Anti-apoptotic action of hepatocyte growth factor through mitogen-activated protein kinase on human aortic endothelial cells

Journal of Hypertension

Volumn 18, Issue 10, 2000, Pages 1411-1420

  Nakagami, Hironori ^a   Morishita, Ryuichi ^a,b   Yamamoto, Kei ^a   Taniyama, Yoshiaki ^a   Aoki, Motokuni ^a   Kim, Shokei ^c   Matsumoto, Kunio ^b   Nakamura, Toshikazu ^b   Higaki, Jitsuo ^a   Ogihara, Toshio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c Osaka City Medical Hospital   (Japan)

Author keywords

Apoptosis; Endothelial cell; Hepatocyte growth factor; Mitogen activated protein kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; DNA FRAGMENT; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PROPIDIUM IODIDE; SCATTER FACTOR; TETRAZOLIUM;

ANIMAL CELL; AORTA; APOPTOSIS; ARTICLE; CELL COUNT; CELL DEATH; CELL GROWTH; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME RELEASE; HUMAN; HYPERTENSION; IMMUNOBLOTTING; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033794623     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-200018100-00008     Document Type: Article

References (42)

1. Endothelium and growth factors in vascular remodeling of hypertension
2. The role of mechanical and humoral factors in growth regulation of vascular smooth muscle cells and cardiac myocytes
3. Hyperpolarization and relaxation of atrial smooth muscle caused by nitric oxide derived from the endothelium
4. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cells motility and growth
5. In vivo activation of met tyrosine kinase by heterodimeric hepatocyte growth factor molecule promotes angiogenesis
6. Autocrine-paracrine effects of overexpression of hepatocyte growth factor gene on growth of endothelial cells
7. Hepatocyte growth factor is a novel member of endothelium-specific growth factors: Additive stimulatory effect of hepatocyte growth factor with basic fibroblast growth factor but not with vascular endothelial growth factor
8. A vascular modulator, hepatocyte growth factor, is associated with systolic pressure
9. Aortic smooth muscle cells express and secrete vascular endothelial growth factor
10. Expression of local hepatocyte growth factor system in vascular tissues
11. The emerging concept of vascular remodeling
12. Angiogenesis in skeletal and cardiac muscle
13. Actions of hepatocyte growth factor as a local modulator in the kidney: Potential role in pathogenesis of renal disease
14. Potential role of hepatocyte growth factor in the maintenance of renal structure: Anti-apoptotic action of HGF on epithelial cells
15. Potential role of endothelium-specific growth factor, hepatocyte growth factor, on endothelial damage in diabetes mellitus
16. Role of hepatocyte growth factor in endothelial regulation: Prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor
17. Mitogen-activated protein kinase pathways
18. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
19. Opposing effects of ERK and JNK-p38 MAP kinase on apoptosis
20. The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation
21. Induction of apoptosis by ASK1, a mammalian MAPKKK that activated SAPK/JNK and p38 signaling pathways
22. Molecular cloning and expression of human hepatocyte growth factor
23. Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocytes
24. Intercellular adhesion molecule-1 gene expression in human endothelial cells
25. A new sulfonated tetrazolium salt that produces a highly water-soluble formazan dye
26. Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-xL
27. Serum deprivation induced apoptosis accompanied by up-regulation of p53 and bax in human aortic vascular smooth muscle cells
28. Bcl-2 expression prevents activation of the ICE protease cascade
29. Fas antigen and bcl-2 expression on lymphocytes cultured with cytomegalovirus and varicellazoster virus antigen
30. Immunohistochemical localization of hepatocyte growth factor protein in pancreas islet A-cells of man and rats
31. The emerging concept of vascular remodeling
32. Mechanisms of vascular remodeling in hypertension: Role of autocrine-paracrine vasoactive factors
33. Structure and function of hepatocyte growth factor
34. Signal transduction by the hepatocyte growth factor receptor, c-35 met. Activation of the phosphatidylinositol 3-kinase
35. Regulation of scatter factor/hepatocyte growth factor responses by ras, rac and rho in MDCK cells
36. Involvement of Rho p21 small GTP-binding protein with its regulation in HGF-induced cell motility
37. VEGF prevents apoptosJs of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling
38. Extracellular signal-regulated pretein kinase/Jun kinase cross-talk underlines vascular endothelial cell growth factor-induced endothelial cell proliferation
39. Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: Up-regulation of essential transcription factor for angiogenesis, ets
40. Structural and functional characterization of the mouse hepatocyte growth factor gene promoter
41. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
42. MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor