gp120 is present on the plasma membrane of apoptotic CD4 cells prepared from lymph nodes of HIV-1-infected individuals: An immunoelectron microscopic study

AIDS

Volumn 11, Issue 1, 1997, Pages 27-32

  Sunila, Inke ^a   Vaccarezza, Mauro ^b   Pantaleo, Giuseppe ^b   Fauci, Anthony S ^b   Orenstein, Jan M ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Apoptosis; CD4+ cells; gp120; HIV; Lymph node

Indexed keywords

CD20 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; GLYCOPROTEIN GP 120; MEMBRANE ANTIGEN;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CASE REPORT; CELL STRUCTURE; CELL SUSPENSION; CELL TYPE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD STAINING; LYMPH NODE; PRIORITY JOURNAL; PROTEIN BINDING; SUPPRESSOR CELL; T LYMPHOCYTE;

ANTIGENS, CD45; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL MEMBRANE; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOPHENOTYPING; LYMPH NODES; MICROSCOPY, IMMUNOELECTRON;

EID: 0031024748     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199701000-00005     Document Type: Article

References (14)

1. Fauci AS: Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 1993, 262:1011-1018.
2. Jowett IBM, Planelles V, Poon B, Shah NP, Chen ML, Chen IS: The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle. J Virol 1995, 69:6304-6313.
3. Orenstein JM: Ultrastructural pathology of human immunodeficiency virus infection. Ultrastruct Pathol 1992, 16:179-210.
4. Harper ME, Marselle LM, Gallo RC, Wong-Staal F: Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization. Proc Natl Acad Sci USA 1986, 83:772-776.
5. Bagasra O, Hauptman SP, Lischner HW, Sachs M, Pomerantz RJ: Detection of human immunodeficiency virus type 1 provirus in mononuclear cells by in situ polymerase chain reaction. N Engl J. Med 1992, 326:1385-1391.
6. Laurent-Crawford AG, Krust B, Muller S, et al.: The cytopathic effect of HIV is associated with apoptosis. Virology 1991, 185:829-839.
7. Terai C, Kornbluth RS, Pauza CD, Richman DD, Carson DA: Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1. J. Clin Invest 1991, 87:1710-1715.
8. Gougeon M-L, Olivier R, Garcia S, et. al.: Mise en evidence d'un processus d'engagement vers la mort cellulaire par apoptose dans les lymphocytes de patients infectes par le VIH. C R Acad Sci Paris 1991, 312:529-537.
9. Groux H, Torpier G, Monte D, Mouton Y, Capron A, Ameisen JC: Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals. ; J. Exp Med 1992, 175:331-340.
10. Gougeon M-L, Garcia S, Heeney J, et al.: Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res Hum Retrovirus 1993, 9:553-563.
11. Oyaizu N, McCloskey TW, Coronesi M, et al.: Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals. Blood 1993, 82:3392-3400.
12. Finkel TH, Tudor-Williams G, Banda NK, et al.: Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nature Med 1995, 1:129-134.
13. Gelderblom HR, Reupke H, Pauli G: Loss of envelope antigens of HTLV-III/LAV, a factor in AIDS pathogenesis. Lancet 1985, ii:1016-1017.
14. Schneider J, Kaaden O, Copeland TD, Oroszlan S, Hunsmann G: Shedding and interspecies type seroreactivity of the envelope glycopolypeptide gp120 of the human immunodeficiency virus. J Gen Virol 1986, 67:2533-2538.