Rapid creation of a novel protein function by in vitro coevolution

Journal of Molecular Biology

Volumn 348, Issue 5, 2005, Pages 1273-1282

  Chen, Zhilei ^a   Zhao, Huimin ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Directed evolution; Nuclear hormone receptor; Nuclear receptor evolution; Protein engineering; Rational design

Indexed keywords

CELL NUCLEUS RECEPTOR; CORTICOSTERONE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HORMONE RECEPTOR; LIGAND; PROGESTERONE; TESTOSTERONE;

ARTICLE; COEVOLUTION; CONTROLLED STUDY; HYPOTHESIS; LIGAND BINDING; METHODOLOGY; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TARGETING; PROTEIN VARIANT; RANDOMIZATION; SITE DIRECTED MUTAGENESIS;

EID: 18044364063     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.02.070     Document Type: Article

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