Potential applications of conventional and molecular imaging to biodefense research

Clinical Infectious Diseases

Volumn 40, Issue 10, 2005, Pages 1471-1480

  Li, King ^a   Thomasson, David ^a   Ketai, Loren ^c   Contag, Chris ^d   Pomper, Martin ^e   Wright, Mary ^b   Bray, Mike ^b  

^a CLINICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^d STANFORD UNIVERSITY   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX; BACILLUS ANTHRACIS; BACTERIAL COLONIZATION; BIOLOGICAL WARFARE; BIOLUMINESCENCE; BLOOD CLOTTING; COMPUTER ASSISTED TOMOGRAPHY; COWPOX; COWPOX VIRUS; DIAGNOSTIC IMAGING; EASTERN EQUINE ENCEPHALOMYELITIS VIRUS; EBOLA VIRUS; ECHOGRAPHY; ECTROMELIA VIRUS; ENCEPHALITIS; FLUORESCENCE ANALYSIS; FRANCISELLA TULARENSIS; HEMORRHAGIC FEVER; HUMAN; IMMUNE RESPONSE; INFECTION; INFLAMMATION; LYMPH NODE; MARBURG VIRUS; MONKEYPOX; MONKEYPOX VIRUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PHOCOMELIA; PLAGUE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOGRAPHY; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SMALLPOX; TISSUE INJURY; TULAREMIA; VACCINIA; VACCINIA VIRUS; VENEZUELAN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; VIRUS REPLICATION; WESTERN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; YERSINIA PESTIS;

BIOTERRORISM; COMMUNICABLE DISEASES; DIAGNOSTIC IMAGING; HUMANS; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 18244374195     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/429723     Document Type: Review

References (55)

1. Franz DR, Jahrling PB, Friedlander AM, et al. Clinical recognition and management of patients exposed to biological warfare agents. JAMA 1997; 278:399-411.
2. Ketai L, Alrahji AA, Hart B, Enria D, Mettler F Jr. Radiologic manifestations of potential bioterrorist agents of infection. AJR Am J Roentgenol 2003; 180:565-75.
3. Pomper MG. Molecular imaging: an overview. Acad Radiol 2001; 8: 1141-53.
4. Doyle TC, Burns SM, Contag CH. In vivo bioluminescence imaging for integrated studies of infection. Cell Microbiol 2004; 6:303-17.
5. Hildebrandt IJ, Gambhir SS. Molecular imaging applications for immunology. Clin Immunol 2004; 111:210-24.
6. Ahuja AT, Ooi CGC. Imaging in SARS. Cambridge, United Kingdom: Cambridge University Press, 2004.
7. Stride E, Saffari N. Microbubble ultrasound contrast agents: a review. Proc Inst Mech Eng [H] 2003; 217:429-47.
8. Reid JM. Imaging with high frequency ultrasound. Ultrasound Med Biol 2001; 27:1577.
9. Louie AY, Huber MM, Ahrens ET, et al. In vivo visualization of gene expression using magnetic resonance imaging. Nat Biotechnol 2000; 18:321-5.
10. Allen MJ, Meade TJ. Synthesis and visualization of a membrane-permeable MRI contrast agent. J Biol Inorg Chem 2003; 8:746-50.
11. Allen MJ, Meade TJ. Magnetic resonance contrast agents for medical and molecular imaging. Met Ions Biol Syst 2004; 42:1-38.
12. Blasberg RG. In vivo molecular-genetic imaging: multimodality nuclear and optical combinations. Nucl Med Biol 2003; 30:879-88.
13. Meade TJ, Taylor AK, Bull SR. New magnetic resonance contrast agents as biochemical reporters. Curr Opin Neurobiol 2003; 13:597-602.
14. Blankenberg FG. Molecular imaging with single photon emission computed tomography: how new tracers can be employed in the nuclear medicine clinic. IEEE Eng Med Biol Mag 2004; 23:51-7.
15. Pomper MG, Hammoud DA. Positron emission tomography in molecular imaging: could the promise of personalized patient care be reaching fruition? IEEE Eng Med Biol Mag 2004; 23:28-37.
16. Hoffman R. Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models. Lancet Oncol 2002; 3: 546-56.
17. Southward CM, Surette MG. The dynamic microbe: green fluorescent protein brings bacteria to light. Mol Microbiol 2002; 45:1191-6.
18. Contag PR, Olomu IN, Stevenson DK, Contag CH. Bioluminescent indicators in living mammals. Nat Med 1998; 4:245-7.
19. Choy G, Choyke P, Libutti SK. Current advances in molecular imaging: noninvasive in vivo bioluminescent and fluorescent optical imaging in cancer research. Mol Imaging 2003; 2:303-12.
20. Nakajima A, Seroogy CM, Sandora MR, et al. Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J Clin Invest 2001; 107:1293-301.
21. Tromberg BJ, Shah N, Lanning R, et al. Non-invasive in vivo characterization of breast tumors using photon migration spectroscopy. Neoplasia 2000; 2:26-40.
22. Bremer C, Ntziachristos V, Weissleder R. Optical-based molecular imaging: contrast agents and potential medical applications. Eur Radiol 2003; 13:231-43.
23. Doubrovin M, Ponomarev V, Blasberg RG. PET-based reporter gene imaging: assessment of endogenous molecular-genetic events. IEEE Eng Med Biol Mag 2004; 23:38-50.
24. Contag CH, Contag PR, Mullins JI, Spilman SD, Stevenson DK, Benaron DA. Photonic detection of bacterial pathogens in living hosts. Mol Microbiol 1995; 18:593-603.
25. Hardy J, Francis KP, DeBoer M, Chu P, Gibbs K, Contag CH. Extracellular replication of Listeria monocytogenes in the murine gall bladder. Science 2004; 303:851-3.
26. McCaffrey A, Kay MA, Contag CH. Advancing molecular therapies through in vivo bioluminescent imaging. Mol Imaging 2003; 2:75-86.
27. Contag PR. Whole-animal cellular and molecular imaging to accelerate drug development. Drug Discov Today 2002; 7:555-62.
28. National Institute of Allergy and Infectious Diseases Biodefense Research website. Available at: http://www.niaid.nih.gov/biodefense/. Accessed 30 March 2005.
29. Inglesby TV, O'Toole T, Henderson DA, et al. Anthrax as a biological weapon, 2002: updated recommendations for management. JAMA 2002; 287:2236-52.
30. Jernigan JA, Stephens DS, Ashford DA, et al. Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States. Emerg Infect Dis 2001; 7:933-44.
31. Wood BJ, DeFranco B, Ripple M, et al. Inhalational anthrax: radiologic and pathologic findings in two cases. AJR Am J Roentgenol 2003; 181: 1071-8.
32. Krol CM, Uszynski M, Dillon EH, et al. Dynamic CT features of inhalational anthrax infection. AJR Am J Roentgenol 2002; 178:1063-6.
33. Earls JP, Cerva D Jr, Berman E, et al. Inhalational anthrax after bioterrorism exposure: spectrum of imaging findings in two surviving patients. Radiology 2002; 222:305-12.
34. Mayer TA, Bersoff-Matcha S, Murphy C, et al. Clinical presentation of inhalational anthrax following bioterrorism exposure: report of 2 surviving patients. JAMA 2001; 286:2549-53.
35. Harisinghani MG, Barentsz J, Hahn PF, et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med 2003; 348:2491-9.
36. Inglesby TV, Dennis DT, Henderson DA, et al. Plague as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA 2000; 283:2281-90.
37. Dennis DT, Inglesby TV, Henderson DA, et al. Tularemia as a biological weapon: medical and public health management. JAMA 2001; 285: 2763-73.
38. Mahanty S, Bray M. Pathogenesis of filoviral haemorrhagic fevers. Lancet Infect Dis 2004; 4:487-98.
39. Geisbert TW, Hensley LE, Larsen T, et al. Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection. Am J Pathol 2003; 163: 2347-70.
40. Bray M, Mahanty S. Ebola hemorrhagic fever and septic shock. J Infect Dis 2003; 188:1613-7.
41. Geisbert TW, Hensley LE, Gibb TR, Steele KE, Jaax NK, Jahrling PB. Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses. Lab Invest 2000; 80:171-86.
42. Blankenberg FG. Recent advances in the imaging of programmed cell death. Curr Pharm Des 2004; 10:1457-67.
43. Henderson DA, Inglesby TV, Bartlett JG, et al. Smallpox as a biological weapon: medical and public health management. Working Group on Civilian Biodefense. JAMA 1999; 281:2127-37.
44. Breman JG, Henderson DA. Diagnosis and management of smallpox. N Engl J Med 2002; 346:1300-8.
45. Bray M, Buller M. Looking back at smallpox. Clin Infect Dis 2004; 38:882-9.
46. Di Giulio DB, Eckburg PB. Human monkeypox. Lancet Infect Dis 2004; 4:199.
47. Cook SH, Griffin DE. Luciferase imaging of a neurotropic viral infection in intact animals. J Virol 2003; 77:5333-8.
48. Zaucha GM, Jahrling PB, Geisbert TW, Swearengen JR, Hensley L. The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis). Lab Invest 2001; 81: 1581-600.
49. Jahrling PB, Hensley LE, Martinez MJ, et al. Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox. Proc Natl Acad Sci U S A 2004; 101:15196-200.
50. Griffin D. Alphaviruses. In: Knipe D, ed. Fields virology. Philadelphia: Lippincott Williams & Wilkins, 2001.
51. Smith JF, Davis K, Hart MK, et al. Viral encephalitides. In: Siddell F, et al., ed. Medical aspects of chemical and biological warfare. Washington, DC: Office of the Surgeon General, 1997.
52. Anderson MG, Frenkel LD, Homann S, Guffey J. A case of severe monkeypox virus disease in an American child: emerging infections and changing professional values. Pediatr Infect Dis J 2003; 22:1093-6; discussion 1096-8.
53. Forsberg F, Piccoli CW, Liu JB, et al. Hepatic tumor detection: MR imaging and conventional US versus pulse-inversion harmonic US of NC100100 during its reticuloendothelial system-specific phase. Radiology 2002; 222:824-9.
54. Deresiewicz RL, Thaler SJ, Hsu L, Zamani AA. Clinical and neuroradiographic manifestations of eastern equine encephalitis. N Engl J Med 1997; 336:1867-74.
55. Olasz EB, Lang L, Seidel J, Green MV, Eckelman WC, Katz SI. Fluorine-18 labeled mouse bone marrow-derived dendritic cells can be detected in vivo by high resolution projection imaging. J Immunol Methods 2002; 260:137-48.