Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

Cell

Volumn 53, Issue 4, 1988, Pages 549-554

  Almoguera, Concepcion ^a   Shibata, Darryl ^b   Forrester, Kathleen ^a   Martin, John ^b   Arnheim, Norman ^c   Perucho, Manuel ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b LAC USC MEDICAL CENTER   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PANCREATIC RIBONUCLEASE; RNA;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CELL CULTURE; CELL LINE; CODON; COLON TUMOR; FEMALE; FIBROBLAST; GALLBLADDER TUMOR; GENE AMPLIFICATION; GENETICS; HUMAN; MALE; MUTATION; NUCLEIC ACID HYBRIDIZATION; ONCOGENE RAS; PAGET NIPPLE DISEASE; PANCREAS TUMOR; PATHOLOGY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CELL LINE; CODON; COLONIC NEOPLASMS; DNA; FEMALE; FIBROBLASTS; GALLBLADDER NEOPLASMS; GENE AMPLIFICATION; GENES, RAS; HUMAN; MALE; MIDDLE AGE; MUTATION; NUCLEIC ACID HYBRIDIZATION; PANCREATIC NEOPLASMS; RIBONUCLEASE, PANCREATIC; RNA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0024292722     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(88)90571-5     Document Type: Article

References (20)

1. ras genes
2. The ras gene family and human carcinogenesis
3. Prevalence of ras gene mutations in human colorectal cancers
4. New human tumor cell lines
5. Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
6. High incidence of c-K-ras oncogenes in human codon cancer detected by the RNAase A mismatch cleavage method
7. Activation of the c-K-ras oncogene in a human pancreas carcinoma
8. Structure and organization of the human Ki-ras protooncogene and a related processed pseudogene
9. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
10. Specific synthesis of DNA in vitro via a polymerase catalysed chain reaction
11. Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA: DNA duplexes
12. Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes
13. Human tumor-derived cell lines contain common and different transforming genes
14. Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice
15. Enzymatic amplification of β-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia
16. Detection of human papilloma virus in paraffin embedded tissue using the polymerase chain reaction
17. The molecular genetics of cellular oncogenes
18. A method to detect and characterize point mutations in transcribed genes: amplification and overexpression of the mutant c-K-ras allele in human tumor cells
19. Activation of a human c-K-ras oncogene