Differential Regulation of Airway Epithelial Integrins by Growth Factors

American Journal of Respiratory Cell and Molecular Biology

Volumn 15, Issue 5, 1996, Pages 664-672

  Wang, Angela ^b   Yokosaki, Yasuyuki ^a   Ferrando, Ronald ^c   Balmes, John ^c   Sheppard, Dean ^c  

^a National Hiroshima Hospital   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTEGRIN; ALPHAVBETA6 INTEGRIN; FIBRONECTIN RECEPTOR; GROWTH PROMOTOR; INTEGRIN; INTEGRIN ALPHA9; MONOCLONAL ANTIBODY; TUMOR ANTIGEN;

ARTICLE; BRONCHUS; CELL CULTURE; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; EPITHELIUM; EPITHELIUM CELL; HUMAN; UPREGULATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; BRONCHI; CELL LINE, TRANSFORMED; CELLS, CULTURED; EPITHELIAL CELLS; EPITHELIUM; GROWTH SUBSTANCES; HUMANS; INTEGRIN ALPHA CHAINS; INTEGRINS; RECEPTORS, FIBRONECTIN; UP-REGULATION;

EID: 0030292416     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.15.5.8918373     Document Type: Article

References (21)

1. Damjanovich, L., S. M. Albelda, S. A. Mette, and C. A. Buck. 1992. Distribution of integrin cell adhesion receptors in normal and malignant lung tissue. Am. J. Respir. Cell Mol. Biol. 6:197-206.
2. Mette, S. A., J. Pilewski, C. A. Buck, and S. M. Albelda. 1993. Distribution of integrin cell adhesion receptors on normal bronchial epithelial and lung cancer cells in vitro and in vivo. Am. J. Respir. Cell Mol. Biol. 8:562-572.
3. Weinacker, A., R. Ferrando, M. Elliot, J. Hogg, J. Balmes, and D. Sheppard. 1995. Distribution of integrins αvβ6 and α9β1 and their known ligands, fibronectin and tenascin, in human airways. Am. J. Respir. Cell Mol. Biol. 12:547-556.
4. Sriramarao, P., P. Steffner, and K. R. Gehlsen. 1993. Biochemical evidence for a homophilic interaction of the α3β1 integrin. J. Biol. Chem. 268: 22036-22041.
5. Symington, B. E., Y. Takada, and W. G. Carter. 1993. Interaction of integrins α3β1 and α2β1: potential role in keratinocyte intercellular adhesion. J. Cell Biol. 120:523-535.
6. Wang, A., L. Patrone, J. A. McDonald, and D. Sheppard. 1995. Expression of the integrin subunit α9 in the murine embryo. Dev. Dyn. 204: 421-431.
7. Palmer, E. L., C. Rüegg, R. Ferrando, R. Pytela, and D. Sheppard. 1993. Sequence and tissue distribution of the integrin α9 subunit, a novel partner of β1 that is widely distributed in epithelia and muscle. J. Cell Biol. 123:1289-1297.
8. Weinacker, A., A. Chen, M. Agrez, R. I. Cone, S. Nishimura, and E. Wayner. 1994. Role of the integrin alpha v beta 6 in cell attachment to fibronectin. J. Biol. Chem. 269:6940-6948.
9. Sheppard, D., D. S. Cohen, A. Wang, and M. Busk. 1992. Transforming growth factor β differentially regulates expression of integrin subunits in guinea pig airway epithelial cells. J. Biol. Chem. 267:17409-17414.
10. Breuss, J. M., L. Gillett, D. Lu, D. Sheppard, and R. Pytela. 1993. Restricted distribution of integrin β6 mRNA in primate epithelial tissues. J. Histochem. Biochem. 41:1521-1527.
11. Breuss, J. M., J. Ballo, H. M. Delisser, I. V. Klimanskaya, H. G. Folkesson, J. F. Pittet, S. L. Nishimura, K. Aldape, D. V. Landers, W. Carpenter, N. Gillet, D. Sheppard, M. A. Matthay, S. M. Albelda, R. H. Kramer, and R. Pytela. 1995. Expression of the β6 integrin in development, inflammation, wound healing, and neoplasia suggest a role in epithelial remodeling. J. Cell Sci. 106:2241-2251.
12. Symington, B. E. 1990. Fibronectin receptor overexpression and loss of transformed phenotype in a stable variant of the K562 cell line. Cell Regul. 1:637-648.
13. Giancotli, F. G., and E. Ruoslahti. 1990. Elevated levels of the alpha 5 beta I fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 60:840-859.
14. Agrez, M., A. Chen, R. I. Cone, R. Pytela, and D. Sheppard. 1994. The αvβ6 integrin promotes proliferation of colon carcinoma cells through a unique region of the β6 cytoplasmic domain. J. Cell Biol. 127:547-566.
15. Huang, X. Z., J. F. Wu, D. Cass, D. Erle, D. Corry, S. G. Young, R. V. Farese, and D. Sheppard. Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lungs and skin. J. Cell Biol. (In press)
16. Yokosaki, Y., E. L. Palmer, A. L. Prieto, K. L. Crossin, M. A. Bourdon, R. Pytela, and D. Sheppard. 1994. The integrin α9β1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of tenascin. J. Biol. Chem. 269:26691-26696.
17. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Transfection of Coprecipitates of Calcium Phosphate and DNA. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
18. Heino, J., R. A. Ignotz, M. E. Hemler, C. Crouse, and J. Massague. 1989. Regulation of cell adhesion receptors by transforming growth factor-beta. Concomitant regulation of integrins that share a common beta 1 subunit. J. Biol. Chem. 264:380-388.
19. Zambruno, G., P. C. Marchisio, A. Marconi, C. Vaschieri, A. Melchiori, and A. Giannetti. 1995. Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing. J. Cell Biol. 129:853-865.
20. Barrow, R. E., C. Z. Wang, M. J. Evans, and D. N. Herndon. 1993. Growth factors accelerate epithelial repair in sheep trachea. Lung 171: 335-344.
21. Khalil, N., R. O'Connor, H. Unruh, P. Warren, A. Kemp, and A. Greenberg. 1991. Enhanced expression and immunohistochemical distribution of transforming growth factor-β in idiopathic pulmonary fibrosis. Chest 99(Suppl.):65S-66S.