Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences

Journal of Cellular Biochemistry

Volumn 84, Issue 2, 2002, Pages 420-432

  Kon, Shigeyuki ^a   Yokosaki, Yasuyuki ^b   Maeda, Masahiro ^c   Segawa, Tatsuya ^d   Horikoshi, Yuko ^a   Tsukagoshi, Hiroe ^b   Rashid, Mohammod M ^c   Morimoto, Junko ^d   Inobe, Manabu ^a   Shijubo, Noriharu ^b   Chambers, Ann F ^c   Uede, Toshimitsu ^a,e  

^a HOKKAIDO UNIVERSITY   (Japan)

^b Saijo cho   (Japan)

^c Immuno Biological Laboratories Co Ltd   (Japan)

^d SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e LONDON REGIONAL CANCER PROGRAM   (Canada)

Author keywords

Integrin binding domain; Osteopontin; RGD tripeptide; Structure function studies; Thrombin cleavage site; 9 integrin; v integrin

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; EPITOPE; INTEGRIN; MONOCLONAL ANTIBODY; OSTEOPONTIN; THROMBIN;

ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

EID: 18244364379     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10039     Document Type: Article

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9. A biochemical characterization of the binding of osteopontin to integrins αvβ1 and αvβ5
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11. Non-RGD domains of osteopontin promote cell adhesion without involving αv integrins
12. CD44 variants but not CD44s cooperate with beta-1 containing integrins to permit cells to bind to osteopontin indenendently of RGD, thereby stimulating cell motility and chemotaxis
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14. A novel cell surface antigen involved in thymocyte and thymic epithelial cell adhesion
15. Antibodies to different peptides in osteopontin reveal complexities in the various secreted forms
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18. Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin
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27. Osteopontin
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32. Osteopontin: A coordinator of host defense system; a cytokine or an extracellular adhesive proteins?
33. Differential regulation of airway epithelial integrins by growth factors
34. Increased expression of osteopontin in activated kupffer cells and hepatic macrophages during macrophage migration in Propionibacterium acnes-treated rat liver
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36. The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin
37. The integrin a9b1 binds to a novel recognition sequence (SVVYGLR) in the thrombin-cleaved amino-terminal fragment of osteopontin
38. Osteopontin-stimulated vascular smooth muscle migration is mediated by β3 integrin