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Volumn 4, Issue SUPPL.1, 2000, Pages 2-9

What is HER2?

Author keywords

Breast cancer; c erbB 2; Human epidermal growth factor receptor 2; Oncogene; Oncogenesis

Indexed keywords


EID: 0002857064     PISSN: 14623889     EISSN: None     Source Type: Journal    
DOI: 10.1054/ejon.2000.0072     Document Type: Article
Times cited : (11)

References (55)
  • 1
    • 0026316096 scopus 로고
    • Growth factors and cancer
    • Aaronson SA (1991) Growth factors and cancer. Science 254: 1146-1153
    • (1991) Science , vol.254 , pp. 1146-1153
    • Aaronson, S.A.1
  • 2
    • 0022658370 scopus 로고
    • Comparative study of Harvey-ras oncogene expression with conventional clinicopathologic parameters of breast cancer
    • Agnantis NJ, Parissi P, Anagnostakis D, Spandidos DA (1986) Comparative study of Harvey-ras oncogene expression with conventional clinicopathologic parameters of breast cancer. Oncology 43: 36-39.
    • (1986) Oncology , vol.43 , pp. 36-39
    • Agnantis, N.J.1    Parissi, P.2    Anagnostakis, D.3    Spandidos, D.A.4
  • 3
    • 0022647432 scopus 로고
    • The product of the human c-erbB-2 gene: A 185-kilodalton glycoprotein with tyrosine kinase activity
    • Akiyama T, Sudo C, Ogawara H, Toyoshima K, Yamamoto T (1986) The product of the human c-erbB-2 gene: A 185-kilodalton glycoprotein with tyrosine kinase activity. Science 232: 1644-1646
    • (1986) Science , vol.232 , pp. 1644-1646
    • Akiyama, T.1    Sudo, C.2    Ogawara, H.3    Toyoshima, K.4    Yamamoto, T.5
  • 4
    • 0023841824 scopus 로고
    • Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells
    • Akiyama T, Saito T, Ogawara H, Toyoshima K, Yamamoto T (1988) Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells. Molecular Cellular Biology 8: 1019-1026
    • (1988) Molecular Cellular Biology , vol.8 , pp. 1019-1026
    • Akiyama, T.1    Saito, T.2    Ogawara, H.3    Toyoshima, K.4    Yamamoto, T.5
  • 5
    • 0030795612 scopus 로고    scopus 로고
    • The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through ligand-receptor combinatorial interactions
    • Alroy I, Yarden Y (1997) The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through ligand-receptor combinatorial interactions. FEBS Letters 410: 83-86
    • (1997) FEBS Letters , vol.410 , pp. 83-86
    • Alroy, I.1    Yarden, Y.2
  • 6
    • 0026508514 scopus 로고
    • Overexpression of the c-erbB-2 oncogene: Why does this occur more frequently in ductal carcinoma in situ than in invasive mammary carcinoma and is this of prognostic significance
    • Barnes DM, Bartkova J, Camplejohn RS Gullick WJ, Smith PJ, Millis RR (1992) Overexpression of the c-erbB-2 oncogene: why does this occur more frequently in ductal carcinoma in situ than in invasive mammary carcinoma and is this of prognostic significance. European Journal of Cancer 28: 644-648
    • (1992) European Journal of Cancer , vol.28 , pp. 644-648
    • Barnes, D.M.1    Bartkova, J.2    Camplejohn, R.S.3    Gullick, W.J.4    Smith, P.J.5    Millis, R.R.6
  • 8
    • 0026511161 scopus 로고
    • Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: Correlation with steroid receptors
    • Berns EM, Klijn JG, van Staveren IL, Portengen H, Noordegraaf E, Foekens JA (1992) Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: correlation with steroid receptors. European Journal of Cancer 28: 697-700
    • (1992) European Journal of Cancer , vol.28 , pp. 697-700
    • Berns, E.M.1    Klijn, J.G.2    Van Staveren, I.L.3    Portengen, H.4    Noordegraaf, E.5    Foekens, J.A.6
  • 9
    • 0026739541 scopus 로고
    • Transformation mediated by the human HER-2 gene independent of epidermal growth factor receptor
    • Chazin VR, Kaleko M, Miller AD, Slamon DJ (1992) Transformation mediated by the human HER-2 gene independent of epidermal growth factor receptor. Oncogene 7: 1859-1866
    • (1992) Oncogene , vol.7 , pp. 1859-1866
    • Chazin, V.R.1    Kaleko, M.2    Miller, A.D.3    Slamon, D.J.4
  • 10
    • 0000880764 scopus 로고    scopus 로고
    • Quantitation of EGFR and c-erbB-2 expression in preinvasive compared to invasive breast cancer
    • abstract 792A
    • Chong D, Cooke TG, Reeves JR, George WD, Mallon EA, Ozanne B (1999a) Quantitation of EGFR and c-erbB-2 expression in preinvasive compared to invasive breast cancer. European Journal of Cancer 35 (Suppl 4): S201 [abstract 792A]
    • (1999) European Journal of Cancer , vol.35 , Issue.4 SUPPL.
    • Chong, D.1    Cooke, T.G.2    Reeves, J.R.3    George, W.D.4    Mallon, E.A.5    Ozanne, B.6
  • 11
    • 0000880765 scopus 로고    scopus 로고
    • Quantitation of c-erbB-2 in primary breast cancer allows identification of a further poor prognostic group
    • abstract 291
    • Chong D, Cooke TG, Reeves JR, George WD, Mallon EA, Ozanne B, Stanton P (1999b) Quantitation of c-erbB-2 in primary breast cancer allows identification of a further poor prognostic group. European Journal of Cancer 35 (Suppl 4): S89 [abstract 291]
    • (1999) European Journal of Cancer , vol.35 , Issue.4 SUPPL.
    • Chong, D.1    Cooke, T.G.2    Reeves, J.R.3    George, W.D.4    Mallon, E.A.5    Ozanne, B.6    Stanton, P.7
  • 12
    • 0025032598 scopus 로고
    • The epidermal growth factor receptor and the product of the neu protooncogene are members of a receptor tyrosine phosphorylation cascade
    • Connelly PA, Stern DF (1990) The epidermal growth factor receptor and the product of the neu protooncogene are members of a receptor tyrosine phosphorylation cascade. Proceedings of the National Academy of Sciences USA 87: 6054-6057
    • (1990) Proceedings of the National Academy of Sciences USA , vol.87 , pp. 6054-6057
    • Connelly, P.A.1    Stern, D.F.2
  • 19
    • 0030944455 scopus 로고    scopus 로고
    • ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalling
    • Graus-Porta D, Beerli RR, Daly JM, Hynes NE (1997) ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalling. EMBO Journal 16: 1647-1655
    • (1997) EMBO Journal , vol.16 , pp. 1647-1655
    • Graus-Porta, D.1    Beerli, R.R.2    Daly, J.M.3    Hynes, N.E.4
  • 20
    • 0026650727 scopus 로고
    • Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations
    • Halter SA, Dempsey P, Matsui Y, Stokes MK, Graves-Deal R, Hogan BL, Coffey RJ (1992) Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations. American Journal of Pathology 140: 1131-1146
    • (1992) American Journal of Pathology , vol.140 , pp. 1131-1146
    • Halter, S.A.1    Dempsey, P.2    Matsui, Y.3    Stokes, M.K.4    Graves-Deal, R.5    Hogan, B.L.6    Coffey, R.J.7
  • 24
    • 0028670125 scopus 로고
    • The biology of erbB-2/neu/ HER-2 and its role in cancer
    • Hynes NE, Stern DF (1994) The biology of erbB-2/neu/ HER-2 and its role in cancer. Biochimica et Biophysica Acta 1198: 165-184
    • (1994) Biochimica et Biophysica Acta , vol.1198 , pp. 165-184
    • Hynes, N.E.1    Stern, D.F.2
  • 25
    • 0032430664 scopus 로고    scopus 로고
    • The interactive effect of ras, HER2, p53 and bcl-2 expression in predicting the survival of non-small cell lung cancer patients
    • Kim YC, Park KO, Kern JA, Park CS, Lim SC, Jang AS, Yang JB (1998) The interactive effect of ras, HER2, p53 and bcl-2 expression in predicting the survival of non-small cell lung cancer patients. Lung Cancer 22: 181-190
    • (1998) Lung Cancer , vol.22 , pp. 181-190
    • Kim, Y.C.1    Park, K.O.2    Kern, J.A.3    Park, C.S.4    Lim, S.C.5    Jang, A.S.6    Yang, J.B.7
  • 26
    • 0024395587 scopus 로고
    • Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts
    • Kokai Y, Meyers JN, Wada T, Brown VI, LeVea CM, Davis JG, Dobashi K, Greene MI (1989) Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts. Cell 58: 287-292
    • (1989) Cell , vol.58 , pp. 287-292
    • Kokai, Y.1    Meyers, J.N.2    Wada, T.3    Brown, V.I.4    LeVea, C.M.5    Davis, J.G.6    Dobashi, K.7    Greene, M.I.8
  • 29
    • 0028104202 scopus 로고
    • Regulation of signal transduction and signal diversity by receptor oligomerization
    • Lemmon MA, Schlessinger J (1994) Regulation of signal transduction and signal diversity by receptor oligomerization. Trends in Biochemical Science 19: 459-463
    • (1994) Trends in Biochemical Science , vol.19 , pp. 459-463
    • Lemmon, M.A.1    Schlessinger, J.2
  • 32
    • 0026545620 scopus 로고
    • The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast
    • Liu E, Thor A, He M, Barcos M, Ljung B-M, Benz C (1992) The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast. Oncogene 7: 1027-1032
    • (1992) Oncogene , vol.7 , pp. 1027-1032
    • Liu, E.1    Thor, A.2    He, M.3    Barcos, M.4    Ljung, B.-M.5    Benz, C.6
  • 33
    • 0024348697 scopus 로고
    • Generation and characterization of monoclonal antibodies specific for the human neu oncogene product, p185
    • McKenzie SJ, Marks PJ, Lam T, Morgan J, Panicali DL, Trimpe KL, Carney WP (1989) Generation and characterization of monoclonal antibodies specific for the human neu oncogene product, p185. Oncogene 4: 543-548
    • (1989) Oncogene , vol.4 , pp. 543-548
    • McKenzie, S.J.1    Marks, P.J.2    Lam, T.3    Morgan, J.4    Panicali, D.L.5    Trimpe, K.L.6    Carney, W.P.7
  • 35
    • 0347507033 scopus 로고    scopus 로고
    • HER2 status: Implications for patients
    • Mark E (1999) HER2 status: implications for patients. Eur J Oncol Nursing 4 (Suppl 1)
    • (1999) Eur J Oncol Nursing , vol.4 , Issue.1 SUPPL.
    • Mark, E.1
  • 39
    • 0029884715 scopus 로고    scopus 로고
    • Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization
    • Pauletti G, Godolphin W, Press MF, Slamon DJ (1996) Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization. Oncogene 13: 63-72
    • (1996) Oncogene , vol.13 , pp. 63-72
    • Pauletti, G.1    Godolphin, W.2    Press, M.F.3    Slamon, D.J.4
  • 40
    • 0026776424 scopus 로고
    • Isolation of the neu/ HER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells
    • Peles E, Bacus SS, Koski RA, Lu HS, Wen D, Ogden SG, Ben Levy R, Yarden Y (1992) Isolation of the neu/ HER-2 stimulatory ligand: a 44 kd glycoprotein that induces differentiation of mammary tumor cells. Cell 69: 205-216
    • (1992) Cell , vol.69 , pp. 205-216
    • Peles, E.1    Bacus, S.S.2    Koski, R.A.3    Lu, H.S.4    Wen, D.5    Ogden, S.G.6    Ben Levy, R.7    Yarden, Y.8
  • 41
    • 0031465112 scopus 로고    scopus 로고
    • Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation
    • Pinkas-Kramarski R, Eilam R, Alroy I, Levkowitz G, Lonai P, Yarden Y (1997) Differential expression of NDF/neuregulin receptors ErbB-3 and ErbB-4 and involvement in inhibition of neuronal differentiation. Oncogene 15: 2803-2815
    • (1997) Oncogene , vol.15 , pp. 2803-2815
    • Pinkas-Kramarski, R.1    Eilam, R.2    Alroy, I.3    Levkowitz, G.4    Lonai, P.5    Yarden, Y.6
  • 43
    • 0025359146 scopus 로고
    • Expression of the HER2/neu proto-oncogene in normal adult and fetal tissues
    • Press MF, Cordon-Cardo C, Slamon DJ (1990) Expression of the HER2/neu proto-oncogene in normal adult and fetal tissues. Oncogene 5: 953-962
    • (1990) Oncogene , vol.5 , pp. 953-962
    • Press, M.F.1    Cordon-Cardo, C.2    Slamon, D.J.3
  • 44
    • 0025905507 scopus 로고
    • Comparative investigation of c-erbB2/neu expression in head and neck tumors and mammary cancer
    • Riviere A, Becker J, Loning T (1991) Comparative investigation of c-erbB2/neu expression in head and neck tumors and mammary cancer. Cancer 67: 2142-2149
    • (1991) Cancer , vol.67 , pp. 2142-2149
    • Riviere, A.1    Becker, J.2    Loning, T.3
  • 46
    • 0031868432 scopus 로고    scopus 로고
    • Dynamic expression and activation of ErbB receptors in the developing mouse mammary gland
    • Schroeder W, Lee DC (1998) Dynamic expression and activation of ErbB receptors in the developing mouse mammary gland. Cell Growth and Differentiation 9: 451-464
    • (1998) Cell Growth and Differentiation , vol.9 , pp. 451-464
    • Schroeder, W.1    Lee, D.C.2
  • 47
    • 0030748009 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-immunohistochemical detection and clinical significance for treatment of primary breast cancer
    • Schroeder W, Biesterfeld S, Zillessen R, Rath W (1997) Epidermal growth factor receptor-immunohistochemical detection and clinical significance for treatment of primary breast cancer. Anticancer Research 17: 2799-2802
    • (1997) Anticancer Research , vol.17 , pp. 2799-2802
    • Schroeder, W.1    Biesterfeld, S.2    Zillessen, R.3    Rath, W.4
  • 49
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the Her-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987). Human breast cancer: correlation of relapse and survival with amplification of the Her-2/neu oncogene. Science 235: 177-182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 53
    • 0020043809 scopus 로고
    • Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus
    • Vennstrom B, Bishop JM (1982) Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus. Cell 28: 135-143
    • (1982) Cell , vol.28 , pp. 135-143
    • Vennstrom, B.1    Bishop, J.M.2
  • 54
    • 0023187324 scopus 로고
    • Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: Immunohistological assessment correlates with gene amplification
    • Venter DJ, Tizi NL, Kumar S, Gullick WJ (1987) Overexpression of the c-erbB-2 oncoprotein in human breast carcinomas: immunohistological assessment correlates with gene amplification. Lancet 2: 69-72
    • (1987) Lancet , vol.2 , pp. 69-72
    • Venter, D.J.1    Tizi, N.L.2    Kumar, S.3    Gullick, W.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.