메뉴 건너뛰기




Volumn 11, Issue 1, 2005, Pages 56-61

Clinical implications of inflammatory bowel disease genetics on phenotype

Author keywords

Crohn's disease; Genotype; Inflammatory bowel disease; Phenotype; Ulcerative colitis

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CORTICOSTEROID; FUNGUS ANTIBODY; HLA ANTIGEN; IMMUNOMODULATING AGENT; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 4; INTERLEUKIN 6; MULTIDRUG RESISTANCE PROTEIN 1; NEUTROPHIL CYTOPLASMIC ANTIBODY; SALAZOSULFAPYRIDINE;

EID: 14844337460     PISSN: 10780998     EISSN: None     Source Type: Journal    
DOI: 10.1097/00054725-200501000-00008     Document Type: Review
Times cited : (35)

References (68)
  • 1
    • 0023713859 scopus 로고
    • Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins: A study of heritability and the influence of smoking
    • Tysk C, Lindberg E, Jarnerot G, et al. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins: a study of heritability and the influence of smoking. Gut. 1988;29:990-996.
    • (1988) Gut , vol.29 , pp. 990-996
    • Tysk, C.1    Lindberg, E.2    Jarnerot, G.3
  • 2
    • 0038620498 scopus 로고    scopus 로고
    • Inflammatory bowel disease in a Swedish twin cohort: A long-term follow-up of concordance and clinical characteristics
    • Halfvarson J, Bodin L, Tysk C, et al. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics. Gastroenterology. 2003; 124:1767-1773.
    • (2003) Gastroenterology , vol.124 , pp. 1767-1773
    • Halfvarson, J.1    Bodin, L.2    Tysk, C.3
  • 3
    • 2442563304 scopus 로고    scopus 로고
    • Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
    • Loftus EV Jr. Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 2004;126:1504-1517.
    • (2004) Gastroenterology , vol.126 , pp. 1504-1517
    • Loftus Jr., E.V.1
  • 4
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411:603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 5
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 2001; 411:599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 6
    • 2442585704 scopus 로고    scopus 로고
    • Functional variants of OCTN cation transporter genes are associated with Crohn's disease
    • Peltekova VD, Wintle RF, Rubin LA, et al. Functional variants of OCTN cation transporter genes are associated with Crohn's disease. Nat Genet. 2004;36:471-475.
    • (2004) Nat. Genet. , vol.36 , pp. 471-475
    • Peltekova, V.D.1    Wintle, R.F.2    Rubin, L.A.3
  • 7
    • 0036288704 scopus 로고    scopus 로고
    • In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis
    • Bridger S, Lee JC, Bjarnason I, et al. In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis. Gut. 2002; 51:21-25.
    • (2002) Gut , vol.51 , pp. 21-25
    • Bridger, S.1    Lee, J.C.2    Bjarnason, I.3
  • 8
    • 0032140047 scopus 로고    scopus 로고
    • Reliability of a Crohn's disease clinical classification scheme based on disease behaviour
    • Steinhart AH, Girgrah N, McLeod RS. Reliability of a Crohn's disease clinical classification scheme based on disease behaviour. Inflamm Bowel Dis. 1998;4:228-234.
    • (1998) Inflamm. Bowel Dis. , vol.4 , pp. 228-234
    • Steinhart, A.H.1    Girgrah, N.2    McLeod, R.S.3
  • 9
    • 0035191781 scopus 로고    scopus 로고
    • Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies
    • Silverberg MS, Daly MJ, Moskovitz DN, et al. Diagnostic misclassification reduces the ability to detect linkage in inflammatory bowel disease genetic studies. Gut. 2001;49:773-776.
    • (2001) Gut , vol.49 , pp. 773-776
    • Silverberg, M.S.1    Daly, M.J.2    Moskovitz, D.N.3
  • 10
    • 0035188740 scopus 로고    scopus 로고
    • Behaviour of Crohn's disease according to the Vienna classification: Changing pattern over the course of the disease
    • Louis E, Collard A, Oger AF, et al. Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease. Gut. 2001;49:777-782.
    • (2001) Gut , vol.49 , pp. 777-782
    • Louis, E.1    Collard, A.2    Oger, A.F.3
  • 11
    • 4644308781 scopus 로고    scopus 로고
    • Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behaviour in Crohn's disease
    • Smith BRK, Arnott IDR, Drummond HE, et al. Disease location, anti-Saccharomyces cerevisiae antibody, and NOD2/CARD15 genotype influence the progression of disease behaviour in Crohn's disease. Inflamm Bowel Dis. 2004;10:521-528.
    • (2004) Inflamm. Bowel Dis. , vol.10 , pp. 521-528
    • Smith, B.R.K.1    Arnott, I.D.R.2    Drummond, H.E.3
  • 12
    • 0036061640 scopus 로고    scopus 로고
    • Long-term evolution of disease behaviour of Crohn's disease
    • Cosnes J, Cattan S, Blain A, et al. Long-term evolution of disease behaviour of Crohn's disease. Inflamm Bowel Dis. 2002;8:244-250.
    • (2002) Inflamm. Bowel Dis. , vol.8 , pp. 244-250
    • Cosnes, J.1    Cattan, S.2    Blain, A.3
  • 13
    • 0035287508 scopus 로고    scopus 로고
    • Modifier genes in mice and humans
    • Nadeau JH. Modifier genes in mice and humans. Nat Rev Genet. 2001;2: 165-174.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 165-174
    • Nadeau, J.H.1
  • 14
    • 0032975986 scopus 로고    scopus 로고
    • Change in the extent of colonoscopic and histological involvement in ulcerative colitis over time
    • Moum B, Ekbom A, Vatn MH, et al. Change in the extent of colonoscopic and histological involvement in ulcerative colitis over time. Am J Gastroenterol. 1999;94:1564-1569.
    • (1999) Am. J. Gastroenterol. , vol.94 , pp. 1564-1569
    • Moum, B.1    Ekbom, A.2    Vatn, M.H.3
  • 15
    • 10744228695 scopus 로고    scopus 로고
    • Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease
    • Mow WS, Vasiliauskas EA, Lin YC, et al. Association of antibody responses to microbial antigens and complications of small bowel Crohn's disease. Gastroenterology. 2004;126:414-424.
    • (2004) Gastroenterology , vol.126 , pp. 414-424
    • Mow, W.S.1    Vasiliauskas, E.A.2    Lin, Y.C.3
  • 16
    • 85044014614 scopus 로고    scopus 로고
    • The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer
    • El-Omar EM, Carrington M, Chow WH, et al. The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer. Nature. 2001;412: 99.
    • (2001) Nature , vol.412 , pp. 99
    • El-Omar, E.M.1    Carrington, M.2    Chow, W.H.3
  • 17
    • 0035793372 scopus 로고    scopus 로고
    • Molecular analysis of commensal host-microbial relationships in the intestine
    • Hooper LV, Wong MH, Thelin T, et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science. 2001;291:881-884.
    • (2001) Science , vol.291 , pp. 881-884
    • Hooper, L.V.1    Wong, M.H.2    Thelin, T.3
  • 18
    • 4344671141 scopus 로고    scopus 로고
    • NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: Evidence for genetic heterogeneity within Europe?
    • Arnott ID, Nimmo ER, Drummond HE, et al. NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? Genes Immun. 2004;5:417-425.
    • (2004) Genes Immun. , vol.5 , pp. 417-425
    • Arnott, I.D.1    Nimmo, E.R.2    Drummond, H.E.3
  • 19
    • 0036306951 scopus 로고    scopus 로고
    • Lack of common NOD2 variants in Japanese patients with Crohn's disease
    • Inoue N, Tamura K, Kinouchi Y, et al. Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology. 2002;123: 86-91.
    • (2002) Gastroenterology , vol.123 , pp. 86-91
    • Inoue, N.1    Tamura, K.2    Kinouchi, Y.3
  • 20
    • 0036373539 scopus 로고    scopus 로고
    • Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease
    • Yamazaki K, Takazoe M, Tanaka T, et al. Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. J Hum Genet. 2002;47:469-472.
    • (2002) J. Hum. Genet. , vol.47 , pp. 469-472
    • Yamazaki, K.1    Takazoe, M.2    Tanaka, T.3
  • 21
    • 0038235697 scopus 로고    scopus 로고
    • NOD2/CARD15 gene polymerphisms and Crohn's disease in the Chinese population
    • Leong RW, Armuzzi A, Ahmad T, et al. NOD2/CARD15 gene polymerphisms and Crohn's disease in the Chinese population. Aliment Pharmacol Ther. 2003;17:1465-1470.
    • (2003) Aliment. Pharmacol. Ther. , vol.17 , pp. 1465-1470
    • Leong, R.W.1    Armuzzi, A.2    Ahmad, T.3
  • 22
    • 0037265610 scopus 로고    scopus 로고
    • Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations
    • Croucher PJ, Mascheretti S, Hampe J, et al. Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations. Eur J Hum Genet. 2003;11:6-16.
    • (2003) Eur. J. Hum. Genet. , vol.11 , pp. 6-16
    • Croucher, P.J.1    Mascheretti, S.2    Hampe, J.3
  • 23
    • 0002338546 scopus 로고    scopus 로고
    • Racial differences in NOD2 variation: Characterization of NOD2 in African-Americans with Crohn's disease
    • Bonen DK, Nicolae DL, Moran A, et al. Racial differences in NOD2 variation: characterization of NOD2 in African-Americans with Crohn's disease. Gastroenterology. 2002; 122:A29.
    • (2002) Gastroenterology , vol.122
    • Bonen, D.K.1    Nicolae, D.L.2    Moran, A.3
  • 24
    • 0036725827 scopus 로고    scopus 로고
    • Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
    • Abreu MT, Taylor KD, Lin YC, et al. Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease. Gastroenterology. 2002;123:679-688.
    • (2002) Gastroenterology , vol.123 , pp. 679-688
    • Abreu, M.T.1    Taylor, K.D.2    Lin, Y.C.3
  • 25
    • 0037373316 scopus 로고    scopus 로고
    • A novel NOD2/CARD15 haplotype conferring risk for Crohn's disease in Ashkenazi Jews
    • Sugimura K, Taylor KD, Lin YC, et al. A novel NOD2/CARD15 haplotype conferring risk for Crohn's disease in Ashkenazi Jews. Am J Hum Genet. 2003;72:509-518.
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 509-518
    • Sugimura, K.1    Taylor, K.D.2    Lin, Y.C.3
  • 26
    • 0036897460 scopus 로고    scopus 로고
    • Variation at NOD2/CARD15 in familial and sporadic cases of Crohn's disease in the Ashkenazi Jewish population
    • Zhou Z, Lin XY, Akolkar PN, et al. Variation at NOD2/CARD15 in familial and sporadic cases of Crohn's disease in the Ashkenazi Jewish population. Am J Gastroenterol. 2002; 97:3095-3101.
    • (2002) Am. J. Gastroenterol. , vol.97 , pp. 3095-3101
    • Zhou, Z.1    Lin, X.Y.2    Akolkar, P.N.3
  • 27
    • 10744227039 scopus 로고    scopus 로고
    • The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants
    • van Heel DA, Dechairo BM, Dawson G, et al. The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants. Hum Mol Genet. 2003; 12:2569-2575.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2569-2575
    • van Heel, D.A.1    Dechairo, B.M.2    Dawson, G.3
  • 28
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2 mediated T helper type 1 responses
    • Watanabe T, Kitani A, Murray PJ, et al. NOD2 is a negative regulator of Toll-like receptor 2 mediated T helper type 1 responses. Nat Immunol. 2004;5:800-808.
    • (2004) Nat. Immunol. , vol.5 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3
  • 29
    • 0033910870 scopus 로고    scopus 로고
    • Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci
    • Rioux JD, Silverberg MS, Daly MJ, et al. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet. 2000;66:1863-1870.
    • (2000) Am. J. Hum. Genet. , vol.66 , pp. 1863-1870
    • Rioux, J.D.1    Silverberg, M.S.2    Daly, M.J.3
  • 30
    • 0037622913 scopus 로고    scopus 로고
    • Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31
    • Armuzzi A, Ahmad T, Ling KL, et al. Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31. Gut. 2003;52:1133-1139.
    • (2003) Gut , vol.52 , pp. 1133-1139
    • Armuzzi, A.1    Ahmad, T.2    Ling, K.L.3
  • 31
    • 0142138025 scopus 로고    scopus 로고
    • Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease
    • Negoro K, McGovern DP, Kinouchi Y, et al. Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease. Gut. 2003;52: 541-546.
    • (2003) Gut , vol.52 , pp. 541-546
    • Negoro, K.1    McGovern, D.P.2    Kinouchi, Y.3
  • 32
    • 0035260923 scopus 로고    scopus 로고
    • Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population
    • Aithal GP, Day CP, Leathart J, et al. Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population. Genes Immun. 2001;2: 44-47.
    • (2001) Genes Immun. , vol.2 , pp. 44-47
    • Aithal, G.P.1    Day, C.P.2    Leathart, J.3
  • 33
    • 0035144144 scopus 로고    scopus 로고
    • The polymorphism at position -174 of the IL-6 gene is not associated with inflammatory bowel disease
    • Klein W, Tromm A, Griga T, et al. The polymorphism at position -174 of the IL-6 gene is not associated with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2001;13:45-47.
    • (2001) Eur. J. Gastroenterol. Hepatol. , vol.13 , pp. 45-47
    • Klein, W.1    Tromm, A.2    Griga, T.3
  • 34
    • 18244370045 scopus 로고    scopus 로고
    • A polymorphism in the CD14 gene is associated with Crohn's disease
    • Klein W, Tromm A, Griga T, et al. A polymorphism in the CD14 gene is associated with Crohn's disease. Scand J Gastroenterol 2002;37:189-191.
    • (2002) Scand. J. Gastroenterol. , vol.37 , pp. 189-191
    • Klein, W.1    Tromm, A.2    Griga, T.3
  • 35
    • 1342331543 scopus 로고    scopus 로고
    • An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis
    • Miner P, Wedel M, Bane B, et al. An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis. Aliment Pharmacol Ther. 2004;19: 281-286.
    • (2004) Aliment. Pharmacol. Ther. , vol.19 , pp. 281-286
    • Miner, P.1    Wedel, M.2    Bane, B.3
  • 36
    • 0035209986 scopus 로고    scopus 로고
    • Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status
    • Braun C, Zahn R, Martin K, et al. Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status. Clin Immunol. 2001;101:357-360.
    • (2001) Clin. Immunol. , vol.101 , pp. 357-360
    • Braun, C.1    Zahn, R.2    Martin, K.3
  • 37
    • 0037215455 scopus 로고    scopus 로고
    • Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population
    • Matsuzawa J, Sugimura K, Matsuda Y, et al. Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population. Gut. 2003;52:75-78.
    • (2003) Gut , vol.52 , pp. 75-78
    • Matsuzawa, J.1    Sugimura, K.2    Matsuda, Y.3
  • 38
    • 2442530967 scopus 로고    scopus 로고
    • Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1
    • Low JH, Williams FA, Yang X, et al. Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. Inflamm Bowel Dis. 2004; 10:173-181.
    • (2004) Inflamm. Bowel Dis. , vol.10 , pp. 173-181
    • Low, J.H.1    Williams, F.A.2    Yang, X.3
  • 39
    • 2442519456 scopus 로고    scopus 로고
    • Genetic variation in DLG5 is associated with inflammatory bowel disease
    • Stoll M, Corneliussen B, Costello CM, et al. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet. 2004;36:476-480.
    • (2004) Nat. Genet. , vol.36 , pp. 476-480
    • Stoll, M.1    Corneliussen, B.2    Costello, C.M.3
  • 40
    • 0347991877 scopus 로고    scopus 로고
    • The safety profile of infliximab in patients with Crohn's disease: The Mayo Clinic experience in 500 patients
    • Colombel J-F, Loftus EV, Tremaine WJ, et al. The safety profile of infliximab in patients with Crohn's disease: the Mayo Clinic experience in 500 patients. Gastroenterology. 2004;126:19-31.
    • (2004) Gastroenterology , vol.126 , pp. 19-31
    • Colombel, J.-F.1    Loftus, E.V.2    Tremaine, W.J.3
  • 41
    • 2442429216 scopus 로고    scopus 로고
    • Clinical relevance of advances in genetics and pharmacogenetics of IBD
    • Ahmad T, Tamboli CP, Jewell D, et al. Clinical relevance of advances in genetics and pharmacogenetics of IBD. Gastroenterology. 2004;126: 1533-1549.
    • (2004) Gastroenterology , vol.126 , pp. 1533-1549
    • Ahmad, T.1    Tamboli, C.P.2    Jewell, D.3
  • 42
    • 0036202336 scopus 로고    scopus 로고
    • The molecular classification of the clinical manifestations of Crohn's disease
    • Ahmad T, Armuzzi A, Bunce M, et al. The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology. 2002;122: 854-866.
    • (2002) Gastroenterology , vol.122 , pp. 854-866
    • Ahmad, T.1    Armuzzi, A.2    Bunce, M.3
  • 43
    • 0036201577 scopus 로고    scopus 로고
    • CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
    • Lesage S, Zouali H, Cezard JP, et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet. 2002;70:845-857.
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 845-857
    • Lesage, S.1    Zouali, H.2    Cezard, J.P.3
  • 44
    • 0036202885 scopus 로고    scopus 로고
    • The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    • Cuthbert AP, Fisher SA, Mirza MM, et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology. 2002;122:867-874.
    • (2002) Gastroenterology , vol.122 , pp. 867-874
    • Cuthbert, A.P.1    Fisher, S.A.2    Mirza, M.M.3
  • 45
    • 10744230291 scopus 로고    scopus 로고
    • Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes
    • Brant SR, Picco MF, Achkar JP, et al. Defining complex contributions of NOD2/CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes. Inflamm Bowel Dis. 2003;9:281-289.
    • (2003) Inflamm. Bowel Dis. , vol.9 , pp. 281-289
    • Brant, S.R.1    Picco, M.F.2    Achkar, J.P.3
  • 46
    • 0034785352 scopus 로고    scopus 로고
    • Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn's disease
    • Rioux JD, Daly MJ, Silverberg MS, et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn's disease. Nat Genet. 2001;29:223-228.
    • (2001) Nat. Genet. , vol.29 , pp. 223-228
    • Rioux, J.D.1    Daly, M.J.2    Silverberg, M.S.3
  • 47
    • 0038389762 scopus 로고    scopus 로고
    • IBD5 is a general risk factor for inflammatory bowel disease: Replication of association with Crohn's disease and identification of a novel association with ulcerative colitis
    • Giallourakis C, Stoll M, Miller K, et al. IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn's disease and identification of a novel association with ulcerative colitis. Am J Hum Genet. 2003;73:205-211.
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 205-211
    • Giallourakis, C.1    Stoll, M.2    Miller, K.3
  • 48
    • 0347362514 scopus 로고    scopus 로고
    • Further evidence of IBD5/CARD15 (NOD2) epistasis in the susceptibility to ulcerative colitis
    • McGovern DP, Van Heel DA, Negoro K, et al. Further evidence of IBD5/CARD15 (NOD2) epistasis in the susceptibility to ulcerative colitis. Am J Hum Genet. 2003;73:1465-1466.
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 1465-1466
    • McGovern, D.P.1    Van Heel, D.A.2    Negoro, K.3
  • 49
    • 0037383554 scopus 로고    scopus 로고
    • Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn's disease
    • Mirza MM, Fisher SA, King K, et al. Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn's disease. Am J Hum Genet. 2003;72:1018-1022.
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 1018-1022
    • Mirza, M.M.1    Fisher, S.A.2    King, K.3
  • 50
    • 0030912011 scopus 로고    scopus 로고
    • Genetic markers may predict disease behaviour in patients with ulcerative colitis
    • Roussomoustakaki M, Satsangi J, Welsh K, et al. Genetic markers may predict disease behaviour in patients with ulcerative colitis. Gastroenterology. 1997;112:1845-1853.
    • (1997) Gastroenterology , vol.112 , pp. 1845-1853
    • Roussomoustakaki, M.1    Satsangi, J.2    Welsh, K.3
  • 51
    • 0032953803 scopus 로고    scopus 로고
    • Genetic markers in clinically well defined patients with ulcerative colitis (UC)
    • Bouma G, Crusius JB, Garcia-Gonzalez MA, et al. Genetic markers in clinically well defined patients with ulcerative colitis (UC). Clin Exp Immunol. 1999;115:294-300.
    • (1999) Clin. Exp. Immunol. , vol.115 , pp. 294-300
    • Bouma, G.1    Crusius, J.B.2    Garcia-Gonzalez, M.A.3
  • 52
    • 10744221095 scopus 로고    scopus 로고
    • CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease
    • Newman B, Silverberg MS, Gu X, et al. CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease. Am J Gastroenterol. 2004;99:306-315.
    • (2004) Am. J. Gastroenterol. , vol.99 , pp. 306-315
    • Newman, B.1    Silverberg, M.S.2    Gu, X.3
  • 53
    • 0031596661 scopus 로고    scopus 로고
    • HLA-DRB1*03, but not the TNFA -308 promoter gene polymorphism, confers protection against fistulising Crohn's disease
    • Bouma G, Poen AC, Garcia-Gonzalez MA, et al. HLA-DRB1*03, but not the TNFA -308 promoter gene polymorphism, confers protection against fistulising Crohn's disease. Immunogenetics. 1998;47:451-455.
    • (1998) Immunogenetics , vol.47 , pp. 451-455
    • Bouma, G.1    Poen, A.C.2    Garcia-Gonzalez, M.A.3
  • 54
    • 0033973568 scopus 로고    scopus 로고
    • Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease
    • Orchard TR, Thiyagaraja S, Welsh KI, et al. Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease. Gastroenterology. 2000;118:274-278.
    • (2000) Gastroenterology , vol.118 , pp. 274-278
    • Orchard, T.R.1    Thiyagaraja, S.2    Welsh, K.I.3
  • 55
    • 0036731117 scopus 로고    scopus 로고
    • Uveitis and erythema nodosum in inflammatory bowel disease: Clinical features and the role of HLA genes
    • Orchard TR, Chua CN, Ahmad T, et al. Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes. Gastroenterology. 2002;123:714-718.
    • (2002) Gastroenterology , vol.123 , pp. 714-718
    • Orchard, T.R.1    Chua, C.N.2    Ahmad, T.3
  • 56
    • 14844308021 scopus 로고    scopus 로고
    • A genetic panel strongly predicts the need for colectomy in ulcerative colitis
    • McGovern DPB, Ahmad T, van Heel D, et al. A genetic panel strongly predicts the need for colectomy in ulcerative colitis. Gastroenterology. 2004;126:A68.
    • (2004) Gastroenterology , vol.126
    • McGovern, D.P.B.1    Ahmad, T.2    van Heel, D.3
  • 57
    • 4644250429 scopus 로고    scopus 로고
    • Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein
    • Dilger K, Schwab S, Fromm MF. Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein. Inflamm Bowel Dis. 2004;10:573-578.
    • (2004) Inflamm. Bowel Dis. , vol.10 , pp. 573-578
    • Dilger, K.1    Schwab, S.2    Fromm, M.F.3
  • 58
    • 0037223561 scopus 로고    scopus 로고
    • Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
    • Schwab M, Schaeffeler E, Marx C, et al. Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis. Gastroenterology. 2003;124:26-33.
    • (2003) Gastroenterology , vol.124 , pp. 26-33
    • Schwab, M.1    Schaeffeler, E.2    Marx, C.3
  • 59
    • 9144224852 scopus 로고    scopus 로고
    • MDR1 Ala893 polymorphism is associated with inflammatory bowel disease
    • Brant SR, Panhuysen CI, Nicolae D, et al. MDR1 Ala893 polymorphism is associated with inflammatory bowel disease. Am J Hum Genet. 2003; 73:1282-1292.
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 1282-1292
    • Brant, S.R.1    Panhuysen, C.I.2    Nicolae, D.3
  • 60
    • 0033959944 scopus 로고    scopus 로고
    • High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy
    • Farrell R, Murphy A, Long A, et al. High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy. Gastroenterology. 2000;118:279-288.
    • (2000) Gastroenterology , vol.118 , pp. 279-288
    • Farrell, R.1    Murphy, A.2    Long, A.3
  • 61
    • 0037624566 scopus 로고    scopus 로고
    • Multidrug resistance 1 gene (P-glycoprotein 170): An important determinant in gastrointestinal disease?
    • Ho GT, Moodie FM, Satsangi J. Multidrug resistance 1 gene (P-glycoprotein 170): an important determinant in gastrointestinal disease? Gut. 2003;52:759-766.
    • (2003) Gut , vol.52 , pp. 759-766
    • Ho, G.T.1    Moodie, F.M.2    Satsangi, J.3
  • 62
    • 3242698642 scopus 로고    scopus 로고
    • Anti-Saccharomyces cerevisiae antibody (ASCA) positivity is associated with increased risk for early surgery in Crohn's disease
    • Forcione DG, Rosen MJ, Kisiel JB, et al. Anti- Saccharomyces cerevisiae antibody (ASCA) positivity is associated with increased risk for early surgery in Crohn's disease. Gut. 2004;53:1117-1122.
    • (2004) Gut , vol.53 , pp. 1117-1122
    • Forcione, D.G.1    Rosen, M.J.2    Kisiel, J.B.3
  • 63
    • 0034775034 scopus 로고    scopus 로고
    • High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis
    • Fleshner PR, Vasiliauskas EA, Kam LY, et al. High level perinuclear antineutrophil cytoplasmic antibody (pANCA) in ulcerative colitis patients before colectomy predicts the development of chronic pouchitis after ileal pouch-anal anastomosis. Gut. 2001; 49:671-677.
    • (2001) Gut , vol.49 , pp. 671-677
    • Fleshner, P.R.1    Vasiliauskas, E.A.2    Kam, L.Y.3
  • 64
    • 0037235935 scopus 로고    scopus 로고
    • The benefits of early treatment in rheumatoid arthritis: Confounding by indication, and the issue of timing
    • Landewe RB. The benefits of early treatment in rheumatoid arthritis: confounding by indication, and the issue of timing. Arthritis Rheum. 2003; 48:1-5.
    • (2003) Arthritis Rheum. , vol.48 , pp. 1-5
    • Landewe, R.B.1
  • 65
  • 66
    • 0036225943 scopus 로고    scopus 로고
    • Early and aggressive treatment of rheumatoid arthritis patients affects the association of HLA class II antigens with progression of joint damage
    • Lard LR, Boers M, Verhoeven A, et al. Early and aggressive treatment of rheumatoid arthritis patients affects the association of HLA class II antigens with progression of joint damage. Arthritis Rheum. 2002;46:899-905.
    • (2002) Arthritis Rheum. , vol.46 , pp. 899-905
    • Lard, L.R.1    Boers, M.2    Verhoeven, A.3
  • 68
    • 0037999892 scopus 로고    scopus 로고
    • Genotype-based phenotyping heralds a new taxonomy for inflammatory bowel disease
    • Ahmad T, Marshall S, Jewell D. Genotype-based phenotyping heralds a new taxonomy for inflammatory bowel disease. Curr Opin Gastroenterol. 2003;19:327-335.
    • (2003) Curr. Opin. Gastroenterol. , vol.19 , pp. 327-335
    • Ahmad, T.1    Marshall, S.2    Jewell, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.