Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosis

Journal of Clinical Investigation

Volumn 115, Issue 5, 2005, Pages 1352-1360

  Cepok, Sabine ^a,b   Zhou, Dun ^a   Srivastava, Rajneesh ^a   Nessler, Stefan ^a   Stei, Susanne ^b   Büssow, Konrad ^c   Sommer, Norbert ^b   Hemmer, Bernhard ^a,b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; RECOMBINANT PROTEIN; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; EPITOPE MAPPING; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREACTIVITY; INFECTION; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TARGETING; T LYMPHOCYTE; VIRUS INFECTION;

ANTIBODIES; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOGLOBULIN G; MULTIPLE SCLEROSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN ARRAY ANALYSIS; T-LYMPHOCYTES; VIRAL PROTEINS;

EID: 18244378502     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200523661     Document Type: Article

References (51)

1. Noseworthy, J.H., Lucchinetti, C., Rodriguez, M., and Weinshenker, B.G. 2000. Multiple sclerosis. N. Engl. J. Med. 343:938-952.
2. Steinman, L. 2001. Multiple sclerosis: a two-stage disease. Nat. Immunol. 2:762-764.
3. Hemmer, B., Archelos, J.J., and Hartung, H.P. 2002. New concepts in the immunopathogenesis of multiple sclerosis. Nat. Rev. Neurosci. 3:291-301.
4. Babbe, H., et al. 2000. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J. Exp. Med. 192:393-404.
5. + T cells in cerebrospinal fluid from multiple sclerosis patients. Brain. 125:538-550.
6. Qin, Y., et al. 1998. Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in muitiple sclerosis. J. Clin. Invest. 102:1045-1050.
7. Baranzini, S.E., et al. 1999. B cell repertoire diversity and clonal expansion in multiple sclerosis brain lesions. J. Immunol. 163:5133-5144.
8. Colombo, M., et al. 2000. Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients. J. Immunol. 164:2782-2789.
9. Owens, G.P., Burgoon, M.P., Anthony, J., Kleinschmidt-DeMasters, B.K., and Gilden, D.H. 2001. The immunoglobulin G heavy chain repertoire in multiple sclerosis plaques is distinct from the heavy chain repertoire in peripheral blood lymphocytes. Clin. Immunol. 98:258-263.
10. Owens, G.P., et al. 2003. Single-cell repertoire analysis demonstrates that clonal expansion is a prominent feature of the B cell response in multiple sclerosis cerebrospinal fluid. J. Immunol. 171:2725-2733.
11. Kabat, E.A., Moore, D.H., and Landow, H. 1942. An electrophoretic study of the protein components in cerebrospinal fluid and their relationship to the serum proteins. J. Clin. Invest. 21:571-577.
12. Mattson, D.H., Roos, R.P., and Arnason, B.G. 1980. Isoelectric focusing of IgG eluted from multiple sclerosis and subacute sclerosing panencephalitis brains. Nature. 287:335-337.
13. Glynn, P., Gilbert, H.M., Newcombe, J., and Cuzner, M.L. 1982. Analysis of immunoglobulin G in multiple sclerosis brain: quantitative and isoelectric focusing studies. Clin. Exp. Immunol. 48:102-110.
14. Mehta, P.D., Miller, J.A., and Tourteltotte, W.W. 1982. Oligoclonal IgG bands in plaques from multiple sclerosis brains. Neurology. 32:372-376.
15. Walsh, M.J., and Tourtellotte, W.W. 1986. Temporal invariance and clonal uniformity of brain and cerebrospinal IgG, IgA, and IgM in multiple sclerosis. J. Exp. Med. 163:41-53.
16. Colombo, M., et al. 2003. Maintenance of B lymphocyte-related clones in the cerebrospinal fluid of multiple sclerosis patients. Eur. J. Immunol. 33:3433-3438.
17. Vandvik, B., Norrby, E., Nordal, H.J., and Degre, M. 1976. Oligoclonal measles virus-specific IgG antibodies isolated from cerebrospinal fluids, brain extracts, and sera from patients with subacute sclerosing panencephalitis and multiple sclerosis. Scand. J. Immunol. 5:979-992.
18. Vartdal, F., Vandvik, B., Michaelsen, T.E., Loe, K., and Norrby, E. 1982. Neurosyphilis: intrathecal synthesis of oligoclonal antibodies to Treponema pallidum. Ann. Neurol. 11:35-40.
19. Wilske, B., et al. 1986. Intrathecal production of specific antibodies against Borrelia burgdorferi in patients with lymphocytic meningoradiculitis (Bannwarth's syndrome). J. Infect. Dis. 153:304-314.
20. Grimaldi, L.M., et al. 1988. HTLV-1-associated myelopathy: oligoclonal immunoglobulin G bands contain anti-HTLV-1 p24 antibody. Ann. Neurol. 24:727-731.
21. Kaiser, R., et al. 1989. Analysis of oligoclonal antibody bands against individual HIV structural proteins in the CSF of patients infected with HIV. J. Neurol. 236:157-160.
22. Cortese, I., et al. 1996. Identification of peptides specific for cerebrospinal fluid antibodies in multiple sclerosis by using phage libraries. Proc. Natl. Acad. Sci. U. S. A. 93:11063-11067.
23. Cortese, I., et al. 1998. CSF-enriched antibodies do not share specificities among MS patients. Mult. Scler. 4:118-123.
24. Archelos, J.J., et al. 1998. Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis. Ann. Neurol. 43:15-24.
25. Cortese, I., Capone, S., Luchetti, S., Cortese, R., and Nicosia, A. 2001. Cross-reactive phage-displayed mimotopes lead to the discovery of mimicry between HSV-1 and a brain-specific protein. J. Neuroimmunol. 113:119-128.
26. Johannsen, E., et al. 2004. Proteins of purified Epstein-Barr virus. Proc. Natl. Acad. Sci. U. S. A. 101:16286-16291.
27. + T cell memory: relationships between epitope specificity, cell phenotype, and immediate effector function. J. Immunol. 167:2019-2029.
28. + T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8:379-385.
29. Giunti, D., et al. 2003. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J. Leukoc. Biol. 73:584-590.
30. Kivisakk, P., et al. 2004. Expression of CCR7 in multiple sclerosis: implications for CNS immunity. Ann. Neurol. 55:627-638.
31. Munch, M., Riisom, K., Christensen, T., Moller-Larsen, A., and Haahr, S. 1998. The significance of Epstein-Barr virus seropositivity in multiple sclerosis patients? Acta Neurol. Scand. 97:171-174.
32. Alotaibi, S., Kennedy, J., Tellier, R., Stephens, D., and Banwell, B., 2004. Epstein-Barr virus in pediatric multiple sclerosis. JAMA. 291:1875-1879.
33. Hernan, M.A., Zhang, S.M., Lipworth, L., Olek, M.J., and Ascherio, A. 2001. Multiple sclerosis and age at infection with common viruses. Epidemiology. 12:301-306.
34. Haahr, S., Koch-Henriksen, N., Moller-Larsen, A., Eriksen, L.S., and Andersen, H.M. 1995. Increased risk of multiple sclerosis after late Epstein-Barr virus infection: a historical prospective study. Mult. Scler. 1:73-77.
35. Martyn, C.N. 1997. Infection in childhood and neurological diseases in adult life. Br. Med. Bull. 53:24-39.
36. Hernan, M.A., Zhang, S.M., Lipworth, L., Olek, M.J., and Ascherio, A. 2001. Multiple sclerosis and age at infection with common viruses. Epidemiology. 12:301-306.
37. Ascherio, A., et al. 2001. Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study. JAMA. 286:3083-3088.
38. Sundstrom, P., et al. 2004. An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study. Neurology. 62:2277-2282.
39. Wandinger, K., et al. 2000. Association between clinical disease activity and Epstein-Barr virus reactivation in MS. Neurology. 55:178-184.
40. Sundstrom, P., et al. 2004. An altered immune response to Epstein-Barr virus in multiple sclerosis: a prospective study. Neurology. 62:2277-2282.
41. Ferrante, P., et al. 1997. Human T-cell lymphotropic virus tax and Epstein-Barr virus DNA in peripheral blood of multiple sclerosis patients during acute attack. Acta Neurol. Scand. Suppl. 169:79-85.
42. Ennas, M.G., et al. 1992. Immunocompetent cell markers in human fetal astrocytes and neurons in culture. J. Neurosci. Res. 32:424-436.
43. Gasque, P., et al. 1996. Identification and characterization of complement C3 receptors on human astrocyres. J. Immunol. 156:2247-2255.
44. Menet, A., et al. 1999. Epstein-Barr virus infection of human astrocyte cell lines. J. Virol. 73:7722-7733.
45. Hilton, D.A., Love, S., Fletcher, A., and Pringle, J.H. 1994. Absence of Epstein-Barr virus RNA in multiple sclerosis as assessed by in situ hybridisation. J. Neurol. Neurosurg. Psychiatr. 57:975-976.
46. Wucherpfennig, K.W., and Strominger, J.L. 1995. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell. 80:695-705.
47. Hemmer, B., et al. 1997. Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone. J. Exp. Med. 185:1651-1659.
48. Lang, H.L., et al. 2002. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat. Immunol. 3:940-943.
49. Ufret-Vincenty, R.L., et al. 1998. In vivo survival of viral antigen-specific T cells that induce experimental autoimmune encephaiomyelitis. J. Exp. Med. 188:1725-1738.
50. McDonald, W.I., et al. 2001. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 50:121-127.
51. Bussow, K., Nordhoff, E., Lubbert, C., Lehrach, H., and Walter, G. 2000. A human cDNA library for high-throughput protein expression screening. Genomics. 65:1-8.