메뉴 건너뛰기




Volumn 4, Issue 12, 2004, Pages 1887-1896

Th1/Th2 cells in inflammatory disease states: Therapeutic implications

Author keywords

Allergy; Autoimmunity; Cancer; CpG; Heat shock proteins; Infectious disease; Inflammation; T cell immunoglobulin mucin domain; T helper; TIM 1; TIM 3

Indexed keywords

AUTACOID; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 2; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 10344220475     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.4.12.1887     Document Type: Review
Times cited : (83)

References (76)
  • 2
    • 0023622458 scopus 로고
    • Two types of mouse helper T cell done. III. Further differences in lymphocyte synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally mono-specific bioassays, and monoclonal antibodies
    • CHERWINSK HM, SCHUMACHER JH, BROWN KD, MOSMANN TR: Two types of mouse helper T cell done. III. Further differences in lymphocyte synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally mono-specific bioassays, and monoclonal antibodies. J. Exp. Med. (1987) 166:1229-1244.
    • (1987) J. Exp. Med. , vol.166 , pp. 1229-1244
    • Cherwinsk, H.M.1    Schumacher, J.H.2    Brown, K.D.3    Mosmann, T.R.4
  • 3
    • 0025923025 scopus 로고
    • Human Th1 and Th2 subsets: Doubts no more, Immunol
    • ROMAGNANI S: Human Th1 and Th2 subsets: doubts no more, Immunol. Today (1991) 12:256-257.
    • (1991) Today , vol.12 , pp. 256-257
    • Romagnani, S.1
  • 4
    • 0348135024 scopus 로고    scopus 로고
    • Dendritic cell control of pathogen driven T cell polarization
    • KAPSENBERG M: Dendritic cell control of pathogen driven T cell polarization. Nat. Rev. Immunol. (2003) 3:984-993.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 984-993
    • Kapsenberg, M.1
  • 5
    • 0038242875 scopus 로고    scopus 로고
    • Toll-like recepror signaling pathways
    • BARTON GM, MEDZHITOV R: Toll-like recepror signaling pathways. Science (2003) 300:1524-1525.
    • (2003) Science , vol.300 , pp. 1524-1525
    • Barton, G.M.1    Medzhitov, R.2
  • 6
    • 10344234914 scopus 로고    scopus 로고
    • Lipolysaccaride-enhanced, Toll like receptor 4 dependent T helper cell Type 2 responses to inhaled antigen
    • EISENBARTH SC, PIGGOTT DA, HULEATT JW, VISINTIN I, HERRICK CA, BOTTOMLY K: Lipolysaccaride-enhanced, Toll like receptor 4 dependent T helper cell Type 2 responses to inhaled antigen. J. Exp. Med. (2002) 197:101-109.
    • (2002) J. Exp. Med. , vol.197 , pp. 101-109
    • Eisenbarth, S.C.1    Piggott, D.A.2    Huleatt, J.W.3    Visintin, I.4    Herrick, C.A.5    Bottomly, K.6
  • 7
    • 1342324768 scopus 로고    scopus 로고
    • Activation of toll like receptor 2 induces a Th2 immune response and promotes experimental asthma
    • REDECKE V, HACKER H, DATTA SK et al.: Activation of toll like receptor 2 induces a Th2 immune response and promotes experimental asthma. J. Immunol (2004) 172:2739-2743.
    • (2004) J. Immunol. , vol.172 , pp. 2739-2743
    • Redecke, V.1    Hacker, H.2    Datta, S.K.3
  • 8
    • 3042798442 scopus 로고    scopus 로고
    • The increased prevalence of allergy and the hygiene hypothesis: Missing immune deviation, reduced immune suppression or both?
    • ROMAGNANI S: The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression or both? Immunology (2004) 112:352-362.
    • (2004) Immunology , vol.112 , pp. 352-362
    • Romagnani, S.1
  • 10
    • 0026610142 scopus 로고
    • Predominant TH2-like bronchoalveolar T lymphocyte population in atopic asthma
    • ROBINSON DS, HAMID Q, YING S et al.: Predominant TH2-like bronchoalveolar T lymphocyte population in atopic asthma. N. Engl. J. Med. (1992) 326:298-304.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 298-304
    • Robinson, D.S.1    Hamid, Q.2    Ying, S.3
  • 11
    • 0027466759 scopus 로고
    • CD4 T lymphocyte activation in asthma is accompanied by increased serum concentrations of Interluekin-5, effects of glucocorticoid therapy
    • CORRIGAN CJ, HACZKU A, GEMOU-ENGESAETH V et al: CD4 T lymphocyte activation in asthma is accompanied by increased serum concentrations of Interluekin-5, effects of glucocorticoid therapy. Am. Rev. Respir. Dis. (1993) 147:540-547.
    • (1993) Am. Rev. Respir. Dis. , vol.147 , pp. 540-547
    • Corrigan, C.J.1    Haczku, A.2    Gemou-Engesaeth, V.3
  • 12
    • 0035804276 scopus 로고    scopus 로고
    • Allergy and allergic disease
    • KAY AB: Allergy and allergic disease. N. Engl. J. Med. (2001) 344:30-37.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 30-37
    • Kay, A.B.1
  • 13
    • 0038387445 scopus 로고    scopus 로고
    • To respond or not respond: T cells in allergic asthma
    • HERRICK C, BOTTOMLY K: To respond or not respond: T cells in allergic asthma. Nat. Rev. Immunol. (2003) 3:405-412.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 405-412
    • Herrick, C.1    Bottomly, K.2
  • 14
    • 0037059509 scopus 로고    scopus 로고
    • Development of spontaneous airway changes consistent with human asthma in lice lacking T-bet
    • FINOTTO S, NEURATH MF, GLICKMAN JN et al.: Development of spontaneous airway changes consistent with human asthma in lice lacking T-bet. Science (2002) 295:336-338.
    • (2002) Science , vol.295 , pp. 336-338
    • Finotto, S.1    Neurath, M.F.2    Glickman, J.N.3
  • 15
    • 0025265156 scopus 로고
    • CD4 T lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status
    • CORRIGAN CJ, KAY AB: CD4 T lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status. Am. Rev. Respir. Dis. (1990) 141:970-977.
    • (1990) Am. Rev. Respir. Dis. , vol.141 , pp. 970-977
    • Corrigan, C.J.1    Kay, A.B.2
  • 16
    • 0029979721 scopus 로고    scopus 로고
    • Nasal mucosal cells in human immunodeficiency virus type 1-seropositive patients with sinusitis
    • MOSS RB, SCOTT TA, GOLDRICH M et al.: Nasal mucosal cells in human immunodeficiency virus type 1-seropositive patients with sinusitis. J. Clin. Lab. Anal. (1996) 10:18-22.
    • (1996) J. Clin. Lab. Anal. , vol.10 , pp. 18-22
    • Moss, R.B.1    Scott, T.A.2    Goldrich, M.3
  • 17
    • 0026534763 scopus 로고
    • Cell mediated immune response to human immunodeficiency virus type 1 in seronegative homosexual men with recent sexual exposure to HIV-1
    • CLERICI M, GIORGI JV, CHOU CC et al.: Cell mediated immune response to human immunodeficiency virus type 1 in seronegative homosexual men with recent sexual exposure to HIV-1. J. Infect. Dis. (1992) 165:1012-1019.
    • (1992) J. Infect. Dis. , vol.165 , pp. 1012-1019
    • Clerici, M.1    Giorgi, J.V.2    Chou, C.C.3
  • 18
    • 0028593518 scopus 로고
    • Regulation of the development of type 2 T-helper cells in allergy
    • ROMAGNANI S: Regulation of the development of type 2 T-helper cells in allergy. Curr. Opin. Immunol. (1994) 6:616-622.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 616-622
    • Romagnani, S.1
  • 19
    • 0027967164 scopus 로고
    • Ability of HIV-1 to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells
    • MAGGI E, MAZZETTI M, RAVINA A et al.: Ability of HIV-1 to promote a Th1 to Th0 shift and to replicate preferentially in Th2 and Th0 cells. Science (1994) 265:244-244.
    • (1994) Science , vol.265 , pp. 244-244
    • Maggi, E.1    Mazzetti, M.2    Ravina, A.3
  • 20
    • 0030590749 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya
    • FOWKE KR, NAGELKERKE NJ, KIMANI J et al.: Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet (1996) 348:1347-1351.
    • (1996) Lancet , vol.348 , pp. 1347-1351
    • Fowke, K.R.1    Nagelkerke, N.J.2    Kimani, J.3
  • 21
    • 18344418801 scopus 로고    scopus 로고
    • Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV resistant prostitutes in Nairobi
    • ROWLAND-JONES SL, DONG T, FOWKE KR et al: Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV resistant prostitutes in Nairobi. J. Clin. Invest. (1998) 102:1758-1765.
    • (1998) J. Clin. Invest. , vol.102 , pp. 1758-1765
    • Rowland-Jones, S.L.1    Dong, T.2    Fowke, K.R.3
  • 22
    • 84862462237 scopus 로고    scopus 로고
    • CD8+ memory T cells require CD4+ T cell help: Implications for therapeutic and preventative HIV vaccines
    • MOSS RB, SALK P: CD8+ memory T cells require CD4+ T cell help: implications for therapeutic and preventative HIV vaccines. AIDSCIENCE (2003):3.
    • (2003) Aidscience , pp. 3
    • Moss, R.B.1    Salk, P.2
  • 23
    • 0028580142 scopus 로고
    • Cell mediated immunologic memory in prevention of and treatment of HIV disease
    • SALK P, SALK J: Cell mediated immunologic memory in prevention of and treatment of HIV disease. Res. Immunol. (1994) 145:629-633.
    • (1994) Res. Immunol. , vol.145 , pp. 629-633
    • Salk, P.1    Salk, J.2
  • 24
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • CHOY E, PANAYI GS: Cytokine pathways and joint inflammation in rheumatoid arthritis. N. Engl. J. Med. (2001) 344:907-916.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 907-916
    • Choy, E.1    Panayi, G.S.2
  • 25
    • 10744227300 scopus 로고    scopus 로고
    • Efficacy and safety of the fully human anti-tumour necrosis factor alpha monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: A 12 week Phase II study
    • VAN DE PUTTE LB, RAU R, BREEDVELD FC et al.: Efficacy and safety of the fully human anti-tumour necrosis factor alpha monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week Phase II study. Ann. Rheum. Dis. (2003) 62:1168-1177.
    • (2003) Ann. Rheum. Dis. , vol.62 , pp. 1168-1177
    • Van De Putte, L.B.1    Rau, R.2    Breedveld, F.C.3
  • 27
    • 0020962424 scopus 로고
    • Multiple sclerosis: Distribution of T cells, T cell subsets, and I-a positive macrophages in lesions of different ages
    • TRAUGOT U, REINHERZ EL, RAINE CS: Multiple sclerosis: distribution of T cells, T cell subsets, and I-a positive macrophages in lesions of different ages. J. Neuroimmunol. (1983) 4:201-221.
    • (1983) J. Neuroimmunol. , vol.4 , pp. 201-221
    • Traugot, U.1    Reinherz, E.L.2    Raine, C.S.3
  • 28
    • 0027253061 scopus 로고
    • Long-term complications of diabetes
    • NATHAN D: Long-term complications of diabetes. N. Engl. J. Med. (1993) 328:1676-1685.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 1676-1685
    • Nathan, D.1
  • 29
    • 0021875480 scopus 로고
    • In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis
    • BOTTAZZO GF, DEAN BM, MCNALLY JM, MACKAY EH, SWIFT PG, GAMBLE DR: In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N. Engl. J. Med. (1985) 313:353-360.
    • (1985) N. Engl. J. Med. , vol.313 , pp. 353-360
    • Bottazzo, G.F.1    Dean, B.M.2    Mcnally, J.M.3    Mackay, E.H.4    Swift, P.G.5    Gamble, D.R.6
  • 30
    • 10344245259 scopus 로고    scopus 로고
    • Cytokines and their roles in pancreatic islet beta cell destruction and insulin dependent diabetes mellitus
    • REBINOVITCH A, SUEREZ-PINZON WL: Cytokines and their roles in pancreatic islet beta cell destruction and insulin dependent diabetes mellitus. Biochem. Phamacol. (1998) 11:39-49.
    • (1998) Biochem. Phamacol. , vol.11 , pp. 39-49
    • Rebinovitch, A.1    Suerez-Pinzon, W.L.2
  • 31
    • 0037198420 scopus 로고    scopus 로고
    • Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
    • HEROLD KC, HAGOPIAN W, AUGER JA et al.: Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N. Engl. J. Med. (2002) 346:1692-1698.
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1692-1698
    • Herold, K.C.1    Hagopian, W.2    Auger, J.A.3
  • 32
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - An inflammatory disease
    • ROSS R: Atherosclerosis - an inflammatory disease. N. Engl J. Med. (1999) 340:115-126.
    • (1999) N. Engl J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 33
    • 0038799651 scopus 로고    scopus 로고
    • Toll-like receptor 4 and atherogenesis
    • KIECHL S, WIEDERMANN CJ, WILLEIT J: Toll-like receptor 4 and atherogenesis. Ann. Med. (2003) 35:164-171.
    • (2003) Ann. Med. , vol.35 , pp. 164-171
    • Kiechl, S.1    Wiedermann, C.J.2    Willeit, J.3
  • 34
    • 0642312183 scopus 로고    scopus 로고
    • Toll-like receptors in cardiovascular diseases
    • DE KLEIJN D, PASTERKAMP G: Toll-like receptors in cardiovascular diseases. Cardiovasc. Res. (2003) 15:58-67.
    • (2003) Cardiovasc. Res. , vol.15 , pp. 58-67
    • De Kleijn, D.1    Pasterkamp, G.2
  • 35
    • 0034704893 scopus 로고    scopus 로고
    • C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
    • RIDKER PH, HENNEKENS CH, BURING JE, RIFAI N: C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N. Engl. J. Med. (2000) 342:836-843.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 836-843
    • Ridker, P.H.1    Hennekens, C.H.2    Buring, J.E.3    Rifai, N.4
  • 36
    • 0141688283 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy for the treatment of patients with cancer
    • DUDLEY ME, ROSENBERG SA: Adoptive cell transfer therapy for the treatment of patients with cancer. Nature (2003) 3:666-674.
    • (2003) Nature , vol.3 , pp. 666-674
    • Dudley, M.E.1    Rosenberg, S.A.2
  • 37
    • 0032858174 scopus 로고    scopus 로고
    • Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo
    • NISHIMURA T, IWAKABE K, SEKIMOTO M et al.: Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo. J. Exp. Med. (1999) 5:617-627.
    • (1999) J. Exp. Med. , vol.5 , pp. 617-627
    • Nishimura, T.1    Iwakabe, K.2    Sekimoto, M.3
  • 38
    • 0037153042 scopus 로고    scopus 로고
    • A controlled trial of a human papillomavirus type 16 vaccine
    • KOUTSKY LA, AULT KA, WHEELER CM et al.: A controlled trial of a human papillomavirus type 16 vaccine. N. Engl. J. Med. (2002) 21:1645-1651.
    • (2002) N. Engl. J. Med. , vol.21 , pp. 1645-1651
    • Koutsky, L.A.1    Ault, K.A.2    Wheeler, C.M.3
  • 39
    • 0041314080 scopus 로고    scopus 로고
    • Cellular immune responses to human papillomavirus (HPV)-16 L1 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles
    • PINTO LA, EDWARDS J, CASTLE PE et al.: Cellular immune responses to human papillomavirus (HPV)-16 L1 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles. J. Infect. Dis. (2003) 188:327-338.
    • (2003) J. Infect. Dis. , vol.188 , pp. 327-338
    • Pinto, L.A.1    Edwards, J.2    Castle, P.E.3
  • 40
    • 0000936302 scopus 로고
    • Studies in human subjects on active immunization against poliomyelitis
    • SALK JE: Studies in human subjects on active immunization against poliomyelitis. JAMA (1953) 151:1081-1098.
    • (1953) JAMA , vol.151 , pp. 1081-1098
    • Salk, J.E.1
  • 41
    • 0036983181 scopus 로고    scopus 로고
    • Overview of the needs and realities for developing new and improved vaccines in the 21st Century
    • HILLEMAN MR: Overview of the needs and realities for developing new and improved vaccines in the 21st Century. Intervirilogy (2002) 45:199-211.
    • (2002) Intervirilogy , vol.45 , pp. 199-211
    • Hilleman, M.R.1
  • 42
    • 0030025111 scopus 로고    scopus 로고
    • Immune dysregulation in Ethiopian immigrants in Israel, relevance to helminth infections?
    • BENTWICH Z, WEISMAN Z, MOROZ C, BAR-YEHUDA S, KALINKOVICH A: Immune dysregulation in Ethiopian immigrants in Israel, relevance to helminth infections? Clin. Exp. Immunol. (1996) 103:239-243.
    • (1996) Clin. Exp. Immunol. , vol.103 , pp. 239-243
    • Bentwich, Z.1    Weisman, Z.2    Moroz, C.3    Bar-Yehuda, S.4    Kalinkovich, A.5
  • 43
    • 0028904083 scopus 로고
    • Immune activation is a dominant factor in the pathogenesis of African AIDS
    • BENTWICH Z, KALINKOVICH A, WEISMAN Z: Immune activation is a dominant factor in the pathogenesis of African AIDS. ImmunoL Today (1995) 16:187-191.
    • (1995) ImmunoL Today , vol.16 , pp. 187-191
    • Bentwich, Z.1    Kalinkovich, A.2    Weisman, Z.3
  • 44
    • 0036737346 scopus 로고    scopus 로고
    • Treatment of intestinal worms is associated with decreased HIV plasma viral load
    • WOLDAY D, MAYAAN S, MARIAM ZG et al: Treatment of intestinal worms is associated with decreased HIV plasma viral load. J. Acquir. Immune Defic. Syndr. (2002) 31:56-62.
    • (2002) J. Acquir. Immune Defic. Syndr. , vol.31 , pp. 56-62
    • Wolday, D.1    Mayaan, S.2    Mariam, Z.G.3
  • 45
    • 10744229112 scopus 로고    scopus 로고
    • Persistent GB virus C infection and survival in HIV-infected men
    • WILLIAMS CF, KLINZMAN D, YAMASHITA T et al.: Persistent GB virus C infection and survival in HIV-infected men. N. Engl. J. Med. (2004) 350:981-990.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 981-990
    • Williams, C.F.1    Klinzman, D.2    Yamashita, T.3
  • 46
    • 0038819952 scopus 로고    scopus 로고
    • Slower progression of HIV-1 Infection in persons with GB virus C co-infection correlates with an intact T helper cytokine profile
    • NUNNARI G, NIGRO L, PALERMO F et al.: Slower progression of HIV-1 Infection in persons with GB virus C co-infection correlates with an intact T helper cytokine profile. Ann. Intern. Med. (2003) 139:26-30.
    • (2003) Ann. Intern. Med. , vol.139 , pp. 26-30
    • Nunnari, G.1    Nigro, L.2    Palermo, F.3
  • 47
    • 2942659318 scopus 로고    scopus 로고
    • Inhibition of replication by GB virus C infection through increase in Rantes, MIP-1α, MIP-1β, and SDF-1
    • XIANG J, GEORGE S, WUNSCHMAN S, CHUG Q, KLINZMAN D, STAPLETON J: Inhibition of replication by GB virus C infection through increase in Rantes, MIP-1α, MIP-1β, and SDF-1. Lancet (2004) 363:2040-2046.
    • (2004) Lancet , vol.363 , pp. 2040-2046
    • Xiang, J.1    George, S.2    Wunschman, S.3    Chug, Q.4    Klinzman, D.5    Stapleton, J.6
  • 48
    • 1542616354 scopus 로고    scopus 로고
    • Parasites and the hygiene hypothesis; regulating the immune system?
    • YAZDANBAKHSH M, MATRICARDI PM: Parasites and the hygiene hypothesis; regulating the immune system? Clin. Rev. Allergy Immunol. (2004) 1:15-24.
    • (2004) Clin. Rev. Allergy Immunol. , vol.1 , pp. 15-24
    • Yazdanbakhsh, M.1    Matricardi, P.M.2
  • 49
  • 50
    • 0030820099 scopus 로고    scopus 로고
    • Immunotherapy of tumors with autologous tumor derived heat shock proteins preparations
    • TAMURA Y, PENG P, LUI K, DAOU M, SRIVASTAVA PK: Immunotherapy of tumors with autologous tumor derived heat shock proteins preparations. Science (1997) 27:117-120.
    • (1997) Science , vol.27 , pp. 117-120
    • Tamura, Y.1    Peng, P.2    Lui, K.3    Daou, M.4    Srivastava, P.K.5
  • 51
    • 10744220813 scopus 로고    scopus 로고
    • Novel heat shock protein HSP70L1 activates dentritic cells and acts as a Th1 polarizing adjuvant
    • WAN T, ZHOU X, CHEN G et al.: Novel heat shock protein HSP70L1 activates dentritic cells and acts as a Th1 polarizing adjuvant. Blood (2004) 103:1747-1754.
    • (2004) Blood , vol.103 , pp. 1747-1754
    • Wan, T.1    Zhou, X.2    Chen, G.3
  • 52
    • 0037833596 scopus 로고    scopus 로고
    • Vaccination with heat shock protein-peptide complexes: From basic science to clinical applications
    • HOOS A, LEVEY DL: Vaccination with heat shock protein-peptide complexes: from basic science to clinical applications. Expert Rev. Vaccines (2003) 3:369-379.
    • (2003) Expert Rev. Vaccines , vol.3 , pp. 369-379
    • Hoos, A.1    Levey, D.L.2
  • 53
    • 0021256125 scopus 로고
    • Antitumor activity of deoxyribunucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and and tumor activity
    • TOKUNAGA T, YAMAMOTO H, SHIMADA S et al.: Antitumor activity of deoxyribunucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and and tumor activity. J. Natl. Cancer Inst. (1984) 72:955-962.
    • (1984) J. Natl. Cancer Inst. , vol.72 , pp. 955-962
    • Tokunaga, T.1    Yamamoto, H.2    Shimada, S.3
  • 54
    • 4243101547 scopus 로고    scopus 로고
    • Dendritic cells: In the forefront of immunopathogenesis and vaccine development - A review
    • MOHAMADAZDEH M, LUFTIG R: Dendritic cells: in the forefront of immunopathogenesis and vaccine development - a review. J. Immune Based Ther. Vaccines (2004) 2:1.
    • (2004) J. Immune Based Ther. Vaccines , vol.2 , pp. 1
    • Mohamadazdeh, M.1    Luftig, R.2
  • 55
    • 0037108812 scopus 로고    scopus 로고
    • Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleeotides induce genital immune responses and protection against intravaginal challenge
    • DUMAIS N, PATRICK A, MOSS RB, DAVIS HL, ROSENTHAL KL: Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleeotides induce genital immune responses and protection against intravaginal challenge. J. Infect. Dis. (2002) 186:1098-1105.
    • (2002) J. Infect. Dis. , vol.186 , pp. 1098-1105
    • Dumais, N.1    Patrick, A.2    Moss, R.B.3    Davis, H.L.4    Rosenthal, K.L.5
  • 56
    • 0034600745 scopus 로고    scopus 로고
    • Beyond Danger: Unmethylated CpG dinudeotides and the immunopathogenesis of disease
    • GOLDBERG B, URNOVIT HB, STRICKER RB: Beyond Danger: unmethylated CpG dinudeotides and the immunopathogenesis of disease. Immunol. Lett. (2000) 73:13-18.
    • (2000) Immunol. Lett. , vol.73 , pp. 13-18
    • Goldberg, B.1    Urnovit, H.B.2    Stricker, R.B.3
  • 57
    • 0034043957 scopus 로고    scopus 로고
    • CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo
    • SEGAL BM, CHANG JT, SHEVACH EM: CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J. Immunol. (2000) 164:5683-5688.
    • (2000) J. Immunol. , vol.164 , pp. 5683-5688
    • Segal, B.M.1    Chang, J.T.2    Shevach, E.M.3
  • 58
    • 0033980073 scopus 로고    scopus 로고
    • The role of CpG motifs in innate immunity
    • KRIEG AM: The role of CpG motifs in innate immunity. Curr. Opin. Immunol. (2000) 12:35-43.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 35-43
    • Krieg, A.M.1
  • 59
    • 0032521274 scopus 로고    scopus 로고
    • Modulation of airway inflammation by CpG oligonucleotides in a murine model of asthma
    • KLINE JN, WALDSCHMIDT TJ, BUSINGA TR et al.: Modulation of airway inflammation by CpG oligonucleotides in a murine model of asthma. J. Immunol. (1998) 160:2555-2559.
    • (1998) J. Immunol. , vol.160 , pp. 2555-2559
    • Kline, J.N.1    Waldschmidt, T.J.2    Businga, T.R.3
  • 60
  • 61
    • 0034040529 scopus 로고    scopus 로고
    • Regulation of T-helper type 2 cell and airway eosinophilia by transmucosal coadminsitration of antigen and oligodeoxynucleotides containing CpG motifs
    • SHIROTA H, SANO K, KIKUCHI T, TAMURA G, SHIRATO K: Regulation of T-helper type 2 cell and airway eosinophilia by transmucosal coadminsitration of antigen and oligodeoxynucleotides containing CpG motifs. Am. J. Respir. Cell Mol. Biol. (2000) 22:176-182.
    • (2000) Am. J. Respir. Cell Mol. Biol. , vol.22 , pp. 176-182
    • Shirota, H.1    Sano, K.2    Kikuchi, T.3    Tamura, G.4    Shirato, K.5
  • 62
    • 0033990194 scopus 로고    scopus 로고
    • In vitro immune function after vaccination with an inactivated, gp 120-depleted HIV-1 antigen with immunostimulatory oligodeoxynucleotides
    • MOSS RB, DIVELEY J, JENSEN F, CARLO DJ: In vitro immune function after vaccination with an inactivated, gp 120-depleted HIV-1 antigen with immunostimulatory oligodeoxynucleotides. Vaccine (2000) 18:1081-1087.
    • (2000) Vaccine , vol.18 , pp. 1081-1087
    • Moss, R.B.1    Diveley, J.2    Jensen, F.3    Carlo, D.J.4
  • 63
    • 0034116281 scopus 로고    scopus 로고
    • RAZE: Immunostimulatoty sequence oligodeoxynucleotides: A novel mucosal adjuvant
    • HORNER AA, RAZE: Immunostimulatoty sequence oligodeoxynucleotides: a novel mucosal adjuvant. Clin. Immmunol. (2000) 95:S19-S29.
    • (2000) Clin. Immmunol. , vol.95
    • Horner, A.A.1
  • 64
    • 0034666740 scopus 로고    scopus 로고
    • CpG DNA as a Th1-promoting adjuvant in immunization against Trypanosoma cruzi
    • CORRAL RS, PETRAY PB: CpG DNA as a Th1-promoting adjuvant in immunization against Trypanosoma cruzi. Vaccine (2000) 19:234-242.
    • (2000) Vaccine , vol.19 , pp. 234-242
    • Corral, R.S.1    Petray, P.B.2
  • 65
    • 0842343142 scopus 로고    scopus 로고
    • Lymphoid follicle destruction and immunsuppression after repeated CpG oligodeoxynucleotide administration
    • HEIKENWALDER M, POLYMENIDOU M, JUNT T et al.: Lymphoid follicle destruction and immunsuppression after repeated CpG oligodeoxynucleotide administration. Nat. Med. (2004) 2:187-192.
    • (2004) Nat. Med. , vol.2 , pp. 187-192
    • Heikenwalder, M.1    Polymenidou, M.2    Junt, T.3
  • 66
    • 0035204919 scopus 로고    scopus 로고
    • Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
    • MCINTIRE JJ, UMETSU SE, AKBARI O et al.: Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat. Immunol. (2001) 2:1109-1116.
    • (2001) Nat. Immunol. , vol.2 , pp. 1109-1116
    • Mcintire, J.J.1    Umetsu, S.E.2    Akbari, O.3
  • 67
    • 0037203867 scopus 로고    scopus 로고
    • Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease
    • MONNEY L, SABATOS CA, GAGLIA JL et al.: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature (2002) 415:536-541.
    • (2002) Nature , vol.415 , pp. 536-541
    • Monney, L.1    Sabatos, C.A.2    Gaglia, J.L.3
  • 68
    • 0032512724 scopus 로고    scopus 로고
    • Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury
    • ICHIMURA T, BONVENTRE JV, BAILLY V et al.: Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. (1998) 273:4135-4142.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4135-4142
    • Ichimura, T.1    Bonventre, J.V.2    Bailly, V.3
  • 69
    • 0029775055 scopus 로고    scopus 로고
    • Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus
    • KAPLAN G, TOTSUKA A, THOMPSON P, AKATSUKA A, MORITSUGU Y, FEINSTON SM: Identification of a surface glycoprotein on African green monkey kidney cells as a receptor for hepatitis A virus. EMBO J. (1996) 15:4282-4296.
    • (1996) EMBO J. , vol.15 , pp. 4282-4296
    • Kaplan, G.1    Totsuka, A.2    Thompson, P.3    Akatsuka, A.4    Moritsugu, Y.5    Feinston, S.M.6
  • 71
    • 0030967169 scopus 로고    scopus 로고
    • Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus
    • MATRICARDI PM, ROSMINI F, FERRIGNO L et al.: Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. Br. Med. J. (1997) 314:999-1003.
    • (1997) Br. Med. J. , vol.314 , pp. 999-1003
    • Matricardi, P.M.1    Rosmini, F.2    Ferrigno, L.3
  • 73
    • 0142259151 scopus 로고    scopus 로고
    • Immunology: Hepatitis A virus link to atopic disease
    • MCINTIRE JJ, UMETSU SE, MACAUBAS C et al.: Immunology: hepatitis A virus link to atopic disease. Nature (2003) 425:576.
    • (2003) Nature , vol.425 , pp. 576
    • Mcintire, J.J.1    Umetsu, S.E.2    Macaubas, C.3
  • 74
    • 0344413475 scopus 로고    scopus 로고
    • The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population
    • CHAE SC, SONG JH, LEE YC, KIM JW, CHUNG HT: The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population. Biocbem. Biophys. Res. Commun. (2003) 312:346-350.
    • (2003) Biocbem. Biophys. Res. Commun. , vol.312 , pp. 346-350
    • Chae, S.C.1    Song, J.H.2    Lee, Y.C.3    Kim, J.W.4    Chung, H.T.5
  • 75
    • 0242708767 scopus 로고    scopus 로고
    • Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance
    • SANCHEZ-FUEYO A, TIAN J, PICARELLA D et al: Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat. Immunol. (2003) 4:1093-1101.
    • (2003) Nat. Immunol. , vol.4 , pp. 1093-1101
    • Sanchez-Fueyo, A.1    Tian, J.2    Picarella, D.3
  • 76
    • 0242539820 scopus 로고    scopus 로고
    • Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
    • SABATOS CA, CHAKRAVARTI S, CHA E et al.: Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance, Nat. Immunol. (2003) 4:1102-1110.
    • (2003) Nat. Immunol. , vol.4 , pp. 1102-1110
    • Sabatos, C.A.1    Chakravarti, S.2    Cha, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.