HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation

Journal of Immunology

Volumn 161, Issue 8, 1998, Pages 4309-4317

  Wang, Ji Ming ^a   Ueda, Hirotsugu ^a   Howard, O M Zack ^b   Grimm, Michael C ^a   Chertov, Oleg ^b   Gong, Xiaoqi ^a   Gong, Wanghua ^b   Resau, James H ^a   Broder, Christopher C ^c   Evans, Gerald ^b   Arthur, Larry O ^b   Ruscetti, Francis W ^a   Oppenheim, Joost J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CELL SURFACE RECEPTOR; CHEMOKINE; CHEMOKINE RECEPTOR; GLYCOPROTEIN GP 120; STAUROSPORINE;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CHEMOTAXIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOMODULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRUS ENVELOPE;

ANTIGENS, CD4; CELLS, CULTURED; CHEMOKINES; DOWN-REGULATION; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; MONOCYTES; RECEPTORS, CXCR4; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 17944391226     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Klatzmann, D., E. Champagne, S. Chamaret, J. Gruest, D. Guetars, T. Hercend, J. C. Gluckman, and L. Montaggnier. 1984. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312:767.
2. Dalgleish, A. G., P. C. Beverley, P. R. Clapham, D. H. Crawford, M. F. Greaves, and R. A. Weiss. 1984. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763.
3. Premack, B. A., and T. J. Schall. 1996. Chemokine receptors: gateways to inflammation and infection. Nat. Med. 2:1174.
4. Bleul, C. C., M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. Sodroski, and T. A. Springer. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829.
5. Oberlin, E., A. Amara, F. Bachelerie, C. Bessia, J.-L. Virelizier, F. Arenzana-Seisdedos, O. Schwartz, J.-M. Heard, I. Clark-Lewis, D. F. Legler, M. Loetscher, M. Baggilini, and B. Moser. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382:833.
6. Feng, Y., C. C. Broder, P. E. Kennedy, and E. A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272:872.
7. Deng, H. K., R. Liu, W. Ellmeier, H. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill, C. Davis, S. C. Peiper, T. J. Schall, D. R. Littman, and N. R. Landau. 1996. Identification of major co-receptor for primary isolates of HIV-1. Nature 381:661.
8. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667.
9. Alkhatib, G., C. Combatiere, C. C. Broder, Y. Feng, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1996. CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955.
10. Liu, R., W. A. Paxton, H. Choe., D. Ceradini, S. R. Martin, R. Horuk, M. E. MacDonald, H. Stuhlmann, R. A. Koup, and N. R. Landau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367.
11. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. Rollins, P. D. Ponath, L. Wu, C. R. Mackay, G. LaRosa, W. Newman, N. Gerard, C. Gerard, and J. Sodroski. 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85:1135.
12. Doranz, B. J., J. Rucker, Y. Yi, R. J. Smyth, M. Samson, S. C. Peiper, M. Parmentier, R. G. Collman, and R. W. Doms. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85:1149.
13. Liao, F., G. Alkhatib, K. W. Peden, G. Sharma, E. A. Berger, and J. M. Farber. 1997. STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J. Exp. Med. 185:2015.
14. Trkola, A., T. Dragic, J. Arthos, J. M. Binley, W. C. Olson, G. P. Allaway, C. Cheng-Mayer, J. Robinson, P. J. Maddon, and J. P. Moore. 1996. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature 384:184.
15. Wu, L., N. P. Gerard, R. Wyatt, H. Choe, C. Parolin, N. Ruffing, A. Borsetti, A. A. Cardoso, E. Desjardin, W. Newman, C. Gerard, and J. Sodroski. 1996. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature 384:179.
16. Ugoni, S., M. Moulard, I. Mondor, N. Barois, D. Demandolx, J. Hoxie, A. Brelot, M. Alizon, J. Davoust, and Q. J. Sattentau. 1997. HIV-1 gp120 induces an association between CD4 and the chemokine receptor CXCR4. J. Immunol. 159: 3000.
17. Kornfeld, H., W. W. Cruikshank, S. W. Pyle, J. S. Berman, and D. M. Center. 1988. Lymphocyte activation by HIV-1 envelope glycoprotein. Nature 335:445.
18. Weissman, D., R. L. Rabin, J. Arthos, A. Rubbert, M. Dybul, R. Swofford, S. Venkatesan, J. M. Farber, and A. Fauci. 1997. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389:982.
19. Smith, P. D., K. Ohura, H. Masur, H. C. Lane, A. S. Fauci, and S. M. Wahl. 1984. Monocyte function in the acquired immune deficiency syndrome: defective chemotaxis. J. Clin. Invest. 74:2121.
20. Wahl, S. M., J. B. Allen, S. Gartner, J. M. Orenstein, M. Popovic, D. E. Chenoweth, L. O. Arthur, W. L. Farrar, and L. M. Wahl. 1989. HIV-1 and its envelope glycoprotein down-regulate chemotactic ligand receptors and chemotactic function of peripheral blood monocytes. J. Immunol. 142:3553.
21. Gelderblom, H. R., E. H. S. Hausmann, M. Ozel, G. Pauli, and M. A. Koch. 1987. Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins. Virology 156:171.
22. Pyle, S. W., G. C. Dubois, W. G. Robey, J. W. Bess, Jr., P. J. Fischinger, and L. O. Arthur. 1988. Purification and characterization of the external envelope glycoprotein from two human immunodeficiency virus type 1 variants, HTLV-IIIB and HTLV-IIIRF. J. Virol. 62:2258.
23. Xu, L. L., D. W. McVicar, A. Ben-Baruch, D. B. Kuhns, J. Johnston, J. J. Oppenheim, and J. M. Wang. 1995. Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors: binding and signaling of MCP3 through shared as well as unique receptors on monocytes and neutrophils. Eur. J. Immunol. 25:2612.
24. Ben-Baruch, A., L. Xu, P. R. Young, K. Bengali, J. J. Oppenheim, and J. M. Wang. 1995. Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1α/RANTES, is also a functional receptor for MCP3. J. Biol. Chem. 270:22123.
25. Cruikshank, W. W., D. M. Center, S. W. Pyle, and H. Kornfeld. 1990. Biologic activities of HIV- 1 envelope glycoprotein: the effects of crosslinking. Biomed. Pharm. 44:5.
26. Murphy, P. M. 1996. Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine Growth Factor Rev. 7:47.
27. Combadiere, C., S. K. Ahuja, H. L. Tiffany, and P. M. Murphy. 1996. Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1β and RANTES. J. Leukocyte Biol. 60:147.
28. Neote, K., D. DiGregorio, J. Y. Mak, R. Horuk, and T. J. Schall. 1993. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor. Cell 72:415.
29. Gao, J. L., D. B. Kuhns, H. L. Tiffany, D. McDermot, X. Li, U. Francke, and P. M. Murphy. 1993. Structure and functional expression of the human macrophage inflammatory protein 1α/RANTES receptor. J. Exp. Med. 177:1421.
30. Gong, X., W. Gong, D. B. Kuhns, A. Ben-Baruch, O. M. Z. Howard, and J. M. Wang. 1997. Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors. J. Biol. Chem. 272:11682.
31. Cocchi, F., A. L. DeVico, A. Garzino-Demo, S. K. Arya, R. C. Gallo, and P. Lusso. 1995. Identification of RANTES, MIP-1α, MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science 270:1811.
32. Cocchi, F., A. L. DeVico, A. Garzino-Demo, R. C. Gallo, and P. Lusso. 1996. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nat. Med. 2:1244.
33. Lapham, C. K., J. Ouyang, B. Chandrasekhar, N. Y. Nguyen, D. S. Dimitrov, and H. Golding. 1996. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. Science 274:602.
34. Oravecz, T., M. Pall, and A. Norcross. 1996. β-Chemokine inhibition of monocytrotropic HIV-1 infection. J. Immunol. 157:1329.
35. Davis, C. B., I. Dikic, D. Unutmaz, C. M. Hill, J. Arthos, M. A. Siani, D. A. Thompson, J. Schlessinger, and D. R. Littman. 1997. Signal transduction due to HIV-1 envelope interaction with chemokine receptors CXCR4 or CCR5. J. Exp. Med. 186:1793.
36. Parada, N. A., W. W. Cruikshank, H. L. Danis, T. C. Ryan, and D. M. Center. 1996. IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C. Cell. Immunol. 168:100.
37. Wahl, L. M., M. L. Corcoran, S. W. Pyle, L. O. Arthur, A. Harel-Bellan, and W. L. Farrar. 1989. Human immunodeficiency virus glycoprotein (gp120) induction of monocyte arachidonic acid metabolites and interleukin 1. Proc. Natl. Acad. Sci. USA 86:621.
38. Golding, H., J. Manischewitz, L. Vujcic, R. Blumenthal, and D. S. Dimitrov. 1994. The phorbol ester phorbol myristate acetate inhibits human immunodeficiency virus type 1 envelope-mediated fusion by modulating an accessory component(s) in CD4-expressing cells. J. Virol. 68:1962.
39. Ravichandran, K. S., T. L. Collins, and S. J. Burakoff. 1996. CD4 and signal transduction. Curr. Top. Microbiol. Immunol. 205:47.
40. Volsky, D. J., M. Simm, M. Shahabuddin, W. Chao, and M. J. Potash. 1996. Interference to human immunodeficiency virus type 1 infection in the absence of down-modulation of the principal virus receptor, CD4. J. Virol. 6:3823.
41. Moore, J. P., Y. Cao, D. D. Ho, and R. A. Koup. 1994. Development of the anti-gp120 antibody response during seroconversion to human immunodeficiency virus type 1. J. Virol. 68:5142.
42. Moore, J. P., and R. F. Jarrett. 1988. Sensitive ELISA for the gp120 and gp160 surface glycoproteins of HIV-1. AIDS Res. Hum. Retroviruses 4:369.
43. Ho, D. D., J. A. McKeating, X. L. Li, T. Moudgil, E. S. Daar, N.-C. Sun, and J. E. Bobinson. 1991. Conformational epitope on gp120 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody. J. Virol. 65:489.
44. Nara, P. L., R. R. Garrity, and J. Goudsmit. 1991. Neutralization of HIV: a paradox of humoral proportions. FASEB J. 5:2437.
45. Sunila, I., M. Vaccarezza, G Pantaleo, A. S. Fauci, and J. M. Orenstein. 1997. Gp120 is present on the plasma membrane of apoptotic CD4 cells prepared from lymph nodes of HIV-1-infected individuals: an immunoelectron microscopic study. AIDS 11:27.