-
1
-
-
0021828903
-
Solubility properties in polymers and biological media. 2. The correlation and prediction of the solubilities of nonelectrolytes in biological tissues and fluids
-
Abraham, M., Kamlet, M.J., Taft, R.W., Doherty, R.M., and Weathersby, RK. (1985) Solubility properties in polymers and biological media. 2. The correlation and prediction of the solubilities of nonelectrolytes in biological tissues and fluids, J. Med. Chem., 28, 865-870.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 865-870
-
-
Abraham, M.1
Kamlet, M.J.2
Taft, R.W.3
Doherty, R.M.4
Weathersby, R.K.5
-
2
-
-
0028139047
-
Hydrogen bonding. 30. Solubility of gases and vapors in biological liquids and tissues
-
Abraham, M.H. and Weathersby, RK. (1994) Hydrogen bonding. 30. Solubility of gases and vapors in biological liquids and tissues, J. Pharm. Sci., 83, 1450-1456.
-
(1994)
J. Pharm. Sci.
, vol.83
, pp. 1450-1456
-
-
Abraham, M.H.1
Weathersby, R.K.2
-
3
-
-
0035478779
-
Predicting the impact of physiological and biochemical processes on oral drug bioavailability
-
Agoram, B., Woltosz, W.S., and Bolger, M.B. (2001) Predicting the impact of physiological and biochemical processes on oral drug bioavailability, Adv. Drug Deliv. Rev., 50, s41-s67.
-
(2001)
Adv. Drug Deliv. Rev.
, vol.50
, pp. s41-s67
-
-
Agoram, B.1
Woltosz, W.S.2
Bolger, M.B.3
-
4
-
-
0023158895
-
Physiologically based pharmacokinetics and the risk assessment process for methylene chloride
-
Andersen, M.E., Clewell, H.J., Gargas, M.L., Smith, F.A., and Reitz, R.H. (1987) Physiologically based pharmacokinetics and the risk assessment process for methylene chloride, Toxicol. Appl. Pharmacol., 87, 185-205.
-
(1987)
Toxicol. Appl. Pharmacol.
, vol.87
, pp. 185-205
-
-
Andersen, M.E.1
Clewell, H.J.2
Gargas, M.L.3
Smith, F.A.4
Reitz, R.H.5
-
5
-
-
0003569292
-
-
Office of Health and Environmental Assessment, EPA, EPA/600/6-88/004, 1-1-7.16, Washington, D.C
-
Arms, A.D. and Travis, C.C. (1988) Reference Physiological Parameters in Pharmacokinetic Modeling, Office of Health and Environmental Assessment, EPA, EPA/600/6-88/004, 1-1-7.16, Washington, D.C.
-
(1988)
Reference Physiological Parameters in Pharmacokinetic Modeling
-
-
Arms, A.D.1
Travis, C.C.2
-
6
-
-
0034458680
-
Current methodologies used for the evaluation of intestinal permeability and absorption
-
Balimane, PV., Chong, S., and Morrison, R.A. (2000) Current methodologies used for the evaluation of intestinal permeability and absorption, J. Pharmacol. Toxicol. Methods, 44, 301-312.
-
(2000)
J. Pharmacol. Toxicol. Methods
, vol.44
, pp. 301-312
-
-
Balimane, P.V.1
Chong, S.2
Morrison, R.A.3
-
7
-
-
0037016837
-
Partition coefficients for the trihalomethanes among blood, urine, water, milk and air
-
Batterman, S., Zhang, L., Wang, S., and Franzblau, A. (2002) Partition coefficients for the trihalomethanes among blood, urine, water, milk and air, Sci. Total Environ. 284, 237-247.
-
(2002)
Sci. Total Environ.
, vol.284
, pp. 237-247
-
-
Batterman, S.1
Zhang, L.2
Wang, S.3
Franzblau, A.4
-
8
-
-
0031876496
-
Evaluation of log Kow and tissue lipid content as predictors of chemical partitioning to fish tissues
-
Bertlesen, S.L., Hoffman, A.D., Gallinat, C.A., Elonen, C.M., and Nichols, J.W. (1998) Evaluation of log Kow and tissue lipid content as predictors of chemical partitioning to fish tissues, Environ. Toxicol. Chem., 17, 1447-1455.
-
(1998)
Environ. Toxicol. Chem.
, vol.17
, pp. 1447-1455
-
-
Bertlesen, S.L.1
Hoffman, A.D.2
Gallinat, C.A.3
Elonen, C.M.4
Nichols, J.W.5
-
9
-
-
0014171822
-
Correlation of serum binding of penicillins with partition coefficients
-
Bird, A.E. and Marshall, A.C. (1967) Correlation of serum binding of penicillins with partition coefficients, Biochem. Pharmacol., 16, 2275-2290.
-
(1967)
Biochem. Pharmacol.
, vol.16
, pp. 2275-2290
-
-
Bird, A.E.1
Marshall, A.C.2
-
10
-
-
0027050440
-
Direct determination of partition coefficients of volatile liquids between oil and gas by gas chromatography and its use in QSAR analysis
-
Cabala, R., Svobodova, J., Feltl, L., and Tichy, M. (1992) Direct determination of partition coefficients of volatile liquids between oil and gas by gas chromatography and its use in QSAR analysis, Chromatographia, 34, 601-606.
-
(1992)
Chromatographia
, vol.34
, pp. 601-606
-
-
Cabala, R.1
Svobodova, J.2
Feltl, L.3
Tichy, M.4
-
11
-
-
0032811868
-
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration
-
Clark, D.E. (1999) Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration, J. Pharm. Sci., 88, 815-821.
-
(1999)
J. Pharm. Sci.
, vol.88
, pp. 815-821
-
-
Clark, D.E.1
-
12
-
-
0027772182
-
Prediction of the partition coefficient of lipophilic compounds in the air-mammal tissue system
-
Connell, D.W., Braddock, R.D., and Mani, S.V. (1993) Prediction of the partition coefficient of lipophilic compounds in the air-mammal tissue system, Sci. Total Environ. Suppl., 2, 1383-1396.
-
(1993)
Sci. Total Environ. Suppl.
, vol.2
, pp. 1383-1396
-
-
Connell, D.W.1
Braddock, R.D.2
Mani, S.V.3
-
13
-
-
0015106768
-
Solubilities of ethylene, cyclopropane, halothane and diethyl ether in human and dog blood at low concentrations
-
Cowles, A.L., Borgstedt, H.H., and Gillies, A.J. (1971) Solubilities of ethylene, cyclopropane, halothane and diethyl ether in human and dog blood at low concentrations, Anesthe-siol, 35, 203-211.
-
(1971)
Anesthe-Siol
, vol.35
, pp. 203-211
-
-
Cowles, A.L.1
Borgstedt, H.H.2
Gillies, A.J.3
-
14
-
-
0025077144
-
Use of linear free energy relationships in toxicology: Prediction of partition coefficients of volatile lipophilic compounds
-
Csanady, G.A. and Laib, R.J. (1990) Use of linear free energy relationships in toxicology: prediction of partition coefficients of volatile lipophilic compounds, Arch. Toxicol., 64, 594-596.
-
(1990)
Arch. Toxicol.
, vol.64
, pp. 594-596
-
-
Csanady, G.A.1
Laib, R.J.2
-
15
-
-
0028812068
-
Metabolic transformation of halogenenated and other alkenes — a theoretical approach. Estimation of metabolic reactivities for in vivo conditions
-
Csanady, G.A., Laib, R.J., and Filser, J.G. (1995) Metabolic transformation of halogenenated and other alkenes — a theoretical approach. Estimation of metabolic reactivities for in vivo conditions, Toxicol. Lett., 75, 217-223.
-
(1995)
Toxicol. Lett.
, vol.75
, pp. 217-223
-
-
Csanady, G.A.1
Laib, R.J.2
Filser, J.G.3
-
16
-
-
0031413080
-
A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans
-
DeJongh, J., Verhaar, H.J., and Hermens, J.L. (1997) A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans, Arch. Toxicol., 72, 17-25.
-
(1997)
Arch. Toxicol.
, vol.72
, pp. 17-25
-
-
Dejongh, J.1
Verhaar, H.J.2
Hermens, J.L.3
-
17
-
-
0000054527
-
Anaesthetic solubility in blood and tissues; values and significance
-
Eger, E.I. and Larson, C.P, Jr. (1964) Anaesthetic solubility in blood and tissues; values and significance, Br. J. Anaesth., 36, 140-149.
-
(1964)
Br. J. Anaesth.
, vol.36
, pp. 140-149
-
-
Eger, E.I.1
Larson, C.P.2
-
18
-
-
0033776103
-
Three-dimensional quantitative structure activity relationship computational approaches for prediction of human in vitro intrinsic clearance
-
Ekins, S. and Obach, R.S. (2000) Three-dimensional quantitative structure activity relationship computational approaches for prediction of human in vitro intrinsic clearance, J. Pharmacol. Exp. Ther., 295, 463-473.
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 463-473
-
-
Ekins, S.1
Obach, R.S.2
-
19
-
-
0034713376
-
A simple model for the prediction of blood-brain partitioning
-
Feher, M., Sourial, E., and Schmidt, J.M. (2000) A simple model for the prediction of blood-brain partitioning, Int. J. Pharm. 201, 239-247.
-
(2000)
Int. J. Pharm.
, vol.201
, pp. 239-247
-
-
Feher, M.1
Sourial, E.2
Schmidt, J.M.3
-
20
-
-
0017069013
-
Estimation of anesthetic solubility in blood
-
Feingold, A. (1976) Estimation of anesthetic solubility in blood, Anesth. Analg, 55, 593-595.
-
(1976)
Anesth. Analg
, vol.55
, pp. 593-595
-
-
Feingold, A.1
-
21
-
-
0021732901
-
Effects of biosolubility on pulmonary uptake and disposition of gases and vapors of lipophilic chemicals
-
Fiserova-Bergerova, V., Tichy, M., and Di Carlo, FJ. (1984) Effects of biosolubility on pulmonary uptake and disposition of gases and vapors of lipophilic chemicals, Drug Metab. Rev., 15, 1033-1070.
-
(1984)
Drug Metab. Rev.
, vol.15
, pp. 1033-1070
-
-
Fiserova-Bergerova, V.1
Tichy, M.2
Di Carlo, F.J.3
-
22
-
-
4243638990
-
A QSAR-type PBPK model for inhaled chlo-roethanes
-
Fouchecourt, M.-O. and Krishnan, K. (2000) A QSAR-type PBPK model for inhaled chlo-roethanes, Toxicol. Sci., 54, 88.
-
(2000)
Toxicol. Sci.
, vol.54
, pp. 88
-
-
Fouchecourt, M.-O.1
Krishnan, K.2
-
23
-
-
85056059877
-
An integrated QSAR-PBPK model for conducting rat-fish extrapolation of the biokinetics of chloroethanes
-
Walker, J., Ed., SETAC Press, Pensacola, FL
-
Fouchecourt, M.-O., Walker, J., and Krishnan, K. (2000) An integrated QSAR-PBPK model for conducting rat-fish extrapolation of the biokinetics of chloroethanes, in Handbook on QSARs for Predicting Effects of Chemicals on Environmental-Human Health Interactions, Walker, J., Ed., SETAC Press, Pensacola, FL.
-
(2000)
Handbook on Qsars for Predicting Effects of Chemicals on Environmental-Human Health Interactions
-
-
Fouchecourt, M.-O.1
Walker, J.2
Krishnan, K.3
-
24
-
-
33947485697
-
A mathematical contribution to structure-activity studies
-
Free, S.M. and Wilson, J. W. (1964) A mathematical contribution to structure-activity studies, J. Med. Chem, 7, 395-399.
-
(1964)
J. Med. Chem
, vol.7
, pp. 395-399
-
-
Free, S.M.1
Wilson, J.W.2
-
25
-
-
0023790133
-
Modeling the tissue solubilities and metabolic rate constant (Vmax) of halogenated methanes, ethanes, and ethylenes
-
Gargas, M.L., Seybold, PG., and Andersen, M.E. (1988) Modeling the tissue solubilities and metabolic rate constant (Vmax) of halogenated methanes, ethanes, and ethylenes, Toxicol. Lett., 43, 235-256.
-
(1988)
Toxicol. Lett.
, vol.43
, pp. 235-256
-
-
Gargas, M.L.1
Seybold, P.G.2
Andersen, M.E.3
-
26
-
-
0024524118
-
Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues
-
Gargas, M.L., Burgess, R.J., Voisard, D.E., Cason, G.H., and Andersen, M.E. (1989) Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues, Toxicol. Appl. Pharmacol., 98, 87-99.
-
(1989)
Toxicol. Appl. Pharmacol.
, vol.98
, pp. 87-99
-
-
Gargas, M.L.1
Burgess, R.J.2
Voisard, D.E.3
Cason, G.H.4
Andersen, M.E.5
-
27
-
-
0035901712
-
The effect of structural QSAR parameters on skin penetration
-
Ghafourian, T. and Fooladi, S. (2001) The effect of structural QSAR parameters on skin penetration, Int. J. Pharm., 217, 1-11.
-
(2001)
Int. J. Pharm.
, vol.217
, pp. 1-11
-
-
Ghafourian, T.1
Fooladi, S.2
-
28
-
-
0037204540
-
Physiologically-based pharmacokinetic simulation modeling
-
Grass, G.M. and Sinko, PJ. (2002) Physiologically-based pharmacokinetic simulation modeling, Adv. Drug Deliv. Rev., 54, 433-451.
-
(2002)
Adv. Drug Deliv. Rev.
, vol.54
, pp. 433-451
-
-
Grass, G.M.1
Sinko, P.J.2
-
29
-
-
0040914011
-
P-o-p analysis. A method for the correlation of biological activity and chemical structure
-
Hansch, C. and Fujita, T. (1964) p-o-p analysis. A method for the correlation of biological activity and chemical structure, J. Am. Chem. Soc., 86, 1616-1626.
-
(1964)
J. Am. Chem. Soc.
, vol.86
, pp. 1616-1626
-
-
Hansch, C.1
Fujita, T.2
-
30
-
-
0001912756
-
The fragment method of calculating partition coefficients
-
Hansch, C. and Leo, A., Eds., Wiley, New York
-
Hansch, C. and Leo, A. (1979) The fragment method of calculating partition coefficients, in Substituent Constants for Correlation Analysis in Chemistry and Biology, Hansch, C. and Leo, A., Eds., Wiley, New York, pp. 18-43.
-
(1979)
Substituent Constants for Correlation Analysis in Chemistry and Biology
, pp. 18-43
-
-
Hansch, C.1
Leo, A.2
-
31
-
-
0009636661
-
QSAR in metabolism
-
Hansch, C. and Leo, A., Eds., ACS Professional Reference Book of American Chemical Society, Washington, D.C
-
Hansch, C. and Leo, A. (1995) QSAR in metabolism, in Exploring QSAR: Fundamentals and Applications in Chemistry and Biology, Hansch, C. and Leo, A., Eds., ACS Professional Reference Book of American Chemical Society, Washington, D.C, pp. 299-343.
-
(1995)
Exploring QSAR: Fundamentals and Applications in Chemistry and Biology
, pp. 299-343
-
-
Hansch, C.1
Leo, A.2
-
32
-
-
0041700890
-
The intrinsic hydrophobic character of organic compounds: Correlations in terms of structural contributions
-
Hine, J. and Mookerjee, PK. (1975) The intrinsic hydrophobic character of organic compounds: correlations in terms of structural contributions, J. Org. Chem., 40, 511-522.
-
(1975)
J. Org. Chem.
, vol.40
, pp. 511-522
-
-
Hine, J.1
Mookerjee, P.K.2
-
33
-
-
0030928558
-
Relationships between the hepatic intrinsic clearance or blood cell-plasma partition coefficient in the rabbit and the lipophilicity of basic drugs
-
Ishizaki, J., Yokogawa, K., Nakashima, E., and Ichimura, F. (1997) Relationships between the hepatic intrinsic clearance or blood cell-plasma partition coefficient in the rabbit and the lipophilicity of basic drugs, J. Pharm. Pharmacol., 49, 768-772.
-
(1997)
J. Pharm. Pharmacol.
, vol.49
, pp. 768-772
-
-
Ishizaki, J.1
Yokogawa, K.2
Nakashima, E.3
Ichimura, F.4
-
34
-
-
0030573058
-
Brain/blood distribution described by a combination of partition coefficients and molecular mass
-
Kalizan, R. and Markuszewski, M. (1996) Brain/blood distribution described by a combination of partition coefficients and molecular mass, Int. J. Pharmacol., 145, 9-16.
-
(1996)
Int. J. Pharmacol.
, vol.145
, pp. 9-16
-
-
Kalizan, R.1
Markuszewski, M.2
-
35
-
-
0028256204
-
Partition coefficients of some acetate esters and alcohols in water, blood, olive oil, and rat tissues
-
Kaneko, T., Wang, PY., and Sato, A. (1994) Partition coefficients of some acetate esters and alcohols in water, blood, olive oil, and rat tissues, Occup. Environ. Med., 51, 68-72.
-
(1994)
Occup. Environ. Med.
, vol.51
, pp. 68-72
-
-
Kaneko, T.1
Wang, P.Y.2
Sato, A.3
-
36
-
-
0027367840
-
3D-Quantitative structure-activity relationships: Describing hydrophobic interactions directly from 3D structures using a comparative molecular field analysis (CoMFA) approach
-
Kim, K.H. (1993) 3D-Quantitative structure-activity relationships: describing hydrophobic interactions directly from 3D structures using a comparative molecular field analysis (CoMFA) approach, Quant. Struct.-Act. Relat., 12, 232-238.
-
(1993)
Quant. Struct.-Act. Relat.
, vol.12
, pp. 232-238
-
-
Kim, K.H.1
-
37
-
-
0000581605
-
Physiologically based pharmacokinetic modeling in toxicology
-
Hayes, A.W., Ed., Taylor & Francis, Philadelphia
-
Krishnan, K. and Andersen, M.E. (2001) Physiologically based pharmacokinetic modeling in toxicology, in Principles and Methods of Toxicology, Hayes, A.W., Ed., Taylor & Francis, Philadelphia, pp. 193-241.
-
(2001)
Principles and Methods of Toxicology
, pp. 193-241
-
-
Krishnan, K.1
Andersen, M.E.2
-
38
-
-
1542605933
-
Estimation of blood/air partition coefficients of organic solvents
-
Hadzi, D. and Jerman-Blazic, B., Eds., Elsevier Science Publishers, Amsterdam
-
Laass, W. (1987) Estimation of blood/air partition coefficients of organic solvents, in QSAR in Drug Design and Toxicology Hadzi, D. and Jerman-Blazic, B., Eds., Elsevier Science Publishers, Amsterdam, pp. 131-134.
-
(1987)
QSAR in Drug Design and Toxicology
, pp. 131-134
-
-
Laass, W.1
-
39
-
-
0023089703
-
Plasma protein binding-lipophilicity relationships: Interspecies comparison of some organic acids
-
Laznicek, M., Kvetina, J., Mazak, J., and Krch, V. (1987) Plasma protein binding-lipophilicity relationships: interspecies comparison of some organic acids, J. Pham. Pharmacol., 39, 79-83.
-
(1987)
J. Pham. Pharmacol.
, vol.39
, pp. 79-83
-
-
Laznicek, M.1
Kvetina, J.2
Mazak, J.3
Krch, V.4
-
40
-
-
0034256965
-
On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: Towards the prediction of human p450 substrate specificity and metabolism
-
Lewis, D.F. (2000) On the recognition of mammalian microsomal cytochrome P450 substrates and their characteristics: towards the prediction of human p450 substrate specificity and metabolism, Biochem. Pharmacol., 60, 293-306.
-
(2000)
Biochem. Pharmacol.
, vol.60
, pp. 293-306
-
-
Lewis, D.F.1
-
41
-
-
0035114457
-
COMPACT: A structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics
-
Lewis, D.F. (2001) COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics, J. Chem. Technol. Biotechnol., 76, 237-244.
-
(2001)
J. Chem. Technol. Biotechnol.
, vol.76
, pp. 237-244
-
-
Lewis, D.F.1
-
42
-
-
0037079889
-
Factors influencing rates and clearance in P450-mediated reactions: QSARs for substrates of the xenobiotic-metabolizing hepatic microsomal P450s
-
Lewis, D.F. and Dickins, M. (2002) Factors influencing rates and clearance in P450-mediated reactions: QSARs for substrates of the xenobiotic-metabolizing hepatic microsomal P450s, Toxicology, 170, 45-53.
-
(2002)
Toxicology
, vol.170
, pp. 45-53
-
-
Lewis, D.F.1
Dickins, M.2
-
43
-
-
0030462889
-
Computation of brain-blood partitioning of organic solutes via free energy calculations
-
Lombardo, F., Blake, J.F., and Curatolo, W.J. (1996) Computation of brain-blood partitioning of organic solutes via free energy calculations, J. Med. Chem., 39, 4750-4755.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 4750-4755
-
-
Lombardo, F.1
Blake, J.F.2
Curatolo, W.J.3
-
44
-
-
0034659425
-
Empirical relations predicting human and rat tissue:Air partition coefficients of volatile organic compounds
-
Meulenberg, C.J. and Vijverberg, H.P (2000) Empirical relations predicting human and rat tissue:air partition coefficients of volatile organic compounds, Toxicol. Appl. Pharmacol., 165, 206-216.
-
(2000)
Toxicol. Appl. Pharmacol.
, vol.165
, pp. 206-216
-
-
Meulenberg, C.J.1
Vijverberg, H.P.2
-
45
-
-
0036096659
-
Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption
-
Moss, G.P, Dearden, J.C., Patel, H., and Cronin, M.T. (2002) Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption, Toxicol. In Vitro, 16, 299-317.
-
(2002)
Toxicol. In Vitro
, vol.16
, pp. 299-317
-
-
Moss, G.P.1
Dearden, J.C.2
Patel, H.3
Cronin, M.T.4
-
46
-
-
0032434917
-
Quantitative structure-pharmacokinetics relationships: II. A mechanistically based model to evaluate the relationship between tissue distribution parameters and compound lipophilicity
-
Nestorov, I., Aarons, L., and Rowland, M. (1998) Quantitative structure-pharmacokinetics relationships: II. A mechanistically based model to evaluate the relationship between tissue distribution parameters and compound lipophilicity, J. Pharmacokinet. Biop-harm., 26, 521-545.
-
(1998)
J. Pharmacokinet. Biop-Harm.
, vol.26
, pp. 521-545
-
-
Nestorov, I.1
Aarons, L.2
Rowland, M.3
-
47
-
-
0037204545
-
Computational approaches to the prediction of the blood-brain distribution
-
Norinder, U. and Haeberlein, M. (2002) Computational approaches to the prediction of the blood-brain distribution, Adv. Drug Deliv. Rev., 54, 291-313.
-
(2002)
Adv. Drug Deliv. Rev.
, vol.54
, pp. 291-313
-
-
Norinder, U.1
Haeberlein, M.2
-
48
-
-
0031172737
-
Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls
-
Parham, F.M., Kohn, M.C., Matthews, H.B., DeRosa, C., and Portier, C.J. (1997) Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls, Toxicol. Appl. Pharmacol., 144, 340-347.
-
(1997)
Toxicol. Appl. Pharmacol.
, vol.144
, pp. 340-347
-
-
Parham, F.M.1
Kohn, M.C.2
Matthews, H.B.3
Derosa, C.4
Portier, C.J.5
-
49
-
-
0031754099
-
Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls. II. Rates of metabolism
-
Parham, F.M. and Portier, C. J. (1998) Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls. II. Rates of metabolism, Toxicol. Appl. Pharmacol., 151, 110-116.
-
(1998)
Toxicol. Appl. Pharmacol.
, vol.151
, pp. 110-116
-
-
Parham, F.M.1
Portier, C.J.2
-
50
-
-
0036675501
-
Quantitative structure-activity relationships (QSARs) for the prediction of skin permeation of exogenous chemicals
-
Patel, H., ten Berge, W., and Cronin, M.T. D. (2002) Quantitative structure-activity relationships (QSARs) for the prediction of skin permeation of exogenous chemicals, Chemo-sphere, 48, 603-613.
-
(2002)
Chemo-Sphere
, vol.48
, pp. 603-613
-
-
Patel, H.1
Ten Berge, W.2
Cronin, M.T.D.3
-
51
-
-
0024312687
-
Correlation of tissue, blood, and air partition coefficients of volatile organic chemicals
-
Paterson, S. and Mackay, D. (1989) Correlation of tissue, blood, and air partition coefficients of volatile organic chemicals, Br. J. Ind. Med., 46, 321-328.
-
(1989)
Br. J. Ind. Med.
, vol.46
, pp. 321-328
-
-
Paterson, S.1
Mackay, D.2
-
52
-
-
0021803133
-
Partition coefficients of some industrial aliphatic hydrocarbons (C5-C7) in blood and human tissues
-
Perbellini, L., Brugnone, F., Caretta, D., and Maranelli, G. (1985) Partition coefficients of some industrial aliphatic hydrocarbons (C5-C7) in blood and human tissues, Br. J. Ind. Med, 42, 162-167.
-
(1985)
Br. J. Ind. Med
, vol.42
, pp. 162-167
-
-
Perbellini, L.1
Brugnone, F.2
Caretta, D.3
Maranelli, G.4
-
53
-
-
0000900027
-
Mechanistic animal-replacement approaches for predicting pharmacokinetics of organic chemicals
-
Salem, H. and Katz, S.A., Eds., Humana Press Inc., Totowa, NJ
-
Poulin, P, Beliveau, M., and Krishnan, K. (1999) Mechanistic animal-replacement approaches for predicting pharmacokinetics of organic chemicals, in Toxicity Assessment Alternatives: Methods, Issues, Opportunities, Salem, H. and Katz, S.A., Eds., Humana Press Inc., Totowa, NJ, pp. 115-139.
-
(1999)
Toxicity Assessment Alternatives: Methods, Issues, Opportunities
, pp. 115-139
-
-
Poulin, P.1
Beliveau, M.2
Krishnan, K.3
-
54
-
-
0028925028
-
A biologically-based algorithm for predicting human tissue: Blood partition coefficients of organic chemicals
-
Poulin, P and Krishnan, K. (1995a) A biologically-based algorithm for predicting human tissue: blood partition coefficients of organic chemicals, Hum. Exp. Toxicol., 14, 273-280.
-
(1995)
Hum. Exp. Toxicol.
, vol.14
, pp. 273-280
-
-
Poulin, P.1
Krishnan, K.2
-
55
-
-
0029144723
-
An algorithm for predicting tissue: Blood partition coefficients of organic chemicals from n-octanol: Water partition coefficient data
-
Poulin, P and Krishnan, K. (1995b) An algorithm for predicting tissue: blood partition coefficients of organic chemicals from n-octanol: water partition coefficient data. J. Toxicol. Environ. Health, 46, 117-129.
-
(1995)
J. Toxicol. Environ. Health
, vol.46
, pp. 117-129
-
-
Poulin, P.1
Krishnan, K.2
-
56
-
-
0030052475
-
A tissue composition-based algorithm for predicting tissue:Air partition coefficients of organic chemicals
-
Poulin, P and Krishnan, K. (1996a) A tissue composition-based algorithm for predicting tissue:air partition coefficients of organic chemicals, Toxicol. Appl. Pharmacol., 136, 126-130.
-
(1996)
Toxicol. Appl. Pharmacol.
, vol.136
, pp. 126-130
-
-
Poulin, P.1
Krishnan, K.2
-
57
-
-
0030048152
-
A mechanistic algorithm for predicting blood:Air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin
-
Poulin, P and Krishnan, K. (1996b) A mechanistic algorithm for predicting blood:air partition coefficients of organic chemicals with the consideration of reversible binding in hemoglobin, Toxicol. Appl. Pharmacol., 136, 131-137.
-
(1996)
Toxicol. Appl. Pharmacol.
, vol.136
, pp. 131-137
-
-
Poulin, P.1
Krishnan, K.2
-
58
-
-
0001300382
-
Molecular structure-based prediction of the partition coefficients of organic chemicals for physiological pharmacokinetic models
-
Poulin, P and Krishnan, K. (1996c) Molecular structure-based prediction of the partition coefficients of organic chemicals for physiological pharmacokinetic models, Toxicol. Methods, 6, 117-137.
-
(1996)
Toxicol. Methods
, vol.6
, pp. 117-137
-
-
Poulin, P.1
Krishnan, K.2
-
59
-
-
0035830672
-
Molecular structure-based prediction of human abdominal skin permeability coefficients for several organic compounds
-
Poulin, P and Krishnan, K. (2001) Molecular structure-based prediction of human abdominal skin permeability coefficients for several organic compounds, J. Toxicol. Environ. Health, 62, 143-159.
-
(2001)
J. Toxicol. Environ. Health
, vol.62
, pp. 143-159
-
-
Poulin, P.1
Krishnan, K.2
-
60
-
-
0032321367
-
Quantitative estimation of hydrogen bond contribution to permeability and absorption processes of some chemicals and drugs
-
Raevsky, O.A. and Schaper, K.-J. (1998) Quantitative estimation of hydrogen bond contribution to permeability and absorption processes of some chemicals and drugs, Eur. J. Med. Chem, 33, 799-807.
-
(1998)
Eur. J. Med. Chem
, vol.33
, pp. 799-807
-
-
Raevsky, O.A.1
Schaper, K.-J.2
-
61
-
-
0035739018
-
A novel approach for prediction of intestinal absorption of drugs in humans based on hydrogen bond descriptors and structural similarity
-
Raevsky, O.A., Schaper, K.-J., Artursson, P, and McFarland, J.W. (2002) A novel approach for prediction of intestinal absorption of drugs in humans based on hydrogen bond descriptors and structural similarity, Quant. Struct.-Act. Relat., 20, 402-413.
-
(2002)
Quant. Struct.-Act. Relat.
, vol.20
, pp. 402-413
-
-
Raevsky, O.A.1
Schaper, K.-J.2
Artursson, P.3
McFarland, J.W.4
-
62
-
-
0021279862
-
A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans
-
Ramsey, J. C. and Andersen, M.E. (1984) A physiologically-based description of the inhalation pharmacokinetics of styrene in rats and humans, Toxicol. Appl. Pharmacol., 73, 159-175.
-
(1984)
Toxicol. Appl. Pharmacol.
, vol.73
, pp. 159-175
-
-
Ramsey, J.C.1
Andersen, M.E.2
-
63
-
-
0023762297
-
Physiologically-based pharmacokinetic modeling with methyl chloroform: Implications for interspecies, high-low dose and dose-route extrapolations
-
Reitz, R.H., McDougal, J.N., Himmelstein, M.W., Nolan, R.J., and Schumann, A.M. (1988) Physiologically-based pharmacokinetic modeling with methyl chloroform: Implications for interspecies, high-low dose and dose-route extrapolations, Toxicol. Appl. Pharmacol., 95, 185-199.
-
(1988)
Toxicol. Appl. Pharmacol.
, vol.95
, pp. 185-199
-
-
Reitz, R.H.1
McDougal, J.N.2
Himmelstein, M.W.3
Nolan, R.J.4
Schumann, A.M.5
-
64
-
-
0017350623
-
Halothane solubility in human blood
-
Saraiva, R.A., Willis, B.A., Steward, A., Lunn, J.N., and Mapleson, W.W. (1977) Halothane solubility in human blood, Br. J. Anaesth., 49, 115-119.
-
(1977)
Br. J. Anaesth.
, vol.49
, pp. 115-119
-
-
Saraiva, R.A.1
Willis, B.A.2
Steward, A.3
Lunn, J.N.4
Mapleson, W.W.5
-
65
-
-
0018693845
-
Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil
-
Sato, A. and Nakajima, T. (1979) Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oil. Br. J. Ind. Med., 36, 231-234.
-
(1979)
Br. J. Ind. Med.
, vol.36
, pp. 231-234
-
-
Sato, A.1
Nakajima, T.2
-
66
-
-
0019767720
-
Quantitative structure-pharmacokinetic relationships and drug design
-
Seydel, J.K. and Schaper, K.J. (1982) Quantitative structure-pharmacokinetic relationships and drug design, Pharmacol. Ther, 15, 131-182.
-
(1982)
Pharmacol. Ther
, vol.15
, pp. 131-182
-
-
Seydel, J.K.1
Schaper, K.J.2
-
67
-
-
0029865450
-
Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics
-
Smith, D.S., Jones, B.C., and Walker, D.K. (1996) Design of drugs involving the concepts and theories of drug metabolism and pharmacokinetics, Medicinal Res. Rev., 16, 243-266.
-
(1996)
Medicinal Res. Rev.
, vol.16
, pp. 243-266
-
-
Smith, D.S.1
Jones, B.C.2
Walker, D.K.3
-
68
-
-
0015598584
-
Solubility coefficients for inhaled anaesthetics for water, oil and biological media
-
Steward, A., Allott, PR., Cowles, A.L., and Mapleson, W.W. (1973) Solubility coefficients for inhaled anaesthetics for water, oil and biological media, Br. J. Anaesth., 45, 282-293.
-
(1973)
Br. J. Anaesth.
, vol.45
, pp. 282-293
-
-
Steward, A.1
Allott, P.R.2
Cowles, A.L.3
Mapleson, W.W.4
-
69
-
-
0033820354
-
The influence of lipophilicity on the pharmacokinetic behavior of drugs: Concepts and examples
-
Testa, B., Crivori, P, Reist, M., and Carrupt, PA. (2000) The influence of lipophilicity on the pharmacokinetic behavior of drugs: concepts and examples, Perspect. Drug Dis-cov. Des, 19, 179-211.
-
(2000)
Perspect. Drug Dis-Cov. Des
, vol.19
, pp. 179-211
-
-
Testa, B.1
Crivori, P.2
Reist, M.3
Carrupt, P.A.4
-
70
-
-
0026378415
-
QSAR approach to estimation of the distribution of xenobiotics and the target organ in the body
-
Tichy, M. (1991a) QSAR approach to estimation of the distribution of xenobiotics and the target organ in the body, Drug Metabol. Drug Interact., 9, 191-200.
-
(1991)
Drug Metabol. Drug Interact.
, vol.9
, pp. 191-200
-
-
Tichy, M.1
-
71
-
-
0026322510
-
QSAR approach to target organ estimation
-
Tichy, M. (1991b) QSAR approach to target organ estimation, Sci. Total Environ., 109-110, 407-410.
-
(1991)
Sci. Total Environ.
, vol.109-110
, pp. 407-410
-
-
Tichy, M.1
-
72
-
-
84958891898
-
Estimation of biosolubility of hydrophilic compounds—QSAR study
-
Tichy, M., Ed., Elsevier Sciences Publishers, Amsterdam
-
Tichy, M., Fiserova-Bergerova, V., and Di Carlo, FJ. (1984) Estimation of biosolubility of hydrophilic compounds—QSAR study, in QSAR in Toxicology andXenobiochemistry, Tichy, M., Ed., Elsevier Sciences Publishers, Amsterdam, pp. 225-231.
-
(1984)
QSAR in Toxicology Andxenobiochemistry
, pp. 225-231
-
-
Tichy, M.1
Fiserova-Bergerova, V.2
Di Carlo, F.J.3
-
73
-
-
0030056293
-
Modeling the cytochrome P450-mediated metabolism of chlorinated volatile organic compounds
-
Waller, C.L., Evans, M.V., and McKinney, J.D. (1996) Modeling the cytochrome P450-mediated metabolism of chlorinated volatile organic compounds, Drug Metab. Dispos, 24, 203-210.
-
(1996)
Drug Metab. Dispos
, vol.24
, pp. 203-210
-
-
Waller, C.L.1
Evans, M.V.2
McKinney, J.D.3
-
74
-
-
0036200162
-
Partitioning of benzene in blood: Influence of hemoglobin type in humans and animals
-
Wiester, M.J., Winsett, D.W., Richards, J.H., Doerfler, D.L., and Costa, D.L. (2002) Partitioning of benzene in blood: influence of hemoglobin type in humans and animals, Environ. Health. Perspect, 110, 255-261.
-
(2002)
Environ. Health. Perspect
, vol.110
, pp. 255-261
-
-
Wiester, M.J.1
Winsett, D.W.2
Richards, J.H.3
Doerfler, D.L.4
Costa, D.L.5
-
75
-
-
0030301082
-
Research to develop a predicting system of mammalian subacute toxicity, (3). Construction of a predictive toxicokinetics model
-
Yamaguchi, T., Yabuki, M., Saito, S., Watanabe, T., Nishimura, H., Isobe, N., Shono, F., and Matsuo, M. (1996) Research to develop a predicting system of mammalian subacute toxicity, (3). Construction of a predictive toxicokinetics model, Chemosphere, 33, 2441-2468.
-
(1996)
Chemosphere
, vol.33
, pp. 2441-2468
-
-
Yamaguchi, T.1
Yabuki, M.2
Saito, S.3
Watanabe, T.4
Nishimura, H.5
Isobe, N.6
Shono, F.7
Matsuo, M.8
-
76
-
-
0025111760
-
Relationships in the structure-tissue distribution of basic drugs in the rabbit
-
Yokogawa, K., Nakashima, E., Ishizaki, J., Maeda, H., Nagano, T., and Ichimura, F. (1990) Relationships in the structure-tissue distribution of basic drugs in the rabbit, Pharm. Res., 7, 691-696.
-
(1990)
Pharm. Res.
, vol.7
, pp. 691-696
-
-
Yokogawa, K.1
Nakashima, E.2
Ishizaki, J.3
Maeda, H.4
Nagano, T.5
Ichimura, F.6
-
77
-
-
0036227660
-
Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: A physiologically based pharmacokinetic model
-
Yokogawa, K., Ishizaki, J., Ohkuma, S., and Miyamoto, K. (2002) Influence of lipophilicity and lysosomal accumulation on tissue distribution kinetics of basic drugs: a physiologically based pharmacokinetic model, Methods Find. Exp. Clin. Pharmacol., 24, 81-93.
-
(2002)
Methods Find. Exp. Clin. Pharmacol.
, vol.24
, pp. 81-93
-
-
Yokogawa, K.1
Ishizaki, J.2
Ohkuma, S.3
Miyamoto, K.4
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