Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations," Circulation 98, 1921-1927 (1998).
    • (1998) Circulation , vol.98 , pp. 1921-1927
    • Van, G.X.1    Shimizu, W.2    Antzelevitch, C.3
  • 9
    • 0035194585 scopus 로고    scopus 로고
    • Electrical heterogeneity within the ventricular wall
    • C. Antzelevitch and J. Fish, "Electrical heterogeneity within the ventricular wall," Basic Res. Cardiol. 96, 517-527 (2001).
    • (2001) Basic Res. Cardiol. , vol.96 , pp. 517-527
    • Antzelevitch, C.1    Fish, J.2
  • 10
    • 0028082351 scopus 로고
    • Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes
    • C. Antzelevitch and S. Sicouri, "Clinical relevance of cardiac arrhythmias generated by afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsade de pointes," J. Am. Coll. Cardiol. 23, 259-277 (1994).
    • (1994) J. Am. Coll. Cardiol. , vol.23 , pp. 259-277
    • Antzelevitch, C.1    Sicouri, S.2
  • 11
    • 0037066015 scopus 로고    scopus 로고
    • Unique topographical distribution of M-Cells underlies reentrant mechanism of torsade de points in the long QT syndrome
    • F. Akar, G. Yan, C. Antzelevitch, and D. Rosenbaum, "Unique topographical distribution of M-Cells underlies reentrant mechanism of torsade de points in the long QT syndrome," Circulation 105, 1247-1253 (2002).
    • (2002) Circulation , vol.105 , pp. 1247-1253
    • Akar, F.1    Yan, G.2    Antzelevitch, C.3    Rosenbaum, D.4
  • 12
    • 0036149136 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the long QT syndrome
    • C. Antzelevitch and W. Shimizu, "Cellular mechanisms underlying the long QT syndrome," Curr. Opin. Cardiol. 17, 43-51 (2002).
    • (2002) Curr. Opin. Cardiol. , vol.17 , pp. 43-51
    • Antzelevitch, C.1    Shimizu, W.2
  • 14
    • 0036669054 scopus 로고    scopus 로고
    • Sympathetic modulation of the long QT syndrome
    • C. Antzelevitch, "Sympathetic modulation of the long QT syndrome," Eur. Heart J. 23, 1246-1252 (2002).
    • (2002) Eur. Heart J. , vol.23 , pp. 1246-1252
    • Antzelevitch, C.1
  • 15
    • 33749361692 scopus 로고
    • Varieties of spiral wave behavior: An experimentalist's approach to the theory of excitable media
    • A. T. Winfree, "Varieties of spiral wave behavior: An experimentalist's approach to the theory of excitable media," Chaos 1, 303-334 (1991).
    • (1991) Chaos , vol.1 , pp. 303-334
    • Winfree, A.T.1
  • 16
    • 0030819433 scopus 로고    scopus 로고
    • Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome
    • W. Shimizu and C. Antzelevitch, "Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome," Circulation 96, 2038-2047 (1997).
    • (1997) Circulation , vol.96 , pp. 2038-2047
    • Shimizu, W.1    Antzelevitch, C.2
  • 17
    • 0032979304 scopus 로고    scopus 로고
    • Pause induced early afterdepolarizations in the long QT syndrome: A simulation study
    • P. C. Viswanathan and Y. Rudy, "Pause induced early afterdepolarizations in the long QT syndrome: A simulation study," Cardiovasc. Res. 42, 530-542 (1999).
    • (1999) Cardiovasc. Res. , vol.42 , pp. 530-542
    • Viswanathan, P.C.1    Rudy, Y.2
  • 18
    • 0035028582 scopus 로고    scopus 로고
    • Cellular consequences of HERG mutations in the long QT syndrome: Precursors to sudden cardiac death
    • C. E. Clancy and Y. Rudy, "Cellular consequences of HERG mutations in the long QT syndrome: Precursors to sudden cardiac death," Cardiovasc. Res. 50, 301-313 (2001).
    • (2001) Cardiovasc. Res. , vol.50 , pp. 301-313
    • Clancy, C.E.1    Rudy, Y.2
  • 19
    • 0034646287 scopus 로고    scopus 로고
    • Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium
    • P. C. Viswanathan and Y. Rudy, "Cellular arrhythmogenic effects of congenital and acquired long-QT syndrome in the heterogeneous myocardium," Circulation 101, 1192-1198 (2000).
    • (2000) Circulation , vol.101 , pp. 1192-1198
    • Viswanathan, P.C.1    Rudy, Y.2
  • 20
    • 0037013175 scopus 로고    scopus 로고
    • Ionic current basis of electrocardiographic waveforms: A model study
    • K. Gima and Y. Rudy, "Ionic current basis of electrocardiographic waveforms: A model study," Circ. Res. 90, 889-896 (2002).
    • (2002) Circ. Res. , vol.90 , pp. 889-896
    • Gima, K.1    Rudy, Y.2
  • 21
    • 0035924942 scopus 로고    scopus 로고
    • Re-entrant cardiac arrhythmias in computational models of long QT myocardium
    • R. H. Clayton, A. Bailey, V. N. Biktashev, and A. V. Holden, "Re-entrant cardiac arrhythmias in computational models of long QT myocardium," J. Theor. Biol. 208, 215-225 (2001).
    • (2001) J. Theor. Biol. , vol.208 , pp. 215-225
    • Clayton, R.H.1    Bailey, A.2    Biktashev, V.N.3    Holden, A.V.4
  • 22
    • 0028233422 scopus 로고
    • A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes
    • C. H. Luo and Y. Rudy, "A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes," Circ. Res. 74, 1071-1096 (1994).
    • (1994) Circ. Res. , vol.74 , pp. 1071-1096
    • Luo, C.H.1    Rudy, Y.2
  • 23
    • 0034026881 scopus 로고    scopus 로고
    • i overloaded cardiac myocytes: A simulation study
    • i overloaded cardiac myocytes: a simulation study," Biophys. J. 78, 2392-2404 (2000).
    • (2000) Biophys. J. , vol.78 , pp. 2392-2404
    • Faber, G.1    Rudy, Y.2
  • 25
    • 0025891531 scopus 로고
    • A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction
    • C. H. Luo and Y. Rudy, "A model of the ventricular cardiac action potential. Depolarization, repolarization, and their interaction," Circ. Res. 68, 1501-1526 (1991).
    • (1991) Circ. Res. , vol.68 , pp. 1501-1526
    • Luo, C.H.1    Rudy, Y.2
  • 26
    • 0017370379 scopus 로고
    • Reconstruction of the action potential of ventricular myocardial fibres
    • G. W. Beeler and H. Reuter, "Reconstruction of the action potential of ventricular myocardial fibres," J. Physiol. (London) 268, 177-210 (1977).
    • (1977) J. Physiol. (London) , vol.268 , pp. 177-210
    • Beeler, G.W.1    Reuter, H.2
  • 28
    • 0033527032 scopus 로고    scopus 로고
    • Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia
    • C. E. Clancy and Y. Rudy, "Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia," Nature (London) 400, 566-569 (1999).
    • (1999) Nature (London) , vol.400 , pp. 566-569
    • Clancy, C.E.1    Rudy, Y.2
  • 29
    • 0037066036 scopus 로고    scopus 로고
    • + channel mutation that causes both Brugada and long-QT syndrome phenotypes: A simulation study of mechanism
    • + channel mutation that causes both Brugada and long-QT syndrome phenotypes: A simulation study of mechanism," Circulation 105, 1208-1213 (2002).
    • (2002) Circulation , vol.105 , pp. 1208-1213
    • Clancy, C.E.1    Rudy, Y.2
  • 30
    • 0032942461 scopus 로고    scopus 로고
    • Influence of electrical coupling on early afterdepolarizations in ventricular myocytes
    • J. Saiz, J. Ferrero, M. Monserrat, J. Ferrero, and N. Thakor, "Influence of electrical coupling on early afterdepolarizations in ventricular myocytes," IEEE Trans. Biomed. Eng. 46, 138-147 (1999).
    • (1999) IEEE Trans. Biomed. Eng. , vol.46 , pp. 138-147
    • Saiz, J.1    Ferrero, J.2    Monserrat, M.3    Ferrero, J.4    Thakor, N.5
  • 31
    • 0034351099 scopus 로고    scopus 로고
    • Ectopic activity in ventricular cells induced by early afterdepolarizations developed in Purkinje cells
    • M. Monserrat, J. Saiz, J. Ferrero, J. Ferrero, and N. Thakor, "Ectopic activity in ventricular cells induced by early afterdepolarizations developed in Purkinje cells," Ann, Biomed. Eng. 28, 1343-1351 (2000).
    • (2000) Ann, Biomed. Eng. , vol.28 , pp. 1343-1351
    • Monserrat, M.1    Saiz, J.2    Ferrero, J.3    Ferrero, J.4    Thakor, N.5
  • 32
    • 0036680904 scopus 로고    scopus 로고
    • Re-entry in computational models of ischaemic myocardium
    • R. H. Clayton, K. Parkinson, and A. V. Holden, "Re-entry in computational models of ischaemic myocardium," Chaos, Solitons Fractals 13, 1671-1683 (2002).
    • (2002) Chaos, Solitons Fractals , vol.13 , pp. 1671-1683
    • Clayton, R.H.1    Parkinson, K.2    Holden, A.V.3
  • 34
    • 0028365308 scopus 로고
    • A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation
    • C. H. Luo and Y. Rudy, "A dynamic model of the cardiac ventricular action potential. II. Afterdepolarizations, triggered activity, and potentiation," Circ. Res. 74, 1097-1113 (1994).
    • (1994) Circ. Res. , vol.74 , pp. 1097-1113
    • Luo, C.H.1    Rudy, Y.2
  • 35
    • 0029756180 scopus 로고    scopus 로고
    • to and action potential notch are smaller in left vs. right canine ventricular epicardium
    • to and action potential notch are smaller in left vs. right canine ventricular epicardium," Am. J. Physiol. 271, H548-H561 (1996).
    • (1996) Am. J. Physiol. , vol.271
    • Diego, J.M.D.1    Sun, Z.Q.2    Antzelevitch, C.3
  • 36
    • 0030245546 scopus 로고    scopus 로고
    • Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia
    • A. Lukas and C. Antzelevitch, "Phase 2 reentry as a mechanism of initiation of circus movement reentry in canine epicardium exposed to simulated ischemia," Cardiovasc. Res. 32, 593-603 (1996).
    • (1996) Cardiovasc. Res. , vol.32 , pp. 593-603
    • Lukas, A.1    Antzelevitch, C.2
  • 39
    • 0031021775 scopus 로고    scopus 로고
    • Involvement of the calcium inward current in cardiac impulse propagation: Induction of unidirectional conduction block by nifedipine and reversal by Bay K 8644
    • S. Rohr and J. P. Kucera, "Involvement of the calcium inward current in cardiac impulse propagation: Induction of unidirectional conduction block by nifedipine and reversal by Bay K 8644," Biophys. J. 72, 754-766 (1997).
    • (1997) Biophys. J. , vol.72 , pp. 754-766
    • Rohr, S.1    Kucera, J.P.2
  • 40
    • 0036707486 scopus 로고    scopus 로고
    • Cytosolic Ca2+ triggers early afterdepolarizations and torsade de pointes in rabbit hearts with type 2 long QT syndrome
    • B. R. Choi, F. Burton, and G. Salama, "Cytosolic Ca2+ triggers early afterdepolarizations and torsade de pointes in rabbit hearts with type 2 long QT syndrome," J. Physiol. (London) 543, 615-631 (2002).
    • (2002) J. Physiol. (London) , vol.543 , pp. 615-631
    • Choi, B.R.1    Burton, F.2    Salama, G.3
  • 42
    • 0023259560 scopus 로고
    • Characteristics of junctional regions between Purkinje and ventricular muscle cells of canine ventricular subendocardium
    • D. A. Rawling and R. W. Joyner, "Characteristics of junctional regions between Purkinje and ventricular muscle cells of canine ventricular subendocardium," Circ. Res. 60, 580-585 (1987).
    • (1987) Circ. Res. , vol.60 , pp. 580-585
    • Rawling, D.A.1    Joyner, R.W.2
  • 43
    • 0029835964 scopus 로고    scopus 로고
    • The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns
    • N. El-Sherif, E. B. Caref, H. Yin, and M. Restivo, "The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns," Circ. Res. 79, 474-492 (1996).
    • (1996) Circ. Res. , vol.79 , pp. 474-492
    • El-Sherif, N.1    Caref, E.B.2    Yin, H.3    Restivo, M.4
  • 44
    • 0030969538 scopus 로고    scopus 로고
    • Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: Reversal by magnesium
    • S. C. Verduyn, M. A. Vos, J. van der Zande, F. F. van der Hulst, and H. J. Wellens, "Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: Reversal by magnesium," Cardiovasc. Res. 34, 453-463 (1997).
    • (1997) Cardiovasc. Res. , vol.34 , pp. 453-463
    • Verduyn, S.C.1    Vos, M.A.2    Van der Zande, J.3    Van der Hulst, F.F.4    Wellens, H.J.5
  • 45
    • 84995302823 scopus 로고    scopus 로고
    • Effects of wall heterogeneity in an anatomically realistic model of canine ventricles: A simulation study
    • E. M. Cherry, W.-J. Rappel, S. Evans, and F. Fenton, "Effects of wall heterogeneity in an anatomically realistic model of canine ventricles: A simulation study," PACE 26, 1109-1109 (2003).
    • (2003) PACE , vol.26 , pp. 1109-1109
    • Cherry, E.M.1    Rappel, W.-J.2    Evans, S.3    Fenton, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.