Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase

Biochemical Journal

Volumn 371, Issue 3, 2003, Pages 957-964

  Xu, Kui ^a   Belunis, Charles ^a   Chu, Wei ^a   Weber, David ^a   Podlaski, Frank ^a   Huang, Kuo Sen ^a   Reed, Steven I ^b   Vassilev, Lyubomir T ^a  

^a HOFFMANN LA ROCHE INC   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cancer; Cks1; p27; Proteasome; Skp2; Ubiquitin

Indexed keywords

BIOASSAY; CELLS; DISSOCIATION; ENZYME INHIBITION; FLUORESCENCE; TUMORS;

PHOSPHORYLATION;

PROTEINS;

E 3 UBIQUITIN LIGASE; LIGASE; PROTEASOME; PROTEIN; PROTEIN P27; PROTEIN SKP 1; PROTEIN SKP 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; ENZYME ANALYSIS; FLUORESCENCE ANALYSIS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; HUMANS; LIGASES; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECOMBINANT PROTEINS; S-PHASE KINASE-ASSOCIATED PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA;

EID: 0038583881     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20021722     Document Type: Article

References (29)

1. Morgan, D. O. (1995) Principles of CDK regulation. Nature (London) 374, 131-134
2. Reed, S. I., Baillly, E., Dulic, V., Hengst, L., Resnitzky, D. and Slingerland, J. (1994) G1 control in mammalian cells. J. Cell Sci. 18, 69-73
3. Sherr, C. J. and Roberts, J. M. (1999) CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512
4. Loda, M., Cukor, B., Tam, S. W., Lavin, P., Fiorentino, M., Draetta, G. F., Jessup, J. M. and Pagano, M. (1997) Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat. Med. (N.Y.) 3, 152-154
5. Esposito, V., Baldi, A., De Luca, A., Groger, A. M., Loda, M., Giordano, G. G., Caputi, M., Baldi, F., Pagano, M. and Giordano, A. (1997) Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. Cancer Res. 57, 3381-3385
6. Slingerland, J. and Pagano, M. (2000) Regulation of the cdk inhibitor p27 and its deregulation in cancer. J. Cell. Physiol. 183, 10-17
7. Montagnoli, A., Fiore, F., Eytan, E., Carrano, A. C., Draetta, G. F., Hershko, A. and Pagano, M. (1999) Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13, 1181-1189
8. kip1, a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome. Mol. Cell. Biol. 19, 1190-1201
9. Vlach, J., Hennecke, S. and Amati, B. (1997) Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 16, 5334-5344
10. Kip1. Genes Dev. 11, 1464-1478
11. Carrano, A. C., Eytan, E., Hershko, A. and Pagano, M. (1999) SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell Biol. 1, 193-199
12. Kip1 degradation and induces S phase in quiescent cells. Nat. Cell Biol. 1, 207-214
13. Skp2 complex through phosphorylated Thr187 in p27. Curr. Biol. 9, 661-664
14. Skowyra, D., Craig, K. L., Tyers, M., Elledge, S. J. and Harper, J. W. (1997) F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. Cell 91, 209-219
15. Zheng, N., Schulman, B. A., Song, L., Miller, J. J., Jeffrey, P. D., Wang, P., Chu, C., Koepp, D. M., Elledge, S. J., Pagano, M. et al. (2002) Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (London) 416, 703-709
16. Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N. et al. (2000) Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J. 19, 2069-2081
17. Skp2-mediated ubiquitinylation of p27. Nat. Cell Biol. 3, 321-324
18. Skp2 to the CDK inhibitor p27Kip1. Mol. Cell 7, 639-650
19. Hayles, J., Beach, D., Durkacz, B. and Nurse, P. (1986) The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function. Mol. Gen. Genet. 202, 291-293
20. Hadwiger, J. A., Wittenberg, C., Mendenhall, M. D. and Reed, S. I. (1989) The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex. Mol. Cell. Biol. 9, 2034-2041
21. Pines, J. (1996) Cell cycle: reaching for a role for the Cks proteins. Curr. Biol. 6, 1399-1402
22. Bourne, Y., Watson, M. H., Hickey, M. J., Holmes, W., Rocque, W., Reed, S. I. and Tainer, J. A. (1996) Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1. Cell 84, 863-874
23. Arvai, A. S., Bourne,Y., Williams, D., Reed, S. I. and Tainer, J. A. (1995) Crystallization and preliminary crystallographic study of human CksHs1: a cell cycle regulatory protein. Proteins 21, 70-73
24. Schulman, B. A., Carrano, A. C., Jeffrey, P. D., Bowen, Z., Kinnucan, E. R., Finnin, M. S., Elledge, S. J., Harper, J. W., Pagano, M. and Pavletich, N. P. (2000) Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature (London) 408, 381-386
25. Zhou, G., Cummings, R., Hermes, J. and Moller, D. E. (2001) Use of homogeneous time-resolved fluorescence energy transfer in the measurement of nuclear receptor activation. Methods 25, 54-61
26. Harper, J. W. (2001) Protein destruction: adapting roles for Cks proteins. Curr. Biol. 11, R431-R435
27. Reference deleted
28. Sitry, D., Seelinger, M. A., Ko, T. K., Ganoth, D. Breward, S. E., Itzhaki, L. S., Pagano, M. and Hershko, A. (2002) Three different binding sites of Cks1 are required for p27-ubiquitin ligation. J. Biol. Chem. 277, 42233-42240
29. Tsihlias, J., Kapusta, L. and Slingerland, J. (1999) The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer. Annu. Rev. Med. 50, 401-423