Osteopontin-induced, integrin-dependent migration of human mammary epithelial cells involves activation of the hepatocyte growth factor receptor (Met)

Journal of Cellular Biochemistry

Volumn 78, Issue 3, 2000, Pages 465-475

  Tuck, Alan B ^a,b,c   Elliott, Bruce E ^d   Hota, Charulata ^a,b,c   Tremblay, Eric ^d   Chambers, Ann F ^a,c  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

^c LONDON REGIONAL CANCER PROGRAM   (Canada)

^d QUEEN S UNIVERSITY   (Canada)

Author keywords

Breast cancer; Cell migration; Hepatocyte growth factor (HGF); Integrin; Mammary epithelial cells; Met; Osteopontin (OPN)

Indexed keywords

BETA1 INTEGRIN; INTEGRIN; MESSENGER RNA; OSTEOPONTIN; PHOSPHOTRANSFERASE; SCATTER FACTOR RECEPTOR;

ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; TUMOR DIFFERENTIATION; TUMOR GROWTH;

BLOTTING, NORTHERN; BLOTTING, WESTERN; BREAST; BREAST NEOPLASMS; CELL MOVEMENT; CELLS, CULTURED; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION; HUMAN; INTEGRINS; PHOSPHOPROTEINS; PHOSPHOTYROSINE; PRECIPITIN TESTS; PROTEIN-TYROSINE KINASE; PROTO-ONCOGENE PROTEIN C-MET; RECOMBINANT PROTEINS; RNA, MESSENGER; SIALOGLYCOPROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0033929141     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4644(20000901)78:3<465::AID-JCB11>3.0.CO;2-C     Document Type: Article

References (58)

1. Anchorage-dependent cell cycle progression
2. Intact vitronectin induces matrix metalloproteinase-2 and tissue inhibitor of metalloproteinases-2 expression and enhanced cellular invasion by melanoma cells
3. Tumor progression in four mammary epithelial cell lines derived from the same patient
4. Expression of the c-Met/HGF receptor in human breast carcinoma: Correlation with tumor progression
5. Scatter factor and hepatocyte growth factor: Activities, properties, and mechanism
6. Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase
7. Tissue structure, nuclear organization, and gene expression in normal and malignant breast
8. CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells
9. Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells
10. Insulin-like growth factor receptor cooperates with integrin αvβ5 to promote tumor cell dissemination in vivo
11. Tyrosine phosphorylation of focal adhesion kinase stimulated by hepatocyte growth factor leads to mitogen-activated protein kinase activation
12. Expression of c-met is a strong independent prognostic factor in breast carcinoma
13. Integrin signaling: Specificity and control of cell survival and cell cycle progression
14. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
15. Signal transduction via platlet-derived growth factor receptors
16. Engagement of the osteoclast integrin αvβ3 by osteopontin stimulates phoshotidylinositol 3-hydroxl kinase activity
17. A biochemical characterization of the binding of osteopontin to integrins alpha v beta 1 and alpha v beta 5
18. Expression of scatter factor and c-met receptor in benign and malignant breast tissue
19. CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis
20. Integrin αvβ3 expression by bone-residing breast cancer metastases
21. The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro
22. Osteopontin involvement in integrin-mediated cell signaling and regulation of expression of alkaline phosphatase during early differentiation of UMR cells
23. Activation of a signal transduction pathway by osteopontin
24. Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol breakdown
25. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
26. Molecular cloning and expression of hepatocyte growth factor
27. Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin
28. The identification of osteopontin as a metastasis-related gene product in a rodent mammary tumour model
29. Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth factor receptors
30. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
31. Tumor-igenicity and metastasis of human breast carcinoma cell lines in nude mice
32. c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells
33. Scatter factor modulates the metastatic phenotype of the EMT6 mouse mammary tumor
34. Adhesion - Growth factor interactions during differentiation: An integrated biological response
35. Integrin signalling and tyrosine phosphorylation: Just the FAKs?
36. Integrins, oncogenes, and anchorage independence
37. Intracellular signaling by growth factors
38. Role of the alpha v beta 3 integrin in human melanoma cell invasion
39. Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin
40. Elevated plasma osteopontin in metastatic breast cancer associated with increased tumor burden and decreased survival
41. The LCC15-MB human breast cancer cell line expresses osteopontin and exhibits an invasive and metastatic phenotype
42. Growth factor-dependent activation of αvβ3 integrin in normal epithelial cells: Implications for tumor invasion
43. Coexpression of hepatocyte growth factor and receptor (met) in human breast carcinoma
44. Osteopontin expression in a group of lymph node negative breast cancer patients
45. Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cells
46. Attachment characteristics and involvement of integrins in adhesion of breast cancer cell lines to extracellular bone matrix components
47. Paracrine regulation of germinal center B cell adhesion through the c-Met-hepatocyte growth factor/scatter factor pathway
48. Met-HGF/SF: Tumorigenesis, invasion and metastasis
49. Cellular adherence elicits ligand-independent activation of the Met cell-surface receptor
50. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression
51. Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
52. Hepatocyte growth factor/scatter factor promotes adhesion of lymphoma cells to extracellular matrix molecules via α4β1 and α5β1 integrins
53. Hepatocyte growth factor/scatter factor (HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation,adhesion and survival of human hematopoietic progenitor cells (CD34+)
54. αv integrins mediate adhesion and migration of breast carcinoma cell lines
55. Recombinant GST-human osteopontin fusion protein is functional in RGD-dependent cell adhesion
56. Site-directed mutagenesis of the arginine-glycine-aspartic acid sequence in osteopontin destroys cell adhesion and migration functions
57. Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer
58. Scatter factor protein levels in human breast cancers: Clinicopathological and biological correlations