Microbubble ultrasound contrast agents: A review

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Volumn 217, Issue 6, 2003, Pages 429-447

  Stride, E ^a   Saffari, N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Microbubble ultrasound contrast agents

Indexed keywords

BUBBLES (IN FLUIDS); CONTRAST MEDIA; DIAGNOSTIC RADIOGRAPHY; EQUATIONS OF MOTION; MATHEMATICAL MODELS; GENE TRANSFER;

MICROBUBBLE; ULTRASOUND CONTRAST AGENTS;

ULTRASONIC IMAGING; ULTRASONICS;

CONTRAST AGENT; EXPERIMENTAL EVIDENCE; GENE DELIVERY; HARMFUL EFFECTS; SCATTERING PROPERTY; ULTRASOUND CONTRAST AGENT; ULTRASOUND DIAGNOSIS; ULTRASOUND IMAGE ENHANCEMENTS;

BIOMATERIAL;

CHEMISTRY; DRUG DELIVERY SYSTEM; ECHOGRAPHY; IMAGE ENHANCEMENT; METHODOLOGY; MICROBUBBLE; RADIATION EXPOSURE; RADIATION SCATTERING; REVIEW; THEORETICAL MODEL; ULTRASOUND; ULTRASOUND THERAPY;

COATED MATERIALS, BIOCOMPATIBLE; DRUG DELIVERY SYSTEMS; IMAGE ENHANCEMENT; MICROBUBBLES; MODELS, THEORETICAL; SCATTERING, RADIATION; ULTRASONIC THERAPY; ULTRASONICS; ULTRASONOGRAPHY;

EID: 1442281835     PISSN: 09544119     EISSN: None     Source Type: Journal    
DOI: 10.1243/09544110360729072     Document Type: Article

References (135)

1. Forsberg, F., Shi, W. T. and Goldberg, B. B. Subharmonic imaging of contrast agents. Ultrasonics, 2000, 38(1), 93-98.
2. Uhlendorf, V. and Hoffmann, C. Non linear acoustic response of coated microbubbles in diagnostic ultrasound. In Proceedings of the IEEE Ultrasonics Symposium, 1994, pp. 1559-1562 (IEEE, New York).
3. Frinking, P. J. A. and de Jong, N. Modelling of ultrasound contrast agents. In Proceedings of the IEEE Ultrasonics Symposium, 1997, pp. 1601-1604 (IEEE, New York).
4. de Jong, N., Hoff, L., Skotland, T. and Bom, N. Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements. Ultrasonics, 1992, 30, 95-103.
5. de Jong, N. and Hoff, L. Ultrasound scattering properties of Albunex microspheres. Ultrasonics, 1993, 31(3), 175-181.
6. Church, C. The effects of an elastic solid surface layer on the radial pulsations of gas bubbles. J. Acoust. Soc. Am., 1995, 97(3), 1510-1520.
7. Frinking, P. J. A. and de Jong, N. Acoustic modelling of shell-encapsulated gas bubbles. Ultrasound Med. Biology, 1998, 24(4), 523-533.
8. Allen, J. S. and Roy, R. A. Dynamics of gas bubbles in viscoelastic fluids. I: linear viscoelasticity. J. Acoust. Soc. Am., 2000, 107(6), 3167-3178.
9. Allen, J. S. and Roy, R. A. Dynamics of gas bubbles in viscoelastic fluids. II: non-linear viscoelasticity. J. Acoust. Soc. Am., 2000, 108(4), 1640-1651.
10. Medwin, H. Counting bubbles acoustically: a review. Ultrasonics, 1977, 15, 7-13.
11. Hoff, L., Sontum, P. and Hovem, J. Oscillations of polymeric microbubbles: Effect of the encapsulating shell. J. Acoust. Soc. Am., 2000, 107(4), 2272-2280.
12. Lauterborn, W. Numerical investigation of non-linear oscillations of gas bubbles in liquids. J. Acoust. Soc. Am., 1976, 59, 283-293.
13. de Jong, N., Cornet, R. and Lancee, C. T. Higher harmonics of vibrating gas-filled microspheres. Part one: simulations. Ultrasonics, 1994, 32(6), 447.
14. Lauterborn, W. and Suchal, E. Bifurcation superstructure in a model of acoustic turbulence. Phys. Rev. Lett., 1984, 53, 2304-2307.
15. Dayton, P. A., Morgan, K. E., Klibanov, A. L., Brandenburger, G. H. and Ferrara, K. W. Optical and acoustical observations of the effects of ultrasound on contrast agents. IEEE Trans. Ultrasonics, Ferroelectrics Frequency Control, 1999, 46(1), 220-236.
16. Rayleigh, Lord On the capillary phenomena of jets. Proc. R. Soc. Lond., 1879, 29, 71-97.
17. Lamb, H. Hydrodynamics, 1895 (Cambridge University Press, Cambridge).
18. Chahine, G. L. Experimental and asymptotic study of nonspherical bubble collapse. In Applied Scientific Research: Mechanics and Physics of Bubbles in Liquids (Ed. Wijngaarden, L.), 1982 (Martinus Nijhoff, The Hague).
19. Longuet-Higgins, M. S. Monopole emission of sound by asymmetric bubble oscillations. Part 1: normal modes. J. Fluid Mechanics, 1989, 201, 525-541.
20. Longuet-Higgins, M. S. Monopole emission of sound by asymmetric bubble oscillations. Part 2: an initial value problem. J. Fluid Mechanics, 1989, 201, 543-565.
21. Cao, J. and Christensen, R. N. Non-spherical bubble collapse mechanics in binary solutions. Int. J. Heat Mass Transfer, 2001, 44(7), 1411-1423.
22. Hilgenfeldt, S., Lohse, D. and Zomack, M. Response of bubbles to diagnostic ultrasound: a unifying theoretical approach. Eur. Phys. J. B, 1998, 4, 247-255.
23. Ye, Z. On sound scattering and attenuation of Albunex bubbles. J. Acoust. Soc. Am., 1996, 100(4), 2011-2028.
24. Allen, J. S., Kruse, D. E. and Ferrara, K. W. Shell waves and acoustic scattering from ultrasound contrast agents. IEEE Trans. Ultrasonics, Ferroelectrics Frequency Control, 2001, 48(2), 409-418.
25. Plesset, M. S. The dynamics of cavitation bubbles. J. Appl. Mechanics, 1949, 16, 277-282.
26. Neppiras, E. Acoustic cavitation. Physics Rep., 1980, 61(3), 159-251.
27. Hilgenfeldt, S., Lohse, D. and Brenner, M. P. Phase diagrams of sonoluminescing bubbles. Physics Fluids, 1996, 8(11), 2808-2826.
28. Plesset, M. S. and Mitchell, T. P. On the stability of the spherical shape of a vapour cavity in a liquid. Q. Appl. Math., 1956, 13, 419-430.
29. Flynn, H. G. In Physical Acoustics (Ed. Mason, W. P.), Vol. IB, 1964, Ch. 9, pp. 57-85 (Academic Press, New York).
30. Apfel, R. Acoustic cavitation. Meth. Exptl Physics: Ultrasonics, 1981, 19(7), 355-411.
31. Apfel, R. E. and Holland, C. K. Gauging the likelihood of cavitation from short-pulse low-duty cycle diagnostic ultrasound. Ultrasound Med. Biology, 1991, 17, 179-185.
32. Holland, C. K. and Apfel, R. E. Fundamentals of the mechanical index and caveats in its application. J. Acoust. Soc. Am., 1999, 105, 1324.
33. Chomas, J. E., Dayton, P., Allen, J., Morgan, K. and Ferrara, K. W. Mechanisms of contrast agent destruction. IEEE Trans. Ultrasonics, Ferroelectrics Frequency Control, 2001, 48(1), 232-248.
34. Frinking, P., de Jong, N. and Cespedes, E. I. Scattering properties of encapsulated gas bubbles at high ultrasound pressures. J. Acoust. Soc. Am., 1999, 105(3), 1989-1996.
35. Stride, E. P. J. and Saffari, N. On the destruction of microbubble ultrasound contrast agents. Ultrasound Med. Biology, 2003, 29(4), 563-573.
36. Leighton, T. G. L. Transient excitation of insonated bubbles. Ultrasonics, 1989, 27(50), 50-53.
37. Leighton, T. G. L. High speed photography of transient excitation. Ultrasonics, 1989, 27(50), 371-373.
38. Bjerknes, V. F. K. Fields of Force, 1906 (Columbia University Press, New York).
39. Bjerknes, V. J. F. Z. Phys. Chem. Unterricht, 1930, 43(1).
40. Omta, R. Oscillations of a cloud of bubbles of small and not so small amplitude. J. Acoust. Soc. Am., 1987, 82(3), 1018-1033.
41. Leighton, T. G. L. Bubble population phenomena in acoustic cavitation. Ultrasonics Sonochemistry, 1995, 2(2), s123-s136.
42. Feuillade, C. Acoustically coupled gas bubbles in fluids: time-domain phenomena. J. Acoust. Soc. Am., 2001, 109(6), 2606-2615.
43. Lloyd, P. and Berry, M. V. Wave propagation through an assembly of spheres. IV: relations between different multiple scattering theories. Proc. Phys. Soc., 1967, 91, 678-688.
44. Ye, Z., Hsu, H. and Hoskinson, E. Phase order and energy localization in acoustic propagation in random bubbly liquids. Physics Lett. A, 2000, 275, 452-458.
45. Chin, C. T. and Burns, P. Predicting the acoustic response of a microbubble population for contrast imaging in medical ultrasound. Ultrasound Med. Biology, 2000, 26(8), 1293-1300.
46. Shi, W. and Forsberg, F. Ultrasonic characterization of the non-linear properties of contrast microbubbles - stabilization and simulations of cyclic changes of size and content. Ultrasound Med. Biology, 2000, 26(1), 93-104.
47. Leighton, T. G. L. The Acoustic Bubble, 1994 (Academic Press, New York).
48. Plesset, M. S. and Chapman, R. B. Collapse of an initially spherical vapour cavity in the neighbourhood of a solid boundary. J. Fluid Mechanics, 1971, 47, 283-290.
49. Lauterborn, W. and Bolle, H. Experimental investigation of cavitation-bubble collapse in the neighbourhood of a solid boundary. J. Fluid Mechanics, 1975, 72, 391-399.
50. Zhong, P., Zhou, Y. and Zhu, S. Dynamics of bubble oscillation in constrained media and mechanisms of vessel rupture in SWL. Ultrasound Med. Biology, 2001, 27(1), 119-134.
51. Krasovitski, B. and Kimmel, E. Gas bubble pulsation in a semiconfined space subjected to ultrasound. J. Acoust. Soc. Am., 2001, 109(3), 891-898.
52. Zhang, S., Duncan, J. H. and Chahine, G. L. The final stage of the collapse of a cavitation bubble in the vicinity of a rigid wall. J. Fluid Mechanics, 1993, 257, 147-181.
53. Chahine, G. L. Cavitation dynamics at microscale level. J. Heart Dis., 1993, 3, 102-116.
54. Sato, K., Tomita, Y. and Shima, A. Numerical analysis of a gas bubble near a rigid boundary in and oscillatory pressure field. J. Acoust. Soc. Am., 1994, 95(5), Part 1, 2416-2424.
55. Dayton, P., Chomas, J., Lum, A., Simon, S. and Ferrara, K. Acoustical and physical dynamics of phagocytosed microbubble contrast agents. In Proceedings of the IEEE Ultrasonics Symposium, 2000, Vol. 2, pp. 1877-1880 (IEEE, New York).
56. Geng, X., Yuan, H. and Prosperetti, A. The oscillation of gas bubbles in tubes: Experimental results. J. Acoust. Soc. Am., 1999, 106 (2), 674-681.
57. de Jong, N., Cornet, R. and Lancee, C. T. Higher harmonics of vibrating gas-filled microspheres. Part two: measurements. Ultrasonics, 1994, 32(6), 455-459.
58. Forsberg, F., Basude, R., Liu, J. B., Alessandro, J., Shi, W. T., Rawool, N. M., Goldberg, B. B. and Wheatley, M. A. Effect of filling gases on the backscatter from contrast microbubbles: theory and in vivo measurements-development of a novel contrast agent for diagnostic ultrasound. Ultrasound Med. Biology, 1999, 25 (8), 1203-1211.
59. Klibanov, A. L., Ferrara, K. W., Hughes, M. S., Wible, J. H., Wojdyla, J. K., Dayton, P. A., Morgan, K. E. and Brandenburger, G. H. Direct microscopic observation of the dynamic effects of ultrasound on ultrasonic contrast microspheres. Investigative Radiology, 1998, 33 (12), 863-870.
60. Kudo, N., Miyaoka, T., Kuribayashi, K. and Yamamoto, K. Study of the mechanism of fragmentation of a microbubble exposed to ultrasound using a high speed observation system. J. Acoust. Soc. Am., 2000, 108 (5), Part 2, 2547.
61. Moran, C. M., Anderson, T., Sboros, V., Sutherland, G. R., Wright R., and McDicken, W. N. Quantification of the enhanced backscatter phenomenon from an intravenous and an intra-arterial contrast agent - stabilization and simulations of cyclic changes of size and content. Ultrasound Med. Biology, 1998, 24 (6), 871-880.
62. Moran, C. M., Anderson, T., Pye, S. D., Sboros, V. and McDicken, W. N. Quantification of microbubble destruction of three fluorocarbon-filled ultrasonic contrast agents. Ultrasound Med. Biology, 2000, 26 (4), 629-639.
63. Kamiyama, N., Moriyasu, F., Mine, Y. and Goto, Y. Analysis of flash echo from contrast agent for designing optimal ultrasound diagnostic systems-in vitro and in vivo observations. Ultrasound Med. Biology, 1999, 25 (3), 411-420.
64. Wei, M., Skyba, D. M., Firschke, M., Jayaweera, A. R., Lindner, M. and Kaul, M. Interactions between microbubbles and ultrasound: in vitro and in vivo observations. J. Am. College Cardiol., 1997, 29 (5), 1081-1088.
65. Miller, D. M., Gies, R. A. and Chrisler, W. B. Ultrasonically induced hemolysis at high cell and gas body concentrations in a thin disc exposure chamber. Ultrasound Med. Biology, 1997, 23 (4), 625-633.
66. Deng, C. X., Lizzi, F. L., Kalisz, A., Rosado, A., Silverman, R. H. and Coleman, D. J. Study of ultrasonic contrast agents using a dual-frequency band technique. Ultrasound Med. Biology, 2000, 26 (5), 819-831.
67. Frinking, P., Cespedes, E. and de Jong, N. Multi-pulse ultrasound contrast imaging based on a decorrelation detection strategy. In Proceedings of the IEEE Ultrasonic Symposium, 1998, pp. 1787-1790 (IEEE, New York).
68. Podell, S., Burrascano, C. and Mehlhaff, P. Physical and biochemical stability of Optison®, an injectable ultrasound contrast agent. Biotechnol. Appl. Biochemistry, 1999, 30(3), 213-223.
69. Chang, P. P., Makin, I. R. S. and Crum, L. A. Acoustic and system parameters affecting destruction of ultrasound contrast agents. J. Acoust. Soc. Am., 1998, 103(5), 3003.
70. Shi, W., Forsberg, F., Tornes, A., Ostensen, J. and Goldberg, B. B. Destruction of contrast microbubbles and the association with inertial cavitation. Ultrasound Med. Biology, 2000, 26(6), 1009-1019.
71. Uhlendorf, V., Scholle, F. D. and Reinhardt, M. Acoustic behaviour of current ultrasound contrast agents. Ultrasonics, 2000, 38, 81-86.
72. Chen, W. S., Matula, T. J. and Crum, L. A. Behaviour of ultrasound contrast agents near the fragmentation threshold. J. Acoust. Soc. Am., 2000, 108, 2547.
73. Church, C. and Carstensen, E. Stable inertial cavitation. Ultrasound Med. Biology, 2001, 27(10), 1435-1437.
74. Flynn, H. G. Cavitation Dynamics II: Free pulsations and models for cavitation bubbles. J. Acoust. Soc. Am., 1975, 58, 1160-1170.
75. Crum, L. A. Bjerknes forces on bubbles in a stationary sound field. J Acoust. Soc. Am., 1975, 57(6), 1363-1370.
76. Duineveld, P. C. The influence of an applied sound field on bubble coalescence. J. Acoust. Soc. Am., 1996, 99(1), 622-624.
77. Dayton, P., Goode, A., Morgan, K., Klibanov, S., Brandenburger, G. and Ferrara, K. Action of microbubbles when insonified: experimental evidence. In Proceedings of the IEEE Ultrasonics Symposium, 1996, pp. 1131-1134 (IEEE, New York).
78. Dayton, P. A., Morgan, K. E., Klibanov, A. L., Brandenburger, G., Nightingale, K. R. and Ferrara, K. W. A preliminary evaluation of the effects of primary and secondary radiation forces on acoustic contrast agents. IEEE Trans. Ultrasonics, Ferroelectrics Frequency Control, 1997, 44(6), 1264-1281.
79. Dayton, P., Klibanov, A., Brandenburger, G. and Ferrara, K. Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles-an in vitro feasibility study. Ultrasound Med. Biology, 1999, 25(8), 1195-1201.
80. Hughes, M., Klibanov, A. L., Marsh, J. N., Miller, J. G. and Brandenburger, G. H. Broadband time domain reflectometry measurement of attenuation and phase velocity in highly attenuating suspensions with application to the ultrasound contrast medium Albunex. J. Acoust. Soc. Am., 2000, 108(2), 813-820.
81. Zhang, D., Gong, X. F., Liu, J. H., Shao, L. Z., Li, X. R. and Zhang, Q. L. The experimental investigation of ultrasonic properties for a sonicated contrast agent and its application in biomedicine. Ultrasound Med. Biology, 2000, 26(2), 347-351.
82. Bracco http://www.bracco.com.
83. Kapodistrias, G. and Dahl, P. Effects of interaction between two bubble scatterers. J. Acoust. Soc. Am., 2000, 107(6), 3006-3017.
84. Lindner, J. R., Song, J., Xu, F., Klibanov, A. L., Singbartl, K., Ley, K. and Kaul, S. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation, 2000, 10, 2745-2750.
85. Morgan, K. E., Allen, J. S., Chomas, J. E., Dayton, P. A. and Ferrara, K. W. Experimental and theoretical analysis of individual contrast agent behavior. In Proceedings of the IEEE Ultrasonics Symposium, 1999, Vol. 2, pp. 1685-1688 (IEEE, New York).
86. Lauterborn, W. and Parlitz, U. On the bifurcation struction of bubble oscillators. In Proceedings of the 12th International Symposium on Non-Linear Acoustics (Ed. Kedrinskii. V.), 1987, pp. 71-80.
87. Mornstein, V. Cavitation-induced risks associated with contrast agents used in ultrasonography. Eur. J. Ultrasound, 1997, 5, 101-111.
88. Nyborg, W. Biological effects of ultrasound: development of safety guidelines. Part II: general review. Ultrasound Med. Biology, 2001, 27(3), 301-333.
89. Uhlendorf, V. Physics of ultrasound contrast imaging: scattering in the linear range. IEEE Trans. Ultrasonics, Ferroelectrics Frequency Control, 1994, 41(1), 70-79.
90. Gormley, G. and Wu, J. Observation of acoustic streaming near Albunex spheres. J. Acoust. Soc. Am., 1998, 104(5), 3115-3118.
91. Hilgenfeldt, S., Lohse, D. and Zomack, M. Sound scattering and localised heat deposition of pulse-driven microbubbles. J. Acoust. Soc. Am., 107(6), 3530-3539.
92. Wu, J. Temperature rise generated by ultrasound in the presence of a contrast agent. Ultrasound Med. Biology, 1998, 24(2), 267-274.
93. Stride, E. and Saffari, N. The potential for thermal damage posed by microbubble ultrasound contrast agents. Ultrasound Med. Biology (submitted for publication).
94. Muir, T. G. and Carstensen, E. L. Prediction of non-linear acoustic effects at biomedical frequencies and intensities. Ultrasound Med. Biology, 1980, 6, 345-357.
95. Starrit, H. C., Duck, D. A. and Humphrey, V. F. Forces acting in the direction of propagation in pulsed ultrasound fields. Physics Med. Biology, 1991, 36, 1474-1485.
96. Miller, D. L., Thomas, R. M. and Williams, A. R. Mechanisms for hemolysis by ultrasonic cavitation in the rotating exposure system. Ultrasound Med. Biology, 1991, 17, 171-178.
97. Miller, D. L., Nyborg, W. L. and Whicombe, C. C. In vitro clumping of platelets exposed to low intensity ultrasound. In Ultrasound in Medicine (Eds D. White and E. A. Lyons), Vol. 4, 1978 (Plenum, New York), pp. 505-507.
98. Tortoli, P., Michelassi, V., Corsi, M., Righi, D. and Takeuchi, Y., On the interaction between ultrasound and contrast agents during Doppler investigations. Ultrasound Med. Biology, 2001, 27(9), 1265-1273.
99. Clarke, P. R. and Hill, C. R. Physical and chemical aspects of ultrasonic disruption of cells. J. Acoust. Soc. Am., 1970, 47, 649-653.
100. Rooney, J. A. Hemolysis near an ultrasonically pulsating gas bubble. Science, 1970, 169, 869-871.
101. Ward, M., Wu, J. and Chiu, J. F. Experimental study of the effects of Optison® concentration on sonoporation in vitro. Ultrasound Med. Biology, 2000, 26(7), 1169-1175.
102. Elder, S. A. Cavitation micro-streaming. J. Acoust. Soc. Am., 1959, 31, 54-64.
103. Lee, C. P. and Wang, T. G. Outer acoustic streaming. J. Acoust. Soc. Am., 1990, 88, 2367-2375.
104. Nyborg, W. Acoustic streaming. In Physical Acoustics (Ed. Mason, W. P.), Vol. IIB, 1965, pp. 265-331 (Academic Press, New York).
105. Wu, J. Theoretical study on shear stress generated by micro-streaming surrounding contrast agents attached to living cells. Ultrasound Med. Biology, 2002, 28(1), 125-129.
106. Noltingk, B. E. and Neppiras, E. Cavitation produced by ultrasonics. Proc. phys. Soc. B, 1950, 63, 674-685.
107. Crum, L. A., Roy, R. A., Dinno, M. A. and Church, C. C. Acoustic cavitation by microsecond pulses of ultrasound: a discussion of some selected results. J. Acoust. Soc. Am., 1992, 91, 1113-1119.
108. Riesz, P. and Kondo, T. Free radical formation induced by ultrasound and its biological implications. Free Radical Biology Med., 1992, 13(3), 247.
109. Khismatullin, D. Acoustic cavitation bio-effects. www.geocities.com/dkhismatullin/drug.htm, October 2001.
110. Dalecki, D., Raeman, C. H., Child, S. Z., Cox, C., Francis, C. W., Meltzer, R. S. and Carstensen, E. L. Hemolysis in vivo from exposure to pulsed ultrasound. Ultrasound Med. Biology, 1997, 23, 307-313.
111. Carstensen, E. L., Gracewski, S. and Dalecki, D. The search for cavitation in vivo. Ultrasound Med. Biology, 2000, 26(9), 1377-1385.
112. Coleman, A. J. and Saunders, J. E. A review of the physical properties and biological effects of the high amplitude acoustic fields used in extracorporeal lithotripsy. Ultrasonics, 1993, 31, 75-89.
113. Delius, M. Medical application and bio-effects of extracorporeal shock waves. Shockwaves, 1994, 4, 55-72.
114. Causemann, C. Bioeffekte der kombinierten Ultraschallund Kontrastmitteleinwirkung. Thesis, Berlin University, 1994.
115. World Federation for Ultrasound in Medicine and Biology Symposium on safety of ultrasound in medicine. Recommendations on the safe use of ultrasound. Ultrasound Med. Biology, 1998, 24, S1, xv-xvi.
116. Shankar, P. M., Dala Khrisna, P. and Newhouse, V. L. Advantages of subharmonic over second harmonic backscatter for contrast to tissue echo enhancement. Ultrasound Med. Biology, 1998, 24(3), 395-399.
117. Shi, W. T., Forsberg, F., Raichlen, J. S., Needleman, L. and Goldberg, B. B. Pressure dependence of subharmonic signals from contrast microbubbles-systolic disappearance of left ventricular contrast after transpulmonary transmission. Ultrasound Med. Biology, 1999, 25(2), 275-283.
118. Basude, R. and Wheatley, M. A. Generation of ultra-harmonics in surfactant based ultrasound contrast agents: use and advantages. Ultrasonics, 2001, 39, 437-444.
119. Hope Simpson, D., Chin, C. and Burns, P. Pulse inversion Doppler: a new method for detecting non linear echoes from microbubble contrast agents. IEEE Trans. Ultrasonics, Ferroelectrics Frequency Control, 1999, 46(2), 372-382.
120. Wei, M., Jayaweera, A. R., Firoozan, S., Linka, A., Skyba, P. and Kaul, M. Quantification of myocardial blood flow with ultrasound induced destruction of microbubbles administered as a constant venous infusion. Circulation, 1998, 97, 473-480.
121. Interuniversity Cardiology Institute of The Netherlands. http://www.icin.knaw.nl/projects21progressmyocardial.html, January 2002.
122. University of California, Davis http:///www.bme.ucdavis.edu/research/track.php?tid=24640, January 2002.
123. Bouakaz, A. and Shung, K. K. Selective destruction of contrast agent microspheres [drug delivery application]. In Proceedings of the IEEE Ultrasonics Symposium, 1999, Vol. 6, pp. 1693-1696 (IEEE, New York).
124. Lindner, J. R. and Kaul, S. Delivery of drugs with ultrasound echocardiography. J. Cardiovascular Ultrasound Allied Techqs, 2001, 18(4), 329-337.
125. University of Virginia http://hsc.virginia.edu/medicine/basicsci/biomed/students/jechomas.html, January 2002.
126. Fowlkes, J. B., Gardner, E. A., Ivey, J. A. and Carson, P. L. The role of acoustic radiation force in contrast enhancement techniques using bubble based ultrasound contrast agents. J. Acoust. Soc. Am., 1993, 93(4), Part 2, 2348.
127. ImaRx Therapeutics http://www.imarx.com/drugdelivery.asp/ 2001.
128. Cav-Con, Inc. http://users.ntplx.net/~cavcon/ 2001.
129. Point Biomedical http://www.pointbio.com/ 2001.
130. Krasovitski, B. and Kimmel, E. http://www.technion.ac.il/technion/agr/members/kimmel.html, January 2002.
131. Psychoudakis, D. On the use of microbubbles for point targets in phase aberration correction. www.-personal.umich.edu/~dpsycho/microbubbles.pdf, January 2001.
132. Ye, Z. http://www.phy.ncu.edu.tw/faculty/prof/zhen/zhen.html, October 2001.
133. Chin, C. T. and Burns, P. www.sunnybrook.utoronto.ca:8080/~chinc/rotterdam/chinc2.html, October 2001.
134. University of Vermont, Physics Department. http://www.uvm.edu/~physics/?Page=research.html 2001.
135. Coleman, A. J., Saunders, J. E., Crum, L. A. and Dyson, M. Acoustic cavitation generated by an extracorporeal shockwave lithotripter. Ultrasound Med. Biology, 1987, 13, 69-76.