Bradykinin-induced p42/p44 MAPK phosphorylation and cell proliferation via Src, EGF receptors, and PI3-K/Akt in vascular smooth muscle cells

Journal of Cellular Physiology

Volumn 203, Issue 3, 2005, Pages 538-546

  Yang, Chuen Mao ^a,b   Lin, Meng I ^a   Hsieh, Hsi Lung ^a   Sun, Chi Chin ^a   Ma, Yunn Hwa ^a   Hsiao, Li Der ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; BRADYKININ; EPIDERMAL GROWTH FACTOR RECEPTOR; ILOMASTAT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN P85; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BRADYKININ; CELL PROLIFERATION; CELLS, CULTURED; ENZYME INHIBITORS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 18244369734     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20250     Document Type: Article

References (47)

1. 2 receptor-mediated mitogen-activated protein kinase activation in COS-7 cells requires dual signaling via both protein kinase C pathway and epidermal growth factor receptor transactivation. Mol Cell Biol 19:5289-5297.
2. Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJC, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA. 1997. Role of translocation in the activation and function of protein kinase B. J Biol Chem 272:31515-31524.
3. Andreev J, Galisteo ML, Kranenburg O, Logan SK, Chiu ES, Okigaki M, Cary LA, Moolenaar WH, Schlessinger J. 2001. Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade. J Biol Chem 276:20130-20135.
4. Burgering BMT, Coffer PJ. 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:099-602.
5. Clerk A, Gillespie-Brown J, Fuller SJ, Sugden PH. 1996. Stimulation of phosphatidylinositol hydrolysis, protein kinase C translocation, and mitogen-activated protein kinase activity by bradykinin in rat ventricular myocytes: Dissociation from the hypertrophic response. Biochem J 317:109-118.
6. Cuevas BD, Lu Y, Mao M, Zhang J, LaPushin R, Siminovitch K, Mills GB. 2001. Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J Biol Chem 276:27455-27461.
7. Daub H, Weiss FU, Wallasch C, Ullrich A. 1996. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors. Nature 379:557-560.
8. Daub H, Wallasch C, Lankenau A, Herrlich A, Ullrich A. 1997. Signal characteristics of G protein-transactivated EGF receptor. EMBO J 16:7032-7044.
9. Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J. 1996. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature 383:547-550.
10. Dixon BS, Dennis MJ. 1996. Interaction between growth factors and kinins in arterial smooth muscle cells. Immunopharmacology 33:16-23.
11. Dixon BS, Sharma RV, Dickerson TY, Fortune J. 1994. Bradykinin and angiotensin II: Activation of protein kinase C in arterial smooth muscle. Am J Physiol 266:C1406-C1420.
12. Eguchi S, Dempsey PJ, Frank GD, Motley ED, Inagami T. 2000. Activation of MAPK's by angiotensin II in vascular smooth muscle cells. J Biol Chem 276:7957-7962.
13. Exton JH. 2002. Phospholipase D-structure, regulation, and function. Rev Physiol Biochem Pharmacol 144:1-94.
14. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736.
15. q/11 protein, phopshatidylinositol 3-kinase β, and protein kinase C ε. J Biol Chem 273:32016-32022.
16. Gutkind JS. 1998. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 273:1839-1842.
17. Hackel PO, Zwick E, Prenzel N, Ullrich A. 1999. Epidermal growth factor receptors: Critical mediators of multiple receptor pathways. Curr Opin Cell Biol 11:184-189.
18. Hafizi S, Wang X, Chester AH, Yacoub MH, Proud CG. 2004. ANG II activates effectors of mTOR via PI3-K signaling in human coronary smooth muscle cells. Am J Physiol 287:H1232-H1238.
19. Hawes BE, Luttrell LM, van Biesen T, Lefkowitz RJ. 1996. Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signaling pathway. J Biol Chem 271:12133-12136.
20. Hemmings BA. 1977. Akt signaling: Linking membrane events to life and death decisions. Science 275:628-630.
21. Hu Q, Klippel A, Muslin AJ, Fantl WJ, Williams LT. 1995. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 268:100-102.
22. Irby RB, Yeatman TJ. 2000. Role of Src expression and activation in human cancer. Oncogene 19:5636-5642.
23. 2+, PYK2, and p60Src. J Biol Chem 275:12619-12625.
24. Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Fikenzeller G, Marme D, Rapp U. 1993. Protein kinase C activates RAF-1 by direct phosphorylation. Nature 364:249-252.
25. i-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc. EMBO J 16:3097-3105.
26. Linas SL, Marzec CR, Ullian ME, O'Brien RF. 1988. Mechanism of the antihypertensive effect of K depletion in the SHR. Kidney Int 34:18-25.
27. Lopez-Illasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R. 1997. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI3-kinaseγ. Sceience 275:394-397.
28. Luttrell LM, Della Rocca GJ, van Biesen T, Luttrell DK, Lefkowitz R. 1997. Gβ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. J Biol Chem 272:4637-4644.
29. Luttrell LM, Daaka Y, Lefkowitz RJ. 1999. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 11:177-183.
30. Marais R, Light Y, Mason C, Paterson H, Olson MF, Marshall CJ. 1998. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science 280:109-112.
31. Marques SA, Dy LC, Southall MD, Yi Q, Smietana E, Kapur R, Marques M, Travers JB, Spandau DF. 2002. The platelet-activating factor receptor activates the extracellular signal-regulated kinase mitogen-activated protein kinase and induces proliferation of epidermal cells through an epidermal growth factor-receptor-dependent pathway. J Pharmacol Exp Ther 300:1026-1035.
32. Moghal N, Sternberg PW. 1999. Multiple positive and negative regulators of signaling by the EGF-receptor. Curr Opin Cell Biol 11:190-196.
33. Moule SK, Welsh GI, Edgell NJ, Foulstone EJ, Proud CG, Denton RM. 1997. Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and β-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and-insensitive mechanisms. J Biol Chem 272:7713-7719.
34. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. 1999. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 402:884-888.
35. Rodgers HC, Pang L, Holland E, Corbett L, Range S, Knox AJ. 2002. Bradykinin increases IL-8 generation in airway epithelial cells via COX-2-derived prostanoids. Am J Physiol 283:L612-L618.
36. Rommel C, Clarke BA, Zimmermann S, Nunez L, Rossman R, Reid K, Moelling K, Yancopoulos GD, Glass DJ. 1999. Differntiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 286:1738-1741.
37. Rosette C, Karin M. 1996. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274:1194-1197.
38. Saito S, Frank GD, Mifune M, Ohba M, Utsunomiya H, Motley ED, Inagami T, Eguchi S. 2002. Ligand-independent trans-activation of the platelet-derived growth factor receptor by reactive oxygen species requires protein kinase C-δ and c-Src. J Biol Chem 277:44695-44700.
39. Tice DA, Biscardi JS, Nickles AL, Parsons SJ. 1999. Mechanism of biological synergy between cellular Src and epidermal growth factor receptor. Proc Natl Acad Sci USA 96:1415-1420.
40. Velarde V, Ullian ME, Morinelli TS, Mayfield RK, Jaffa AA. 1999. Mechanisms of MAPK activation by bradykinin in vascular smooth muscle cells. Am J Physiol 277:C253-C261.
41. Venkatakrishnan G, Salgia R, Groopman JE. 2000. Chemokine receptors CXCR-1/2 activate mitogen-activated protein kinase via the epidermal growth factor receptor in ovarian cancer cells. J Biol Chem 275:6868-6875.
42. Vlahos CJ, Matter WF, Hui KY, Brown RF. 1994. A specific inhibitor of phosphatidylinositol 3-kinase. 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241-5248.
43. Wennstrom S, Downward J. 1999. Role of phosphoinositide 3-kinase in activation of Ras and mitogen-activated protein kinase by epidermal growth factor. Mol Cell Biol 19:4279-4288.
44. Yang CM, Tsai YJ, Pan SL, Wu WB, Wang CC, Lee YS, Lin CC, Huang SCM, Chiu CT. 1999a. Pharmacological and functional characterization of bradykinin receptors in rat cultured vascular smooth muscle cells. Cell Signal 11:853-862.
45. 2+ mobilization by phorbol ester in rat cultured vascular smooth muscle cells. Cell Signal 11:899-907.
46. 2 receptor-mediated proliferation via activation of the Ras/Raf/MEK/MAPK pathway in rat vascular smooth muscle cells. J Biomed Sci 10:208-218.
47. Zwick E, Daub H, Aoki N, Yamaguchi-Aoki Y, Tinhofer I, Maly K, Ullrich A. 1997. Critical role of calcium-dependent epidermal growth factor receptors transactivation in PC12 cell membrane depolarization and bradykinin aignaling. J Biol Chem 272:24767-24700.