Pleiotropic Effects of Ubp6 Loss on Drug Sensitivities and Yeast Prion Are Due to Depletion of the Free Ubiquitin Pool

Journal of Biological Chemistry

Volumn 278, Issue 52, 2003, Pages 52102-52115

  Chernova, Tatiana A ^a   Allen, Kim D ^b,c   Wesoloski, Lisa M ^a,d   Shanks, John R ^a   Chernoff, Yury O ^b   Wilkinson, Keith D ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; DRUG PRODUCTS; FLUORESCENCE; GENES; MICROSCOPIC EXAMINATION; PROTEINS;

NUCLEAR LOCALIZATION;

YEAST;

4 NITROQUINOLINE 1 OXIDE; ANISOMYCIN; CADMIUM; CANAVANINE; CHLORAMPHENICOL; CYCLOHEXIMIDE; GENE PRODUCT; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MESYLIC ACID METHYL ESTER; METHOTREXATE; PROTEASOME; TRICHODERMIN; UBIQUITIN; UBP6 PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DRUG SENSITIVITY; EUKARYOSIS; FLUORESCENCE; GENE; GENE DELETION; GENE OVEREXPRESSION; NONHUMAN; PHENOTYPE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; UBP6 GENE; YEAST;

CATALYSIS; CELL NUCLEUS; CYCLOHEXIMIDE; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; ESCHERICHIA COLI; GENE DELETION; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOBLOTTING; KINETICS; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MULTIENZYME COMPLEXES; MUTATION; PHENOTYPE; PLASMIDS; PRIONS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TIME FACTORS; UBIQUITIN; UBIQUITIN THIOLESTERASE;

EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0347993105     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M310283200     Document Type: Article

References (71)

1. Hershko, A., and Ciechanover, A. (1998) Annu. Rev. Biochem. 67, 425-479
2. Tran, P. B., Miller, R. J. (1999) Trends Neurosci. 22, 194-197
3. Mayer, R. J. (2003) Drug News Perspect. 16, 103-108
4. Ciechanover, A. (2003) Biochem. Soc. Trans. 31, 474-481
5. Bence, N. F., Sampat, R. M., and Kopito, R. R. (2001) Science 292, 1552-1555
6. Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H. D., Mayer, T. U., and Jentsch, S. (1999) Cell 96, 635-644
7. Wilkinson, K. D. (2000) Semin. Cell Dev. Biol. 3, 141-148
8. Wilkinson, K. D. (1997) FASEB J. 11, 1245-1256
9. Finley, D. (2002) Nat. Cell Biol. 4, E121-E123
10. Lam, Y. A., Xu, W., DeMartino, G. N., and Cohen, R. E. (1997) Nature 385, 737-740
11. Borodovsky, A., Kessler, B. M., Casagrande, R., Overkleeft, H. S., Wilkinson, K. D., and Ploegh, H. L. (2001) EMBO J. 20, 5187-5196
12. Leggett, D. S., Hanna, J., Borodovsky, A., Crosas, B., Schmidt, M., Baker, R. T., Walz, T., Ploegh, H., and Finley, D. (2002) Mol. Cell 10, 495-507
13. Papa, F. R., Amerik, A. Y., and Hochstrasser, M. (1999) Mol. Biol. Cell 10, 741-756
14. Verma, R., Chen, S., Feldman, R., Schieltz, D., Yates, J., Dohmen, J., and Deshaies, R. J. (2000) Mol. Biol. Cell 11, 3425-3439
15. Verma, R., Aravind, L., Oania, R., MeDonald, W. H., Yates, I. J., Koonin, E. V., and Deshaies, R. J. (2002) Science 298, 611-615
16. Yao, T., and Cohen, R. E. (2002) Nature 419, 403-407
17. Wilson, S. M., Bhattacharyya, B., Rachel, R. A., Coppola, V., Tessarollo, L., Householder, D. B., Fletcher, C. F., Miller, R. J., Copeland, N. G., and Jenkins, N. A. (2002) Nat. Genet. 32, 420-425
18. Chernoff, Y. O. (2001) Mutat. Res. 488, 39-64
19. Amerik, A. Y., Li, S. J., and Hechstrasser, M. (2000) Biol. Chem. 381, 981-992
20. Chernoff, Y. O., Galkin, A. P., Lewitin, E., Chernova, T. A., Newnam, G. P., and Belenkiy, S. M. (2000) Mol. Microbiol. 35, 865-876
21. Chernoff, Y. O., Uptain, S. M., and Lindquist, S. L. (2002) Methods Enzymol. 351, 499-538
22. Chernoff, Y. O., Newnam, G. P., Kumar, J., Allen, K., and Zink, A. D. (1999) Mol. Cell. Biol. 19, 8103-8112
23. Chernoff, Y. O., Lindquist, S. L., Ono, B., Inge-Vechtomov, S. G., and Liebman, S. W. (1995) Science 268, 880-884
24. Sherman, F., Fink, G. R., and Hicks, J. B. (1986) Methods in Yeast Genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
25. Ausubel, F. M., B., R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A., and Struhl, K. (1989) Current Protocols in Molecular Biology, John Wiley & Sons, Inc., New York
26. Finley, D., Sadis, S., Monia, B. P., Boucher, P., Ecker, D. J., Crooke, S. T., and Chau, V. (1994) Mol. Cell. Biol. 14, 5501-5509
27. Derkatch, I. L., Chernoff, Y. O., Kushnirov, V. V., Inge-Vechtemov, S. G., and Liebman, S. W. (1996) Genetics 144, 1375-1386
28. Bailleul, P. A., Newnam, G. P., Steenbergen, J. N., and Chernoff, Y. O. (1999) Genetics 153, 81-94
29. Newnam, G. P., Wegrzyn, R. D., Lindquist, S. L., and Chernoff, Y. O. (1999) Mol. Cell. Biol. 19, 1325-1333
30. Longtine, M. S., McKenzie, A., III, Demarini, D. J., Shah, N. G., Wach, A., Brachat, A., Philippsen, P., and Pringle, J. R. (1998) Yeast 14, 953-961
31. Jones, A. L., Quimby, B. B., Hood, J. K., Ferrigno, P., Keshava, P. H., Silver, P. A., and Corbett, A. H. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 3224-3229
32. Yin, L., Krantz, B., Russell, N. S., Deshpande, S., and Wilkinson, K. D. (2000) Biochemistry 39, 10001-10010
33. Glickman, M. H., Rubin, D. M., Fried, V. A., and Finley, D. (1998) Mol. Cell. Biol. 18, 3149-3162
34. Hochstrasser, M., Johnson, P. R., Arendt, C. S., Amerik, A., Swaminathan, S., Swanson, R., Li, S. J., Laney, J., Pals-Rylaarsdam, R., Nowak, J., and Connerly, P. L. (1999) Philos. Trans. R. Soc. Lond-Biol. Sci. 354, 1513-1522
35. Mayer, A. N., and Wilkinson, K. D. (1989) Biochemistry 28, 166-172
36. Wilkinson, K. D., Cox, M. J., Mayer, A. N., and Frey, T. (1986) Biochemistry 25, 6644-6649
37. Miller, R. J., and Wilson, S. M. (2003) Trends Pharmacol. Sci. 24, 18-23
38. Wyndham, A. M., Baker, R. T., and Chelvanayagam, G. (1999) Protein Sci. 8, 1268-1275
39. Keeven, J., Ko, D., Shallom, J., Uccelini, B., and Golin, J. (2002) Curr. Genet 41, 11-19
40. Papa, F. R., and Hochstrasser, M. (1993) Nature 366, 313-319
41. Amerik, A., Swaminathan, S., Krantz, B. A., Wilkinson, K. D., and Hochstrasser, M. (1997) EMBO J. 16, 4826-4838
42. Schnell, J. D., and Hicke, L. (2003) J. Biol. Chem. 278, 35857-35860
43. Dubiel, W., and Gordon, C. (1999) Curr. Biol. 12, R554-R557
44. Pickart, C. M. (1997) FASEB J. 11, 1055-1066
45. Arnason, T., and Ellison, M. J. (1994) Mol. Cell. Biol. 14, 7876-7883
46. Spence, J., Sadis, S., Haas, A. L., and Finley, D. (1995) Mol. Cell. Biol. 15, 1265-1273
47. Swaminathan, S., Amerik, A. Y., and Hochstrasser, M. (1999) Mol. Biol. Cell 10, 2583-2594
48. Spence, J., Gali, R. R., Dittmar, G., Sherman, F., Karin, M., and Finley, D. (2000) Cell 102, 67-76
49. Fleming, J. A., Lightcap, E. S., Sadis, S., Thoroddsen, V., Bulawa, C. E., and Blackman, R. K. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 1461-1466
50. Lee, J. C., and Peter, M. E. (2003) Immunol. Rev. 193, 39-47
51. Kenward, N., Hope, J., Landon, M., and Mayer, R. J. (1994) J. Neurochem. 62, 1870-1877
52. Yedidia, Y., Horonchik, L., Tzaban, S., Yanai, A., and Taraboulos, A. (2001) EMBO J. 20, 5383-5391
53. Jungmann, J., Reins, H. A., Schobert, C., and Jentsch, S. (1993) Nature 361, 369-371
54. Chen, P., and Hochstrasser, M. (1995) EMBO J. 14, 2620-2630
55. Mastrandrea, L. D., You, J., Niles, E. G., and Pickart, C. M. (1999) J. Biol. Chem. 274, 27299-27306
56. Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., and Chen, Z. J. (2000) Cell 103, 351-361
57. Elsasser, S., Gali, R. R., Schwickart, M., Larsen, C. N., Leggett, D. S., Muller, B., Feng, M. T., Tubing, F., Dittmar, G. A., and Finley, D. (2002) Nat. Cell Biol. 4, 725-730
58. Funakoshi, M., Sasaki, T., Nishimoto, T., and Kobayashi, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 745-750
59. Schauber, C., Chen, L., Tongaonkar, P., Vega, I., Lambertson, D., Potts, W., and Madura, K. (1998) Nature 391, 715-718
60. Watkins, J. F., Sung, P., Prakash, L., and Prakash, S. (1993) Mol. Cell. Biol. 13, 7757-7765
61. Lambertson, D., Chen, L., and Madura, K. (2003) Curr. Genet 42, 199-208
62. Russell, S. J., Steger, K. A., and Johnston, S. A. (1999) J. Biol. Chem. 274, 21943-21952
63. Wilkinson, C. R., Wallace, M., Morphew, M., Perry, P., Allshire, R., Javerzat, J. P., McIntosh, J. R., and Gordon, C. (1998) EMBO J. 17, 6465-6476
64. McDonald, H. B., and Byers, B. (1997) J. Cell Biol. 137, 539-553
65. Holzl, H., Kapelari, B., Kellermann, J., Seemuller, E., Sumegi, M., Udvardy, A., Medalia, O., Sperling, J., Muller, S. A., Engel, A., and Baumeister, W. (2000) J. Cell Biol. 150, 119-130
66. Li, T., Naqvi, N. I., Yang, H., and Teo, T. S. (2000) Biochem. Biophys. Res. Commun. 272, 270-275
67. Maytal-Kivity, V., Reis, N., Hofmann, K., and Glickman, M. H. (2002) BMC Biochem. 3, 1-12
68. Guterman, A., and Glickman, M. H. (2003) Yeast 20, (suppl.) S139
69. Finley, D., Tanaka, K., Mann, C., Feldmann, H., Hochstrasser, M., Vierstra, R., Johnston, S., Hampton, R., Haber, J., McCusker, J., Silver, P., Frontali, L., Thorsness, P., Varshavsky, A., Byers, B., Madura, K., Reed, S. I., Wolf, D., Jentsch, S., Sommer, T., Baumeister, W., Goldberg, A., Fried, V., Rubin, D. M., Toh-e, A., et al. (1998) Trends Biochem. Sci. 23, 244-245
70. Glickman, M. H., Rubin, D. M., Coux, O., Wefes, I., Pfeifer, G., Cjeka, Z., Baumeister, W., Fried, V. A., and Finley, D. (1998) Cell 94, 615-623
71. Chen, P., Johnson, P., Sommer, T., Jentsch, S., and Hochstrasser, M. (1993) Cell 74, 357-369