Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 3, 2002, Pages 319-323

  Nantermet, Philippe G ^a   Barrow, James C ^a   Lundell, George F ^a   Pellicore, Janetta M ^a   Rittle, Kenneth E ^a   Young, MaryBeth ^a   Freidinger, Roger M ^a   Connolly, Thomas M ^a   Condra, Cindra ^a   Karczewski, Jerzy ^a   Bednar, Rodney A ^a   Gaul, Stanley L ^a   Gould, Robert J ^a   Prendergast, Kris ^a   Selnick, Harold G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOXAZOLE DERIVATIVE; PEPTIDE; PROTEINASE ACTIVATED RECEPTOR 1; RECEPTOR BLOCKING AGENT; THROMBIN; THROMBIN RECEPTOR; THROMBIN RECEPTOR ACTIVATING PEPTIDE;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR SIZE; STRUCTURE ACTIVITY RELATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

AZEPINES; BLOOD PLATELETS; DRUG DESIGN; HUMANS; INDICATORS AND REAGENTS; ISOXAZOLES; PEPTIDE FRAGMENTS; PIPERIDINES; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 18244372993     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00745-4     Document Type: Article

References (33)