메뉴 건너뛰기




Volumn 20, Issue 3, 2000, Pages 636-644

p53, p21(WAF1/CIP1), and MDM2 involvement in proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells

Author keywords

Cell line; MDM2; p21(WAF1 CIP1); p53; SV 40; Vascular smooth muscle

Indexed keywords

PROTEIN MDM2; PROTEIN P21; PROTEIN P53; VIRUS LARGE T ANTIGEN;

EID: 0034021808     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.3.636     Document Type: Article
Times cited : (19)

References (37)
  • 1
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 2
    • 0031969967 scopus 로고    scopus 로고
    • Proliferation and the monoclonal origin of atherosclerotic lesions
    • Schwartz SM, Murry CE. Proliferation and the monoclonal origin of atherosclerotic lesions. Annu Rev Med. 1998;49:437-460.
    • (1998) Annu Rev Med , vol.49 , pp. 437-460
    • Schwartz, S.M.1    Murry, C.E.2
  • 4
    • 0025063879 scopus 로고
    • Rat vascular smooth muscle cells immortalized with SV40 large T antigen possess defined smooth muscle cell characteristics including growth inhibition by heparin
    • Reilly CF. Rat vascular smooth muscle cells immortalized with SV40 large T antigen possess defined smooth muscle cell characteristics including growth inhibition by heparin. J Cell Physiol. 1990;142: 342-351.
    • (1990) J Cell Physiol , vol.142 , pp. 342-351
    • Reilly, C.F.1
  • 5
    • 0025781917 scopus 로고
    • Characterization of human vascular smooth muscle cells transformed by the early genetic region of SV40 virus
    • Legrand A, Greenspan P, Nagpal ML, Nachtigal SA, Nachtigal M. Characterization of human vascular smooth muscle cells transformed by the early genetic region of SV40 virus. Am J Pathol. 1991;139:629-640.
    • (1991) Am J Pathol , vol.139 , pp. 629-640
    • Legrand, A.1    Greenspan, P.2    Nagpal, M.L.3    Nachtigal, S.A.4    Nachtigal, M.5
  • 6
    • 0030043373 scopus 로고    scopus 로고
    • Conditional differentiation of heart-and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen
    • Jahn L, Sadoshima J, Greene A, Parker C, Morgan KG, Izumo S. Conditional differentiation of heart-and smooth muscle-derived cells transformed by a temperature-sensitive mutant of SV40 T antigen. J Cell Sci. 1996;109:397-407.
    • (1996) J Cell Sci , vol.109 , pp. 397-407
    • Jahn, L.1    Sadoshima, J.2    Greene, A.3    Parker, C.4    Morgan, K.G.5    Izumo, S.6
  • 7
    • 0028827560 scopus 로고
    • Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice: Characterization of cell lines with distinct properties
    • Ehler E, Jat PS, Noble MD, Citi S, Draeger A. Vascular smooth muscle cells of H-2Kb-tsA58 transgenic mice: characterization of cell lines with distinct properties. Circulation. 1995;95:3289-3296.
    • (1995) Circulation , vol.95 , pp. 3289-3296
    • Ehler, E.1    Jat, P.S.2    Noble, M.D.3    Citi, S.4    Draeger, A.5
  • 8
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88:323-331.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 10
    • 0026769713 scopus 로고
    • An immunochemical analysis of the human nuclear phosphoprotein p53: New monoclonal antibodies and epitope mapping using recombinant p53
    • Vojtesek B, Bartek J, Midgley CA, Lane DP. An immunochemical analysis of the human nuclear phosphoprotein p53: new monoclonal antibodies and epitope mapping using recombinant p53. J Immunol Methods. 1992;151:237-244.
    • (1992) J Immunol Methods , vol.151 , pp. 237-244
    • Vojtesek, B.1    Bartek, J.2    Midgley, C.A.3    Lane, D.P.4
  • 12
    • 0019401161 scopus 로고
    • Monoclonal antibodies specific for simian virus 40 tumor antigens
    • Harlow E, Crawford LV, Pim DC, Williamson NM. Monoclonal antibodies specific for simian virus 40 tumor antigens. J Virol. 1981;39: 861-869.
    • (1981) J Virol , vol.39 , pp. 861-869
    • Harlow, E.1    Crawford, L.V.2    Pim, D.C.3    Williamson, N.M.4
  • 14
    • 0028341062 scopus 로고
    • Analysis of proviral integration in human mammary epithelial cell lines immortalized by retroviral infection with a temperature-sensitive SV40 T-antigen construct
    • Stamps AC, Davies SC, Burman J, O'Hare MJ. Analysis of proviral integration in human mammary epithelial cell lines immortalized by retroviral infection with a temperature-sensitive SV40 T-antigen construct. Int J Cancer. 1994;57:865-874.
    • (1994) Int J Cancer , vol.57 , pp. 865-874
    • Stamps, A.C.1    Davies, S.C.2    Burman, J.3    O'Hare, M.J.4
  • 15
    • 0024592630 scopus 로고
    • Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature
    • Jat PS, Sharp PA. Cell lines established by a temperature-sensitive simian virus 40 large-T-antigen gene are growth restricted at the nonpermissive temperature. Mol Cell Biol. 1989;9:1672-1681.
    • (1989) Mol Cell Biol , vol.9 , pp. 1672-1681
    • Jat, P.S.1    Sharp, P.A.2
  • 17
    • 0029666060 scopus 로고    scopus 로고
    • Effects of angiotensin II on the expression of the early growth response gene c-fos and DNA synthesis in human vascular smooth muscle cells
    • Patel MK, Betteridge LJ, Hughes AD, Clunn GF, Schachter M, Shaw RJ, Sever PS. Effects of angiotensin II on the expression of the early growth response gene c-fos and DNA synthesis in human vascular smooth muscle cells. J Hypertens. 1996;14:341-347.
    • (1996) J Hypertens , vol.14 , pp. 341-347
    • Patel, M.K.1    Betteridge, L.J.2    Hughes, A.D.3    Clunn, G.F.4    Schachter, M.5    Shaw, R.J.6    Sever, P.S.7
  • 18
    • 0027163464 scopus 로고
    • Replicative senescence of human fibroblast-like cells in culture
    • Cristofalo VJ, Pignolo RJ. Replicative senescence of human fibroblast-like cells in culture. Physiol Rev. 1993;73:617-638.
    • (1993) Physiol Rev , vol.73 , pp. 617-638
    • Cristofalo, V.J.1    Pignolo, R.J.2
  • 19
    • 0027472323 scopus 로고
    • Cellular and molecular mechanisms of aging
    • Dice JF. Cellular and molecular mechanisms of aging. Physiol Rev. 1993;73:149-159.
    • (1993) Physiol Rev , vol.73 , pp. 149-159
    • Dice, J.F.1
  • 20
    • 0028365839 scopus 로고
    • The transforming activity of simian virus 40 large tumor antigen
    • Manfredi JJ, Prives C. The transforming activity of simian virus 40 large tumor antigen. Biochim Biophys Acta. 1994;1198:65-83.
    • (1994) Biochim Biophys Acta , vol.1198 , pp. 65-83
    • Manfredi, J.J.1    Prives, C.2
  • 21
    • 0027496456 scopus 로고
    • The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen
    • Shay JW, Van Der Haegen BA, Ying Y, Wright WE. The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen. Exp Cell Res. 1993;209:45-52.
    • (1993) Exp Cell Res , vol.209 , pp. 45-52
    • Shay, J.W.1    Van Der Haegen, B.A.2    Ying, Y.3    Wright, W.E.4
  • 22
    • 0032489850 scopus 로고    scopus 로고
    • Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques
    • Bennett MR, MacDonald K, Chan S-W, Boyle JL, Weissberg PL. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques. Circ Res. 1998;82:704-712.
    • (1998) Circ Res , vol.82 , pp. 704-712
    • Bennett, M.R.1    MacDonald, K.2    Chan, S.-W.3    Boyle, J.L.4    Weissberg, P.L.5
  • 23
    • 0027093642 scopus 로고
    • Heparin inhibition of human vascular smooth muscle cell hyperplasia
    • Chan P, Mill S, Mulloy B, Kakkar V, Demoliou-Mason C. Heparin inhibition of human vascular smooth muscle cell hyperplasia. Int Angiol. 1992;11:261-267.
    • (1992) Int Angiol , vol.11 , pp. 261-267
    • Chan, P.1    Mill, S.2    Mulloy, B.3    Kakkar, V.4    Demoliou-Mason, C.5
  • 24
    • 0029671050 scopus 로고    scopus 로고
    • Suppression of platelet-derived growth factor alpha-and beta-receptor mRNA levels in human fibroblasts by SV40 T/T antigen
    • Wang JL, Nister M, Bongcamrudloff E, Ponten J, Westermark B. Suppression of platelet-derived growth factor alpha-and beta-receptor mRNA levels in human fibroblasts by SV40 T/T antigen. J Cell Physiol. 1996;166:12-21.
    • (1996) J Cell Physiol , vol.166 , pp. 12-21
    • Wang, J.L.1    Nister, M.2    Bongcamrudloff, E.3    Ponten, J.4    Westermark, B.5
  • 25
    • 0031825703 scopus 로고    scopus 로고
    • Histological patterns of atherosclerotic plaques in unstable angina patients vary according to clinical presentation
    • Mann JM, Kaski JC, Pereira WI, Arie S, Ramirez JA, Pileggi F. Histological patterns of atherosclerotic plaques in unstable angina patients vary according to clinical presentation. Heart. 1998;80:19-22.
    • (1998) Heart , vol.80 , pp. 19-22
    • Mann, J.M.1    Kaski, J.C.2    Pereira, W.I.3    Arie, S.4    Ramirez, J.A.5    Pileggi, F.6
  • 28
    • 0027459198 scopus 로고
    • MDM2 expression is induced by wild type p53 activity
    • Barak Y, Juven T, Haffner R, Oren M. MDM2 expression is induced by wild type p53 activity. EMBO J. 1993;12:461-468.
    • (1993) EMBO J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 29
    • 0026649648 scopus 로고
    • The MDM-2 oncogene product forms a complex with p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Oslon DC, George D, Levine AJ. The MDM-2 oncogene product forms a complex with p53 protein and inhibits p53-mediated transactivation. Cell. 1992;69:1237-1245.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Oslon, D.C.3    George, D.4    Levine, A.J.5
  • 30
  • 31
    • 0031875104 scopus 로고    scopus 로고
    • Co-expression of p53 and MDM2 in human atherosclerosis: Implications for the regulation of cellularity of atherosclerotic lesions
    • Ihling C, Haendeler J, Menzel G, Hess RD, Fraedrich G, Schaefer HE, Zeiher AM. Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions. J Pathol. 1998;185:303-312.
    • (1998) J Pathol , vol.185 , pp. 303-312
    • Ihling, C.1    Haendeler, J.2    Menzel, G.3    Hess, R.D.4    Fraedrich, G.5    Schaefer, H.E.6    Zeiher, A.M.7
  • 33
    • 0030850752 scopus 로고    scopus 로고
    • E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
    • Hsieh J-K, Fredersdorf S, Kouzarides T, Martin K, Lu X. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 1997;11:1840-1852.
    • (1997) Genes Dev , vol.11 , pp. 1840-1852
    • Hsieh, J.-K.1    Fredersdorf, S.2    Kouzarides, T.3    Martin, K.4    Lu, X.5
  • 34
    • 0029317383 scopus 로고
    • Origins of G1 arrest in senescent human fibroblasts
    • Stein GH, Dulic V. Origins of G1 arrest in senescent human fibroblasts. Bioessays. 1995;17:537-543.
    • (1995) Bioessays , vol.17 , pp. 537-543
    • Stein, G.H.1    Dulic, V.2
  • 35
    • 0029022554 scopus 로고
    • Apoptosis in human atherosclerosis and restenosis
    • Isner JM, Kearney M, Bortman S, Passen J. Apoptosis in human atherosclerosis and restenosis. Circulation. 1995;91:2703-2711.
    • (1995) Circulation , vol.91 , pp. 2703-2711
    • Isner, J.M.1    Kearney, M.2    Bortman, S.3    Passen, J.4
  • 36
    • 0032978142 scopus 로고    scopus 로고
    • The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
    • Guevara NV, Kim HS, Antonova El, Chan L. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med. 1999;5:335-339.
    • (1999) Nat Med , vol.5 , pp. 335-339
    • Guevara, N.V.1    Kim, H.S.2    Antonova, E.3    Chan, L.4
  • 37
    • 0028782754 scopus 로고
    • The role of the p53 protein in the apoptotic response. Phil
    • Lane D, Lu X, Hupp T, Hall PA. The role of the p53 protein in the apoptotic response. Phil Trans R Soc Land B Biol Sci. 1994;345:277-280.
    • (1994) Trans R Soc Land B Biol Sci , vol.345 , pp. 277-280
    • Lane, D.1    Lu, X.2    Hupp, T.3    Hall, P.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.