Directed evolution of specific receptor-ligand pairs for use in the creation of gene switches

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 16, 2005, Pages 5691-5696

  Chockalingam, Karuppiah ^a   Chen, Zhilei ^a   Katzenellenbogen, John A ^a   Zhao, Huimin ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Gene therapy; Nuclear hormone receptor; Orthogonal ligand receptor pairs; Protein engineering

Indexed keywords

4,4' DIHYDROXYBENZIL; ENZYME; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HORMONE RECEPTOR; HYDROXYBENZOIC ACID DERIVATIVE; LIGAND; NUCLEAR HORMONE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; ENDOMETRIUM CANCER; ENZYME SPECIFICITY; GENE CONTROL; GENE SWITCHING; GENE THERAPY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LIGAND BINDING; METABOLIC ENGINEERING; MUTAGENESIS; NONHUMAN; PHENOTYPE; PLEIOTROPY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ENGINEERING;

BINDING SITES; CELL LINE, TUMOR; DIRECTED MOLECULAR EVOLUTION; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RANDOM ALLOCATION; TRANS-ACTIVATION (GENETICS); TWO-HYBRID SYSTEM TECHNIQUES;

EID: 17644419994     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0409206102     Document Type: Article

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