-
1
-
-
0037260139
-
Cancer statistics, 2003
-
Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun M. Cancer statistics, 2003. CA Cancer J Clin 2003;53:5-26.
-
(2003)
CA Cancer J Clin
, vol.53
, pp. 5-26
-
-
Jemal, A.1
Murray, T.2
Samuels, A.3
Ghafoor, A.4
Ward, E.5
Thun, M.6
-
2
-
-
0036322185
-
Current therapy for multiple myeloma
-
Mayo Clinic Myeloma, Amyloid, and Dysproteinemia Group
-
Rajkumar S, Gertz M, Kyle R, Greipp P, Mayo Clinic Myeloma, Amyloid, and Dysproteinemia Group. Current therapy for multiple myeloma. Mayo Clin Proc 2002;77:813-22.
-
(2002)
Mayo Clin Proc
, vol.77
, pp. 813-822
-
-
Rajkumar, S.1
Gertz, M.2
Kyle, R.3
Greipp, P.4
-
3
-
-
0036220361
-
Nontraditional cytotoxic therapies for relapsed/ refractory multiple myeloma
-
Hussein M. Nontraditional cytotoxic therapies for relapsed/ refractory multiple myeloma. Oncologist 2002;7 (suppl 1):20-9.
-
(2002)
Oncologist
, vol.7
, Issue.1 SUPPL.
, pp. 20-29
-
-
Hussein, M.1
-
4
-
-
0035215395
-
Proteasome inhibition in cancer: Development of PS-341
-
Adams J. Proteasome inhibition in cancer: development of PS-341. Semin Oncol 2001;28:613-9.
-
(2001)
Semin Oncol
, vol.28
, pp. 613-619
-
-
Adams, J.1
-
5
-
-
0023701618
-
Proteasomes (multi-protease complexes) as 20 S ring-shaped particles in a variety of eukaryotic cells
-
Tanaka K, Yoshimura T, Kumatori A, Ichihara A, Ikai A, Nishigai M, et al. Proteasomes (multi-protease complexes) as 20 S ring-shaped particles in a variety of eukaryotic cells. J Biol Chem 1988;263:16209-17.
-
(1988)
J Biol Chem
, vol.263
, pp. 16209-16217
-
-
Tanaka, K.1
Yoshimura, T.2
Kumatori, A.3
Ichihara, A.4
Ikai, A.5
Nishigai, M.6
-
6
-
-
0029664304
-
Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor-kappa B
-
Cobb R, Felts K, Parry G, Mackman N. Proteasome inhibitors block VCAM-1 and ICAM-1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor-kappa B. Eur J Immunol 1996;26:839-45.
-
(1996)
Eur J Immunol
, vol.26
, pp. 839-845
-
-
Cobb, R.1
Felts, K.2
Parry, G.3
Mackman, N.4
-
7
-
-
0026783274
-
Regulation of gene expression of proteasomes (multi-protease complexes) during growth and differentiation of human hematopoietic cells
-
Shimbara N, Orino E, Sone S, Ogura T, Takashina M, Shono M, et al. Regulation of gene expression of proteasomes (multi-protease complexes) during growth and differentiation of human hematopoietic cells. J Biol Chem. 1992;267:18100-9.
-
(1992)
J Biol Chem.
, vol.267
, pp. 18100-18109
-
-
Shimbara, N.1
Orino, E.2
Sone, S.3
Ogura, T.4
Takashina, M.5
Shono, M.6
-
8
-
-
0029789637
-
The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase
-
Brandeis M, Hunt T. The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. EMBO J 1996;15:5280-9.
-
(1996)
EMBO J
, vol.15
, pp. 5280-5289
-
-
Brandeis, M.1
Hunt, T.2
-
9
-
-
0029957947
-
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation
-
Clurman B, Sheaff R, Thress K, Groudine M, Roberts J. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation. Genes Dev 1996;10:1979-90.
-
(1996)
Genes Dev
, vol.10
, pp. 1979-1990
-
-
Clurman, B.1
Sheaff, R.2
Thress, K.3
Groudine, M.4
Roberts, J.5
-
10
-
-
0032429122
-
Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts
-
An B, Goldfarb R, Siman R, Dou Q. Novel dipeptidyl proteasome inhibitors overcome Bcl-2 protective function and selectively accumulate the cyclin-dependent kinase inhibitor p27 and induce apoptosis in transformed, but not normal, human fibroblasts. Cell Death Differ 1998;5:1062-75.
-
(1998)
Cell Death Differ
, vol.5
, pp. 1062-1075
-
-
An, B.1
Goldfarb, R.2
Siman, R.3
Dou, Q.4
-
11
-
-
0029952441
-
In vivo ubiquitination and proteasome-mediated degradation of p53(1)
-
Maki C, Huibregtse J, Howley P. In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res 1996;56:2649-54.
-
(1996)
Cancer Res
, vol.56
, pp. 2649-2654
-
-
Maki, C.1
Huibregtse, J.2
Howley, P.3
-
12
-
-
0032508414
-
NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and C-IAP2 to suppress caspase-8 activation
-
Wang C, Mayo M, Korneluk R, Goeddel D, Baldwin A, Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and C-IAP2 to suppress caspase-8 activation. Science 1998;281:1680-3.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.1
Mayo, M.2
Korneluk, R.3
Goeddel, D.4
Baldwin Jr., A.5
-
13
-
-
0030885492
-
Proteasome inhibition attentuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis
-
Conner E, Brand S, Davis J, Laroux F, Palombella V, Fuseler J, et al. Proteasome inhibition attentuates nitric oxide synthase expression, VCAM-1 transcription and the development of chronic colitis. J Pharmacol Exp Ther 1997;282:1615-22.
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 1615-1622
-
-
Conner, E.1
Brand, S.2
Davis, J.3
Laroux, F.4
Palombella, V.5
Fuseler, J.6
-
14
-
-
0030926777
-
Lactacystin and clasto-lactacystin b-lactone modify multiple proteasome b-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation
-
Craiu A, Gaczynska M, Akopian T, Gramm C, Fenteany G, Goldberg A, et al. Lactacystin and clasto-lactacystin b-lactone modify multiple proteasome b-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J Biol Chem 1997;272:13437-45.
-
(1997)
J Biol Chem
, vol.272
, pp. 13437-13445
-
-
Craiu, A.1
Gaczynska, M.2
Akopian, T.3
Gramm, C.4
Fenteany, G.5
Goldberg, A.6
-
15
-
-
0035736099
-
The proteasome: A new target for novel drug therapies
-
Elliott P, Ross J. The proteasome: a new target for novel drug therapies. Am J Clin Pathol 2001;116:637-46.
-
(2001)
Am J Clin Pathol
, vol.116
, pp. 637-646
-
-
Elliott, P.1
Ross, J.2
-
16
-
-
0034062989
-
Proteasome inhibition: A new strategy in cancer treatment
-
Adams J, Palombella V, Elliott P. Proteasome inhibition: a new strategy in cancer treatment. Invest New Drugs 2000;18:109-21.
-
(2000)
Invest New Drugs
, vol.18
, pp. 109-121
-
-
Adams, J.1
Palombella, V.2
Elliott, P.3
-
17
-
-
0033105537
-
Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines
-
Damiano J, Cress A, Hazlehurst L, Shtil A, Dalton W. Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines. Blood 1999;93:1658-67.
-
(1999)
Blood
, vol.93
, pp. 1658-1667
-
-
Damiano, J.1
Cress, A.2
Hazlehurst, L.3
Shtil, A.4
Dalton, W.5
-
18
-
-
0029165187
-
Regulation of interleukin 6 in multiple myeloma and bone marrow stromal cells
-
Chauhan D, Uchiyama H, Urashima M, Yamamoto K, Anderson K. Regulation of interleukin 6 in multiple myeloma and bone marrow stromal cells. Stem Cells 1995;13 (suppl 2):35-9.
-
(1995)
Stem Cells
, vol.13
, Issue.2 SUPPL.
, pp. 35-39
-
-
Chauhan, D.1
Uchiyama, H.2
Urashima, M.3
Yamamoto, K.4
Anderson, K.5
-
19
-
-
0242496212
-
Molecular sequelae of proteasome inhibition in human multiple myeloma cells
-
Mitsiades N, Mitsiades C, Poulaki V, Chauhan D, Fanourakis G, Gu X, et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci USA 2002;99:14374-9.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 14374-14379
-
-
Mitsiades, N.1
Mitsiades, C.2
Poulaki, V.3
Chauhan, D.4
Fanourakis, G.5
Gu, X.6
-
20
-
-
0035958517
-
The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: Therapeutic applications
-
Hideshima T, Chauhan D, Schlossman R, Richardson P, Anderson K. The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications. Oncogene 2001;20:4519-27.
-
(2001)
Oncogene
, vol.20
, pp. 4519-4527
-
-
Hideshima, T.1
Chauhan, D.2
Schlossman, R.3
Richardson, P.4
Anderson, K.5
-
21
-
-
0036240701
-
The proteasome: A novel target for cancer chemotherapy
-
Almond J, Cohen G. The proteasome: a novel target for cancer chemotherapy. Leukemia 2002;16:433-43.
-
(2002)
Leukemia
, vol.16
, pp. 433-443
-
-
Almond, J.1
Cohen, G.2
-
22
-
-
0033152760
-
Proteasome inhibitors: A novel class of potent and effective antitumor agents
-
Adams J, Palombella V, Sausville E, Johnson J, Destree A, Lazarus D, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 1999;59:2615-22.
-
(1999)
Cancer Res
, vol.59
, pp. 2615-2622
-
-
Adams, J.1
Palombella, V.2
Sausville, E.3
Johnson, J.4
Destree, A.5
Lazarus, D.6
-
23
-
-
0035207110
-
The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma
-
Berenson J, MA H, Vescio R. The role of nuclear factor-kappaB in the biology and treatment of multiple myeloma. Semin Oncol 2001;28:626-33.
-
(2001)
Semin Oncol
, vol.28
, pp. 626-633
-
-
Berenson, J.1
Ma, H.2
Vescio, R.3
-
24
-
-
18544367201
-
NF-kappa B as a therapeutic target in multiple myeloma
-
Hideshima T, Chauhan D, Richardson P, Mitsiades C, Mitsiades N, Hayashi T, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem 2002;277:16639-47.
-
(2002)
J Biol Chem
, vol.277
, pp. 16639-16647
-
-
Hideshima, T.1
Chauhan, D.2
Richardson, P.3
Mitsiades, C.4
Mitsiades, N.5
Hayashi, T.6
-
25
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D, Palombella V, Elliott P, Adams J, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001;61:3071-6.
-
(2001)
Cancer Res
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
Palombella, V.4
Elliott, P.5
Adams, J.6
-
26
-
-
0034888319
-
Targeted therapy to multiple myeloma
-
Anderson K. Targeted therapy to multiple myeloma. Semin Hematol 2001;38:286-94.
-
(2001)
Semin Hematol
, vol.38
, pp. 286-294
-
-
Anderson, K.1
-
27
-
-
0037443551
-
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
-
Mitsiades N, Mitsiades C, Richardson P, Poulaki V, Tai Y, Chauhan D, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003;101:2377-80.
-
(2003)
Blood
, vol.101
, pp. 2377-2380
-
-
Mitsiades, N.1
Mitsiades, C.2
Richardson, P.3
Poulaki, V.4
Tai, Y.5
Chauhan, D.6
-
28
-
-
0037097595
-
Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: Therapeutic implications
-
Mitsiades N, Mitsiades C, Poulaki V, Chauhan D, Richardson P, Hideshima T, et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002;99:4525-30.
-
(2002)
Blood
, vol.99
, pp. 4525-4530
-
-
Mitsiades, N.1
Mitsiades, C.2
Poulaki, V.3
Chauhan, D.4
Richardson, P.5
Hideshima, T.6
-
29
-
-
0035437171
-
TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: Therapeutic applications
-
Mitsiades C, Treon S, Mitsiades N, Shima Y, Richardson P, Schlossman R, et al. TRAIL/Apo2L ligand selectively induces apoptosis and overcomes drug resistance in multiple myeloma: therapeutic applications. Blood 2001;98:795-804.
-
(2001)
Blood
, vol.98
, pp. 795-804
-
-
Mitsiades, C.1
Treon, S.2
Mitsiades, N.3
Shima, Y.4
Richardson, P.5
Schlossman, R.6
-
30
-
-
0036735298
-
Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
-
LeBlanc R, Catley L, Hideshima T, Lentzsch S, Mitsiades C, Mitsiades N, et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res 2002;62:4996-5000.
-
(2002)
Cancer Res
, vol.62
, pp. 4996-5000
-
-
LeBlanc, R.1
Catley, L.2
Hideshima, T.3
Lentzsch, S.4
Mitsiades, C.5
Mitsiades, N.6
-
31
-
-
0037111832
-
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
-
Orlowski R, Stinchcombe T, Mitchell B, Shea T, Baldwin A, Stahl S, et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002;20:4420-7.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4420-4427
-
-
Orlowski, R.1
Stinchcombe, T.2
Mitchell, B.3
Shea, T.4
Baldwin, A.5
Stahl, S.6
-
32
-
-
0036023407
-
A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
-
Aghajanian C, Soignet S, Dizon D, Pien C, Adams J, Elliott P, et al. A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 2002;8:2505-11.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2505-2511
-
-
Aghajanian, C.1
Soignet, S.2
Dizon, D.3
Pien, C.4
Adams, J.5
Elliott, P.6
-
33
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson P, Barlogie B, Berenson J, Singhal S, Jagannath S, Irwin D, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003;348:2609-17.
-
(2003)
N Engl J Med
, vol.348
, pp. 2609-2617
-
-
Richardson, P.1
Barlogie, B.2
Berenson, J.3
Singhal, S.4
Jagannath, S.5
Irwin, D.6
-
34
-
-
18244428600
-
Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation
-
Blade J, Samson D, Reece D, Apperley J, Bjorkstrand B, Gahrton G, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Br J Haematol 1998;102:1115-23.
-
(1998)
Br J Haematol
, vol.102
, pp. 1115-1123
-
-
Blade, J.1
Samson, D.2
Reece, D.3
Apperley, J.4
Bjorkstrand, B.5
Gahrton, G.6
-
35
-
-
0142200670
-
Experience with long-term therapy using the proteasome inhibitor, bortezomib, in advanced multiple myeloma (MM)
-
Berenson J, Jagannath S, Barlogie B, Siegel D, Alexanian R, Irwin D, et al. Experience with long-term therapy using the proteasome inhibitor, bortezomib, in advanced multiple myeloma (MM). Proc Am Soc Clin Oncol 2003;22:581.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 581
-
-
Berenson, J.1
Jagannath, S.2
Barlogie, B.3
Siegel, D.4
Alexanian, R.5
Irwin, D.6
-
37
-
-
1642448415
-
Phase I study of bortezomib (PS-341, VELCADE®), a proteasome inhibitor, in patients with refractory or relapsed acute leukemias and myelodysplastic syndromes
-
Cortes J, Estey E, Giles F, O'Brien S, Keating M, McConkey D, et al. Phase I study of bortezomib (PS-341, VELCADE®), a proteasome inhibitor, in patients with refractory or relapsed acute leukemias and myelodysplastic syndromes. Blood 2002;100:560a.
-
(2002)
Blood
, vol.100
-
-
Cortes, J.1
Estey, E.2
Giles, F.3
O'Brien, S.4
Keating, M.5
McConkey, D.6
-
38
-
-
0142231752
-
Phase II clinical experience with the proteasome inhibitor bortezomib (formerly PS-341) in patients with indolent lymphomas
-
O'Connor O, Wright J, Moskowitz C, Macgregor-Cortelli B, Straus D, Horse-Grant D, et al. Phase II clinical experience with the proteasome inhibitor bortezomib (formerly PS-341) in patients with indolent lymphomas. Proc Am Soc Clin Oncol 2003;22:566.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 566
-
-
O'Connor, O.1
Wright, J.2
Moskowitz, C.3
Macgregor-Cortelli, B.4
Straus, D.5
Horse-Grant, D.6
-
39
-
-
0142200669
-
Report of a phase II study of proteasome inhibitor bortezomib in patients with relapsed or refractory indolent aggressive B-cell lymphoma
-
Goy A, East K, Mesina O, Cabanillas F, Fayad L, Hagemeister F, et al. Report of a phase II study of proteasome inhibitor bortezomib in patients with relapsed or refractory indolent aggressive B-cell lymphoma. Proc Am Soc Clin Oncol 2003;22:570.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 570
-
-
Goy, A.1
East, K.2
Mesina, O.3
Cabanillas, F.4
Fayad, L.5
Hagemeister, F.6
-
40
-
-
22144478912
-
Myelodysplastic syndrome patients show a variety of hematologic responses to proteasome inhibitor bortezomib (PS 341)
-
Raza A, Lisak L, Tahir S, Billmeier J, Willmann H, Bellak D, et al. Myelodysplastic syndrome patients show a variety of hematologic responses to proteasome inhibitor bortezomib (PS 341). Blood 2002;100:338b.
-
(2002)
Blood
, vol.100
-
-
Raza, A.1
Lisak, L.2
Tahir, S.3
Billmeier, J.4
Willmann, H.5
Bellak, D.6
-
41
-
-
0142139035
-
Phase I study of the proteasome inhibitor bortezomib and pegylated and liposomal doxorubicin in patients with refractory hematologic malignancies
-
Orlowski R, Voorhees P, Garcia R, Hall M, Adams J, Esseltine D, et al. Phase I study of the proteasome inhibitor bortezomib and pegylated and liposomal doxorubicin in patients with refractory hematologic malignancies. Proc Am Soc Clin Oncol 2003;22:200.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 200
-
-
Orlowski, R.1
Voorhees, P.2
Garcia, R.3
Hall, M.4
Adams, J.5
Esseltine, D.6
-
42
-
-
0346336804
-
Treatment of multiple myeloma
-
Barlogie B, Shaughnessy J, Tricot G, Jacobson J, Zangari M, Anaissie E, et al. Treatment of multiple myeloma. Blood 2004;103:20-32.
-
(2004)
Blood
, vol.103
, pp. 20-32
-
-
Barlogie, B.1
Shaughnessy, J.2
Tricot, G.3
Jacobson, J.4
Zangari, M.5
Anaissie, E.6
-
43
-
-
0346117944
-
A phase I/II study of combination treatment with bortezomib and melphalan (Vc + M) in patients with relapsed or refractory multiple myeloma (MM)
-
Yang H, Vescio R, Adams J, Schenkein D, Berenson J. A phase I/II study of combination treatment with bortezomib and melphalan (Vc + M) in patients with relapsed or refractory multiple myeloma (MM). Proc Am Soc Clin Oncol 2003;22:582.
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, pp. 582
-
-
Yang, H.1
Vescio, R.2
Adams, J.3
Schenkein, D.4
Berenson, J.5
|