Etiopathogenesis of systemic lupus erythematosus: Itineraries of Three Troikas

Systemic Lupus Erythematosus, Fourth Edition

Volumn , Issue , 2004, Pages 93-107

  Alarcón Segovia, Donato ^a   Alarcón Riquelme, Marta E ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 17244374423     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012433901-9/50006-5     Document Type: Chapter

References (144)

1. D. Alarcón-Segovia (1984) The pathogenesis of immune dysregulation in systemic lupus erythematosus: A Troika. J. Rheumatol. 11 588.
2. M.C. Hochberg (1987) The application of genetic epidemiology to systemic lupus erythematosus. J. Rheumatol. 14 867.
3. J.S. Lawrence, C.L. Martins and G.L. Drake (1987) A family survey of lupus erythematosus 1. Heritability. J. Rheumatol. 14 913.
4. J.P. Hugot, M. Chamaillard and H. Zouali (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 599.
5. S.R. Block (1993) Twin studies: Genetic factors are important. Arthritis Rheum. 36 135.
6. D. Deapen, A. Escalante, L. Weinrib, et al. (1992) A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis Rheum. 35 311.
7. M. Reichlin, J.B. Harley and M.D. Lockshin (1992) Serologic studies of monozygotic twins with systemic lupus erythematosus. Arthritis Rheum. 35 457.
8. J.E. Moore and W.B. Lutz (1955) The natural history of systemic lupus erythematosus: An approach to its study through chronic biologic false positive reactors. J. Chron. Dis. 1 297.
9. M.R. Arbuckle, J.A. James, K.F. Kohalhase, et al. (2001) Development of anti-dsDNA antibodies before the clinical diagnosis of systemic lupus erythematosus. Scand. J. Immunol. 54 211.
10. J.D. Reveille (1991) The molecular genetics of systemic lupus erythematosus and Sjogren's syndrome. Curr. Opin. Rheumatol. 3 722.
11. F.C. Arnett and J.D. Reveille (1992) Genetics of systemic lupus erythematosus. Rheum. Dis. Clin. North. Am. 18 865.
12. F.C. Grumet, A. Coukell, J.G. Bodmer, W.F. Bodmer and H.O. McDevitt (1971) Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus: A possible genetic predisposition to disease. N. Engl. J. Med. 285 193.
13. A. Gibofsky, R.J. Winchester, M. Patarroyo, M. Fotino and H.G. Kunkel (1978) Disease associations of the Ialike human alloantigens: Contrasting patterns in rheumatoid arthritis and systemic lupus erythematosus. J. Exp. Med. 148 1728.
14. J.L. Reinertsen, J.H. Klippel, A.H. Johnson, A.D. Steinberg, J.L. Decker and D.L. Mann (1978) B-lymphocyte alloantigens associated with systemic lupus erythematosus. N. Engl. J. Med. 299 515.
15. P.H. Schur, I. Meyer, M. Garovoy and C.B. Carpenter (1982) Associations between systemic lupus erythematosus and the major histocompatibility complex: Clinical and immunological considerations. Clin. Immunol. Immunopathol. 24 263.
16. F.C. Arnett (1985) HLA and genetic predisposition to lupus erythematosus and other dermatologic disorders. J. Am. Acad. Dermatol. 13 472.
17. J.A. James, K.M. Kaufman, A.D. Farris, E. Taylor-Albert, T.J. Lehman and J.B. Harley (1997) An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus. J. Clin. Invest. 100 3019.
18. L. Morel, U.H. Rudofsky, J.A. Longmate, J. Schiffenbauer and E.K. Wakeland (1994) Polygenic control of susceptibility to murine systemic lupus erythematosus. Immunity 1 219.
19. D.H. Kono, R.W. Burlingame and D.G. Owens (1994) Lupus susceptibility loci in New Zealand mice. Proc. Natl. Acad. Sci. USA 91 10168.
20. S.J. Rozzo, J.D. Allard, D. Choubey, et al. (2001) Evidence for an interferon-inducible gene, Ifi202, in the susceptibility ot systemic lupus. Immunity 15 435.
21. L. Morel, K.R. Blenman, B.P. Croker and E. Wakeland (2001) The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc. Natl. Acad. Sci. USA 98 1787.
22. Y.W. Song, C.W. Han, S.W. Kang, et al. (1998) Abnormal distribution of Fc gamma receptor type IIa polymorphisms in Korean patients with systemic lupus erythematosus. Arthritis Rheum. 41 421.
23. A.J. Duits, H. Bootsma, R.H. Derksen, et al. (1995) Skewed distribution of IgG Fc receptor IIa (CD 32) polymorphism is associated with renal disease in systemic lupus erythematosus patients. Arthritis Rheum. 38 1832.
24. K. Manger, R. Repp, B.M. Spriewald, et al. (1998) Fc gamma receptor IIa polymorphism in Caucasian patients with systemic lupus erythematosus: Association with clinical symptoms. Arthritis Rheum. 41 1181.
25. M. Botto, E. Theodoridis, E.M. Thompson, et al. (1996) Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): No association with disease. Clin. Exp. Immunol. 104 264.
26. J. Wu, J.C. Edberg, P.B. Redecha, et al. (1997) A novel polymorphism of Fc gammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. J. Clin. Invest. 100 1059.
27. H.R. Koene, M. Kleijer, A.J. Swaak, et al. (1998) The Fc gammaRIIIA- 158F allele is a risk factor for systemic lupus erythematosus. Arthritis Rheum. 41 1813.
28. E. Lander and L. Kruglyak (1995) Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nature Genet. 11 241.
29. A.K. Lindqvist, K. Steinsson, B. Johanneson, et al. (2000) A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q. J. Autoimmun. 14 169.
30. K.L. Moser, B.R. Neas, J.E. Salmon, et al. (1998) Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees. Proc. Natl. Acad. Sci. USA 95 14869.
31. P.M. Gaffney, G.M. Kearns, K.B. Shark, et al. (1998) A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc. Natl. Acad. Sci. USA 95 14875.
32. P.M. Gaffney, W.A. Ortmann, S.A. Selby, et al. (2000) Genome screening in human systemic lupus erythematosus: Results from a second Minnesota cohort and combined analyses of 187 sib-pair families. Am. J. Hum. Genet. 66 547.
33. R. Shai, F.P. Quismorio Jr., L. Li, et al. (1999) Genomewide screen for systemic lupus erythematosus susceptibility genes in multiplex families. Hum. Mol. Genet. 8 639.
34. V. magnusson, A.K. Lindqvist, C. Castillejo-Lopez, et al. (2000) Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus. Genomics 70 307.
35. M.J. Daly, J.D. Rioux, S.F. Schaffner, T.J. Hudson and E.S. Lander (2001) High-resolution haplotype structure in the human genome. Nature Genet. 29 229.
36. D.E. Weeks, E. Sobel, J.R. O'Connell and K. Lange (1995) Computer programs for multilocus haplotyping of general pedigrees. Am. J. Hum. Genet. 56 1506.
37. N. Patil, A.J. Berno, et al. (2001) Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 294 1719.
38. E.J. Davies, G. Steers, W.E. Olliver, et al. (1995) Relative contributions of HLA-DQA and complement C4A loci in determining susceptibility to systemic lupus erythematosus. Br. J. Rheumatol. 34 221.
39. G.H. Hong, H.Y. Kim, F. Takeuchi, et al. (1994) Association of complement C4 and HLA-DR alleles with systemic lupus erythematosus in Koreans. J. Rheumatol. 21 442.
40. S. Skarsvag (1995) The importance of C4A null genes in Norwegian patients with systemic lupus erythematosus. Scand. J. Immunol. 42 572.
41. J. Granados, G. Vargas-Alarcón, F. Andrade, et al. (1996) The role of HLA-DR alleles and complotypes though the ethnic barrier in systemic lupus erythematosus in Mexicans. Lupus 5 182.
42. H. Kaneoka, K.C. Hsu, Y.L. Takeda, G.C. Sharp and R.W. Hoffman (1992) Molecular genetic analysis of HLA-DR and HLA-DQ genes among anti-U1-70-kd autoantibody positive connective tissue disease patients. Arthritis Rheum. 35 83.
43. M.E. Kemp, J.P. Atkinson and V.M. Skanes (1987) Deletion of C4A genes in patients with systemic lupus erythematosus. Arthritis Rheum. 30 1015.
44. J.D. Reveille, M.J. MacLeod and K. Whitington (1991) Specific amino acids residues in the second hypervariable region of HLA-DQA1 and DQB1 chain genes promote Ro (SS-A/La(SS-B autoantibody responses. J. Immunol. 146 3871.
45. A. Rascu, R. Repp, N.A. Westerdaal, J.R. Alden and J.G. van de Winkel (1997) Clinical relevance of Fc gamma receptor polymorphism. Ann. N.Y. Acad. Sci. 815 382.
46. J.E. Salmon, S. Millard, L.A. Schachter, et al. (1996) FcγRIIA alleles are heritable risk factors for lupus nephritis in African Americans. J. Clin. Invest. 97 1348.
47. A.J. Duits, H. Bootsman, R.H. Derksen, et al. (1995) Sw? kewed distribution of IgG Fc receptor lia (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus. Arthritis Rheum. 18 1832.
48. M. Botto, E. Theodoridis, E.M. Thompson, et al. (1996) Fc gamma RIIa polymorphism in systemic lupus erythematosus (SLE): No association with disease. Clin. Exp. Immunol. 104 264.
49. J. Wu, J.C. Edberg, P.B. Redecha, et al. (1997) A novel polymorphism of FcγRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. J. Clin. Invest. 100 1059.
50. R. Clynes, C. Dumitru and J.V. Ravetch (1998) Uncoupling of immune complex formation and kidney damage in autoimmune glom erulonephritis. Science 279 1052.
51. R. Watanabe-Fukunaga, C.I. Brennan, N.G. Copeland, et al. (1992) Lymphoproliferative disorder in mice explained by defects in as antigen that mediates apoptosis. Nature 356 314.
52. F. Rieux-Laucat, F. Le Deist, C. Hivroz, et al. (1995) Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268 1347.
53. G.H. Fisher, F.J. Rosenberg, S.E. Straus, et al. (1995) Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81 935.
54. E. Mysler, P. Bini, J. Drappa, et al. (1994) The apoptosis-1/fas protein in human systemic lupus erythematosus. J. Clin. Invest. 93 1029.
55. J.B. Howie and B.J. Helyer (1968) The immunology and pathology of NZB mice. Adv. Immunol. 9 215.
56. E.S. Lander and D. Botstein (1989) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121 185.
57. L. Kruglyak and E.S. Lander (1995) High resolution genetic mapping of complex traits. Am. J. Hum. Genet. 56 1212.
58. S.L. Peng, J. Moslehi, M.E. Robert and J. Craft (1998) Perforin protects against autoimmunity in lupus-prone mice. J. Immunol. 160 652.
59. M.L. Watson, J.K. Rao, G.S. Gilkeson, et al. (1992) Genetic analysis of MRL-1pr mice: Relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J. Exp. Med. 176 1645.
60. H. Carlsten, R. Holmdahl and A. Tarkowski (1991) Analysis of the genetic encoding of oestradiol suppression of delayed-type hypersensitivity in (NZBxNZW) F1 mice. Immunology 73 186.
61. J.E. Brick, D.A. Wilson and S.E. Walker (1985) Hormonal modulation of responses to thymus-independent and thymus-dependent antigens in autoimmune NZB/W mice. J. Immunol. 134 4693.
62. M. Blank, S. Mendlovic, H. Fricke, et al. (1990) Sex hormone involvement in the induction of experimental systemic lupus erythematosus by a pathogenic anti-DNA idiotype in naive mice. J. Rheumatol. 17 311.
63. H. Carlsten, N. Nilsson, R. Jonsson and A. Tarkowski (1991) Differential effects of estrogen in murine lupus: Acceleration of glomerulonephritis and amelioration of T cell-mediated lesions. J. Autoimmun. 4 845.
64. K.A. Melez, J.P. Reeves and A.D. Steinberg (1978) Modification of murine lupus by sex hormones. Ann. Immunol. (Paris) 129C 707.
65. C. Lavalle, E. Loyo, R. Paniagua, et al. (1990) Correlation study between prolactin and androgens in male patients with systemic lupus erythematosus. J. Rheumatol. 14 268.
66. M. Folomeev, T. Prokaeva, V. Nassonova, et al. (1990) Prolactin levels in men with SLE and RA. J. Rheumatol. 17 1569.
67. D.H. Russell, R. Kibler, L. Matrisian, et al. (1985) Prolactin receptors on human T and B lymphocytes: Antagonism of prolactin binding by cyclosporine. J. Immunol. 134 3027.
68. Y. Pellegrini, J.J. Lebrun, S. Ali and P.A. Kelly (1992) Expression of prolactin and its receptor in human lymphoid cells. Mol. Endocrinol. 6 1023.
69. A. Vidaller, L. Llorente, F. Larrea, et al. (1986) T-cell dysregulation in patients with hyperprolactinemia: Effect of bromocriptine treatment. Clin. Immunol. Immunopathol. 38 337.
70. F. Larrea, A. Martínez-Castillo, V. Cabrera, et al. (1997) A bioactive 60-kilodalton prolactin species is preferentially secreted in cultures of mitogen-stimulate and non-stimulated peripheral blood mononuclear cells from subjects with systemic lupus erythematosus. J. Clin. Endocrinol. Metab. 82 3664.
71. A.M. Jacobi, W. Rohde, H.-D. Volk, et al. (2001) Prolactin enhances the in vitro production of IgG in peripheral blood mononuclear cells from patients with systemic lupus erythematosus but not from healthy controls. Ann. Rheum. Dis. 60 242.
72. R.G. Lahita, H.L. Bradlow, H.G. Kunkel and J. Fishman (1979) Alterations of estrogen metabolism in systemic lupus erythematosus. Arthritis Rheum. 22 1195.
73. R.G. Lahita, H.L. Bradlow, H.G. Kunkel and J. Fishman (1981) Icreased 16α-hydroxylation of estradiol in systemic lupus erythematosus. J. Clin. Endocrinol. Metab. 53 174.
74. R. Bucala, R.G. Lahita, J. Fishman and A. Cerami (1985) Increased levels of 16 alpha-hydroxyestronemodified protein in pregnancy and systemic lupus erythematosus. J. Clin. Endocrinol. Metab. 60 841.
75. R.G. Lahita, H.L. Bradlow, E. Ginzler and S. Pang (1987) New M: Low plasma androgens in women with systemic lupus erythematosus. Arthritis Rheum 30 241.
76. R.G. Lahita, H.L. Bradlow, J. Fishman and H.G. Kunkel (1982) Abnormal estrogen and androgen metabolism in the human with systemic lupus erythematosus. Am. J. Kidney Dis. Suppl. 2 206.
77. C.G. Mackworth-Young, A.L. Parke, K.D. Morley, K. Fotherby and G.R.V. Hughes (1983) Sex hormones in male patients with systemic lupus erythematosus: A comparison with other disease groups. Eur. J. Rheum. Inflamm. 6 228.
78. J.F. Sequeira, G. Keser, B. Greenstein, et al. (1993) Systemic lupus eryematosus: Sex hormones in male patients. Lupus 2 315.
79. R.G. Lahita and H.L. Bradlow (1987) Klinefelter's syndrome: Hormone metabolism in hypogonadal males with systemic lupus erithematosus. J. Rheumatol. 14(Suppl. 3), 154.
80. R.L. Woosley, D.E. Drayer, M.D. Reidenberg, et al. (1978) Effect of acetylatorphenotype on the rate at which procainamide induces antinuclear antibodies and the lupus syndrome. N. Engl. J. Med 298 1157.
81. M.M. Reidenberg, M. Levy, D.E. Drayer, E. Zylber-Katz and W.C. Robbins (1980) Acetylator phenotype in idiopathic systemic lupus erythematosus. Arthritis Rheum. 23 569.
82. J.A. James, K.M. Kaufman, A.D. Farris, et al. (1997) An increased prevalence of Epstein-Barr virus infection in young patients suggest a possible etiology for systemic lupus erythematosus. J. Clin. Invest. 100 3019.
83. J.H. Vaughan (1997) The Epstein-Barr virus and systemic lupus erythematosus. J. Clin. Invest. 100 2939.
84. M. Satoh and W.H. Reeves (1994) Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane. J. Exp. Med. 180 2341.
85. S.L. Kalled, A.H. Cutler and L.C. Burkly (2001) Apoptosis and altered dentritic cell home ostasis in lupus nephritis are limited by anti-CD154 treatment. J. Immunol. 167 1740.
86. R. Gonzáez-Amaro, J. Alcocer-Varela and D. Alarcón-Segovia (1988) Natural killer cell activity in the systemic connective tissue disease. J. Rheumatol. 15 223.
87. D.A. Horwitz, J.D. Gray, K. Ohtsuka, et al. (1997) The immunoregulatory effects of NK cells: The role of TGF-β and implications for autoimmunity. Immunol. Today 18 538.
88. S. Yamagiwa, J.D. Gray, S. Hashimoto and D.A. Horwitz (2001) A role of TGF-β in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J. Immunol. 166 7282.
89. A. Ruíz-Argüelles, D. Alarcón-Segovia, L. Llorente and J.A. Del Giudice-Knipping (1980) Heterogeneity of the spontaneously expanded and mitogen-induced generation of suppressor cell function of cells on B cells in systemic lupus erythematosus. Arthritis Rheum. 23 1004.
90. E.M. Shevach (2000) Regulatory T cells in autoimmunity. Annu. Rev. Immunol. 18 423.
91. M. Converso, M.T. Bertero, A. Vallario and F. Caligaris-Cappio (2000) Analysis of T cell clones in systemic lupus erythematosus. Haematologica 85 118.
92. E. Robak, H. Niewiadomska, T. Robak, J. Bartkowiak, L. Pomorski and Sysa-Jedrzejowska (2001) Lymphocytes Tγδ in clinically normal skin and peripheral bood of patients with systemic lupus erythematosus and their correlation with disease activity. Mediators Inflamm. 10 179.
93. D.A. Horwitz, J.D. Gray, S.C. Behredsen, M. Kubin, et al. (1998) Decreased production of interleukin-12 and other Th-1-type cytokines in patients with recentonset systemic lupus erythematosus. Arthritis Rheum. 41 838.
94. D. Alarcón-Segovia, J. Alcocer-Varela and E. Díaz-Jouanen (1985) The connective tissue diseases as disorders of immune regulation. Clin. Rheum. Dis. 11 451.
95. B. Liang, M.J. Kashgarian, A.H. Sharpe and M.J. Mamula (2000) Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus. J. Immunol. 165 3436.
96. N. Mishra, I.U. Khan, G.C. Tsokos and G.M. Kammer (2000) Association of deficient type II protein kinase A activity with aberrant nuclear translocation of the RIIB subunit in systemic lupus erythematosus T lymphocytes. J. Immunol. 165 2830.
97. J.G. Cyster and C.C. Godnow (1995) Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate. Immunity 3 691.
98. L. Mandik-Nayak, A. Bui, H. Noorchashm, A. Eaton and J. Erikson (1997) Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: Localization to the T-B interface of the splenic follicle. J. Exp. Med. 186 1257.
99. A.R. Cabral and E. Alarcón-Segovia (1996) Bromelain-treat erythrocyte autoantibodies. J.B. Peter, Y. Shoenfeld (Eds) Auto antibodies Amsterdam: Elsevier Science 120-125.
100. O. Chan and M.J. Shlomchlk (1998) A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice. J. Immunol. 160 51.
101. M. González, F. Mackay, J.L. Browning, M.H. Kosko-Vilbois and R.J. Noelle (1999) The sequential role of lymphotoxin and B cell in the development of splenic follicles. J. Exp. Med. 187 997.
102. P.E. Lipsky (2001) Systemic lupus erythematosus: An autoimmune disease of B cell hyperactivity. Nature Immunol. 2 764.
103. J. Zhang, V. Roschke, K.P. Baker, et al. (2001) A role for B lymphocyte stimulator in systemic lupus erythematosus. J. Immunol. 166 6.
104. M. Odendahl, A. Jacobi, A. Hansen, et al. (2000) Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J. Immunol. 165 5970.
105. J. Alcocer-Varrela and D. Alarcón-Segovia (1982) Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J. Clin. Invest. 69 1388.
106. J. Alcocer-Varela, A. Laffón and D. Alarcón-Segovia (1984) Defective monocyte production of and T lymphocyte response to, interleukin-1 in the peripheral blood of patients with systemic lupus erythematosus. Clin. Exp. Immunol. 55 125.
107. Y.P. Huang, L.H. Pertin, P.A. Miescher and R.H. Zubler (1988) Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus. J. Immunol. 141 827.
108. E.E. Solomou, Y.-T. Juang, M.F. Gourley, G.M. Kammer and G.C. Tsokos (2001) Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus. J. Immunol. 166 4216.
109. S. Hirose, G. Ueda, K. Noguchi, et al. (1986) Requirement of H-2 heterozygozity for autoimmunity in (NZBxNZW)F1 hybrid mice. Eur. J. Immunol. 16 1631.
110. E. Martínez-Cordero, J. Alcocer-Varela and D. Alarcón-Segovia (1986) Stimulating and differentiation factors for human B lymphocytes in systemic lupus erythematosus. Clin. Exp. Immunol. 65 598.
111. L. Llorente, Y. Richaud-Patin, J. Wijdenes, et al. (1993) Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus. Eur. Cytokine. Netw. 4 421.
112. L. Llorente, W. Zou, Y. Levy, et al. (1995) Role of interleukin-10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J. Exp. Med. 181 839.
113. L. Llorente, Y. Richaud-Patin and C. García-Padilla (2000) Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus. Arthritis Rheum. 43 1790.
114. L. Llorente, Y. Richaud-Patin, J. Coudere, et al. (1997) Dysregulation of interleukin-10 production in relatives of patients with systemic lupus erythematosus. Arthritis Rheum. 40 1429.
115. J. Eskdale, P. Wordsworth, S. Bowman, M. Field and G. Gallagher (1977) Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus. Tissue Antigen 49 635.
116. M. Lazarus, A.H. Hajeer, D. Turner, et al. (1997) Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus. J. Rheumatol. 24 2314.
117. M.E. Alarcón-Riquelme, A.K.B. Lindqvist, Y. Jonasson, et al. (1999) Genetic analysis of the contribution of IL-10 to systemic lupus erythematosus. J. Rheumatol. 26 2148.
118. M.T. Vargas, K. Gustilo, D.M. Andrea, et al. (1997) Structural features of nephritogenic lupus autoantibodies. Immun. Methods 11 62.
119. D. Alarcón-Segovia and E. Díaz-Jouanen (1980) Lupus subsets: Relationship to genetic and environmental factors. Semin. Arthritis Rheum. 10 18.
120. E.R. Eivazova, J.M. McDonnell, B.J. Sutton and N.A. Staines (2001) Specificity and binding kinetics of murine lupus anti-DNA monoclonal antibodies implicate different stimuli for their production. Immunology 101 171.
121. D. Male (1996) Hypersensitivity: Type II. Y. Roitt, J. Brostoff, D. Male (Eds) Immunology London: Mosby 23.1-23.10.
122. D. Buskila and Y. Shoenfeld (1994) Anti-DNA antibodies: Their idiotypes and SLE. Clin. Rev. Allergy. 12 237.
123. H.M. Dijstelbloem, M. Bijl, R. Fijnheer, et al. (2001) Fcγ receptor polymorphisms in systemic lupus erythematosus: Association with disease and in clearance of immune complexes. Arthritis Rheum. 43 2793.
124. D. Alarcón-Segovia and A.R. Cabral (1994) Antiphospholipid antibodies: Where do they come from? Where do they go? J. Rheumatol. 21 982.
125. R.A.S. Roubey, R.A. Eisenberg, M.F. Harper and J.B. Winfield (1995) “Anticardiolipin” autoantibodies recognize B2-glycoprotein I in the absence of phospholipid: Importance of antigen density and bivalent binding. J. Immunol. 154 954.
126. D. Alarcón-Segovia and A.R. Cabral (1996) The antiphospholipid/cofactor syndromes. J. Rheumatol. 23 1319.
127. A.R. Cabral, J. Cabiedes and D. Alarcón-Segovia (1990) Hemolytic anemia related to an IgM autoantibody to phosphatidylcholine that binds in vitro to stored and to bromelain-treated human erythrocytes. J. Autoimmun. 3 773.
128. D. Alarcón-Segovia, M.E. Pérez-Vázquez, A.R. Villa, C. Drenkard and J. Cabiedes (1992) Preliminary classification criteria for the antiphospholipid syndrome within systemic lupus erythematosus. Semin. Arthritis Rheum. 21 275.
129. A.R. Cabral, J. Cabiedes and D. Alarcón-Segovia (1992) Phospholipid specificity and requirement of β2-glycoprotein-1 for reactivity of antibodies from patients with primary antiphospholipid syndrome. J. Autoimmun. 5 787.
130. A. Leanos, D. Pascoe, A. Fraga and F. Blanco-Favela (1998) Anti-prolactin autoantibodies in systemic lupus erythematosus patients with associated hyperprolactinemia. Lupus 7 398.
131. G.J. Ruíz-Argüelles, J. Garcés-Eisele, D. Alarcón-Segovia and A. Ruíz-Argüelles (1996) Activated protein C resistance phenotype and genotype in patients with primary antiphospholipid syndrome. Blood Coagul. Fibrinol. 7 344.
132. D. Alarcón-Segovia, A. Ruíz-Argüelles and E. Fishbein (1978) Antibody to nuclear ribonucleoprotein penetrates live human mononuclear cells through Fc receptors. Nature 271 67.
133. D. Alarcón-Segovia, A. Ruíz-Argüelles and L. Llorente (1996) Broken dogma: Penetration of autoantibodies into living cells. Immunol. Today 17 163.
134. D. Alarcón-Segovia, A. Ruíz-Argüelles and L. Llorente (1979) Antibody penetration into living cells. II. Antiribonucleoprotein IgG penetrates into T lymphocytes causing their deletion and the abrogation of suppressor function. J. Immunol. 122 1855.
135. D. Alarcón-Segovia, L. Llorente and A. Ruíz-Argüelles (1982) Antibody penetration into living cells. III. Effect of antiribonucleoprotein IgG on the cell cycle of human peripheral blood mononuclear cells. Clin. Immunol. Immunopathol. 23 22.
136. D. Alarcón-Segovia, L. Llorente, E. Fishbein and E. Díaz-Jouanen (1982) Abnormalities in the content of nucleic acids of peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Arthritis Rheum. 25 304.
137. D. Alarcón-Segovia, L. Llorente, A. Ruíz-Argüelles, Y. Richaud-Patin and B. Pérez-Romano (1995) Penetration of anti-DNA antibodies into mononuclear cells (MNC) causes apoptosis. Arthritis Rheum. 38 S182. [Abstract]
138. D. Alarcón-Segovia, L. Llorente and A. Ruíz-Argüelles (1996) The penetration of autoantibodies into cell may induce tolerance to self by apoptosis of autoreactive lymphocytes and cause autoimmune disease by dysregulation and/or of cell damage. J. Autoimmun. 9 295.
139. S. Schmid-Acevedo, B. Pérez-Romano and A. Ruíz-Argüelles (2000) LE cells result from phagocytosis of apoptotic bodies induced by antinuclear antibodies. J. Autoimmun. 15 15.
140. M. Koscec, E. Koren, M. Wolfson-Reichlin, et al. (1997) Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture. J. Immunol. 159 2033.
141. M. Hulsey, R. Goldstein, S. Scully, W. Surbeck and M. Reichlin (1995) Antiribosomal P antibodies in systemic lupus erythematosus: A case-control study correlating hepatic and renal disease. Clin. Immunol. Immunopathol. 74 252.
142. D. Alarcón-Segovia, L. Llorente and A. Ruíz-Argüelles (1996) Autoantibodies that penetrate into living cells. J.B. Peter, Y. Shoenfeld (Eds) Autoantibodies Amsterdam: Elsevier Science 96-102.
143. N. Seddiki, F. Nato, P. Lafaye, Z. Amoura, J.-C.H. Piette and J.-C. Mazié (2001) Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies. J. Immunol. 166 6423.
144. K. Nakamura, M. Robertson, G. Liu, P. Dickie, K. Nakamura, J. Qing-Guo, H. Duff, M. Opas, K. Kavanagh and M. Michalak (2001) Complete heart block and sudden death in mice overexpressing calreticulin. J. Clin. Invest. 107 1245.